scholarly journals Severe dry eye associated with Steven Johnson Syndrome: A case report

2021 ◽  
Vol 7 (2) ◽  
pp. 225-228
Author(s):  
Namrata Shree ◽  
Baby Deka ◽  
Rajneel Bhattacharjee
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Acute Stage ◽  
Stevens Johnson Syndrome ◽  
Corneal Surface ◽  
Eye Pain ◽  
Johnson Syndrome ◽  
Mucous Membranes ◽  
Life Threatening ◽  
Steven Johnson Syndrome

: Stevens-Johnson-Syndrome (SJS), and its severe variant, toxic epidermal necrolysis (TEN), are life-threatening diseases of skin and mucous membranes. Cases with pseudo-membrane formation and epithelial defects, have higher risk of ocular sequelae. Severe dry eye in SJS includes three mechanisms: (1) aqueous tear deficiency, (2) decreased wettability of corneal surface, and (3) increased evaporation.: A 47-year-old male patient presented in OPD with chief complaint of severe discomfort and grittiness in both eyes since last 21 years. Proper history taking and examination was done. Patient was given conservative treatment and was explained about recent advancements of treatment that can help in improving his condition.: In SJS patients, dryness causes eye pain, and unstable tear film causes diminution of vision. After acute stage reactions, visual impairment and severe dry eye are observed as ocular sequelae.

scholarly journals Rifampicin- and allopurinol-induced Stevens-Johnson syndrome: A case series

2021 ◽  
Vol 65 ◽  
pp. 51-54
Author(s):  
Bhavana Srivastava ◽  
Reena Bhardwaj ◽  
Renu Khanchandani ◽  
Zafar Masood Ansari ◽  
Gunjita Belwal
Keyword(s):  
Adverse Effects ◽  
Pulmonary Tuberculosis ◽  
Causality Assessment ◽  
Case Series ◽  
Young Male ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome ◽  
Mucous Membranes ◽  
Life Threatening ◽  
Severe Skin Reaction

Stevens-Johnson syndrome (SJS) is a rare, serious disorder and may be life threatening affecting mainly mucocutaneous tissues. It is a type of generalised, multisystemic hypersensitivity reaction directly linked to the drug intake. It is one of the few serious adverse effects of drugs involving skin and mucous membranes which are characterised by rash, bullae and blisters spread on skin, mucous membranes, swelling with erosive lesions on lips and face and hyperpigmentation. Normally, SJS is a self-resolving condition but it has potential to be converted into life-threatening disease. Here, we describe and present a case series of SJS inflicted by rifampicin and allopurinol. First one is a 28-year-old-female and second case is a 50-year-old male, both received rifampicin for pulmonary tuberculosis. Third patient is a 22-year-old young male taken allopurinol for hyperuricemia. All these patients noticed a severe skin reaction which is a part of erythema multiforme spectrum. Causality assessment was done in these patients with the help of Naranjo’s algorithm and diagnosed as cases of SJS.

scholarly journals Stevens-Johnson Syndrome in a Child on Phenytoin, Exacerbated with Cefixime

2019 ◽  
Vol 39 (3) ◽  
pp. 193-196 ◽  
Author(s):  
Yam Bahadur Roka ◽  
Sabrina Shrestha ◽  
Narayani Roka ◽  
Mohan Karki
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Whole Body ◽  
Stevens Johnson Syndrome ◽  
Intravenous Fluids ◽  
Oral Ulceration ◽  
Topical Antibiotics ◽  
Johnson Syndrome ◽  
Life Threatening ◽  
History Of ◽  
Steven Johnson Syndrome

Steven Johnson syndrome and toxic epidermal necrolysis are rare but potentially life threatening muco-cutaneous disorders. Their incidence ranges from 1.2 to six per million patient-years for Steven Johnson syndrome and 0.4 to 1.2 per million patient-years for toxic epidermal necrolysis. Drugs are the primary cause for these syndromes in majority cases. They might also be due to infections with Mycoplasma Pneumoniae or Herpes Simplex. The mortality ranges from five to 40% in these cases. We report a 10-year old girl who presented with history of multiple skin eruptions involving whole body and oral ulceration for five days. She was a known case of seizure disorder on phenytoin and had been prescribed Cefexime for fever. She was managed with intravenous fluids, corticosteroids, opiates, antacids and topical antibiotics. We want to highlight the possibility of Steven Johnson syndrome following the combination of these two drugs.

scholarly journals Blepharoconjunctivitis as Manifestation of Stevens-Johnson syndrome

