Effects of Irradiation on Cervical Lymph Nodes

1979 ◽  
Vol 88 (4) ◽  
pp. 502-508 ◽  
Author(s):  
Louis W. Welsh ◽  
Frank Campellone
Keyword(s):  
Lymph Nodes ◽  
Relative Concentration ◽  
Lymph Flow ◽  
Cervical Region ◽  
Local Infection ◽  
Cervical Lymph Nodes ◽  
Post Irradiation ◽  
Secondary Damage ◽  
Relative Migration ◽  
Effects Of Irradiation On

The effects of irradiation upon the functional integrity of lymph nodes were studied in the isolated cervical region of the dog. After 6000 rads were applied in one dose plan, the measure of lymph flow was determined by the migration of radiogold from the larynx to the associated primary lymphatic terminals at intervals of 2, 4, and 12 weeks, and six months post-irradiation. Interference with lymph flow was identified by radionuclide stasis in the injection depot; alteration in the direction of flow was identified by relative concentration of the tracer item in the associated nodal terminals. The lymph flow was minimally distorted by irradiation in the test period unless secondary damage to the associated lymphatic channels intervened. The relative migration was consistent with the normal data in 52%, depressed in 13% and increased in 35% of the cases studied. Major obstruction and rerouting of lymph flow contralaterally was evident in 19% of the subjects due to fibrosis secondary to local infection.

scholarly journals Postoperative recurrence with right cervical lymph node metastasis in hepatocellular carcinoma: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Kiyonori Tanoue ◽  
Yota Kawasaki ◽  
Yoichi Yamasaki ◽  
Satoshi Iino ◽  
Masahiko Sakoda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cervical Lymph Node ◽  
Metastatic Lymph Node ◽  
Cervical Region ◽  
Cervical Lymph Nodes ◽  
Lymph Node Recurrence ◽  
Metastatic Lymph ◽  
The Right

Abstract Background Hepatocellular carcinoma (HCC) patients with metastases to the cervical lymph nodes are extremely rare, and its clinical course is characterized by rapidly progressive disease. Hence, there have been no reports of metastatic cervical lymph node recurrence indicated after a long postoperative surveillance period. Case presentation The patient was a 63-year-old male who underwent right hepatectomy for HCC of the right upper lobe. Three years after resection, metastatic lymph node recurrence was detected in the subdiaphragm, superior mediastinum, and right cervical lymph nodes. The patient underwent excisional biopsy of the cervical lymph node, followed by molecular-targeted therapy and radiation therapy. Lenvatinib reduced the size of all metastatic lymph nodes and the patient survived for a relatively long period of 43 months after the recurrence was detected. Conclusions After resection of HCC in the right upper lobe, there is the possibility of metastatic lymph node recurrence in unusual sites, including the cervical region, and lenvatinib may be effective in those recurrences.

The Clinical and Histological Characterization of Malignant Lymphoma, Kikuchi-Fujimoto Disease and L-Forms Acid-Fast Bacillus Infection

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 5275-5275
Author(s):  
Jie He ◽  
Rui-ping Li ◽  
Jian-hua Wang ◽  
Bao-An Chen
Keyword(s):  
Lymph Nodes ◽  
Malignant Lymphoma ◽  
Antibiotic Treatment ◽  
Acid Fast Bacillus ◽  
Cervical Region ◽  
Excision Biopsy ◽  
Cervical Lymph Nodes ◽  
Inappropriate Treatment ◽  
Acid Test

