Adoption of Color Doppler Ultrasound in the Measurement of Fetal Hypoxia in Late Pregnancy

2021 ◽  
Vol 11 (2) ◽  
pp. 563-567
Author(s):  
Wenying Wu ◽  
Li Zhao ◽  
Peiming Feng ◽  
Xiaoyan Wang ◽  
Minghui Nie
Keyword(s):  
Blood Flow ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Color Doppler ◽  
Color Doppler Ultrasound ◽  
Control Group ◽  
Fetal Hypoxia ◽  
Neonatal Asphyxia ◽  
Intrauterine Hypoxia ◽  
Peak Blood

Objective: In order to improve the detection rate of fetal hypoxia in the third trimester and reduce the probability of adverse pregnancy outcome, color doppler ultrasound (CDU), and contractions were used to assess the severity of fetal hypoxia. Methods: The 61 pregnant women diagnosed with intrauterine hypoxia in South District of The Affiliated Hospital of Chengde Medical College from October 2017 to September 2019 were classified as the sick group. Meanwhile, the 61 normal pregnant women were selected as the control group. CDU was used to detect the relevant indexes of umbilical artery (UA) and middle cerebral artery (MCA) in the two groups, including pulse index (PI), resistance index (RI), systolic peak blood flow velocity (S) and diastolic peak blood flow velocity (D). The Apgar scale was used to score neonatal status. According to the score results, newborns were divided into Apgar ≤ 7 group and Apgar > 7 group. The indexes of UA and MCA were compared between the two groups. The amniotic fluid status of pregnant women was assessed using the contractile stimulation test (CST). The rate of amniotic fluid pollution in pregnant women and the incidence of neonatal asphyxia were calculated. Pregnant women were grouped according to the CST score. The correlation between CST score and amniotic fluid pollution and neonatal asphyxia in pregnant women was analyzed. Results: First, the index of fetal UA was obviously higher than that of the control group, while the index of MCA was obviously lower than that of the control group (P < 0.05). Second, the indexes of fetal UA in Apgar ≤ 7 group were obviously higher than those in Apgar > 7 group, while those in MCA were obviously lower than those in Apgar > 7 group (P < 0.05). Third, the incidence of amniotic fluid pollution and neonatal asphyxia in low and middle groups of pregnant women was obviously higher than that in high groups (P < 0.01). Conclusion: This indicates that the CDU technology combined with uterine contraction stimulation experiment can assess the degree of intrauterine hypoxia in the late stage of pregnancy, which provides a feasible scheme for clinical detection of intrauterine hypoxia.

scholarly journals Ultrasound Parameters of Umbilical Artery Blood Flow Are Associated with Amniotic Fluid and Umbilical Artery Concentrations of Erythropoietin and Oxidative Stress Injury

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Jiewen Tao ◽  
JingWang ◽  
Weiqi Jiang ◽  
Qi Meng ◽  
Mingjuan Xu
Keyword(s):  
Blood Flow ◽  
Nadph Oxidase ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Umbilical Artery ◽  
Stress Injury ◽  
Blood Flows ◽  
Nadph Oxidase 4 ◽  
Intrauterine Hypoxia ◽  
Ultrasound Parameters

Intrauterine hypoxia is the most frequent adverse intrauterine condition that occurs under a variety of circumstances including preeclampsia, placental insufficiency, high-altitude pregnancy, and any inflammatory condition during pregnancy resulting from gestational diabetes or even maternal obesity. However, early diagnosis of intrauterine hypoxia is still a challenge. In this study, we comparatively analyzed the systolic to diastolic ratio (S/D), resistant index (RI), and pulse index (PI) of the umbilical artery (UmA) and middle cerebral artery (MCA) blood flows obtained from 46 pregnant women with intrauterine hypoxia and 80 normal pregnant women at 28-31, 32-36, and 37-41 gestational weeks. Results found that the S/D, RI, and PI of UmA and MCA blood flows at 28-31, 32-36, and 37-41 gestational weeks were all increased in hypoxic fetuses than in normal fetuses ( P < 0.05 ). The malondialdehyde (MDA) level was elevated but superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities were reduced in the UmA blood of pregnant women with intrauterine hypoxia compared with normal pregnant women ( P < 0.05 ). It was found that the NADPH oxidase 2 (Nox2) and NADPH oxidase 4 (Nox4) activities were increased in the UmA blood of pregnant women with intrauterine hypoxia compared with normal pregnant women ( P < 0.05 ). Results of ELISA methods showed that the expression level of survivin was lower but the expression levels of caspase-3, caspase-6, and caspase-9 were higher in the placental tissues of pregnant women with intrauterine hypoxia than those in normal pregnant women ( P < 0.05 ). The concentrations of erythropoietin in the amniotic fluid and UmA blood were increased in pregnant women with intrauterine hypoxia compared with normal pregnant women ( P < 0.05 ). The Spearman correlation analysis showed that the S/D, RI, and PI of UmA blood flow at 37-41 gestational weeks were positively correlated with the levels of Nox2, Nox4, and MAD and the UmA concentration of erythropoietin but negatively correlated with the activities of SOD, GSH-Px, and CAT ( P < 0.05 ). In summary, the study indicates that ultrasound parameters of the UmA blood flow including S/D, RI, and PI could serve as predictors of intrauterine hypoxia.

