Incremental Value of Arterial Stiffness Over Traditional Risk Factors in Predicting Subclinical Cardiovascular Remodeling in Patients With Moderate Chronic Renal Failure

Angiology ◽  
2011 ◽  
Vol 62 (8) ◽  
pp. 662-668 ◽  
Author(s):  
Cristian-Razvan Ticulescu ◽  
Olga Vriz ◽  
Lina Sparacino ◽  
Bogdan A Popescu ◽  
Carmen Ginghina ◽  
...  
Keyword(s):  
Risk Factors ◽  
Arterial Stiffness ◽  
Intima Media Thickness ◽  
Left Ventricular ◽  
Stage Iii ◽  
Similar Degree ◽  
Cardiovascular Remodeling ◽  
Incremental Value ◽  
Traditional Risk Factors ◽  
Echo Tracking

Cardiovascular remodeling in chronic kidney disease (CKD) is responsible for the high mortality found in this condition. A total of 89 consecutive outpatients with stage III CKD and 52 patients with stage II CKD with similar degree of traditional atherosclerotic risk factors underwent routine echocardiographic and carotid Doppler examination, evaluating vascular and cardiac remodeling (intima—media thickness [IMT] and left ventricular mass index [LVMi]), and its relation with arterial stiffness, determined in the same examination, using an echo-tracking technique. Also the absolute values of LVMi and IMT were statistically similar between the 2 groups, their determinants were completely different, only in stage III the markers of renal impairment and arterial stiffness being independent predictors of cardiac and vascular modifications. We concluded that macroanatomical measurements do not fully describe cardiovascular remodeling in this setting. Arterial stiffness echo-tracking derived could add valuable information, being an easy-to-perform parameter during a routine examination.

scholarly journals Effect of uric acid serum levels on carotid arterial stiffness and intima-media thickness: A high resolution Echo-Tracking Study

2019 ◽  
Vol 89 (1) ◽  
Author(s):  
Francesco Antonini-Canterin ◽  
Concetta Di Nora ◽  
Marco Pellegrinet ◽  
Olga Vriz ◽  
Salvatore La Carrubba ◽  
...  
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Carotid Artery ◽  
Arterial Stiffness ◽  
Serum Uric Acid ◽  
Intima Media Thickness ◽  
Stiffness Index ◽  
Artery Stiffness ◽  
Echo Tracking ◽  
Carotid Arterial

Serum uric acid (UA) has been shown to be a predictor of cardiovascular (CV) morbidity and mortality, and it may play a role in the pathogenesis of CV disease affecting vascular structure and function. However, there is limited evidence of its specific association with carotid artery stiffness and structure. The aim of our study was to evaluate whether UA is associated with early signs of atherosclerosis, namely local carotid arterial stiffness and intima-media thickening. We evaluated 698 consecutive asymptomatic patients, referred to the Cardiovascular Department for risk factors evaluation and treatment. All patients underwent carotid artery ultrasonography with measurement of common carotid intima-media thickness (IMT) and echo-tracking carotid artery stiffness index Beta. Patients with hyperuricemia (defined as serum uric acid ≥7 mg/dL in men and ≥6 mg/dL in women) had higher IMT (0.97±0.22 vs 0.91±0.18, p<0.001) and stiffness index Beta (8.3±3.2 vs 7.5±2.7, p=0.005). UA levels correlated with both IMT (r=0.225; p<0.001) and stiffness index Beta (r=0.154; p<0.001); the correlations were statistically significant in males and females. In a multivariate model which included age, arterial pressure, serum glucose and LDL-cholesterol, serum UA emerged as an independent explanatory variable of IMT and stiffness index Beta. Carotid IMT and local arterial stiffness are related to UA independently of established CV risk factors; UA may play a role in the early development of atherosclerosis.

scholarly journals Evaluation of arterial stiffness in systolic heart failure

2021 ◽  
Vol 67 (2) ◽  
pp. 86-89
Author(s):  
Lajos Fehérvári ◽  
István Adorján Szabó ◽  
Lóránd Kocsis ◽  
Attila Frigy
Keyword(s):  
Heart Failure ◽  
Arterial Stiffness ◽  
Statistical Significance ◽  
Systolic Heart Failure ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Chi Square ◽  
Ventricular Ejection Fraction

