Waist circumference, hip circumference, arm span, and waist-to-hip ratio high risk of polycystic ovarian syndrome

2021 ◽  
pp. 003693302110432
Author(s):  
Tazkia Mawaddatina ◽  
Uki Retno Budihastuti ◽  
Dwi Rahayu
Keyword(s):  
High Risk ◽  
Waist Circumference ◽  
Polycystic Ovarian Syndrome ◽  
Hip Circumference ◽  
Waist To Hip Ratio ◽  
Control Approach ◽  
Arm Span ◽  
High Prevalence ◽  
Reproductive Problem ◽  
Ovarian Syndrome

Background and Aims Polycystic ovarian syndrome is a reproductive problem of women with high prevalence cases accompanied by obesity conditions. Obesity condition can be seen from the size of waist circumference, hip circumference, arm span, and waist-to-hip ratio. This study aims to find out the risk factors between waist circumference size, hip circumference, arm span, and waist-to-hip ratio with polycystic ovarian syndrome. Methods This research is an analytical observation using a case-control approach conducted at Sekar Fertility Clinic and Poly Obgyn Dr Moewardi General Hospital Surakarta. Subjects were 150 consisting of 75 polycystic ovarian syndrome women and 75 normal fertile women. Sampling techniques used in this study are purposive sampling, researchers doing anthropometric measurements in the form of waist circumference, hip circumference, arm span, and waist-to-hip ratio simultaneously. The results were analyzed using Statistic Product and Service Solution 25. Results The results of the study obtained waist circumference with polycystic ovarian syndrome ( b = 3.002; CI 95% = 3.41–123.5; p = 0.001), hip circumference ( b = −2.671; CI 95% = 0.01–0.37; p = 0.002), arm span ( b = 5.318; CI 95% = 32.23–129.58; p < 0.001) and waist-to-hip ratio ( b = 1.761; CI 95% = 1.02–33.01; p = 0.047). Conclusion Waist circumference size, hip circumference, arm span, and waist-to-hip ratio correlate to a high risk of polycystic ovarian syndrome. Arm span is more dominant as an indicator of high risk to polycystic ovarian syndrome compared to waist circumference, hip circumference, and waist-to-hip ratio.

scholarly journals Polycystic Ovarian Syndrome: Correlation between clinical hyperandrogenism, anthropometric, metabolic and endocrine parameters

2019 ◽  
Vol 35 (5) ◽  
Author(s):  
Ayesha Khan ◽  
Nasim Karim ◽  
Jahan Ara Ainuddin ◽  
Muhammad Faisal Faheem
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Pearson Correlation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Testosterone ◽  
Hip Circumference ◽  
Waist To Hip Ratio ◽  
Infertile Women ◽  
Endocrine Parameters ◽  
Ovarian Syndrome

Objective: To evaluate the correlation between clinical hyperandrogenism-hirsutism assessed by modified Ferriman-Gallwey (F-G) score, anthropometric, metabolic and endocrine parameters among PCOS infertile women. Methods: This observational study after approval of FRC & ERC of BUMDC was conducted from September 2018-March 2019. It included seventy women aged 20-40 years who presented in infertility clinic of a local Hospital in Karachi. After written informed consent participants were enrolled as per the inclusion criteria of the study and evaluated for cyclical pattern (oligomenorrhoea, amenorrhoea, polymenorrhea), physical (weight, height, BMI), anthropometric, (waist circumference, hip circumference, waist to hip ratio, hirsutism), metabolic (carbohydrate, lipid & protein) and endocrine parameters (serum FSH, LH, LH/FSH ratio, serum testosterone, prolactin and progesterone level). Hirsutism was assessed by visual method through modified F-G score and Pearson correlation was determined between hirsutism and other study parameters. Results: A positive Pearson correlation is found between hirsutism and body weight, BMI, waist and hip circumference, waist to hip ratio (WHR), very low density lipoprotein, cholesterol, triglycerides and testosterone levels. Conclusion: Hirsutism has correlation with anthropometric, metabolic and hyperandrgenic disorders in PCOS infertile women as assessed by modified F-G score. doi: https://doi.org/10.12669/pjms.35.5.742 How to cite this:Khan A, Karim N, Ainuddin JA, Fahim MF. Polycystic Ovarian Syndrome: Correlation between clinical hyperandrogenism, anthropometric, metabolic and endocrine parameters. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.742 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Maximum Vasodilatory Reserve is Negatively Correlated with Bmi and Waist Circumference in Women with Polycystic Ovarian Syndrome

1998 ◽  
Vol 95 (s39) ◽  
pp. 2P-2P
Author(s):  
WG Liddell ◽  
MJ Davies ◽  
AC Shore ◽  
J Howe ◽  
JE Tooke
Keyword(s):  
Waist Circumference ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals INTERRELATIONS BETWEEN LEPTIN & OBESITY

1969 ◽  
Vol 3 (1) ◽  
pp. 252-257
Author(s):  
MOHAMMAD SHAFIQUE ◽  
HABIBULLAH QURESHI ◽  
FAIZA SAJID
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Body Mass ◽  
Fasting Blood Glucose ◽  
Hip Circumference ◽  
Serum Leptin ◽  
Waist To Hip Ratio ◽  
Obese Subjects