2021 ◽  
Vol 5 (2) ◽  
pp. 26-32
Author(s):  
Putu Ayu Adindhya Saraswati Surya ◽  
Ni Nyoman Sunariasih
Keyword(s):  
Sharp Decrease ◽  
Stevens Johnson Syndrome ◽  
Eye Drops ◽  
Corneal Ulcers ◽  
Corneal Erosion ◽  
Ocular Manifestations ◽  
Johnson Syndrome ◽  
Mucous Membranes ◽  
Life Threatening ◽  
History Of

Background: Stevens Johnson syndrome (SJS) is a collection of acute and life threatening skin symptoms caused by an allergic drug reaction. SJS also attacks the other mucous membranes, one of which is the eye. SJS is a rare case. The initial complaint of SJS is the eruption on the skin in the form of redness followed by blisters and attacking other mucous membranes. The ocular manifestations of SJS are conjunctivitis, corneal erosion, corneal ulcers, and blepharitis. Methods: Treatment of SJS’s ocular manifestation is administration of drugs and surgical intervention. Administration of drugs that often done in the acute phase is antibiotic eye drops with steroids to prevent complications. Complications that can occur include symblepharon, districhiasis, and keratitis. This complication can cause a sharp decrease in vision. Results: This case report discusses a 68 year old male patient with blisters all over his body accompanied by swelling in both eyes, redness in both eyes, and difficult to open eyes. Patients with history of taking the new drug a month ago. No history of drug allergy. The patient suffered from hypertension, non-hemorrhagic stroke, and epilepsy with irregular treatment. Patient was performed a fluorescein test. In this case, the patient is given antibiotic ointment and artificial tears with steroids. In this case there were no complications. Conclusion: The ocular manifestations of SJS if handled quickly and properly can prevent long-term complications.

scholarly journals A CASE REPORT ON AMOXICILLIN INDUCED STEVENS- JOHNSON SYNDROME

2021 ◽  
Vol 12 (7) ◽  
pp. 22-24
Author(s):  
Rispa Darabadi ◽  
Karasani Harini
Keyword(s):  
Case Report ◽  
Mucous Membrane ◽  
Case Reports ◽  
The Body ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome ◽  
Oral Consumption ◽  
Life Threatening ◽  
Steven Johnson Syndrome

Steven-Johnson syndrome (SJS) is a rare, serious disorder of the skin and mucous membrane that is usually a reaction to medication. It usually starts with flu-like symptoms, followed by a painful rash that spreads and blisters. Other symptoms include Fever, sore mouth and throat, Fatigue, burning eyes, extensive skin and mucous membrane lesions (i.e., mouth, nose, esophagus, anus, and genitalia), epidermis detachment, and acute skin blisters. In 95% of case reports, drugs were identified to be an important cause for the development of SJS. The below is a case report of A 37-year-old male patient hospitalized with rashes over the body and fever, after oral consumption of Amoxicillin drug for cough and sore throat through OTC prescription. The patient has taken three doses of Amoxicillin and due to lack of awareness on Adverse drug reactions, the patient ignored the rashes that were developed after the first dose. This case study discusses the possibility of serious hypersensitivity reactions with Amoxicillin that rarely occur and can be extremely harmful and life threatening, brief knowledge on Stevens-Johnson syndrome and also some of the preventive measures to control the adverse reactions due to drugs.

Stevens-Johnson syndrome

2016 ◽  
Vol 19 (4) ◽  
pp. 216-220
Author(s):  
O. Yu Olisova ◽  
O. V Grabovskaya ◽  
N. P Teplyuk ◽  
A. A Lepekhova ◽  
D. V Ignatiev ◽  
...  
Keyword(s):  
Clinical Case ◽  
Clinical Presentation ◽  
Stevens Johnson Syndrome ◽  
High Dose ◽  
Treatment And Prevention ◽  
Johnson Syndrome ◽  
Mucous Membranes ◽  
Systemic Glucocorticoids ◽  
Life Threatening ◽  
Methods Of Treatment

The literature review of the epidemiology, etiology and pathogenesis, clinical presentation and diagnosis of the syndrome of Stevens-Johnson severe life-threatening disease characterized by extensive lesions of the skin and mucous membranes, fever and bone and muscle aches, often induced by medication is presented. A review on the methods of treatment and prevention of this disease is presented. The clinical case of patient with the syndrome of Stevens-Johnson is described. The successful treatment of Syndrome Stevens-Johnson with high-dose systemic glucocorticoids was performed.

