The Clinical and Histological Characterization of Malignant Lymphoma, Kikuchi-Fujimoto Disease and L-Forms Acid-Fast Bacillus Infection

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 5275-5275
Author(s):  
Jie He ◽  
Rui-ping Li ◽  
Jian-hua Wang ◽  
Bao-An Chen
Keyword(s):  
Lymph Nodes ◽  
Malignant Lymphoma ◽  
Antibiotic Treatment ◽  
Acid Fast Bacillus ◽  
Cervical Region ◽  
Excision Biopsy ◽  
Cervical Lymph Nodes ◽  
Inappropriate Treatment ◽  
Acid Test

Abstract Objective: Malignant lymphoma (ML), Kikuchi-Fuljimoto disease (KFD) and L-forms Acid-fast bacillus infection (L-forms TB) usually affect the cervical lymph nodes. KFD and L-form TB are often confused with ML and take misdiagnosis and inappropriate treatment. The diagnosed of these diseases is on basis of an excision biopsy of affected lymph nodes. Methods: We analyzed 63 patients (including case diagnosed in our hospital) by clinical characteristic, laboratory, pathological morphology, histochemistry and immunohistochemistry. Results: Of 63 cases, 43 were ML, 17 were KFD and 3 were L-forms TB. In ML disease, 46% were male and 54% were female, mean age was 54 (11–82). 9% cases have persistent fever and associated with hepatosplenomegaly. In KFD, 47% were male and 53% were female, mean age was 26 (17–45). 59% cases with cervical hymphadenopath and no fever, 41% had painful, accompanied by fever. hepathosplenomegaly, occasionally leucopenia and lypadenopathy especially involving cervical region not responsive to antibiotic treatment. 29% lymph tissues were morphologically, and characterized by a necrosis in the cortical or paracortical areas of enlarged lymph node around the necrotic area. T lymphocytes were found and absence of granulocytes. 30% cases were mistaken to ML. L-forms TB disease, there were fever, clinical and histological were similar KFD and ML. 3 cases were misdiagnosis to ML or KFD. Laboratory analyses: PAM and PAS were positive, and anti acid test to found L-forms bacterium in tissues. Conclusions: Kikuchi-Fujimoto disease and L-forms Acid-Fast bacillus infection are easily confused histological and clinically with malignant lymphoma. Clinicians and pathologists must be aware of this condition. Although Malignant lymphoma, Kikuchi-Fujimoto disease and L-forms Acid-fast bacillus infection can be found any age, but should be considered for malignant lymphoma in older patients. Kikuchi-Fujimoto disease is predominantly a self-limiting disease of the young and most cases with fever, nodal biopsy showing fragmentation necrosis and karyorrhexis, not responsive to antibiotic treatment. In the L-forms Acid-fast bacillus infection, the PAM and PAS are positive, and have an effective antibiotic treatment.

Distinct kinetics for nucleotide hydrolysis in lymphocytes isolated from blood, spleen and cervical lymph nodes: Characterization of ectonucleotidase activity

2021 ◽  
Author(s):  
Pedro H. Doleski ◽  
Fernanda L. Cabral ◽  
Stephen A. Adefegha ◽  
Matheus H. Jantsch ◽  
Renan S. Ebone ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cervical Lymph Nodes ◽  
Nucleotide Hydrolysis

scholarly journals Rare Presentation of Self-Limiting Kikuchi–Fujimoto Disease in Relapsing Nature

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Karo Servatyari ◽  
Hero Yazdanpanah ◽  
Chamara Dalugama
Keyword(s):  
Lymph Nodes ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Cervical Lymphadenopathy ◽  
Excision Biopsy ◽  
Presentation Of Self ◽  
Rare Presentation ◽  
Cervical Lymph Nodes ◽  
One Year ◽  
Loss Of Appetite

Background. Kikuchi–Fujimoto disease (KFD) is a rare, benign, and self-limiting disease that is commonly associated with cervical lymphadenopathy and fever. The disease has a wide spectrum of clinical manifestations, and definitive diagnosis is based on the histological appearance in the excision biopsy of the lymph nodes. Recurrence of KFD is reported rarely. Case Presentation. A 56-year-old Iranian woman with a background history of thrombocytopenia presented with fever, malaise, loss of appetite, and weight loss with cervical lymphadenopathy. The excision biopsy of the cervical lymph nodes confirmed the diagnosis of KFD, and she made a full recovery with improvement of symptoms, regression of cervical lymph nodes, and normalization inflammatory markers. One year after remission, she presented with similar clinico-biochemical profile, and repeat biopsy confirmed KFD. Conclusion. Although the rate of recurrence of the disease is very low, the treating physician should consider the possibility and confirm it histologically.

