scholarly journals Incidence and Risk Factors of Dry Eye in Children and Adolescents With Diabetes Mellitus: A 3-Year Follow-Up Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhangling Chen ◽  
Ying Xiao ◽  
Yu Qian ◽  
Qiurong Lin ◽  
Zhaoyu Xiang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Children And Adolescents ◽  
Incidence Rate ◽  
Dry Eye ◽  
Study Cohort ◽  
Children And Adolescent ◽  
Eye Pain ◽  
Long Course

Purpose: To investigate the incidence and risk factors of dry eye in children with diabetes mellitus (DM) over a period of 3 years.Methods: Children and adolescents with DM (age: 3–14 years) from the Shanghai Children and Adolescent Diabetes Eye (SCADE) study cohort who did not have dry eye in January 2018 were followed-up for 3 years and re-examined in January 2021, and the incidence rate and risk factors for dry eye were calculated.Results: Forty children and adolescents with DM came for follow-up in 2021. Nine of them were diagnosed with dry eye, resulting in a 3-year incidence rate of 22.5% and an annual mean incidence rate of 7.5% for dry eye. Univariate regression analysis confirmed that decreased corneal sensation (OR [Odds Ratio] = 25.60; 95%CI [Confidence Interval] = 1.31~501.69; P = 0.03) was the risk factor for dry eye incidence. Long course of DM (OR = 1.80; 95%CI = 0.96~3.38; P = 0.07), eye pain (OR = 12.27; 95%CI = 0.65~231.48; P = 0.09), and dry eye in parents (OR = 15.99; 95%CI = 0.76~337.75; P = 0.08) may interfere with the incidence of dry eye in them.Conclusions: The incidence of dry eye in children and adolescents with DM is high.

scholarly journals C, the diabetics Risk Factors for Type 1 Diabetes Mellitus among children and Adolescents at Suleimani Chronic Diabetes Health Center

2021 ◽  
pp. 56-68
Author(s):  
Pary Mohammad Azize ◽  
Chia H. Sadiq
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 1 Diabetes ◽  
Family History ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Health Center ◽  
Factors Affecting ◽  
Children And Adolescent

Diabetes mellitus is one of the most common chronic health condition worldwide and the most common endocrine disease in children and adolescences. The aim of this study is to find out the risk factors, which lead to pathogenesis of type 1 diabetes mellitus among children and adolescent in diabetes health center Suleimani city. A descriptive cross sectional study was conducted at a special center for Type 1 Diabetes Miletus A questionnaire was developed and administered to a convenience sample of (170 ) mothers or fathers. Descriptive statistics data (frequency, percentage, mean and stander deviation) and also Factorial analysis (principal component analysis) was used in order to identify the effective factors affecting diabetes in children and Adolescents. The finding show that, 39.4 %  of samples were aged between (9-13) years old, which stated as the highest rate among all age groups, while the minority of age was between (1-4) years old, which was equal to 8.2% of the total and the (Mean ±S.D) was equal to 10.44±4.04 respectively. The majority of age at diagnosis was between (5-8) years old, which is 35.3% and their food habit was normal diet, which is 73.5%, while the Sugar diet and Fatty diet were 25.9% and 0.6%y respectively. Most of the participants, 19.4% of  family history was Type 2 diabetes, which was the first rank of the family history and majority of them were Kurdish in nationality. Age at diagnosis and mode of delivery considered as the first factor affect the type 1 diabetics mellitus. The second most common factor effect on diabetes disease in children and adolescents are maternal habit and maternal disease followed by Gestational age at birth and Neonatal disease, then food habits, Neonatal weight was estimated as the fourth component factors affecting Type 1 diabetes mellitus.  Residency and Family history of autoimmune disease were ranked in the fifth line of factor, finally the weakest factor is nationality by total variance of 8.552%. The first years of life is play an important role in triggering and the development of  type 1 diabetes mellitus among children and adolescent , also maternal diseases ( gestational diabetes, pre-eclampsia and perinatal infection during pregnancy), healthy diet during pregnancy and education programs are recommended  

scholarly journals 1003Modifiable risk factors and incidence of diabetes mellitus progressing in the prediabetic Population

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Kwan Hong ◽  
Eun Sun Yu ◽  
Byung Chul Chun
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Alcohol Consumption ◽  
Incidence Rate ◽  
National Health ◽  
Progression Rate ◽  
Modifiable Risk Factors ◽  
Adjusted Incidence Rate ◽  
Adjusted Incidence

