A novel arthritis model induced by wind, damp, cold and heat in female rats

2019 ◽  
Vol 54 (5) ◽  
pp. 433-442
Author(s):  
Chuang Ge ◽  
Jingchao Hao ◽  
Xiaodong Wu ◽  
Chencheng Li ◽  
Rui Zhi ◽  
...  
Keyword(s):  
Complex Disease ◽  
Histopathological Change ◽  
Female Rats ◽  
Serum Cytokine ◽  
Physical Conditions ◽  
The World ◽  
Elevated Expression ◽  
Clear Insight ◽  
First Time ◽  
Insight Into

Animal models are in constant development to benefit scientific research. Rheumatoid arthritis (RA) is considered a very complex disease due to its complicated pathogenesis, and patients with rheumatic disease around the world are still unable to obtain effective, simple and curable treatment. In order to obtain a clear insight into the pathogenesis of RA, a rat model was established based on the concept of Bi syndrome in Traditional Chinese Medicine by simulating the conditions of RA as much as possible via the change in the physical conditions wind, damp, cold and heat (WDCH). For the first time, a new WDCH-induced RA model in female rats was successfully established and evaluated by body-weight change, paw swelling, blood cells analysis, spleen and thymus coefficients, autoantibodies and serum cytokine changes and histopathology. This model is characterised by its objectivity, no exogenous induction, short modelling time, extremely elevated expression level of autoantibodies and obvious histopathological change. The establishment of such a new model may provide more benefits in the research of the pathogenesis of RA.

scholarly journals A Review on the Treatments for Monocular Visual Impairment for the Development of a Visual Aid

2018 ◽  
Vol 7 (4.35) ◽  
pp. 282
Author(s):  
Nirvenesh Ravindran ◽  
Hassan Mohamed
Keyword(s):  
Visual Impairment ◽  
Perceptual Learning ◽  
Depth Perception ◽  
Pharmacological Treatment ◽  
External Factors ◽  
Occlusion Therapy ◽  
The World ◽  
Visual Aid ◽  
Clear Insight ◽  
Insight Into

Amblyopia is the most commonly found monocular visual impairment in the world. This paper presents an initial investigation into developing a visual aid for monocular visual impaired patients. The investigations conducted in this paper include those from direct interviews from consultant ophthalmologist. Investigations include reviewing the principle required to be embedded into the visual aid such as the distance and depth perception. Stereoscopic cameras and algorithms are also further discussed to interlink with the concepts of depth perception. Monocular visual impairment can most of the time be caused by medical conditions like amblyopia or glaucoma, and rarely caused by accidents and external factors. Thus, existing treatments for amblyopia, the effectiveness and challenges of the treatment are also clearly investigated and scrutinized in this paper. Some of the existing treatments include refractive therapy, occlusion therapy, atropine injections, perceptual learning, pharmacological treatment and acupuncture. This study has provided a clear insight into the requirements of developing a visual aid, thus further addressing the challenges faced by the treatments in this impairment.

XVII. On Brochantite and its associations

1881 ◽  
Vol 4 (20) ◽  
pp. 259-263
Author(s):  
W. Semmons
Keyword(s):  
Sulphuric Acid ◽  
Large Series ◽  
Mineral Species ◽  
Parallel Lines ◽  
Clear Insight ◽  
First Time ◽  
Insight Into

The large series of combinations of copper with sulphuric acid found in mineral veins, present many features which call for attentive study.Some of the series, as Chalcanthite and Pisanite, are easily soluble in water, while others, as Brochantite and the members of the group allied to it, are insoluble therein, and the solubility seems to run in parallel lines with the percentage of copper.The “Basic ” sulphates have of late received considerable notice, and English mineralogists must remember with pleasure that the masterly essay by Prof. Maskelyne “On the minerals of the Brochantite group,” gave us for the first time a clear insight into the characters of some of its constituents. This elaborate, paper shewed that the ortho-rhombic varieties were clearly entitled to be divided into distinct mineral species.

Travelling Through the Rock to the Otherworld: The Shamanic ‘Grammar of Mind’ Within the Rock Art of Siberia

2017 ◽  
Vol 27 (3) ◽  
pp. 413-432
Author(s):  
Andrzej Rozwadowski
Keyword(s):  
Rock Art ◽  
The Other ◽  
Rock Surface ◽  
Upper Palaeolithic ◽  
The World ◽  
First Time ◽  
The Relationship ◽  
Universal Nature ◽  
Insight Into ◽  
Cave Art

One of the aspects of the relationship between rock art and shamanism, which has been supposed to be of a universal nature, inspired by trance experience, concerns the intentional integration of the images with rock. Rock surface therefore has been interpreted, in numerous shamanic rock-art contexts, as a veil beyond which the otherworld could be encountered. Such an idea was originally proposed in southern Africa, then within Upper Palaeolithic cave art and also other rock-art traditions in diverse parts of the world. This paper for the first time discusses the relevance of this observation from the perspective of unquestionable shamanic culture in Siberia. It shows that the idea of the otherworld to be found on the other side of the rock actually is a widespread motif of shamanic beliefs in Siberia, and that variants of this belief provide a new mode of insight into understanding the semantics of Siberian rock art. Siberian data therefore support previous hypotheses of the shamanic nature of associating rock images with rock surface.

