Tumor Protein p53 (TP53) Gene and Left Main Coronary Artery Disease

Angiology ◽  
2018 ◽  
Vol 69 (8) ◽  
pp. 730-735 ◽  
Author(s):  
Vana Kolovou ◽  
Angelos Tsipis ◽  
Constantinos Mihas ◽  
Niki Katsiki ◽  
Vasiliki Vartela ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Tp53 Gene ◽  
Control Group ◽  
Left Main ◽  
Control Groups ◽  
Replication Studies ◽  
Risk Patients ◽  
Artery Disease ◽  
And Control

Patients with left main (LM) coronary artery disease (CAD) are at the highest risk of cardiovascular events. We evaluated possible gene polymorphisms of tumor protein 53 ( TP53, rs1042522, p.Arg72Pro) that can differentiate LM-CAD from patients with more peripheral CAD (MP-CAD) and healthy participants (control group) in 520 individuals (LM-CAD, n = 175; MP-CAD, n = 185; and control group, n = 160). Patients with LM-CAD had the lowest Arg/Arg genotype frequency (36.0%) compared with the MP-CAD (57.3%) and control groups (61.9%), P < .001 for both comparisons. Similarly, the Arg allele was more frequent in the control group than in patients with MP-CAD (78.8% vs 73.2%; P = .007) and LM-CAD (78.8% vs 64.0%; P < .001). The Arg/Pro genotype was more frequent in the LM-CAD group compared with the MP-CAD and control groups (56.0, 31.9, and 33.8, respectively, P < .001 for both comparisons). Furthermore, the frequency of Arg/Arg genotypes was the lowest in the LM-CAD group compared with the MP-CAD and control groups. Knowing that TP53 is an antioncogene protein that acts as a tumor suppressor and regulator of apoptosis, the lowest frequency of Arg/Arg genotype observed in these high-risk patients may indicate lower protection from the atherosclerosis process. Replication studies are needed to evaluate this association.

Abstract 150: Association Between Serum Ghrelin Levels and Coronary Artery Disease: a Meta-analysis

2015 ◽  
Vol 117 (suppl_1) ◽  
Author(s):  
Pradyumna Agasthi ◽  
Sivakanth Aloor ◽  
Avantika Chenna ◽  
Anekwe Onwuanyi
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Meta Analysis ◽  
Control Group ◽  
Cross Sectional ◽  
Median Serum ◽  
Artery Disease ◽  
Differentiation And Proliferation ◽  
And Control ◽  
Serum Gh

Background: Ghrelin (GH) is a gastrointestinal endocrine peptide regulating multiple biological processes including adipogenesis, glucose metabolism, cell differentiation and proliferation. Recent studies demonstrated that GH inhibits pro-atherogenic changes in vessel wall via inhibition of nuclear factor - B activity, a transcriptional factor mediating production pro-inflammatory cytokines and adhesion molecule expression in the endothelium. The aim of the current study is to conduct a meta-analysis to evaluate the relationship between serum GH levels and coronary artery disease (CAD). Methods: We searched MEDLINE, CINHAL and COCHRANE databases for studies reporting serum GH levels in the CAD and non CAD study population. We included case controls, cohort and cross-sectional studies. We calculated the weighted standardized mean difference (SMD) in serum GH levels between the CAD and control groups. Results: Our search strategy yielded 285 articles and we included 10 studies enrolling 1855 participants. The median age of the CAD group was 62 yrs. (IQR 60 - 63) compared to 61 yrs. (IQR 58 - 65) in the control group. The median body mass index in the CAD group was 28 kg/m2 (IQR 27.9 - 28) compared to 27 kg/m2 (IQR 26 - 27) in the control group. The unweighted median serum GH levels in the CAD group were 0.66 ng/ml (IQR 0.3 - 1.6) compared to 0.76 ng/ml (IQR 0.38 - 4.9) in the control group. The SMD of GH level was -0.44 (95% CI -0.56,-0.31) p<0.001 comparing those in the CAD group and control group. Conclusion: Serum GH levels are significantly and inversely associated with CAD. Current findings warrant the need to further investigate the role of GH in the pathogenesis of CAD.

scholarly journals Association of the waist-hip ratio with plasma adiponectin related to coronary artery disease