Warning against long-acting sulphonamides

1966 ◽  
Vol 4 (4) ◽  
pp. 13-13
Keyword(s):  
United States ◽  
Mortality Rate ◽  
Erythema Multiforme ◽  
The United States ◽  
Stevens Johnson Syndrome ◽  
Warning Letter ◽  
Johnson Syndrome ◽  
The Us ◽  
Mucous Membranes ◽  
Long Acting

Last month the US Food and Drug Administration required American manufacturers of long-acting sulphonamides (sulphamethoxypyridazine, Lederkyn - Lederle and Midicel - PD; sulphadimethoxine - Madribon - Roche) to warn prescribers that in rare cases the Stevens-Johnson syndrome may develop as a severe and sometimes fatal side effect. This syndrome is a type of erythema multiforme in which large blisters appear on the skin and especially on the mucous membranes. The manufacturers were also to advise doctors ‘to consider prescribing short-acting sulphonamides first because they are effective for most of the same conditions’. The three drug firms concerned accordingly sent a joint warning letter to all doctors, pointing out that the Stevens-Johnson syndrome is a serious complication with a mortality rate of about 25%. So far 116 cases of this syndrome have been reported in association with the use of long-acting sulphonamides, most of them in the United States. Almost two thirds of the patients were children.

scholarly journals Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis; Extensive Review of Reports of Drug-Induced Etiologies, and Possible Therapeutic Modalities

2018 ◽  
Vol 6 (4) ◽  
pp. 730-738 ◽  
Author(s):  
Adegbenro Omotuyi John Fakoya ◽  
Princess Omenyi ◽  
Precious Anthony ◽  
Favour Anthony ◽  
Precious Etti ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Toxic Epidermal Necrolysis ◽  
Stevens Johnson Syndrome ◽  
Hypersensitivity Reactions ◽  
Extensive Review ◽  
Drug Induced ◽  
Therapeutic Modalities ◽  
Johnson Syndrome ◽  
Mucous Membranes ◽  
Degrees Of Severity

Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis are adverse hypersensitivity reactions that affect the skin and mucous membranes. They are characterised by erythematous macules and hemorrhagic erosions of the mucous membranes. Epidermal detachments of varying degrees of severity also occur in these conditions. Various aetiologies are associated with these conditions, with adverse drug reaction being the most common. Though the worldwide incidence of these conditions is recorded as low, diverse types of medication are being observed to lead to these conditions. This review compiles information on the details of Stevens-Johnson syndrome and Toxic Epidermal Necrolysis, the pathophysiology, therapeutic management, and largely considers the drug-induced etiologies associated with these conditions.

scholarly journals Fatal case of toxic epidermal necrolysis induced by ciproflfl oxacin in a child

2021 ◽  
Vol 12 (Supp 1) ◽  
pp. 26-29
Author(s):  
Thomas Schiestel
Keyword(s):  
Case Report ◽  
Toxic Epidermal Necrolysis ◽  
Adverse Reactions ◽  
Pediatric Population ◽  
Fatal Case ◽  
Stevens Johnson Syndrome ◽  
Delayed Treatment ◽  
Drug Eruptions ◽  
Johnson Syndrome ◽  
Life Threatening

Bullous drug eruptions such as Toxic Epidermal Necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare but known adverse reactions of fluoroquinolones. Although uncommon, TEN can be life-threatening for the patient, especially in the context of delayed treatment and in fragile patients such as the pediatric population. In the present case, TEN occurred in a 13-year-old girl with no medical history following initiation of ciprofloxacin treatment for an inguinal cyst. We hope that the case report will make interrogate the practices concerning the use of antibiotics, in particular fluoroquinolones in the context of an use not prescribed by the Marketing Authorization of the drug in children.

scholarly journals Toxic Epidermal Necrolysis/Stevens-Johnson Syndrome at A University Hospital in Saudi: Causative Factors and Outcomes

2022 ◽  
Author(s):  
Amal A Kokandi
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Small Sample Size ◽  
Intravenous Immunoglobulins ◽  
Small Sample ◽  
University Hospital ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome ◽  
Causative Agents ◽  
Life Threatening ◽  
King Abdulaziz University

Abstract Introduction:Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare, life-threatening conditions caused mainly by drugs. Their management relies on the withdrawal of the culprit medication and supportive measures. Different pharmacotherapies have varied effects. However, data related to TEN and SJS in Saudi is limited. This study aimed to identify the causative agents, associated factors, and outcomes of TEN/SJS cases admitted to a teaching hospital (King Abdulaziz University) in Jeddah during the last 10 years.Methods: We retrospectively analyzed the data of TEN/SJS patients admitted to the hospital over the last 10 years.Results: We identified 12 patients with TEN/SJS. Of these, nine survived the condition and were discharged. The culprit medication was identified in eight of them, including antibiotics in six cases and Tegretol and allopurinol in one case each. Most of the patients received systemic steroids and intravenous immunoglobulins.Conclusion: TEN/SJS is mainly caused by medications of which antibiotics are the most implicated. Consistent with other studies, the mortality rate associated with TEN/SJS in Saudi is 25%. Limitations: restricted to a single center and small sample size.

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