scholarly journals UTILITY OF ULTRASONOGRAPHY DIAGNOSIS FOR CERVICAL LYMPHADENOPATHY IN CENTRAL INDIAN POPULATION- A HOSPITAL BASED OBSERVATIONAL STUDY

2019 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. Neerja Jain Sudhakar ◽  
Dr. C. Sudhakar ◽  
Dr. Priyadershini Rangari
Keyword(s):  
Lymph Nodes ◽  
Indian Population ◽  
Cervical Lymphadenopathy ◽  
Excision Biopsy ◽  
Tuberculous Lymphadenitis ◽  
Metastatic Node ◽  
Cervical Lymph Nodes ◽  
Round Shape ◽  
Time Linear ◽  
Keywords Ultrasonography

Background: Cervical lymph nodes are frequently involved in a number of disease conditions. The most commonly seen causes of cervical lymphadenopathy are tuberculosis, distant metastasis and lymphoma. Objective: To assess the usefulness of ultrasonography in the differential diagnosis of cervical lymphadenopathy. Methods: ultrasonography of cervical lymph nodes was performed with a real-time linear scanner using a 7.5- or 11-MHz probe. Ultrasonography findings were retrospectively reviewed in 432 lymphnodes of 120 patients. USG findings were reevaluated by FNAC, CECT neck, MRI and core needle biopsy wherever required. Results: out of 432 lymphnodes; 108 tuberculous lymphadenitis, 46 metastatic, 59 lymphoma, 114 inflammatory and 105 normal lymph nodes were observed. Ultrasonography features were found to be stronger in tubercular, metastatic and lymphomatous lymphnodes. Hypoechoic center was prominently observed in tubercular and metastatic form. In most of the patients, FNAC result was equivocal and a subsequent excision biopsy of the lymph node was carried out to confirm the diagnosis. Lymphadenitis was diagnosed with a sensitivity of 100% and a specificity of 100%. Conclusion: This study concluded that cervical group of lymph nodes with ultrasonography features such as round shape, absence of hilar echo, sharp nodal borders, Hypoechoic internal echogenicity and presence of intranodal necrosis were highly suggestive of metastatic cervical lymph nodes. Ultrasonography along with other radiological and histopathological parameters can be very effective in early diagnosis of high risk diseases. Keywords: Ultrasonography; Tuberculous Lymphadenitis; Malignant Lymphoma; Metastatic Node

scholarly journals Postoperative recurrence with right cervical lymph node metastasis in hepatocellular carcinoma: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Kiyonori Tanoue ◽  
Yota Kawasaki ◽  
Yoichi Yamasaki ◽  
Satoshi Iino ◽  
Masahiko Sakoda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cervical Lymph Node ◽  
Metastatic Lymph Node ◽  
Cervical Region ◽  
Cervical Lymph Nodes ◽  
Lymph Node Recurrence ◽  
Metastatic Lymph ◽  
The Right

Abstract Background Hepatocellular carcinoma (HCC) patients with metastases to the cervical lymph nodes are extremely rare, and its clinical course is characterized by rapidly progressive disease. Hence, there have been no reports of metastatic cervical lymph node recurrence indicated after a long postoperative surveillance period. Case presentation The patient was a 63-year-old male who underwent right hepatectomy for HCC of the right upper lobe. Three years after resection, metastatic lymph node recurrence was detected in the subdiaphragm, superior mediastinum, and right cervical lymph nodes. The patient underwent excisional biopsy of the cervical lymph node, followed by molecular-targeted therapy and radiation therapy. Lenvatinib reduced the size of all metastatic lymph nodes and the patient survived for a relatively long period of 43 months after the recurrence was detected. Conclusions After resection of HCC in the right upper lobe, there is the possibility of metastatic lymph node recurrence in unusual sites, including the cervical region, and lenvatinib may be effective in those recurrences.