scholarly journals The World Heritage Naracoorte Caves beyond 500 ka: U-Pb dating and charcoal analysis from speleothems with implications for Pleistocene vertebrate fossil deposits

2021 ◽  
Author(s):  
Rieneke Weij ◽  
Jon Woodhead ◽  
Liz Reed ◽  
Kale Sniderman ◽  
John Hellstrom ◽  
...  
Keyword(s):  
Climate Change ◽  
World Heritage ◽  
Charcoal Analysis ◽  
Past Climate ◽  
The Past ◽  
Spin Resonance ◽  
The World ◽  
Past Climate Change ◽  
First Time ◽  
Insight Into

<p>Under the current rapid global warming, studying how environments responded to past climate change becomes increasingly important to better understand what impact climate variability has on regional flora and fauna. Our new multi-proxy study to the World Heritage Naracoorte Caves in southern Australia provides a unique window into the past climate as they are heavily decorated with speleothems but also contain in-fill deposits rich in Pleistocene vertebrate fossils including the extinct Australian megafauna. Until now, these speleothems have been dated using U-Th series and the fossil-bearing sediments with Optical Stimulated Luminescence and Electro Spin Resonance techniques, but only up to ca. 500 ka. We have U-Pb dated speleothems from the Naracoorte Caves for the first time and extended the record beyond 500 ka. We combined precise chronology with analyses of pollen and charcoal within the speleothems which allows us to better understand how southern Australia’s climate and its vegetation changed during the Quaternary. It also provides a unique insight into the timing and extent of cave opening with important potential for much older vertebrate fossil deposits than previously thought.</p>

Finding Time for the Old Stone Age

2007 ◽  
Author(s):  
Anne O'Connor
Keyword(s):  
Nineteenth Century ◽  
Geological Survey ◽  
Stone Age ◽  
The World ◽  
First Time ◽  
Insight Into

Finding Time for the Old Stone Age explores a century of colorful debate over the age of our earliest ancestors. In the mid nineteenth century curious stone implements were found alongside the bones of extinct animals. Humans were evidently more ancient than had been supposed--but just how old were they? There were several clocks for Stone-Age (or Palaeolithic) time, and it would prove difficult to synchronize them. Conflicting timescales were drawn from the fields of geology, palaeontology, anthropology, and archaeology. Anne O'Connor draws on a wealth of lively, personal correspondence to explain the nature of these arguments. The trail leads from Britain to Continental Europe, Africa, and Asia, and extends beyond the world of professors, museum keepers, and officers of the Geological Survey: wine sellers, diamond merchants, papermakers, and clerks also proposed timescales for the Palaeolithic. This book brings their stories to light for the first time--stories that offer an intriguing insight into how knowledge was built up about the ancient British past.

Un exercice épistolaire arabe adressé au gouverneur Ǧābir ibn al-ʾʾAšʿ at̲

2014 ◽  
Vol 60 (2) ◽  
Author(s):  
Naïm Vanthieghem
Keyword(s):  
The World ◽  
First Time ◽  
Insight Into

AbstractEdition of an Arabic school exercise mentioning the Arabic governor of Egypt Ǧābir ibn al-ʾʾAšʿat̲ . The paper gives an insight into the world of Arabic school exercises and attempts for the first time to establish a typology of such exercises.

Why I Became an Occupational Physician and Other Occupational Health Stories

2020 ◽  
Keyword(s):  
Occupational Health ◽  
Occupational Medicine ◽  
Occupational Physician ◽  
Occupational Physicians ◽  
The World ◽  
First Time ◽  
Insight Into

This volume brings together the fascinating and diverse ‘filler’ articles published in the journal Occupational Medicine. Originally included to fill the blank spaces at the end of main features, the pieces first explored the reasons why doctors chose to become occupational physicians, later expanding to include all facets of occupational medicine. This book collects the articles into one volume for the first time, giving a rare insight into the world of the occupational physician.

