Oxidized Porous Silicon Nanoparticles Covalent-Bonded with Levofloxacin in Hydrogel Polymer as a Drug Delivery System

2020 ◽  
Vol 20 (8) ◽  
pp. 4619-4623
Author(s):  
Hajin Kim ◽  
Honglae Sohn
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Porous Silicon ◽  
Silicon Nanoparticles ◽  
Excitation Wavelength ◽  
Potential Candidate ◽  
Buffer Solution ◽  
Covalently Bonded ◽  
Oxidized Porous Silicon ◽  
Hydrogel Polymer

Oxidized porous silicon (OPS) nanoparticles covalent-bonded with levofloxacin in hydrogel polymer are prepared and used to measure the efficiency for the controlled release drug delivery. Levofloxacin is covalently bonded to a Si–OH surface of OPS nanoparticles by catalytic condensation. The average size of these particles is about 100 nm. Since levofloxacin has a fluorescence property, the release of levofloxacin has been measured by fluorescence spectrometer. The quantity of levofloxacin release from the OPS nanoparticles is measured at the emission wavelength at 455 nm with an excitation wavelength of 330 nm on a time scale in pH 7 aqueous buffer solution. The analysis of release profile reveals that the OPS covalently bonded with levofloxacin (Levo-OPS) exhibits a great potential candidate for controlled release. The drug-release rate depends on the hydrolysis of silyl ester from the surface of OPS nanoparticles.

scholarly journals Oxidized Porous Silicon Particles Covalently Grafted with Daunorubicin as a Sustained Intraocular Drug Delivery System

2013 ◽  
Vol 54 (2) ◽  
pp. 1268 ◽  
Author(s):  
Jay Chhablani ◽  
Alejandra Nieto ◽  
Huiyuan Hou ◽  
Elizabeth C. Wu ◽  
William R. Freeman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Porous Silicon ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oxidized Porous Silicon ◽  
Intraocular Drug Delivery ◽  
Silicon Particles

scholarly journals A fluorous biphase drug delivery system triggered by low frequency ultrasound: controlled release from perfluorous discoidal porous silicon particles

2020 ◽  
Vol 2 (8) ◽  
pp. 3561-3569
Author(s):  
Jing Liu ◽  
Shuo Li ◽  
Lina Liu ◽  
Zhiling Zhu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Porous Silicon ◽  
Drug Delivery System ◽  
Delivery System ◽  
Low Frequency ◽  
Efficient Delivery ◽  
Low Frequency Ultrasound ◽  
Silicon Particles ◽  
Frequency Ultrasound

A fluorous biphase drug delivery system (FB-DDS) trigged by low frequency ultrasound (LFUS) was developed for efficient delivery of fluorine containing pharmaceuticals.

scholarly journals Chitosan-Coated PLGA Nanoparticles Encapsulating Triamcinolone Acetonide as a Potential Candidate for Sustained Ocular Drug Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1590
Author(s):  
Madhuri Dandamudi ◽  
Peter McLoughlin ◽  
Gautam Behl ◽  
Sweta Rani ◽  
Lee Coffey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Triamcinolone Acetonide ◽  
Particle Diameter ◽  
Statistical Design ◽  
Plga Nanoparticles ◽  
Ocular Drug Delivery ◽  
Potential Candidate ◽  
Water Emulsion ◽  
Surface Modified