Objective: Excess body weight is the sixth most important risk factor contributing to the overall burden ofdisease worldwide. The circulating leptins have been found to play a vital role in the regulation of appetite,glucose homeostasis and body fat. Therefore, this study was designed to measure serum leptin and insulinresistance in non obese and obese young adults and to correlate them with obesity parameters: body massindex, waist circumference, waist-to-hip ratio and metabolic indices.Methods: A total of 43 non- obese subjects, 20 male and 23 female aged 20- 25 years and 46 obese subjects,25 male and 21 female with age 28- 37 years were studied. All subjects selected for study were normotensiveand non-diabetic. Variables measured were Body Mass Index (BMI), waist to hip ratio(WHR), bloodpressure, serum leptin, insulin, fasting blood glucose, oral glucose tolerance test (OGTT), and lipid profile.Results: Serum leptin was significantly higher in females than males 8.8 ± 2.10 SEM and 2.2 ± 0.26 ng/mlSEM respectively in non-obese.As well, Serum leptin was significantly higher in females than males 23.0 ±3.98 SEM and 12.5 ± 2.24 ng/ml SEM respectively in obese group. Serum leptin was significantly higher inobese males, and obese females compared to non- obese subjects. Serum leptin significantly, and positivelycorrelated with BMI (r = 0.440), hip circumference (r =0.425), insulin (r = 0.334), and homeostasis Model ofAssessment - Insulin Resistance (HOMA-IR)r= 0.334 whereas HOMA-IR positively correlated with BMI,waist Circumference, fasting insulin, fasting blood glucose, triglycerides (TG), TG/HDL-Cholesterol ratioand negatively correlated with HDL-Cholesterol.Conclusions: Serum leptin levels increase with obesity, and are higher in females in both non-obese andobese individuals. Serum leptin significantly correlated with hip circumference. Increased serum leptin,especially in obese subjects, should be taken as a warning sign of energy imbalance, poor diet,hyperinsulinemia, insulin resistance, or changes in other metabolic risk factors that are stronglyassociated with cardiovascular diseases and type 2 diabetes. Key words: Anthropometry, body mass index, insulin resistance, leptin, obesity,

scholarly journals Novel HumanMethylatyion450 Analyses Reveal DNA Methylation Predictors of Future Diabetes Onset in Women With Polycystic Ovarian Syndrome

2021 ◽  
Author(s):  
Mark Kitchen ◽  
Ayesha Manzur ◽  
Anthony Fryer ◽  
Pensee Wu
Keyword(s):  
Dna Methylation ◽  
High Risk ◽  
Polycystic Ovarian Syndrome ◽  
Good Health ◽  
High Risk Population ◽  
Diabetes Onset ◽  
Increased Risk ◽  
Illumina Humanmethylation450 Beadchip ◽  
Ovarian Syndrome ◽  
Future Diabetes

Abstract Aims. Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterised by ovarian morphological, systemic biochemical, and menstrual changes. Women with PCOS are at significantly increased risk of raised fasting glucose, impaired glucose tolerance, and diabetes. Recognition of these complications and early intervention are key to good health outcomes. We sought to identify DNA methylation patterns that may predict future diabetes onset in this high-risk PCOS population. Patients and Methods. Peripheral blood samples from women with PCOS and women with PCOS who later developed diabetes, were analysed by Illumina HumanMethylation450 BeadChip-arrays. Bisulphite-Pyrosequencing™ was used to validate and confirm array methylation data. Results. Array analyses identified 273 differentially methylated CpG loci (≥ 0.2 β-value change) at initial diagnosis of PCOS, between women who did or did not later develop diabetes. 19 of these sites demonstrated differential methylation in the same direction in ≥ five sample pairs. Methylation in three of the candidates (cg11897887, cg02819655, and cg25542007) showed the best concordance with corresponding array β-values, and, most clearly differentiated ‘cases’ from ‘controls’. Conclusions. We have identified novel methylation biomarkers that could predict future onset of diabetes in this high-risk population. Use of methylation analyses to identify women who are likely to develop diabetes at diagnosis of PCOS may facilitate timely lifestyle interventions to reduce future morbidity.

scholarly journals Coagulation Biomarkers in Women with Recurrent Miscarriage and Polycystic Ovarian Syndrome: Systematic Review and Meta-Analysis

2019 ◽  
Vol 79 (07) ◽  
pp. 697-704 ◽  
Author(s):  
Marcelo Borges Cavalcante ◽  
Manoel Sarno ◽  
Candice Torres de Melo Bezerra Cavalcante ◽  
Edward Araujo Júnior ◽  
Ricardo Barini
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Polycystic Ovarian Syndrome ◽  
Recurrent Miscarriage ◽  
Meta Analysis ◽  
Factor V Leiden ◽  
Coagulation Disorders ◽  
Mthfr Polymorphism ◽  
Search Terms ◽  
Ovarian Syndrome