Integrated 2D Doppler indices of uteroplacental and fetal blood flow in diagnosis of intrauterine hypoxia

2021 ◽  
Vol 25 (4) ◽  
pp. 290-297
Author(s):  
Natallia V. Matskevich ◽  
Marina P. Famina
Keyword(s):  
Blood Flow ◽  
Prognostic Significance ◽  
Perinatal Outcomes ◽  
Control Group ◽  
Fetal Blood ◽  
Fetal Hypoxia ◽  
Term Infants ◽  
Intrauterine Hypoxia ◽  
Doppler Indices ◽  
Fetal Vessels

Relevance . Intrauterine hypoxia associated with placental disorders is a significant factor of ante-, intra- and postnatal fetal and newborn death. Despite clinical examination of pregnant women using ultrasound and cardiotocography, cases of intrauterine hypoxia often remain undetected prenatally. Clinical manifestation of placental disorders and intrauterine hypoxia are associated with pathological changes of blood flow resistance in the uterine, placental and fetal vessels. A combined Doppler assessment of blood flow in the uterine, placental and fetal vessels could improve detection of intrauterine hypoxia. The aim of the study was to assess the prognostic significance of integrated 2D Doppler indices of uteroplacental and fetal blood flow for the detection of fetal hypoxia in the 3rd trimester and to predict unfavorable perinatal outcomes. Materials and Methods. The outcomes of pregnancy of 48 women with fetal hypoxia delivered at 29 - 40 gestational weeks (study group), and 21 women who gave birth to healthy full-term infants (control group) were retrospectively analyzed. On the eve of delivery all women had 2D Doppler assessment of the uterine arteries, umbilical arteries, and fetal middle cerebral artery with an assessment of the cerebro-placental ratio, umbilical-cerebral ratio and cerebro-placental-uterine ratio. Results and Discussion . Analysis of the obtained values of cerebro-placental-uterine ratio, cerebro-placental ratio and umbilical-cerebral ratio showed the benefit from use of integrated 2D Doppler indices in the diagnosis of fetal hypoxia at 29 - 40 gestations weeks and in predicting complications in newborns. The high sensitivity of the cerebro-placental-uterine ratio (90.5%) makes it possible to effectively use this index for the diagnosis of intrauterine hypoxia. Conclusion. Pathological cerebro-placental-uterine ratio 2.44 is a clinically significant 2D Doppler criterion that predicts a high risk of asphyxia, respiratory distress syndrome, hypotrophy, and perinatal hypoxic-ischemic encephalopathy. Lower values of the cerebro-placental ratio and umbilical-cerebral ratio sensitivity (77.1% and 81.3%, respectively) limit their use for the diagnosis of fetal hypoxia as compared with cerebro-placental-uterine ratio.

Diagnostics of the chronic fetal hypoxia during pregnancy

1980 ◽  
Vol 61 (4) ◽  
pp. 58-59
Author(s):  
S. Ya. Malinovskaya ◽  
I. P. Laricheva ◽  
P. A. Klimenko ◽  
Z. H. Baideva
Keyword(s):  
Amniotic Fluid ◽  
Pregnant Women ◽  
Cardiac Activity ◽  
The State ◽  
Placental Lactogen ◽  
Fetal Hypoxia

In order to clarify the significance of various methods for determining the state of the fetus during its hypoxia, we studied the content of placental lactogen (PLH) in the blood and amniotic fluid, the activity of histidase and urocaninase in them, and also studied the cardiac activity of the fetus using the oxytocin test in 109 pregnant women.

