scholarly journals Optogenetic Inhibition of Nav1.8 Expressing Corneal Afferents Reduces Persistent Dry Eye Pain

2021 ◽  
Vol 62 (14) ◽  
pp. 15
Author(s):  
Neal E. Mecum ◽  
Rachel Russell ◽  
Jun Lee ◽  
Cara Sullivan ◽  
Ian D. Meng
Keyword(s):  
Dry Eye ◽  
Eye Pain

scholarly journals Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study

2021 ◽  
Vol 10 (2) ◽  
pp. 250
Author(s):  
Hyeon Jeong Yoon ◽  
Jonghwa Kim ◽  
Jee Myung Yang ◽  
Edward T. Wei ◽  
Seong Jin Kim ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pilot Study ◽  
Pain Intensity ◽  
Dry Eye ◽  
Associated Factors ◽  
Treatment Result ◽  
Ocular Pain ◽  
Eye Pain ◽  
Validated Questionnaire

Background: Activation of TRPM8, a cold-sensing receptor located on the cornea and eyelid, has the potential to relieve the neuropathic ocular pain (NOP) in dry eye (DE) by inhibiting other aberrant nociceptive inputs. We aimed to investigate the effect of a topical TRPM8 agonist, cryosim-3 (C3), on relieving DE-associated NOP. Methods: We conducted a prospective pilot study of 15 patients with DE-associated NOP. These patients applied topical C3 to their eyelid, 4 times/day for 1 month. The patients underwent clinical examinations. They also completed the Ocular Pain Assessment Survey (OPAS), which is a validated questionnaire for NOP, at baseline, 1 week, and 1 month after treatment. Result: At 1 week, the OPAS scores of eye pain intensity, quality of life (driving/watching TV, general activity, sleep, and enjoying life/relations with other people), and associated factors (burning sensation, light sensitivity, and tearing) improved. The total OPAS scores of eye pain intensity, quality of life, and associated factors remained improved at 1 month. The Schirmer test scores also improved at 1 month. Conclusion: TRPM8 agonist (C3) could be a novel agent for treating patients with DE-associated NOP who are unresponsive to conventional treatments.

scholarly journals Incidence and Risk Factors of Dry Eye in Children and Adolescents With Diabetes Mellitus: A 3-Year Follow-Up Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhangling Chen ◽  
Ying Xiao ◽  
Yu Qian ◽  
Qiurong Lin ◽  
Zhaoyu Xiang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Children And Adolescents ◽  
Incidence Rate ◽  
Dry Eye ◽  
Study Cohort ◽  
Children And Adolescent ◽  
Eye Pain ◽  
Long Course

Purpose: To investigate the incidence and risk factors of dry eye in children with diabetes mellitus (DM) over a period of 3 years.Methods: Children and adolescents with DM (age: 3–14 years) from the Shanghai Children and Adolescent Diabetes Eye (SCADE) study cohort who did not have dry eye in January 2018 were followed-up for 3 years and re-examined in January 2021, and the incidence rate and risk factors for dry eye were calculated.Results: Forty children and adolescents with DM came for follow-up in 2021. Nine of them were diagnosed with dry eye, resulting in a 3-year incidence rate of 22.5% and an annual mean incidence rate of 7.5% for dry eye. Univariate regression analysis confirmed that decreased corneal sensation (OR [Odds Ratio] = 25.60; 95%CI [Confidence Interval] = 1.31~501.69; P = 0.03) was the risk factor for dry eye incidence. Long course of DM (OR = 1.80; 95%CI = 0.96~3.38; P = 0.07), eye pain (OR = 12.27; 95%CI = 0.65~231.48; P = 0.09), and dry eye in parents (OR = 15.99; 95%CI = 0.76~337.75; P = 0.08) may interfere with the incidence of dry eye in them.Conclusions: The incidence of dry eye in children and adolescents with DM is high.

scholarly journals The dry eye syndrome in patients treated for breast cancer and methods to correct it

2014 ◽  
Vol 7 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Mariya Aleksandrovna Kovalevskaya ◽  
Yekaterina Konstantinovna Turovets
Keyword(s):  
Breast Cancer ◽  
Dry Eye ◽  
Diagnostic Tests ◽  
Normal Values ◽  
Local Treatment ◽  
Dry Eye Syndrome ◽  
Artificial Tears ◽  
Eye Pain ◽  
Ocular Movements ◽  
Inflammatory Component