Abstract Objective: Malignant lymphoma (ML), Kikuchi-Fuljimoto disease (KFD) and L-forms Acid-fast bacillus infection (L-forms TB) usually affect the cervical lymph nodes. KFD and L-form TB are often confused with ML and take misdiagnosis and inappropriate treatment. The diagnosed of these diseases is on basis of an excision biopsy of affected lymph nodes. Methods: We analyzed 63 patients (including case diagnosed in our hospital) by clinical characteristic, laboratory, pathological morphology, histochemistry and immunohistochemistry. Results: Of 63 cases, 43 were ML, 17 were KFD and 3 were L-forms TB. In ML disease, 46% were male and 54% were female, mean age was 54 (11–82). 9% cases have persistent fever and associated with hepatosplenomegaly. In KFD, 47% were male and 53% were female, mean age was 26 (17–45). 59% cases with cervical hymphadenopath and no fever, 41% had painful, accompanied by fever. hepathosplenomegaly, occasionally leucopenia and lypadenopathy especially involving cervical region not responsive to antibiotic treatment. 29% lymph tissues were morphologically, and characterized by a necrosis in the cortical or paracortical areas of enlarged lymph node around the necrotic area. T lymphocytes were found and absence of granulocytes. 30% cases were mistaken to ML. L-forms TB disease, there were fever, clinical and histological were similar KFD and ML. 3 cases were misdiagnosis to ML or KFD. Laboratory analyses: PAM and PAS were positive, and anti acid test to found L-forms bacterium in tissues. Conclusions: Kikuchi-Fujimoto disease and L-forms Acid-Fast bacillus infection are easily confused histological and clinically with malignant lymphoma. Clinicians and pathologists must be aware of this condition. Although Malignant lymphoma, Kikuchi-Fujimoto disease and L-forms Acid-fast bacillus infection can be found any age, but should be considered for malignant lymphoma in older patients. Kikuchi-Fujimoto disease is predominantly a self-limiting disease of the young and most cases with fever, nodal biopsy showing fragmentation necrosis and karyorrhexis, not responsive to antibiotic treatment. In the L-forms Acid-fast bacillus infection, the PAM and PAS are positive, and have an effective antibiotic treatment.

A real-time prediction model for post-irradiation malignant cervical lymph nodes

2017 ◽  
Vol 43 (2) ◽  
pp. 477-482
Author(s):  
W.-C. Lo ◽  
P.-W. Cheng ◽  
P.-W. Shueng ◽  
C.-H. Hsieh ◽  
Y.-L. Chang ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Prediction Model ◽  
Real Time ◽  
Cervical Lymph Nodes ◽  
Post Irradiation ◽  
Time Prediction

scholarly journals A rare lesion of cervical lymph nodes: Angiomyomatous hamartoma

2021 ◽  
Vol 8 (3) ◽  
pp. 187-188
Author(s):  
Mecdi Gurhan Balci ◽  
Mahir Tayfur
Keyword(s):  
Smooth Muscle ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Smooth Muscle Cells ◽  
Histopathological Examination ◽  
Muscle Cells ◽  
Cervical Region ◽  
Pathology Laboratory ◽  
Cervical Lymph Nodes ◽  
Vascular Structures

Objective: Angiomyomatous hamartomas are extremely rare, tumor-like lesions of the lymph nodes. They are usually seen in the inguinal region lymph nodes. They are rarely seen in the lymph nodes of the cervical region. Histopathologically, fibrous tissues, smooth muscle cells, and vascular structures are seen in the lymph node structure. It is important to distinguish it from benign and malignant lesions of the lymph node. Case: A 1 cm diameter lymph node excision material removed from the cervical region of a 26-year-old male patient was sent to the pathology laboratory with a pre-diagnosis of lymphadenitis. 4- micron sections were taken from the paraffin blocks prepared from the tissues belonging to the lesion. The samples were examined by staining Hematoxylin-Eosin. In histopathological examination, it was found that almost all of the lymph node structure consisted of vascular structures and smooth muscle cells located on a fibrous ground. The case was reported as angiomyomatous hamartoma. Conclusion: Angiomyomatous hamartomas are extremely rare lesions of the cervical lymph nodes and their consideration in differential diagnosis will reduce the risk of possible diagnostic error.