The current treatment for the acquired retinal vasculopathies involves lifelong repeated intravitreal injections of either anti-vascular endothelial growth factor (VEGF) therapy or modulation of inflammation with steroids. Consequently, any treatment modification that decreases this treatment burden for patients and doctors alike would be a welcome intervention. To that end, this research aims to develop a topically applied nanoparticulate system encapsulating a corticosteroid for extended drug release. Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) supports the controlled release of the encapsulated drug, while surface modification of these NPs with chitosan might prolong the mucoadhesion ability leading to improved bioavailability of the drug. Triamcinolone acetonide (TA)-loaded chitosan-coated PLGA NPs were fabricated using the oil-in-water emulsion technique. The optimized surface-modified NPs obtained using Box-Behnken response surface statistical design were reproducible with a particle diameter of 334 ± 67.95 to 386 ± 15.14 nm and PDI between 0.09 and 0.15. These NPs encapsulated 55–57% of TA and displayed a controlled release of the drug reaching a plateau in 27 h. Fourier-transform infrared spectroscopic (FTIR) analysis demonstrated characteristic peaks for chitosan (C-H, CONH2 and C-O at 2935, 1631 and 1087 cm−1, respectively) in chitosan-coated PLGA NPs. This result data, coupled with positive zeta potential values (ranged between +26 and +33 mV), suggests the successful coating of chitosan onto PLGA NPs. Upon coating of the NPs, the thermal stability of the drug, polymer, surfactant and PLGA NPs have been enhanced. The characteristics of the surface-modified NPs supports their use as potential candidates for topical ocular drug delivery for acquired retinal vasculopathies.

Water Soluble Silicon Quantum Dots Grafted with Amoxicillin as a Drug Delivery System

2020 ◽  
Vol 20 (8) ◽  
pp. 4624-4628 ◽  
Author(s):  
Dowoo Ki ◽  
Honglae Sohn
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Controlled Release ◽  
Ultra Violet ◽  
Water Soluble ◽  
Burst Release ◽  
Potential Candidate ◽  
Silicon Quantum Dots ◽  
Hydrolysis Of ◽  
Soluble Silicon

Water soluble silicon quantum dots (Si QDs) are prepared and used for the measurement of the efficiency for the controlled release drug delivery. Amoxicillin, antibiotics, is covalently grafted with Si QDs through a surface derivatization reaction. Si QDs are embedded in hydrogel polymer. The release of amoxicillin has been measured by using Ultra violet-visible (UV-vis) absorption spectrometer. Amoxicillin-embedded hydrogels exhibit a burst release for 1 h, however covalently loaded Amoxi-Si QDs hydrogel composite exhibited very slow release. Absorption analysis reveals that the Si QDs exhibits a great potential candidate for controlled release of drug. The controlled drugrelease profiles depend on the hydrolysis of amoxicillin from the surface of Si QDs.

scholarly journals Nanoporous Silicon as Drug Delivery Systems for Cancer Therapies

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Sazan M. Haidary ◽  
Emma P. Córcoles ◽  
Nihad K. Ali
Keyword(s):  
Drug Delivery ◽  
Porous Silicon ◽  
Silicon Nanoparticles ◽  
Degradation Products ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
Electrochemical Anodization ◽  
Medical Applications

Porous silicon nanoparticles have been established as excellent candidates for medical applications as drug delivery devices, due to their excellent biocompatibility, biodegradability, and high surface area. The simple fabrication method by electrochemical anodization of silicon and its photoluminescent properties are some of the merits that have contributed to the increasing interest given to porous silicon. This paper presents the methods of fabrication, which can be customized to control the pore size, various chemical treatments used for the modification of silicon surfaces, and the characterization and pore morphology of silicon structures. Different approaches used for drug loading and the variety of coatings used for the controlled released are revised. The monitoring of the toxicity of silicon degradation products and the in vivo release of a drug in a specific site are described taking into account its significance on medical applications, specifically on cancer therapy.

scholarly journals Tunable sustained intravitreal drug delivery system for daunorubicin using oxidized porous silicon

2014 ◽  
Vol 178 ◽  
pp. 46-54 ◽  
Author(s):  
Huiyuan Hou ◽  
Alejandra Nieto ◽  
Feiyan Ma ◽  
William R. Freeman ◽  
Michael J. Sailor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Porous Silicon ◽  
Drug Delivery System ◽  
Delivery System ◽  
Intravitreal Drug Delivery ◽  
Oxidized Porous Silicon
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