Abstract Background Although the prevention of diabetes mellitus is important, factors related to its progression in the prediabetic population are rarely revealed. This study aimed to estimate the rate of progression and uncover the modifiable risk factors leading to progression. Methods We constructed a group from the National Health Screening Cohort, consisting of adults who received national health screening tests in 2002. After selecting a prediabetic population, we classified them into two groups based on their diabetes progression after a 13-year follow up. The adjusted incidence rate was estimated, and the Cox proportional hazard modelling was performed to identify risk factors for progression. Results The progression rate of diabetes in the prediabetic population (88,330) was 22.85% (20,184), with an adjusted incidence rate of 25.18 (95% confidence interval, CI: 24.44 – 26.02) per 1,000 person-year, ages 40-64 and 25.69 (95% CI: 24.46 – 26.95) in those 65 or older. Among modifiable risk factors, smoking showed the highest hazard ratio, 1.21 (95% CI: 1.16 – 1.25), followed by BMI and alcohol consumption with hazard ratios of 1.06 (95% CI: 1.06 – 1.07) and 1.06 (95% CI: 1.02 – 1.09), respectively. Conclusions Considering the high progression rate of the prediabetic population, modifiable risk factors, such as smoking, should be managed. Key messages The progression rate of the prediabetic population was 25–26% per 1,000 person-year. At the 13-year follow up, modifiable risk factors, such as smoking, BMI, and alcohol consumption, affected the prediabetic population.

scholarly journals Incidence and risk factors of type 2 diabetes mellitus in an overweight and obese population: a long-term retrospective cohort study from a Gulf state

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e035813 ◽  
Author(s):  
Dybesh Regmi ◽  
Saif Al-Shamsi ◽  
Romona D. Govender ◽  
Juma Al Kaabi
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Incidence Rate ◽  
Retrospective Cohort ◽  
Outpatient Clinics ◽  
Type 2 Dm

ObjectivesA high body mass index (BMI) is associated with risk of type 2 diabetes mellitus (DM). The United Arab Emirates (UAE) is experiencing a marked increase in obesity. Nonetheless, no data are available regarding the incidence of type 2 DM in the high-risk adult UAE population. Therefore, this study aimed to evaluate the incidence rate and risk of developing type 2 DM among individuals with above-normal BMI in the UAE.DesignA retrospective cohort study.SettingOutpatient clinics at a tertiary care centre in Al Ain, UAE.ParticipantsThree hundred and sixty-two overweight or obese adult UAE nationals who visited outpatient clinics between April 2008 and December 2008.Primary outcome measurePatients with type 2 DM were identified based on diagnosis established by a physician or through glycated haemoglobin (HbA1c) levels ≥6.5% during the follow-up period (until April 2018).ResultsThe overall incidence rate of type 2 DM during the median follow-up time of 8.7 years was 16.3 (95% CI 12.1 to 21.4) cases per 1000 person-years. Incidence rates in men and women were 17.7 (95% CI 11.6 to 25.9) and 15.0 (95% CI 9.8 to 22.2) cases per 1000 person-years, respectively. Multivariable Cox proportional hazard analysis determined older age and obesity in women and pre-diabetes in men to be independent risk factors for developing type 2 DM.ConclusionsThe incidence rate of type 2 DM in overweight and obese UAE nationals is high. In addition to screening, current strategies should strongly emphasise lifestyle modifications to decrease HbA1c and BMI levels in this high-risk population.

scholarly journals Factors Associated with Poor Glycemic and Lipid Levels in Ambulatory Diabetes Mellitus Type 2 Patients in Asmara, Eritrea: A Cross-Sectional Study

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Oliver Okoth Achila ◽  
Millen Ghebretinsae ◽  
Abraham Kidane ◽  
Michael Simon ◽  
Shewit Makonen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Waist Circumference ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Specific Lipid

Objective. There is a dearth of relevant research on the rapidly evolving epidemic of diabetes mellitus (particularly Type 2 diabetes mellitus) in sub-Saharan Africa. To address some of these issues in the Eritrean context, we conducted a cross-sectional study on glycemic and lipid profiles and associated risk factors. Methods. A total of 309 patients with diabetes mellitus on regular follow-up at the Diabetic and Hypertensive Department at Halibet Regional Referral Hospital, Asmara, were enrolled for the study. Data on specific clinical chemistry and anthropomorphic parameters was collected. Chi-squared (χ2) test or Fischer’s exact test was used to evaluate the relationship between specific variables. Multivariate logistic regression (backward: conditional) was undertaken to identify the factors associated with increased odds of suboptimal values in glucose and specific lipid panel subfractions. Results. High proportions of patients (76.7%) had suboptimal levels of HbA1c with a mean±SD of 8.6%±1.36, respectively. In multivariate regression analysis, the likelihood of HbA1c≥7% was higher in patients with abnormal WHR (AOR=3.01, 95% CI, 3.01 (1.15–7.92=0.024)) and in patients without hypertension (AOR=1.97, 95% CI (1.06–3.56), p=0.021). A unit reduction in eGFR was also associated with HbA1c≥7% (AOR=0.99, 95% CI (0.98–1=0.031)). In a separate analysis, the data shows that 80.9% of the patients had dyslipidemia. In particular, 62.1% of the patients had TC≥200 mg/dL (risk factors: sex, hypertension, and HbA1c concentration), 81.6% had LDL‐C≥100 mg/dL (risk factors: sex and hypertension), 56.3% had TG≥150 (risk factors: sex, HbA1c, and waist circumference), 62.8% had abnormal HDL-C (risk factors: waist circumference), 78.3% had non‐HDL<130 mg/dL (risk factors: duration of disease, reduced estimated glomerular filtration rate, and HbA1c), and 45.3% had abnormal TG/HDL (risk factors: sex, age of patient, FPG, and waist circumference). Conclusions. The quality of care, as measured by glycemic and specific lipid targets, in this setting is suboptimal. Therefore, there is an urgent need for simultaneous improvements in both indicators. This will require evidence-based optimization of pharmacological and lifestyle interventions. Therefore, additional studies, preferably longitudinal studies with long follow-up, are required on multiple aspects of DM.