Evolution of the Clinically Negative Neck

1980 ◽  
Vol 89 (6) ◽  
pp. 551-555 ◽  
Author(s):  
E. M. Skolnik ◽  
A. H. Katz ◽  
S. P. Becker ◽  
R. Mantravadi ◽  
S. Stal
Keyword(s):  
Lymph Nodes ◽  
Neck Dissection ◽  
Recurrence Rate ◽  
Failure Rate ◽  
Radical Neck Dissection ◽  
Cervical Region ◽  
Nodal Disease ◽  
Cervical Lymph Nodes ◽  
Group 2 ◽  
Group 1

A retrospective study was done of 602 patients with primary squamous cell carcinoma of the upper aerodigestive tract and a clinically negative neck (N o) seen at the University of Illinois Hospital between 1960–1975. There was no uniform policy as to the treatment of N o neck during this period; therefore in many of the patients, cervical lymph nodes were treated with elective neck dissection and others were followed until they became positive clinically. It was this difference which formed the basis for this study. All the patients were treated surgically; the patients were placed into two groups depending on whether they had radical neck dissection at the same time as resection of the primary. Group 1 consisted of 149 patients and had surgery for the primary only. The 253 patients of group 2 had surgery for the primary and also had a neck dissection. Both groups were analyzed for recurrences in the cervical region. In group 1, 12.9 % of the patients developed either ipsilateral or contralateral metastases. Of the group 2 patients, 22% developed palpable nodal disease. The evolution of palpable nodal disease was analyzed by primary site, T-stage, and according to whether the tumor at the primary was controlled. Only 3% of the patients developed lymph nodes when the primary was controlled. The pathology reports of the neck specimens were studied to determine the relationship between a) positive node histology and b) number of nodes positive to the recurrence rate in the neck Our results showed a 23% failure rate for the histologically positive group and a 21% failure rate for the negative group. The number of positive nodes did not seem to affect the recurrence rate.

Benign thyroid inclusions in cervical lymph nodes

JAMA ◽  
1965 ◽  
Vol 194 (1) ◽  
pp. 1-4 ◽  
Author(s):  
A. D. Nicastri
Keyword(s):  
Lymph Nodes ◽  
Cervical Lymph Nodes ◽  
Benign Thyroid

Role of Clinical Palpation in Evaluation of Cervical Lymph Node in Oral Squamous Cell Carcinoma

2013 ◽  
Vol 1 (2) ◽  
pp. 02-06
Author(s):  
SM Anwar Sadat ◽  
Sufia Nasrin Rita ◽  
Shoma Banik ◽  
Md Nazmul Hasan Khandker ◽  
Md Mahfuz Hossain ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
Cervical Lymph Node ◽  
Betel Quid ◽  
Cervical Lymph Nodes

A cross sectional study of 29 cases of oral squamous cell carcinoma with or without  cervical lymph node metastasis was done among Bangladeshi patients from January 2006 to December 2007. Majority of the study subjects (34.5%) belonged to the age group of 40-49 years. 58.6% of the study subjects were male, while remaining 41.4% of them were female. 51.7% of the lesions were located in the alveolar ridge where the other common sites were buccal mucosa (27.6%) and retro molar area (13.8%). Half of the study subjects (51.7%) were habituated to betel quid chewing followed by 37.9% and 10.3% were habituated to smoking and betel quid-smoking respectively. Grade I lesions was most prevalent (75.9%) in the study subjects.  Majority of cases presented with Stage IV lesions (55.2%). The sensitivity, specificity, positive predictive value, negative predictive value & accuracy of clinical palpation method for determining metastatic cervical lymph nodes were 93.33%, 64.29%, 73.68%, 90% and 79.3% respectively. Careful and repeated clinical palpation plays important role in evaluation of cervical lymph nodes though several modern techniques may help additionally in the management of oral cancer.DOI: http://dx.doi.org/10.3329/updcj.v1i2.13978 Update Dent. Coll. j. 2011: 1(2): 02-06

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