Abstract Objective: Micro- and macrovascular changes can occur in heart failure, and could influence its prognosis and management. In a prospective study, we proposed the evaluation of arterial stiffness (macrovascular function) and its correlations in patients with systolic heart failure. Methods: 40 patients (32 men, 8 women, mean age 63±2.9 years), with hemodynamically stable systolic heart failure (left ventricular ejection fraction, EF<40%) were enrolled in the study. In every patient, beyond routine explorations (ECG, cardiac and carotid ultrasound, laboratory measurements), arterial stiffness was assessed by measuring pulse wave velocity (PWV). The correlations of PWV with clinical and echo-cardiographic characteristics were studied using t-test and chi-square test (p<0.05 being considered for statistical significance). Results: The average PWV was 8.55±2.2 m/s, and 16 patients had increased PWV (>10 m/s). We found significantly higher PWV values in patients older than 65 years (p<0.001), in patients with eGFR <60 ml/min/1.73 m2 (p<0.001), hypertension (p=0.006), and increased (>1 mm) carotid intima-media thickness (p=0.016). PWV was found to be significantly lower when EF was <30% (p=0.049). Furthermore, the presence of an increased PWV was correlated significantly with age (p<0.001), and (with borderline significance) with eGFR <60 ml/min/1.73 m2 and, inversely, with EF<30%. Conclusions: Increased arterial stiffness reflected by high PWV is frequently present in patients with systolic heart failure, and is mainly correlated with general risk factors of arterial involvement. Low EF, due to low stroke volume and decreased systolic arterial wall tension can influence the values and the interpretation of PWV.

scholarly journals Study protocol: The INTERMAP China Prospective (ICP) study

2019 ◽  
Vol 4 ◽  
pp. 154 ◽  
Author(s):  
Li Yan ◽  
Ellison Carter ◽  
Yu Fu ◽  
Dongshuang Guo ◽  
Pinchun Huang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Data Collection ◽  
Arterial Stiffness ◽  
Vascular Function ◽  
Cardiovascular Effects ◽  
Intima Media Thickness ◽  
Repeated Measurements ◽  
Nutritional Risk ◽  
Media Thickness ◽  
Urine Specimens

Background: Unfavourable blood pressure (BP) level is an established risk factor for cardiovascular diseases (CVD), while the exact underlying reasons for unfavourable BP are poorly understood.  The INTERMAP China Prospective (ICP) Study is a prospective cohort to investigate the relationship of environmental and nutritional risk factors with key indicators of vascular function including BP, arterial stiffness, and carotid-intima media thickness. Methods: A total of 839 Chinese participants aged 40-59 years from three diverse regions of China were enrolled in INTERMAP in 1997/98; data collection included repeated BP measurements, 24-hour urine specimens, and 24-hour dietary recalls.  In 2015/16, 574 of these 839 persons were re-enrolled along with 208 new participants aged 40-59 years that were randomly selected from the same study villages.  Participant’s environmental and dietary exposures and health outcomes were assessed in this open cohort study, including BP, 24-hour dietary recalls, personal exposures to air pollution, grip strength, arterial stiffness, carotid-media thickness and plaques, cognitive function, and sleep patterns.  Serum and plasma specimens were collected with 24-hour urine specimens. Discussion:  Winter and summer assessments of a comprehensive set of vascular indicators and their environmental and nutritional risk factors were conducted with high precision.  We will leverage advances in exposome research to identify biomarkers of exposure to environmental and nutritional risk factors and improve our understanding of the mechanisms and pathways of their hazardous cardiovascular effects.  The ICP Study is observational by design, thus subject to several biases including selection bias (e.g., loss to follow-up), information bias (e.g., measurement error), and confounding that we sought to mitigate through our study design and measurements.  However, extensive efforts will apply to minimize those limitations (continuous observer training, repeated measurements of BP, standardized methods in data collection and measurements, and on-going quality control).

AN EMBEDDED MICROPROCESSOR UNIT-BASED PORTABLE NONINVASIVE ARTERIOSCLEROSIS DETECTING SYSTEM AND ITS EXPERIMENTAL STUDY

2013 ◽  
Vol 25 (06) ◽  
pp. 1350051
Author(s):  
Wei He ◽  
Songnong Li ◽  
Hanguang Xiao ◽  
Chuanxiang Yu ◽  
Haitao Lin
Keyword(s):  
Risk Factors ◽  
Clinical Trial ◽  
Arterial Stiffness ◽  
Doppler Ultrasonography ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Stiffness Index ◽  
Cardiovascular Morbidity And Mortality ◽  
Embedded Microprocessor ◽  
Arterial Stiffness Index

