AbstractBackgroundBrazil reported 123,780 deaths across 27 administrative regions, making it the second-worst affected country after the US in terms of COVID-19 deaths as of 3 September 2020. Understanding the role of weather factors in COVID-19 in Brazil is helpful in the long-term mitigation strategy of COVID-19 in other tropical countries because Brazil experienced early large-scale outbreak among tropical countries. Recent COVID-19 studies indicate that relevant weather factors such as temperature, humidity, UV Index (UVI), precipitation, ozone, pollution and cloud cover may influence the spread of COVID-19. Yet, the magnitude and direction of those associations remain inconclusive. Furthermore, there is only limited research exploring the impact of these weather factors in a tropical country like Brazil. In this observational study, we outline the roles of 7 relevant weather factors including temperature, humidity, UVI, precipitation, ozone, pollution (visibility) and cloud cover in COVID-19 death growth rates in Brazil.MethodsWe use a log-linear fixed-effects model to a panel dataset of 27 administrative regions in Brazil across 182 days (n=3882) and analyze the role of relevant weather factors by using daily cumulative COVID-19 deaths in Brazil as the dependent variable. We carry out robustness checks using case-fatality-rate (CFR) as the dependent variable.FindingsWe control for all region-specific time-fixed factors as well as potentially confounding time-varying factors. We observe a significant negative association of COVID-19 daily deaths growth rate in Brazil with weather factors - UVI, temperature, ozone and cloud cover. Specifically, a unit increase in UVI, maximum temperature, and ozone level independently associate with 6.0 percentage points [p<0.001], 1.8 percentage points [p<0.01] and 0.3 percentage points [p<0. 1] decline in COVID-19 deaths growth rate. Further, a percentage point increase in cloud cover associates with a decline of 0.148 percentage points [p<0.05] in COVID-19 deaths growth rate. Surprisingly, contrary to other studies, we do not find evidence of any association between COVID-19 daily deaths growth rate and humidity, visibility and precipitation. We find our results to be consistent even when we use the CFR as the dependent variable.InterpretationWe find independent protective roles of UVI, temperature, ozone and cloud cover in mitigating COVID-19 deaths growth rate, even in a tropical country like Brazil. We observe these results to be consistent across various model specifications, especially for UVI and cloud cover, even after incorporating additional time-varying weather parameters such as dewpoint, pressure, wind speed and wind gust. These results could guide health-related policy decision making in Brazil as well as similar tropical countries.