Kikuchi Disease in Korean Children: Clinical Features and Disease Courses.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2285-2285 ◽  
Author(s):  
Jun Eun Park ◽  
Hyun Joo Jung ◽  
Chul-Ho Kim ◽  
Jeong Hong ◽  
Jae Ho Han
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Medical Center ◽  
University Hospital ◽  
First Episode ◽  
Excision Biopsy ◽  
Cervical Lymph Nodes ◽  
Korean Children ◽  
Presenting Symptoms

Abstract OBJECTIVES: Kikuchi’s disease (KD) is a benign, self-limiting disorder of unknown origin with lymphadenopathy and fever, and prevalent in young Asian women. The initial presentations mimic malignancies or other serious infections, and the biopsy of lymph nodes affected is the only definite diagnostic tool of KD. We analyzed data from a series of pediatric cases collected at a single medical center and suggest proper guideline of management for patients with KD. METHODS: The medical records of children under 16 years of age, who underwent lymph node biopsies and received histiopathologic diagnosis of KD at Ajou University Hospital, South Korea from January 2000 to June 2007, were retrospectively reviewed. RESULTS: Twenty six pediatric patients with KD included 10 boys and 16 girls. In all cases except two, the cervical lymph nodes were involved. Twenty (76.9%) patients had fever as a presenting symptom, and 5 patients (19.2%) had various skin rash. Leukopenia was noted in 8 cases (30.8%), but there was no case of leukocytosis. The levels of ESR and LDH were slightly elevated, but CRP and liver enzymes were within normal range. No KD patients in this study developed any other autoimmune disorders during follow-up period. Eleven (55%) cases with fever improved immediately after excision biopsy of affected lymph nodes. Eight (30.8%) cases treated with steroid showed dramatic responses. Six patients (23.1%) had resolutions of symptoms simply with symptomatic treatments. The recurrence happened in 6 (23.1%) children within a few weeks from the first episode. CONCLUSIONS: Contrary to previous reports on Asian cases, KD in Korean children is not rare in young boys, and fever is more common presenting symptoms. It’s relationship with autoimmune diseases or infection of EBV is not clear. Symptoms such as fever improved in some cases only by the removal of affected lymph node for excision biopsy. In agreement with previous reports, patients treated with steroid recovered dramatically. Therefore, we suggest an earlier excision biopsy for patients suspicious with KD and an immediate treatment of cases with severe symptoms with steroid. The recurrence rate in this study was higher than that in previous studies, therefore, a spell of follow-up period after disappearance of symptoms is advisable for patients with original diagnosis of KD.

Characterization of cervical lymph-nodes using a multi-parametric and multi-modal approach for an early prediction of tumor response to chemo-radiotherapy

2016 ◽  
Vol 32 (12) ◽  
pp. 1672-1680 ◽  
Author(s):  
Elisa Scalco ◽  
Simona Marzi ◽  
Giuseppe Sanguineti ◽  
Antonello Vidiri ◽  
Giovanna Rizzo
Keyword(s):  
Lymph Nodes ◽  
Tumor Response ◽  
Early Prediction ◽  
Cervical Lymph Nodes ◽  
Modal Approach

Effects of Irradiation on Cervical Lymph Nodes

1979 ◽  
Vol 88 (4) ◽  
pp. 502-508 ◽  
Author(s):  
Louis W. Welsh ◽  
Frank Campellone
Keyword(s):  
Lymph Nodes ◽  
Relative Concentration ◽  
Lymph Flow ◽  
Cervical Region ◽  
Local Infection ◽  
Cervical Lymph Nodes ◽  
Post Irradiation ◽  
Secondary Damage ◽  
Relative Migration ◽  
Effects Of Irradiation On

The effects of irradiation upon the functional integrity of lymph nodes were studied in the isolated cervical region of the dog. After 6000 rads were applied in one dose plan, the measure of lymph flow was determined by the migration of radiogold from the larynx to the associated primary lymphatic terminals at intervals of 2, 4, and 12 weeks, and six months post-irradiation. Interference with lymph flow was identified by radionuclide stasis in the injection depot; alteration in the direction of flow was identified by relative concentration of the tracer item in the associated nodal terminals. The lymph flow was minimally distorted by irradiation in the test period unless secondary damage to the associated lymphatic channels intervened. The relative migration was consistent with the normal data in 52%, depressed in 13% and increased in 35% of the cases studied. Major obstruction and rerouting of lymph flow contralaterally was evident in 19% of the subjects due to fibrosis secondary to local infection.