2018 ◽  
Vol 17 (2) ◽  
pp. 290-295
Author(s):  
Premtim Rashiti ◽  
Ibrahim Behluli ◽  
Albiona Bytyçi
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Medical Science ◽  
Control Group ◽  
Serum Samples ◽  
Waist Hip Ratio ◽  
Significant Difference ◽  
Artery Disease ◽  
A Prospective Study ◽  
And Control

Objective: By enrolling a prospective study of 82 patients that underwent non-urgent coronary angiography for coronary artery disease (CAD), it is aimed to investigate the correlation between adiponectin and waist-hip-ratio with severity of CAD.Materials and methods: The results of the angiography, divided the patients into two groups, patients admitted with a diagnosis of CAD and non-CAD. In the conducted hospital based research, two groups were involved: the study group with documented angiographically CAD and control group without angiographic evidence of CAD. Some of the baseline adiponectin levels in stored serum samples of all patients, anthropometric and biochemical risk factors were assessed in both groups.Result and discussion: As the result, we have seen the presence of CAD that was associated with current smoking, male gender, waist–hip ratio (WHR).While, no significant difference between median adiponectin levels at baseline were observed between cases and controls.Conclusion: There is a significant positive correlation between waist - hip ratio and presence of severity of coronary artery disease.Bangladesh Journal of Medical Science Vol.17(2) 2018 p.290-295

Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease

2011 ◽  
Vol 19 (3) ◽  
pp. 412-418 ◽  
Author(s):  
Ephraim B Beck ◽  
Sandra Erbs ◽  
Sven Möbius-Winkler ◽  
Volker Adams ◽  
Felix J Woitek ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Growth Factors ◽  
Coronary Artery ◽  
Exercise Training ◽  
Control Group ◽  
Serum Concentrations ◽  
Vascular Growth ◽  
Endothelial Response ◽  
Artery Disease ◽  
And Control

Objective: Exercise training partially corrects endothelial dysfunction in patients with coronary artery disease (CAD). Growth factors like vascular endothelial growth factor (VEGF) as well as erythropoietin (EPO) are known to modulate the bioavailability of nitric oxide and, thereby, contribute to the maintenance of a normal vascular tone. The aim of the present study was to determine the impact of 4 weeks of exercise training on circulating growth factors and to elucidate their involvement in the training-induced changes in vasomotion in patients with CAD. Methods and results: A total of 39 patients were enrolled (training group: n = 20; control group: n = 19). At start of study and after 4 weeks, average peak flow velocity (APV) of the left internal mammary artery (LIMA) in response to acetylcholine was measured invasively in the treatment and control groups. Serum concentrations of VEGF and EPO were determined by enzyme-linked immunosorbent assay. After exercise training, LIMA APV in response to acetylcholine was increased by 93% (from 69 ± 17% at start of study to 133 ± 16% at 4 weeks, p < 0.01 vs. start of study and control). At start of study, there was no association between any of the vascular growth factors and endothelial function. However, after exercise training a close correlation was apparent between the acetylcholine-induced change in APV and EPO ( r = 0.69, p < 0.01) and VEGF ( r = 0.76, p < 0.01) serum concentrations. In the control group, these correlations were not evident and there was no change in endothelial function either. Conclusion: Exercise training improves agonist-mediated endothelium-dependent vasodilatation in CAD, partially through a restoration of the endothelial response to EPO and VEGF.

Transcriptome-wide N6-methyladenosine methylation landscape of coronary artery disease

Epigenomics ◽  
2021 ◽  
Author(s):  
Keyong Deng ◽  
Xiaotong Ning ◽  
Xiaoxiao Ren ◽  
Bin Yang ◽  
Jianxin Li ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Mononuclear Cells ◽  
Bioinformatic Analysis ◽  
Control Group ◽  
Peripheral Blood Mononuclear ◽  
Differentially Methylated Genes ◽  
Rna Immunoprecipitation ◽  
Artery Disease ◽  
And Control

Aim: To reveal transcriptome-wide N6-methyladenosine (m6A) methylome of coronary artery disease (CAD). Materials & methods: The m6A levels of RNA from peripheral blood mononuclear cells measured by colorimetry were significantly decreased in CAD cases. Transcriptome-wide m6A methylome profiled by methylated RNA immunoprecipitation sequencing (MeRIP-seq) identified differentially methylated m6A sites within both mRNAs and lncRNAs between CAD and control group. Results: Bioinformatic analysis indicated that differentially methylated genes were involved in the pathogenesis of atherosclerosis. MeRIP-quantitative real-time PCR assay confirmed the reliability of MeRIP-seq data. Finally, the rat carotid artery balloon injury model was performed to confirm the role of m6A demethylase FTO in neointima formation. Conclusion: Our study provided a resource of differentially methylated m6A profile for uncovering m6A biological functions in the pathogenesis of CAD.