Qualitative Diagnosis of Solid Breast Mass by Blood Flow in Solid Breast Mass Based on Color Doppler Ultrasound

2021 ◽  
Vol 11 (6) ◽  
pp. 1608-1615
Author(s):  
Ding Zuopeng ◽  
Liu Weiyong ◽  
Hu Chunmei ◽  
Wang Tao ◽  
Wang Mingming
Keyword(s):  
Breast Cancer ◽  
Blood Flow ◽  
Differential Diagnosis ◽  
Color Doppler ◽  
Flow Characteristics ◽  
Flow Distribution ◽  
Color Doppler Ultrasound ◽  
Blood Flow Distribution ◽  
Breast Masses ◽  
Malignant Breast

The incidence of breast cancer ranks first among female malignant tumor. With the increase of the sensitivity of color Doppler ultrasound blood flow, the blood flow distribution in and around the tumor can be clearly displayed, and the analysis of hemodynamic parameters is provided, which provides convenience for the study of tumor blood flow characteristics. Studies have shown that tumor cells can secrete a substance called angiogenesis factor, which makes the tumor site form a rich vascular network to promote tumor growth and metastasis. The tumor has many new blood vessels, abnormal structure, thin wall, lack of muscle layer, and is prone to form arteriovenous rash. These characteristics provide a pathological basis for color Doppler flow imaging (CDFI) for the diagnosis of breast cancer. This article discusses the role of two-dimensional sonographic features in the differential diagnosis of benign and malignant breast masses, CDFI was used to study the blood flow distribution and hemodynamic characteristics in benign and malignant breast masses; explore the value of blood flow characteristics and blood flow parameters in the differential diagnosis of breast masses. The experimental results show that the detection rate of blood flow signals and the classification of blood flow signals in the malignant group are higher than those in the benign group, mainly level II and III blood flow, and the irregular branched blood flow is more common, especially when the tumor appears penetrating blood flow supports the diagnosis of malignancy. PSV, RI and PI have a certain differential meaning in the diagnosis of benign and malignant breast masses. PSV, RI and PI of malignant masses are higher than benign masses. For tumors without obvious necrosis, the larger the tumor diameter, the richer the blood flow and the higher the blood flow grade is. The malignant tumors have more blood flow than the benign ones.

scholarly journals Perinatal outcome in meconium-stained amniotic fluid at term: a single center prospective study

2020 ◽  
Vol 10 (1) ◽  
pp. 107
Author(s):  
Vandana Mohapatra ◽  
Sujata Misra ◽  
Tapas Ranjan Behera
Keyword(s):  
Caesarean Section ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Perinatal Outcome ◽  
Mode Of Delivery ◽  
Birth Asphyxia ◽  
Control Group ◽  
Study Group ◽  
The Mean ◽  
Meconium Stained Amniotic Fluid

Background: The presence of meconium-stained amniotic fluid is a sign of fetal compromise and is associated with increased perinatal morbidity. The objective of this study was to determine the perinatal outcome in pregnant women at term with meconium-stained amniotic fluid (MSAF) and compare it with the outcome associated with clear liquor. Methods: A prospective observational, study was conducted in the department of obstetrics and gynecology, VIMSAR, Burla from January, 2013 to June, 2013. Pregnant women with singleton pregnancy, cephalic presentation at term were included in the study. Total 135 cases of MSAF (study group) were compared with 165 randomly selected controls with clear liquor. Outcome measures were fetal heart rate (FHR) abnormality, mode of delivery, Apgar score, neonatal intensive care unit (NICU) admission, diagnosis of meconium aspiration syndrome (MAS), birth asphyxia and neonatal death. Statistical analysis was done by using the mean and Chi-square test with or without Yates’ correction.  Results: The mean gestational age for meconium staining in the present study was 40.31±0.48 weeks. Caesarean section was the most common mode of delivery in MSAF group whereas vaginal delivery was most common in control group. Significantly higher number of babies in the study group required NICU admissions. The incidence of MAS and birth asphyxia too was statistically higher among babies born to study group as compared to control group.Conclusions: MSAF has significant adverse effect on the perinatal outcome, as it increases the caesarean section rates, NICU admissions, MAS and birth asphyxia.