Investment in the Development of Latvian Music Pedagogy by Latvians Living beyond Latvia

2015 ◽  
Vol 3 ◽  
pp. 533
Author(s):  
Maruta Sīle
Keyword(s):  
Child Development ◽  
Music Pedagogy ◽  
National History ◽  
Heritage Foundation ◽  
History Of Art ◽  
The World ◽  
The Future ◽  
History Of ◽  
Clear Insight ◽  
Insight Into

History of music pedagogy is developed by great personalities. Wherever Latvia’s musicians have been brought by their life routes – music has been above any difficulties encountered. The artist’s education has to be represented in two directions – historical and systematic. Without a clear insight into one’s own national history of art, no one can grow into a real artist. Explorations in history of music pedagogy can more objectively assess the present and prognosticate perspectives in the future. The more we learn about the Latvian by descent artists’ creative activities, their working methods and results beyond Latvia, the greater is our desire to use their experiences in our own work, as the child development is always in the centre of researches. One of collaboration ways is the’’ International Latvian Young Musicians Camp’’ headed by the director – professor, Dr.paed. Ingrīda Gutberga, a Latvian living abroad, well-known as an organist, conductor, pianist, chair person of Boston Latvian Heritage foundation. The participants of the camp are young musicians from all over the world enjoying guidance of internationally renowned music pedagogues.

Ultrastructure of neuromuscular relationships in the canine heartworm (dirofilaria immitis)

1986 ◽  
Vol 44 ◽  
pp. 278-279
Author(s):  
W. L. Steffens ◽  
Nancy B. Roberts ◽  
J. M. Bowen
Keyword(s):  
Dirofilaria Immitis ◽  
Domestic Dogs ◽  
Structural Description ◽  
Pharmacological Effects ◽  
Free Living ◽  
Canine Heartworm ◽  
The World ◽  
Synaptic Region ◽  
Muscle Innervation ◽  
Insight Into

The canine heartworm is a common and serious nematode parasite of domestic dogs in many parts of the world. Although nematode neuroanatomy is fairly well documented, the emphasis has been on sensory anatomy and primarily in free-living soil species and ascarids. Lee and Miller reported on the muscular anatomy in the heartworm, but provided little insight into the peripheral nervous system or myoneural relationships. The classical fine-structural description of nematode muscle innervation is Rosenbluth's earlier work in Ascaris. Since the pharmacological effects of some nematacides currently being developed are neuromuscular in nature, a better understanding of heartworm myoneural anatomy, particularly in reference to the synaptic region is warranted.

SEROPREVALENCE OF HIV AND HBsAg AMONGST BLOOD DONORS IN A TERTIARY CARE HOSPITAL, CHHATTISGARH.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Anusha P ◽  
Bankar Nandkishor J ◽  
Karan Jain ◽  
Ramdas Brahmane ◽  
Dhrubha Hari Chandi
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Tertiary Care ◽  
Laboratory Diagnosis ◽  
Blood Bank ◽  
Care Hospital ◽  
Medical College ◽  
The World ◽  
First Time

INTRODUCTION: India being the second highly populated nation in the world. HIV/AIDS has acquired pandemic proportion in the world. Estimate by WHO for current infection rate in Asia. India has the third largest HIV epidemic in the world. HIV prevalence in the age group 15-49 yrs was an estimate of 0.2%. India has been classified as an intermediate in the Hepatitis B Virus (HBV) endemic (HBsAg carriage 2-7%) zone with the second largest global pool of chronic HBV infections. Safety assessment of the blood supply, the quality of screening measures and the risk of transfusion transmitted infectious diseases (TTIs) in any country can be estimated by scrutinizing the files of blood donors. After the introduction of the blood banks and improved storage facilities, it became more extensively used. Blood is one of the major sources of TTIs like hepatitis B, hepatitis C, HIV, syphilis, and many other blood borne diseases. Disclosure of these threats brought a dramatic change in attitude of physicians and patients about blood transfusion. The objective of this study is to determine the seroprevalence of transfusion transmitted infections amidst voluntary blood donors at a rural tertiary healthcare teaching hospital in Chhattisgarh. MATERIAL AND METHODS: This retrospective study was carried out in Chandulal Chandrakar Memorial Medical College, Kachandur, Durg. Blood donors were volunteers, or and commercial donors who donated the blood and paid by patients, their families, or friends to replace blood used or expected to be used for patients from the blood bank of the hospital. After proper donation of blood routine screening of blood was carried out according to standard protocol. Laboratory diagnosis of HIV 1 and HIV 2 was carried out by ELISA test. Hepatitis B surface antigen was screened by using ELISA. RESULTS: A total of 1915 consecutive blood donors’ sera were screened at Chandulal Chandrakar Memorial Medical College, blood bank during study period. Of these 1914 were male and 1 female. The mean age of patients was found to be 29.34 years with standard deviation (SD) of 11.65 Years. Among all blood donors in present study, 759(39.63%) were first time donors and 1156(60.37%) were repeated donors. 1 patient was HIV positive in first donation group while 3 (75%) were positive in repeat donation group. 7 (38.9%) were HBsAg positive in in first donation group while 11(61.1%) were positive in repeat donation group. Two patients in first donation group had dual infection of HIV and HBsAg. CONCLUSION: Seropositivity was high in repeated donors as compared to first time donors. The incidence of HIV is observed to be 0.2% and that of HBsAg is 0.94%. Strict selection of blood donors should be done to avoid transfusion-transmissible infections during the window period.

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