Hydroxyl-Functional Groups on Graphene Trigger the Targeted Delivery of Antitumor Drugs

2018 ◽  
Vol 14 (8) ◽  
pp. 1420-1429 ◽  
Author(s):  
Mimi Lin ◽  
Suyan Shan ◽  
Peipei Liu ◽  
Liwei Ma ◽  
Libin Huang ◽  
...  
Keyword(s):  
Functional Groups ◽  
Targeted Delivery ◽  
Antitumor Drugs

scholarly journals Functionalized Particles Designed for Targeted Delivery

Polymers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2022
Author(s):  
Teresa Basinska ◽  
Mariusz Gadzinowski ◽  
Damian Mickiewicz ◽  
Stanislaw Slomkowski
Keyword(s):  
Functional Groups ◽  
Self Assembly ◽  
Targeted Delivery ◽  
Direct Synthesis ◽  
Drug Carriers ◽  
Cell Types ◽  
Bioactive Substances ◽  
Particle Preparation ◽  
Specific Receptors ◽  
Micrometer Size

Pure bioactive compounds alone can only be exceptionally administered in medical treatment. Usually, drugs are produced as various forms of active compounds and auxiliary substances, combinations assuring the desired healing functions. One of the important drug forms is represented by a combination of active substances and particle-shaped polymer in the nano- or micrometer size range. The review describes recent progress in this field balanced with basic information. After a brief introduction, the paper presents a concise overview of polymers used as components of nano- and microparticle drug carriers. Thereafter, progress in direct synthesis of polymer particles with functional groups is discussed. A section is devoted to formation of particles by self-assembly of homo- and copolymer-bearing functional groups. Special attention is focused on modification of the primary functional groups introduced during particle preparation, including introduction of ligands promoting anchorage of particles onto the chosen living cell types by interactions with specific receptors present in cell membranes. Particular attention is focused on progress in methods suitable for preparation of particles loaded with bioactive substances. The review ends with a brief discussion of the still not answered questions and unsolved problems.

Development polymeric micellar system for targeted delivery of antitumor drugs

2021 ◽  
Author(s):  
L. Kunitskaya ◽  
T. Zheltonozhskaya ◽  
V. Gerda ◽  
V. Klepko
Keyword(s):  
Targeted Delivery ◽  
Antitumor Drugs ◽  
Micellar System

Expression, Regulation, and Role of an Oligopeptide Transporter: PEPT1 in Tumors

2021 ◽  
Vol 28 ◽  
Author(s):  
Xi Wang ◽  
Yiming Chen ◽  
Yongjuan Wang ◽  
Bangmao Wang ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Malignant Tumor ◽  
Targeted Delivery ◽  
Intestinal Tract ◽  
Malignant Tumors ◽  
Critical Role ◽  
Expression Regulation ◽  
Antitumor Drugs ◽  
Molecular Biomarker ◽  
Tumor Tissues

: PEPT1 is a vital member of the proton-dependent oligopeptide transporters family (POTs). Many studies have confirmed that PEPT1 plays a critical role in the absorption of dipeptides, tripeptides, and pseudopeptides in the intestinal tract. In recent years, several studies have found that PEPT1 is highly expressed in malignant tumor tissues and cells. The abnormal expression of PEPT1 in tumors may be closely related to the progress of tumors, and hence, could be considered as a potential molecular biomarker for the diagnosis, treatment, and prognosis in malignant tumors. Furthermore, PEPT1 can be used as the delivery target to mediate the targeted delivery of antitumor drugs. Herein, the expression, regulation, and role of PEPT1 in tumors in recent years were reviewed.

Enhanced Anti-tumor Activity of Drug through pH-Triggered Release and Dual Targeting by Calcium Phosphate-Covered Mesoporous Silica Vehicles

2021 ◽  
Author(s):  
Juan Liu ◽  
Xixue Hu ◽  
Shubin Jin ◽  
Xing-Jie Liang ◽  
Xiaowei Ma
Keyword(s):  
Controlled Release ◽  
Calcium Phosphate ◽  
Targeted Delivery ◽  
Antitumor Drugs ◽  
Triggered Release ◽  
Dual Targeting ◽  
Rapid Release ◽  
Main Factors ◽  
Anti Tumor Activity

Rapid release and clearance of antitumor drugs in vivo are the main factors to evade the effectiveness of chemotherapeutics. Targeted delivery and controlled release of drugs are the most pressing...