New glycemic metrics and traditional clinical and laboratory profiles of children and adolescents with type 1 diabetes mellitus in an outpatient follow-up

2021 ◽  
Vol 173 ◽  
pp. 108680
Author(s):  
Ricardo Rodrigues ◽  
Isabela Cristina Borges Rossi ◽  
Bruno Franco Rossi ◽  
Débora Cristiane Gomes ◽  
Nilson Penha-Silva
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents

scholarly journals Epidemiology of Heart Failure Stages in Middle‐Aged Black People in the Community: Prevalence and Prognosis in the Atherosclerosis Risk in Communities Study

2021 ◽  
Author(s):  
Ramachandran S. Vasan ◽  
Solomon K. Musani ◽  
Kunihiro Matsushita ◽  
Walter Beard ◽  
Olushola B. Obafemi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Heart Failure ◽  
Cardiovascular Disease ◽  
Left Ventricular ◽  
Study Cohort ◽  
Atherosclerosis Risk In Communities ◽  
Cardiovascular Morbidity And Mortality ◽  
Atherosclerosis Risk

Background Black individuals have a higher burden of risk factors for heart failure (HF) and subclinical left ventricular remodeling. Methods and Results We evaluated 1871 Black participants in the Atherosclerosis Risk in Communities Study cohort who attended a routine examination (1993–1996, median age 58 years) when they underwent echocardiography. We estimated the prevalences of 4 HF stages: (1) Stage 0 : no risk factors; (2) Stage A : presence of HF risk factors (hypertension, diabetes mellitus, obesity, smoking, dyslipidemia, coronary artery disease without clinical myocardial infarction), no cardiac structural/functional abnormality; (3) Stage B : presence of prior myocardial infarction, systolic dysfunction, left ventricular hypertrophy, regional wall motion abnormality, or left ventricular enlargement; and (4) Stage C/D : prevalent HF. We assessed the incidence of clinical HF, atherosclerotic cardiovascular disease events, and all‐cause mortality on follow‐up according to HF stage. The prevalence of HF Stages 0, A, B, and C/D were 3.8%, 20.6%, 67.0%, and 8.6%, respectively, at baseline. On follow‐up (median 19.0 years), 309 participants developed overt HF, 390 incurred new‐onset cardiovascular disease events, and 651 individuals died. Incidence rates per 1000 person‐years for overt HF, cardiovascular disease events, and death, respectively, were Stage 0, 2.4, 0.8, and 7.6; Stage A, 7.4, 9.7, and 13.5; Stage B 13.6, 15.9, and 22.0. Stage B HF was associated with a 1.5‐ to 2‐fold increased adjusted risk of HF, cardiovascular disease events and death compared with Stages 0/A. Conclusions In our large community‐based sample of Black individuals, we observed a strikingly high prevalence of Stage B HF in middle age that was a marker of high cardiovascular morbidity and mortality.

scholarly journals Respiratory morbidity of preterm infants of less than 33 weeks gestation without bronchopulmonary dysplasia: a 12-month follow-up of the CASTOR study cohort

2013 ◽  
Vol 142 (7) ◽  
pp. 1362-1374 ◽  
Author(s):  
B. FAUROUX ◽  
J.-B. GOUYON ◽  
J.-C. ROZE ◽  
C. GUILLERMET-FROMENTIN ◽  
I. GLORIEUX ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Respiratory Morbidity ◽  
Study Cohort ◽  
Recurrent Wheezing ◽  
Term Infants ◽  
Independent Risk Factors ◽  
Syncytial Virus

SUMMARYThe aim of this study was to describe the incidence and risk factors for respiratory morbidity during the 12-month period following the first respiratory syncytial virus (RSV) season in 242 preterm infants [<33 weeks gestational age (GA)] without bronchopulmonary dysplasia and 201 full-term infants (39–41 weeks GA) from the French CASTOR study cohort. Preterm infants had increased respiratory morbidity during the follow-up period compared to full-terms; they were more likely to have wheezing (21% vs. 11%, P = 0·007) and recurrent wheezing episodes (4% vs. 1%, P = 0·049). The 17 infants (14 preterms, three full-terms) who had been hospitalized for RSV-confirmed bronchiolitis during their first RSV season had significantly more wheezing episodes during the follow-up period than subjects who had not been hospitalized for RSV-confirmed bronchiolitis (odds ratio 4·72, 95% confidence interval 1·71–13·08, P = 0·003). Male gender, birth weight <3330 g and hospitalization for RSV bronchiolitis during the infant's first RSV season were independent risk factors for the development of wheezing episodes during the subsequent 12-month follow-up period.

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