Treatment for breast cancer in women promotes the dry eye syndrome and its worsening during chemo- and hormonotherapy courses, this fact being warranted by dry eye syndrome diagnostic tests. It is the authors’ opinion, that the dry eye syndrome treatment using a Cyclosporine A based medication in combination with artificial tears leads to considerable improvement. I case of inflammatory component overlay (redness, eye pain at ocular movements), such therapy is most effective. In all patients, the treatment was well tolerated, with positive dynamics noted. After a local treatment course, dry eye syndrome diagnostic tests’ results reached normal values.

scholarly journals Severe dry eye associated with Steven Johnson Syndrome: A case report

2021 ◽  
Vol 7 (2) ◽  
pp. 225-228
Author(s):  
Namrata Shree ◽  
Baby Deka ◽  
Rajneel Bhattacharjee
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Acute Stage ◽  
Stevens Johnson Syndrome ◽  
Corneal Surface ◽  
Eye Pain ◽  
Johnson Syndrome ◽  
Mucous Membranes ◽  
Life Threatening ◽  
Steven Johnson Syndrome

: Stevens-Johnson-Syndrome (SJS), and its severe variant, toxic epidermal necrolysis (TEN), are life-threatening diseases of skin and mucous membranes. Cases with pseudo-membrane formation and epithelial defects, have higher risk of ocular sequelae. Severe dry eye in SJS includes three mechanisms: (1) aqueous tear deficiency, (2) decreased wettability of corneal surface, and (3) increased evaporation.: A 47-year-old male patient presented in OPD with chief complaint of severe discomfort and grittiness in both eyes since last 21 years. Proper history taking and examination was done. Patient was given conservative treatment and was explained about recent advancements of treatment that can help in improving his condition.: In SJS patients, dryness causes eye pain, and unstable tear film causes diminution of vision. After acute stage reactions, visual impairment and severe dry eye are observed as ocular sequelae.

scholarly journals Dysfunctional Coping Mechanisms Contribute to Dry Eye Symptoms

2019 ◽  
Vol 8 (6) ◽  
pp. 901 ◽  
Author(s):  
Sneh Patel ◽  
Elizabeth R Felix ◽  
Roy C Levitt ◽  
Constantine D. Sarantopoulos ◽  
Anat Galor
Keyword(s):  
Pain Intensity ◽  
Dry Eye ◽  
Ocular Surface ◽  
Pain Catastrophizing ◽  
Pain Severity ◽  
Separate Analysis ◽  
Coping Behaviors ◽  
Ocular Pain ◽  
Eye Pain ◽  
The Impact

Dysfunctional coping behaviors, such as catastrophizing, have been implicated in pain severity and chronicity across several pain disorders. However, the impact of dysfunctional coping has not been examined under the context of dry eye (DE). This study evaluates relationships between catastrophizing and measures of DE, including pain severity and pain-related daily interference. The population consisted of patients seen at Miami Veterans Affairs eye clinic between April 2016 and October 2017. Patients filled out standardized questionnaires assessing symptoms of DE and eye pain, non-ocular pain, mental health, coping behaviors (Pain Catastrophizing Scale, PCS), and pain-related daily interference as a perceived impact on quality of life (Multidimensional Pain Inventory, Interference Subscale, MPI-Interference), and all patients underwent an ocular surface examination. In total, 194 patients participated, with a mean age of 58.8 ± 9.6 years, the majority being male, non-Hispanic, and black. PCS (catastrophizing) was correlated with DE symptom severity, including Dry-Eye Questionnaire 5 (DEQ5; r = 0.41, p < 0.0005), Ocular Surface Disease Index (OSDI; r = 0.40, p < 0.0005), and neuropathic-like eye pain (Neuropathic Pain Symptom Inventory-Eye (NPSI-Eye; r = 0.48, p < 0.0005). Most tear metrics, on the other hand, did not correlate with PCS. Linear regressions showed that PCS, non-ocular pain intensity, and number of pain conditions were significant predictors of DEQ5 (overall DE symptoms), while PCS and non-ocular pain intensity were predictors of NPSI-Eye scores, as were insomnia scores and analgesic use. In a separate analysis, PCS and DE symptoms (OSDI) associated with pain-related interference (MPI-Interference) along with non-ocular pain intensity, post-traumatic stress disorder (PTSD), number of pain conditions, and non-Hispanic ethnicity. These findings suggest that catastrophizing is not significantly related to signs of DE, but is strongly associated to pain-related symptoms of DE and daily interference due to pain.