Multifunctional dual-mesoporous silica nanoparticles loaded with a protein and dual antitumor drugs as a targeted delivery system

2019 ◽  
Vol 43 (44) ◽  
pp. 17284-17297 ◽  
Author(s):  
Fangxiang Song ◽  
Yan Li ◽  
Shuai Wang ◽  
Li Zhang ◽  
QianLin Chen
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Delivery System ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Mesoporous Structure ◽  
Antitumor Drugs ◽  
Carboxyl Groups ◽  
System P ◽  
Targeted Delivery System

Herein, dual-mesoporous structure silica (with pore sizes from 2 to 4 nm and from 4 to 16 nm) simultaneously modified with amino and carboxyl groups was successfully synthesized.

Monodisperse mesoporous cobalt ferrite nanoparticles: synthesis and application in targeted delivery of antitumor drugs

2011 ◽  
Vol 21 (25) ◽  
pp. 9185 ◽  
Author(s):  
Sasmita Mohapatra ◽  
Smruti R. Rout ◽  
Swatilekha Maiti ◽  
Tapas K. Maiti ◽  
Asit B. Panda
Keyword(s):  
Targeted Delivery ◽  
Cobalt Ferrite ◽  
Ferrite Nanoparticles ◽  
Antitumor Drugs ◽  
Cobalt Ferrite Nanoparticles ◽  
Nanoparticles Synthesis

Carbon Nanotubes as A High-Performance Platform for Target Delivery of Anticancer Quinones

2019 ◽  
Vol 24 (43) ◽  
pp. 5207-5218 ◽  
Author(s):  
H.V. Grushevskaya ◽  
N.G. Krylova
Keyword(s):  
Carbon Nanotubes ◽  
Targeted Delivery ◽  
High Performance ◽  
Biological Fluid ◽  
Specific Interaction ◽  
Antitumor Drugs ◽  
Anthracycline Antibiotics ◽  
Delivery Platform ◽  
Characteristic Features ◽  
Tumor Microenviroment

<P>Background: In spite of considerable efforts of researchers the cancer deseases remain to be incurable and a percentage of cancer deseases in the structure of mortality increases every year. At that, high systemic toxicity of antitumor drugs hampers their effective use. Because of this fact, the development of nanosystems for targeted delivery of antitumor drugs is one of the leading problem in nanomedicine and nanopharmacy. </P><P> Objective: To critically examine the modern strategies for carbon nanotubes (CNTs)-based delivery of anticancer quinones and to summarize the mechanisms which can provide high effectiveness and multifunctionality of the CNT-based quinone delivery platform. </P><P> Results: Quinones, including anthracycline antibiotics – doxorubicin and daunorubicin, are among the most prospective group of natural and syntetic compounds which exhibit high antitumor activity against different type of tumors. In this review, we focus on the possibilities of using CNTs for targeted delivery of antitumor compounds with quinoid moiety which is ordinarily characterized by high specific interaction with DNA molecules. Quinones can be non-covalently adsorbed on CNT surface due to their aromatic structure and π-conjugated system of double bonds. The characteristic features of doxorubicine-CNT complex are high loading efficiency, pH-dependent release in acidic tumor microenviroment, enough stability in biological fluid. Different types of CNT functionalization, targeting strategies and designs for multifunctional CNT-based doxorubicine delivery platform are disscussed. </P><P> Conclusion: Nanosystems based on functionalized CNTs are very promising platform for quinone delivery resulting in significant enhancement of cancer treatment efficiency. Functionalization of CNTs with the polymeric shell, especially DNA-based shells, can provide the greatest affinity and mimicry with biological structures.</P>

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