How Variable Is the Volar Subcutaneous Tissue of the Digits on B-Mode and Color Doppler Ultrasound in Non-Psoriatic Individuals and Could It Be Included in a Dactylitis Score?

2020 ◽  
Author(s):  
Ana Rebollo-Giménez ◽  
Lina Martínez-Estupiñán ◽  
Otto Olivas-Vergara ◽  
Gema Fuensalida-Novo ◽  
Jesús Garrido ◽  
...  
Keyword(s):  
Blood Flow ◽  
Clinical Features ◽  
Subcutaneous Tissue ◽  
Color Doppler ◽  
Color Doppler Ultrasound ◽  
Dominant Hand ◽  
Scanning Method ◽  
Skin Contact ◽  
Gel Layer ◽  
The Impact

Abstract Background Digital subcutaneous tissue (SCT) changes are involved in dactylitis, a hallmark feature of psoriatic arthritis (PsA). There are no studies on the ultrasound (US) characteristics of the digital SCT in the general population. Objectives To investigate the variability in US-measured thickness (TH) and color Doppler (CD)-detected blood flow of the SCT of the volar aspects of the fingers in a non-psoriatic population and to investigate the impact of the scanning method and demographics and clinical features on these measurements. Methods SCT TH and semiquantitative (SQD) and quantitative (QD) Doppler signals were measured in the bilateral second finger at the proximal and middle phalanges in 81 non-psoriatic volunteers [49 female, 32 men; 18–78 years]. Two scanning methods with and without (thick gel layer interposition) probe-skin contact were used. Demographics and clinical features were collected. Results There was high variability of SCT TH and Doppler measurements between individuals. All US measurements obtained without probe-skin contact were significantly greater than their corresponding measurements obtained with the probe contacting the skin (p < 0.001). SCT TH was positively related to dominant hand, age, masculine gender, weight, height, body mass index, and alcohol consumption while Doppler measurements were positively related to age and non-dominant hand. Conclusions US-measured SCT thickness and Doppler-detected SCT blood flow of the volar aspect of the fingers seem to be highly variable in the non-psoriatic population as well as highly dependent on the US scanning method. This variability is of utmost importance for assessing dactylitis in PsA.

scholarly journals Correlation study between increased fetal movement during the third trimester and neonatal outcome

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Cuiqin Huang ◽  
Wei Han ◽  
Yajing Fan
Keyword(s):  
Amniotic Fluid ◽  
Pregnant Women ◽  
Gestational Age ◽  
Neonatal Outcome ◽  
Stress Test ◽  
Neonatal Outcomes ◽  
Control Group ◽  
Third Trimester ◽  
The Third ◽  
Fetal Movements

Abstract Background We aimed to analyze the correlation between increased fetal movements in the third trimester and neonatal outcomes. Methods We enrolled pregnant women (n = 219) who reported increased/excessive fetal movements in the third trimester in our hospital. A control group of healthy women (n = 278) who had undergone regular childbirth and delivery in our hospital during the same period and did not report abnormal fetal movements were also recruited. All pregnant women underwent fetal non-stress test. We analyzed the neonatal weight, appearance, pulse, grimace, activity, and respiration score, degrees of amniotic fluid contamination, amniotic fluid volume, conditions of umbilical cord around the neck and cord length, and incidence of small for gestational age. In addition, the incidence of preterm delivery, cesarean section rate, postpartum hemorrhage, and other postpartum complications were also analyzed. We then analyzed the correlation between increased/excessive fetal activity and neonatal outcomes. Results Women with complaints of increased/excessive fetal movements exhibited increased fetal movements mainly around 31 and 39 weeks of gestation. Several pregnancy variables, including number of previous delivery, gestational age (less than 34 weeks and more than 37 weeks) and vaginal birth rate, were associated with increased/excessive fetal movements. In addition, women who reported increased/excessive fetal movements had higher odds of large for gestational age (LGA), particularly those with gestational age over 37 weeks. Conclusion Increased/excessive fetal movements may be used to predict adverse neonatal outcome such as LGA.

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