scholarly journals New Perspectives in the Pathophysiology and Treatment of Pain in Patients with Dry Eye Disease

2021 ◽  
Vol 11 (1) ◽  
pp. 108
Author(s):  
Giuseppe Giannaccare ◽  
Carla Ghelardini ◽  
Alessandra Mancini ◽  
Vincenzo Scorcia ◽  
Lorenzo Di Cesare Mannelli
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Pain Perception ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Endogenous Opioid ◽  
Eye Pain ◽  
Paradoxical Situation ◽  
Ocular Discomfort ◽  
Maladaptive Plasticity

Ocular discomfort and eye pain are frequently reported by patients with dry eye disease (DED), and their management remains a real therapeutic challenge for the Ophthalmologist. In DED patients, injury at the level of each structure of the ocular surface can determine variable symptoms, ranging from mild ocular discomfort up to an intolerable pain evoked by innocuous stimuli. In refractory cases, the persistence of this harmful signal is able to evoke a mechanism of maladaptive plasticity of the nervous system that leads to increased pain responsiveness. Peripheral and, subsequently, central sensitization cause nociceptor hyperexcitability and persistent pain perception that can culminate in the paradoxical situation of perceiving eye pain even in the absence of ocular surface abnormalities. Effective therapeutic strategies of these cases are challenging, and new options are desirable. Recently, a theoretical novel therapeutic approach concerns enkephalins thanks to the evidence that eye pain sensations are modulated by endogenous opioid peptides (enkephalins, endorphins and dynorphins). In this regard, new topical agents open up a new theoretical scenario in the treatment of ocular discomfort and eye pain in the setting of DED, such as, for example, a multimolecular complex based on proteins and glycosaminoglycans also containing opiorphin that may assist the physiological pain-relieving mechanism of the eye.

Eye Pain and Dry Eye in Patients with Fibromyalgia

Pain Medicine ◽  
2018 ◽  
Vol 19 (12) ◽  
pp. 2528-2535 ◽  
Author(s):  
Alexander Karl-Georg Schuster ◽  
Markus Wettstein ◽  
Andreas Gerhardt ◽  
Wolfgang Eich ◽  
Christiane Bieber ◽  
...  
Keyword(s):  
Dry Eye ◽  
Eye Pain

scholarly journals Evaluation of Eye-Pain Severity between Dry-Eye Subtypes

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 166
Author(s):  
Yamato Yoshikawa ◽  
Norihiko Yokoi ◽  
Hiroaki Kato ◽  
Rieko Sakai ◽  
Aoi Komuro ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Visual Analog Scale ◽  
Dry Eye ◽  
Short Form ◽  
Objective Assessment ◽  
Pain Severity ◽  
Mcgill Pain Questionnaire ◽  
Analog Scale ◽  
Eye Pain ◽  
Total Pain

The aim of this study was to assess eye pain between dry eye (DE) subtypes using questionnaires and the PainVision® (Osachi) apparatus. This study involved 52 eyes of 52 DE patients with eye pain (43 females and 9 males; mean age: 64.2 ± 13.2 (mean ± SD) years) who were classified into three DE subtypes (aqueous deficient DE (ADDE); decreased wettability DE (DWDE); and increased evaporation DE (IEDE)) based on fluorescein breakup pattern. In all subjects, severity of eye pain was evaluated using PainVision®, the DE-symptom-questionnaire visual analog scale (DSQ-VAS), and the Short-Form McGill Pain Questionnaire 2 (SF-MPQ-2). The severity of eye pain was compared between the three DE subtypes. PainVision® findings revealed greater severity of eye pain in ADDE and DWDE than in IEDE (p < 0.05, respectively), despite no difference being found in each questionnaire. A significant correlation was found between eye pain in DSQ-VAS and continuous pain, intermittent pain, neuropathic pain, and total pain in SF-MPQ-2 (R = 0.50, 0.49, 0.47, and 0.56, respectively) (all: p < 0.001). Greater severity of eye pain was found in ADDE and DWDE than in IEDE, and PainVision® was found useful for the objective assessment of eye pain.

Dry Eye Responds Best to Combination Therapy

2008 ◽  
Vol 39 (2) ◽  
pp. 69
Author(s):  
CAROLINE HELWICK
Keyword(s):  
Combination Therapy ◽  
Dry Eye
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