Abstract 147: Elevated Serum Resistin Levels are Associated with Angiographically Significant Coronary Artery Disease: A Meta-analysis.

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Pradyumna Agasthi ◽  
Sivakanth Aloor ◽  
Srinadh Annangi ◽  
Kalaivani Sivakumar ◽  
Tirumala Rao Dammalapati ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Meta Analysis ◽  
Elevated Serum ◽  
Significant Coronary Artery Disease ◽  
Control Group ◽  
Resistin Level ◽  
Serum Resistin Level ◽  
Artery Disease ◽  
And Control

Background: Resistin is a novel inflammatory cytokine secreted primarily by mononuclear inflammatory cells and adipocytes. It upregulates the expression of vascular adhesion molecules and stimulates smooth muscle cell proliferation, thereby contributing to atherogenesis in the vascular wall. We conducted a meta-analysis to evaluate the association between serum resistin levels and presence of angiographically significant coronary artery disease (CAD) in patients undergoing diagnostic coronary angiography (DCA). Methods: We searched MEDLINE, CINAHL and COCHRANE databases for studies reporting serum resistin levels in the patients with history of angina or positive stress test undergoing DCA. Patients with coronary stenosis > 50% in at least 1 coronary artery were considered to have significant CAD. They were included in the study group, and rest were included in control group. A calculation of weighted standardized mean difference (SMD) in serum resistin level between the CAD and control groups was conducted. Results: A literature search yielded 158 articles, but only 11 studies enrolling 3291 patients were included in the meta-analysis. The median age and body mass index (BMI) of the CAD group was 63 yrs (IQR 61-65) and 27 kg/m2 (IQR 25-29) versus 59 yrs (IQR 57-61) and 28 kg/m2 (IQR 26-29) in the control group. There were more females in the control group 48% (IQR 46-58) versus 27% (IQR 24-33) in CAD group. The unweighted median serum resistin levels in the CAD group were 5.7 ng/ml (IQR 4.1-16.1) vs 4.3 ng/ml (IQR 3.1-8.2) in the control group. The SMD of serum resistin level was 0.38 (95% CI 0.18- 0.57), P<0.001 comparing those in the CAD group and control group. None of the covariates (age, BMI and sex) accounted for statistical significance. Conclusion: An elevated serum resistin level is independently associated with the presence of angiographically significant CAD. Serum resistin levels can potentially be used as a biomarker for cardiac risk stratification.

scholarly journals Cardiac Work-Up Protocol for Liver Transplant Candidates: Experience from a Single Liver Transplant Centre

2012 ◽  
Vol 26 (11) ◽  
pp. 806-810 ◽  
Author(s):  
Carrie Ye ◽  
Meghana Saincher ◽  
Puneeta Tandon ◽  
Glenda Meeberg ◽  
Randy Williams ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Liver Transplant ◽  
Control Group ◽  
Control Groups ◽  
Cardiac Screening ◽  
Cardiac Outcomes ◽  
Screening Protocol ◽  
Artery Disease ◽  
And Control ◽  
Coronary Angiograms

