Montmorillonite Intercalated Norfloxacin and Tobramycin for New Drug-Delivery Systems

The urgent need of safe, therapeutically and patient-compliant drug delivery systems (DDSs) continuously stimulates researchers to explore novel tools and strategies to monitor the loading and release of drugs. In this context, this study demonstrates that montmorillonite clay (MMT) is an appropriate material for changing the release behavior of Tobramycin and Norfloxacin drugs into medium. The DDSs were prepared by the intercalation of Tobramycin or Norfloxacin between MMT layers. The MMT-drug systems were analyzed using X-ray diffraction (XRD) analysis, scanning electron microscope (SEM), and Fourier transforms infrared (FT-IR). After insertion of the drugs between the layers of MMT, the periodicity in c-axis changed because of the formation of layered hybrid structures. The release of drugs was investigated using UV-spectrophotometer. The release rates are found to be dependent on pH of the medium. Moreover, we found that the percentage of release increases as the pH increases, however the release rate is low. These findings would be beneficial for controlled release of drugs for prolonged time in the future.

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Use of isothermal heat conduction microcalorimetry, X-ray diffraction, and optical microscopy for characterisation of crystals grown in steroid combination-containing transdermal drug delivery systems

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/s0939-6411(03)00120-6 ◽

2004 ◽

Vol 57 (2) ◽

pp. 397-410 ◽

Cited By ~ 6

Author(s):

Silvia Latsch ◽

Torsten Selzer ◽

Lothar Fink ◽

Michael Horstmann ◽

Jörg Kreuter

Keyword(s):

Drug Delivery ◽

Heat Conduction ◽

Optical Microscopy ◽

Transdermal Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

X Ray Diffraction ◽

X Ray ◽

Transdermal Drug Delivery Systems

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A study on using expanded perlite with hydroxyapatite: Reinforced bio-composites

Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine ◽

10.1177/0954411921996565 ◽

2021 ◽

pp. 095441192199656

Author(s):

Erdoğan Karip ◽

Mehtap Muratoğlu

Keyword(s):

Body Fluid ◽

Xrd Analysis ◽

Cold Isostatic Pressing ◽

Expanded Perlite ◽

X Ray Diffraction ◽

Pressing Method ◽

X Ray ◽

Infra Red ◽

Ft Ir

People are exposed to different kinds of diseases or various accidents in life. Hydroxyapatite (HA) has been widely employed for bone treatment applications. In this study, HA was extracted from sheep bones. Bio-composites were doped with 1, 5, and 10 wt.% of expanded perlite and 5 wt.% of ZrO2–MgO-P2O5. The bio-composites were prepared by the cold isostatic pressing method (250 MPa) and sintered at 900°C for 1 h. In order to evaluate the characteristics of the bio-composites, microhardness, density, X-ray diffraction (XRD), Fourier transform infra-red spectroscopy (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) analyses were carried out on them. Additionally, the specimens whose characteristics were determined were kept in synthetic body fluid (SBF), and their in vitro behavior was examined. As a result, it was observed that microhardness increased as both the weight and the grain size of the expanded perlite were increased. Calcium silicate, tri-calcium phosphate, and hydroxyapatite were observed in the XRD analysis of all samples, and the formation of apatite structures was increased by addition of ZrO2–MgO–P2O5.

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A review of nanotechnology with an emphasis on Nanoplex

Brazilian Journal of Pharmaceutical Sciences ◽

10.1590/s1984-82502015000200002 ◽

2015 ◽

Vol 51 (2) ◽

pp. 255-263

Author(s):

Rupali Nanasaheb Kadam ◽

Raosaheb Sopanrao Shendge ◽

Vishal Vijay Pande

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Drug Loading ◽

X Ray Diffraction ◽

Scanning Calorimetry ◽

X Ray ◽

Conventional Drug ◽

Anionic Drugs ◽

Oppositely Charged ◽

The Brain

<p>The use of nanotechnology based on the development and fabrication of nanostructures is one approach that has been employed to overcome the challenges involved with conventional drug delivery systems. Formulating Nanoplex is the new trend in nanotechnology. A nanoplex is a complex formed by a drug nanoparticle with an oppositely charged polyelectrolyte. Both cationic and anionic drugs form complexes with oppositely charged polyelectrolytes. Compared with other nanostructures, the yield of Nanoplex is greater and the complexation efficiency is better. Nanoplex are also easier to prepare. Nanoplex formulation is characterized through the production yield, complexation efficiency, drug loading, particle size and zeta potential using scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and dialysis studies. Nanoplex have wide-ranging applications in different fields such as cancer therapy, gene drug delivery, drug delivery to the brain and protein and peptide drug delivery.</p>

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The Characteristic Evaluation of Hydroxyapatite Powders Synthesized from CaCO3 Refined from Oyster Shell and H3PO4

Solid State Phenomena ◽

10.4028/www.scientific.net/ssp.118.639 ◽

2006 ◽

Vol 118 ◽

pp. 639-644

Author(s):

Hye Sung Kim ◽

Su Chak Ryu

Keyword(s):

Bone Density ◽

Inductively Coupled Plasma ◽

Oyster Shell ◽

Atomic Emission ◽

Xrd Analysis ◽

X Ray Diffraction ◽

X Ray ◽

Inductively Coupled ◽

Infra Red ◽

Ft Ir

Hydroxyapatite (Ca10(PO4)6(OH)2, HAp) powders is synthesized using the mixed powders of CaCO3 refined from oyster shells and phosphoric acid (H3PO4-98%, Daejung) as starting materials. The characteristic evaluation and chemical analysis of the synthesized powders is performed by X-ray diffraction (XRD), Fourier-transformed infra-red spectroscopy (FT-IR), and inductively-coupled plasma atomic emission spectroscopy (ICPAES). XRD analysis of synthetic powder by heat treatment at 1300°C for 2hrs shows only HAp peaks corresponding to stoichiometric HAp. It is confirmed by ICP-AES test that impurities such as Zn, In, Ti, Ba, Cd, Pb, and Mn, is not detected at all, but small amounts of Ti and Be is observed (0.099ppm Ti and 0.002ppm Ba). Variation of bone density is measured by giving medication of HAp powder with drinking water into human body continuously for three month. After the medication, the bone density is higher than the medication before. This means that HAp powder made from this process can be used as improver of bone density.

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