Pulse wave velocity (PWV) and arterial stiffness index (ASI) are considered as the independent predictors of cardiovascular morbidity and mortality — the effective methods to assess arterial stiffness. A portable noninvasive arterial elasticity detecting system (PNAEDS) was developed based on embedded microprocessor unit. This system can simultaneously measure PWV, ASI and other arteriosclerosis critical risk factors. Algorithm of main critical risk factors and design of the system were described in detail. To verify the performance of the PNAEDS, laboratory prospective validation and clinical trial were launched. Reliability of the system and superiority of improved PWV algorithm were validated in laboratory prospective validation. Subsequently, the authors implemented a comparative clinical trial (60 subjects) between measured values obtained by the PNAEDS and carotid intima-media thickness (IMT) value that Doppler ultrasonography measured. Clinical testing results revealed that the measurement with the PNAEDS was consistent with the measurement with the Doppler ultrasonography. In summary, the system may be used to reliably determine the arteriosclerosis critical risk factors and to the early diagnosis and prevention of cardiovascular disease.

Arterial stiffness changes in patients with cardiovascular risk factors but normal carotid intima–media thickness

2013 ◽  
Vol 14 (9) ◽  
pp. 622-628 ◽  
Author(s):  
Moemen Mohammed ◽  
Concetta Zito ◽  
Maurizio Cusmà-Piccione ◽  
Gianluca Di Bella ◽  
Francesco Antonini-Canterin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Arterial Stiffness ◽  
Cardiovascular Risk Factors ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

Intima-Media Thickness is Associated With Non-Traditional Risk Factors and Ischemic Heart Disease in Hemodialysis Patients

2011 ◽  
Vol 16 (1) ◽  
pp. 104-106 ◽  
Author(s):  
Cleto Álvarez-Aguilar ◽  
Daniel Lara-Romero ◽  
Javier Piñón-Escobedo ◽  
Anel Gómez-García ◽  
Alfonso R Álvarez-Paredes
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Intima Media Thickness ◽  
Hemodialysis Patients ◽  
Ischemic Heart ◽  
Media Thickness ◽  
Traditional Risk Factors

Obesity is a determinant of arterial stiffness independent of traditional risk factors in Asians with young-onset type 2 diabetes

2014 ◽  
Vol 236 (2) ◽  
pp. 286-291 ◽  
Author(s):  
Jian-Jun Liu ◽  
Chee Fang Sum ◽  
Subramaniam Tavintharan ◽  
Lee Ying Yeoh ◽  
Xiao Wei Ng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Arterial Stiffness ◽  
Young Onset ◽  
Onset Type ◽  
Traditional Risk Factors

Carotid arterial stiffness is increased and related to left ventricular function in patients with hypertrophic cardiomyopathy

2019 ◽  
Vol 21 (8) ◽  
pp. 923-931
Author(s):  
Monica Roşca ◽  
Leonard Mandeş ◽  
Daniela Ciupercă ◽  
Andreea Călin ◽  
Carmen C Beladan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Elastic Modulus ◽  
Hypertrophic Cardiomyopathy ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Left Ventricular Function ◽  
Pulse Wave ◽  
Left Ventricular ◽  
Carotid Arterial

Abstract Aims To assess the carotid mechanical properties in patients with hypertrophic cardiomyopathy and the relation between arterial stiffness and left ventricular function in this setting. Methods and results We have prospectively enrolled 71 patients (52 ± 16 years, 34 men) with hypertrophic cardiomyopathy, divided into two groups depending on the presence (46 patients) or absence (25 patients) of cardiovascular risk factors associated with increased arterial stiffness. Twenty-five normal subjects similar by age and gender with hypertrophic cardiomyopathy patients without risk factors formed the control group. A comprehensive echocardiography was performed in all subjects. Carotid arterial stiffness index (β index), pressure–strain elastic modulus, arterial compliance, and pulse wave velocity were also obtained using an echo-tracking system. β index, pulse wave velocity, and pressure–strain elastic modulus were significantly higher in hypertrophic cardiomyopathy patients without risk factors compared to controls. After linear regression analysis, the increase in carotid β index was independently correlated with the presence of hypertrophic cardiomyopathy [beta = 0.49, 95% confidence interval (CI) = 1.04–3.02; P &lt; 0.001]. In the entire hypertrophic cardiomyopathy population arterial stiffness parameters correlated with age, gender, hypertension degree, presence of hypercholesterolaemia, and the E/e′ ratio. In multivariable analysis, β index (beta = 0.36, 95% CI = 0.32–1.25; P = 0.001), global left ventricular longitudinal strain, and the presence of left ventricular outflow tract obstruction were independently correlated with the E/e′ ratio. Conclusion In patients with hypertrophic cardiomyopathy arterial stiffness is increased independently of age or presence of cardiovascular risk factors. Carotid artery stiffness is independently related to left ventricular filling pressure, increased arterial stiffness representing a possible marker of a more severe phenotype.

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