Kikuchi-Fujimoto Disease of the Neck Update

1993 ◽  
Vol 102 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Carlos E. García ◽  
Harsha V. Girdhar-Gopal ◽  
David M. Dorfman
Keyword(s):  
Antibiotic Therapy ◽  
Lymph Nodes ◽  
Malignant Lymphoma ◽  
Illustrative Case ◽  
Rare Entity ◽  
Disease Entity ◽  
Review Of The Literature ◽  
Cervical Lymph Nodes ◽  
Benign Course

Kikuchi-Fujimoto disease (KFD) is a rare entity of uncertain cause that commonly presents with persistently enlarged cervical lymph nodes unresponsive to antibiotic therapy. Although it usually follows a benign course, KFD has been repeatedly misdiagnosed as malignant lymphoma; hence, clinicians and pathologists alike need to be aware of this disease entity. The newest developments regarding the etiology and course of KFD are presented through a review of the literature and a recent illustrative case.

scholarly journals The use of the ultrasound for otorhinolaryngology, head and neck diseases (literature review)

2020 ◽  
pp. 92-100
Author(s):  
D. V. Trukhin ◽  
I. A. Kim ◽  
E. V. Nosulya ◽  
E. A. Zubareva ◽  
T. I. Garashchenko
Keyword(s):  
Literature Review ◽  
Lymph Nodes ◽  
High Sensitivity ◽  
Diagnostic Methods ◽  
Chronic Tonsillitis ◽  
Excision Biopsy ◽  
Malignant Neoplasms ◽  
Cervical Lymph Nodes ◽  
Systemic Complications ◽  
Ultrasound Diagnostics

Despite the fact that otorhinolaryngologists are already very busy finding a solution to the problem of chronic tonsillitis, it remains unresolved. The prevalence of chronic tonsillitis does not decrease, but rather increases. Diseases of the tonsils are characteristic primarily of the child and adult working population. Chronic tonsillitis attracts attention not only as an independent disease, but as a cause of frequent local and especially systemic complications, which number more than 100. All these facts speak about the unresolved and urgency of the problem of chronic tonsil disease. In the diagnosis of neck diseases, one of the most common methods is ultrasound. It has a number of significant advantages over other methods, such as high sensitivity and specificity, the ability to detect minor changes in the organs, non-invasiveness of the study, painlessness, accessibility, and the absence of ionizing radiation. The aim of the literature review is to identify, analyze, and systematize literature data on the application of the ultrasonic research method in neck organ pathology. Ultrasound diagnostics in the neck is widely used and is actively studied in acute inflammatory-purulent pathology (paratonsillar abscesses, phlegmon), in the pathology of the larynx and trachea, salivary and thyroid glands, as well as in the metastasis of malignant neoplasms to the lymph nodes. There are several methods for diagnosing lymph nodes, such as: puncture and excision biopsy, lymphography, scintigraphy, thermography and ultrasound ultrasound. Despite such a variety of diagnostic methods, ultrasound is the method of choice for imaging cervical lymph nodes. One of the most modern methods in ultrasound diagnostics is elastography. This method is most informative in cases when changes in tissues are small in size and cannot be detected using standard ultrasound modes.

scholarly journals A rare lesion of cervical lymph nodes: Angiomyomatous hamartoma

2021 ◽  
Vol 8 (3) ◽  
pp. 187-188
Author(s):  
Mecdi Gurhan Balci ◽  
Mahir Tayfur
Keyword(s):  
Smooth Muscle ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Smooth Muscle Cells ◽  
Histopathological Examination ◽  
Muscle Cells ◽  
Cervical Region ◽  
Pathology Laboratory ◽  
Cervical Lymph Nodes ◽  
Vascular Structures

Objective: Angiomyomatous hamartomas are extremely rare, tumor-like lesions of the lymph nodes. They are usually seen in the inguinal region lymph nodes. They are rarely seen in the lymph nodes of the cervical region. Histopathologically, fibrous tissues, smooth muscle cells, and vascular structures are seen in the lymph node structure. It is important to distinguish it from benign and malignant lesions of the lymph node. Case: A 1 cm diameter lymph node excision material removed from the cervical region of a 26-year-old male patient was sent to the pathology laboratory with a pre-diagnosis of lymphadenitis. 4- micron sections were taken from the paraffin blocks prepared from the tissues belonging to the lesion. The samples were examined by staining Hematoxylin-Eosin. In histopathological examination, it was found that almost all of the lymph node structure consisted of vascular structures and smooth muscle cells located on a fibrous ground. The case was reported as angiomyomatous hamartoma. Conclusion: Angiomyomatous hamartomas are extremely rare lesions of the cervical lymph nodes and their consideration in differential diagnosis will reduce the risk of possible diagnostic error.

Sign in / Sign up

Export Citation Format

Share Document