BACKGROUND: Ischemic cardiac events can cause significant morbidity and mortality postliver transplantation; however, no validated protocols to screen patients before transplantation exist.OBJECTIVES: To report the introduction of a noninvasive cardiac screening protocol used at the Liver Unit, University of Calgary (Calgary, Alberta); to determine whether the protocol decreases use of coronary angiograms; and to compare cardiac outcomes using the new protocol with an appropriately matched historical control group.METHODS: A new cardiac screening protocol was introduced into the program in 2005, which uses perfusion scintigraphy to screen high-risk cardiac patients, reserving coronary angiograms for abnormal results. Transplanted patients screened using this protocol were compared with matched historical controls. Electronic charts were reviewed for cardiac outcomes intra- and postliver transplantation.RESULTS: A total of 396 patients were screened between April 2005 and February 2009. Eighty-two were transplanted by February 2009 and included in the study. Eighty-one patients were successfully matched according to age, sex, cardiac history and presence of diabetes. Twelve of 82 (14.6%) and 11 of 81 (13.6%) in the study and control groups, respectively, underwent coronary angiograms (P=0.85). Coronary artery disease was found in six of 12 (50.0%) study patients and three of 11 (27.3%) control patients who underwent coronary angiography (P=0.27). The mean (± SD) length of the follow-up period was 1.87±0.91 years and 4.45±1.89 years in the study and control groups, respectively. One of 81 in the control group and zero of 82 in the study group experienced an acute coronary syndrome event postoperatively.CONCLUSIONS: Coronary events are infrequent in liver transplant recipients. The described protocol is an effective method of coronary artery disease screening before liver transplant but does not reduce the number of cardiac investigations performed.

scholarly journals ASSOCIATION BETWEEN FACTOR V LEIDEN (FV G1691A) MUTATION AND CORONARY ARTERY DISEASE DEVELOPMENT IN GAZA STRIP - PALESTINE

2020 ◽  
Vol 2 (1) ◽  
pp. 132-139
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gaza Strip ◽  
Factor V Leiden ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Factor V ◽  
Artery Disease ◽  
And Control

Introduction: Coronary Artery Disease(CAD) is multi-factorial and usually results from a combination of acquired environmental and inherited factors with a change in lifestyle. One of these inherited factors is the G1691A factor V. Factor V Leiden (FVL) is the most common heritable thrombophilic disorder. It is concomitant with an increased the risk of thrombosis and may lead to CAD. The aim of this study is to investigate the relation of this mutation with CAD in Gaza strip population. Methods: it is a retrospective study which includes 180 samples; patients with CAD, n=90 and control group, n=90. An interview with questionnaire was applied. EDTA samples were collected for DNA extraction. The FVL mutation was identified by PCR-RFLP. Results: The frequency of FVL genotypes were: wild type 83.2%, heterozygous16.7% and complete absence of mutant homozygous in control group, whereas in CAD patients were: 70%,26.7% and 3.3%. The FVL G and A alleles frequencies of the participants were: for case group 0.833 and 0.167 while 0.917 and 0.083 were in control group. Furthermore, the distribution of FVL heterozygote and mutant(AA) genotypes were not significantly different between the study and control groups. The GA and AA genotypes increase the risk of developing CAD in patients by 1.9 and 8.3 times respectively. The presence of FVL A allele increases the risk of exposure to heart attack among CAD patient (OR =1.7). The frequency of A allele among diabetic patients increases the risk of developing CAD 1.5 fold. Conclusion: Factor V Leiden A allele is associated with the development CAD.

scholarly journals Benson’s Relaxation for Fatigue Patient with Coronary Artery Disease

2020 ◽  
Vol 2 (1) ◽  
pp. 63-69
Author(s):  
Mulyanti Roberto Muliantino ◽  
Tuti Herawati ◽  
Masfuri
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiac Rehabilitation ◽  
Recovery Period ◽  
Intervention Group ◽  
Relaxation Technique ◽  
Pharmacological Intervention ◽  
Control Group ◽  
Artery Disease ◽  
And Control

Fatigue is the major symptoms in patients with coronary artery disease, during recovery period after cardiac events and during cardiac rehabilitation. Benson’s relaxation is one of relaxation as modalities therapy to reduce fatigue, however few studies related to this technique in planned intervention. This study was to measure the effectiveness of Benson’s relaxation in fatigue of coronary artery disease patients during cardiac rehabilitation. It was a quasi-experimental pretest posttest control group design. This study included 29 respondents in Dr.M. Djamil Hospital were assigned to intervention group which receiving Benson’s relaxation technique (n=15) and control group with routine care (n=14). Benson’s relaxation technique was administered for 5 days 2 times a day, each 20 minutes to intervention group. Fatigue was measured using Maastricht Questionnaire (MQ). The result indicated significant reduction in mean of fatigue between intervention and control group (p value < 0,001). The study concluded that Benson’s relaxation technique is an effective non-pharmacological intervention to reduce fatigue in coronary artery disease patients. Keywords: Benson’s relaxation; fatigue; coronary artery disease

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