Abstract Introduction Pregnant women with polycystic ovarian syndrome (PCOS) have high risk of pregnancy loss. Pathophysiological mechanisms appear to be associated with obesity, hormonal factors, or blood clotting disorders. Our aim is to perform a systematic review and meta-analysis on the relationship between coagulation disorders and risk of recurrent miscarriage (RM) in patients with PCOS and to identify coagulation biomarkers for this condition. Material and Methods PubMed and MEDLINE databases were searched for publications in English language. The search terms used included “RM”, “polycystic ovary syndrome”, “coagulation disorders”, and “thrombophilia”. Odds ratios (ORs) and 95% confidence intervals (CIs) for miscarriage in different RM groups (with and without PCOS). Results A total of 575 publications including the search terms were identified. Six studies were included for qualitative analysis, and five were included for quantitative analysis (meta-analysis). We found no association between RM and inherited thrombophilias in patients with PCOS: (1) Factor V Leiden (OR, 0.74; 95% CI, 0.38 – 1.45; p = 0.38); (2) C677T methylenetetrahydrofolate reductase polymorphism (MTHFR) (OR, 1.01; 95% CI, 0.64 – 1.59; p = 0.97); and (3) A1297C MTHFR polymorphism (OR, 1.08; 95% CI, 0.62 – 1.89; p = 0.77). Other potential biomarkers were identified, with emphasis on plasminogen activator inhibitor type 1. Conclusion Data available in the current literature revealed that there was no association between RM and inherited thrombophilias in patients with PCOS. RM patients with PCOS have a high risk of thromboembolic events.

scholarly journals A prospective analysis of polycystic ovarian syndrome in infertile women

2018 ◽  
Vol 8 (1) ◽  
pp. 299
Author(s):  
Soumya Patil ◽  
Saraswathi Ramesh ◽  
Harinath Srinivasa Murthy Kharidhi
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Menstrual Irregularity ◽  
Cardiovascular Risks ◽  
Menstrual Cycles ◽  
Infertile Women ◽  
Gynecological Examination ◽  
High Prevalence ◽  
Proper Diagnosis ◽  
A Prospective Study ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is a frequently occurring metabolic and reproductive endocrinopathy. Young women with PCOS mainly present with reproductive problems such as hyperandrogenism, menstrual irregularities, infertility and chronic anovulation. Despite its high prevalence and implications on reproductive health, PCOS is underdiagnosed. The objective was to study the prevalence of PCO in women with infertility, their symptomatology, endocrine profiles and coexisting factors of infertility in women with PCOS.Methods: A prospective study was performed over a period of 6 months. Women presenting with infertility were subjected to detailed history taking, general and gynecological examination. Women with features of PCOS on ultrasound were identified and advised investigations such as serum FSH, LH, prolactin and laparoscopy when indicated.Results: During the study period, 102 patients consulted the infertility clinic, out of which 56 were diagnosed with PCOS. The prevalence of PCOS was found to be 54.9% among infertile women. Menstrual irregularity was found in 33 (59%) women, however, 23 (41%) had regular menstrual cycles. 4 among the 33 patients complained of dysmenorrhea, 5 had heavy menstrual bleeding. On examination, 19 (33.9%) were found hirsute, 8 (14.28%) had thyroid enlargement and 2 (3.57%) had galactorrhea. Investigations revealed mean FSH and LH levels of 8.7±2SD and 13.7±2SD respectively and mean LH/FSH ratio of 1.57±2SD.Conclusions: PCOS is a heterogenous disorder and with its high prevalence in infertile women, proper diagnosis and management is essential as it has many potential metabolic and cardiovascular risks if not managed appropriately.

scholarly journals COMPARISION OF MYO-INOSITOL VERSUS METFORMIN ON ANTHROPOMETRIC PARAMETERS IN POLYCYSTIC OVARIAN SYNDROME IN WOMEN

2017 ◽  
Vol 9 (4) ◽  
pp. 144 ◽  
Author(s):  
Jyoti Nehra ◽  
Jyoti Kaushal ◽  
Savita Rani Singhal ◽  
Veena Singh Ghalaut
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Hip Circumference ◽  
Anthropometric Parameters ◽  
Insulin Sensitizers ◽  
Significant Difference ◽  
Comparative Clinical Study ◽  
Group A ◽  
Group B ◽  
To Receive ◽  
Ovarian Syndrome

Objective: The objective of the study was to evaluate and compare the effect of insulin sensitizers i.e. metformin and myoinositol on anthropometric parameters in patients of the Polycystic ovarian syndrome (PCOS).Methods: A prospective, open-labeled, randomized, comparative, clinical study was conducted on 60 patients. The patients were randomly divided into two groups of 30 each to receive either of the following two treatments: group A: Tablet myoinositol 1g twice daily. group B: Tablet metformin 500 mg thrice daily for 24 w. Anthropometric parameters were assessed by measuring body weight, Body mass index (BMI), waist circumference, hip circumference, waist-hip ratio (WHR) at baseline and subsequently at the end of 12 w and 24 w.Results: In both the groups, there was a statistically significant improvement in over a period of 24 w. In group A, the values for weight at baseline, 12 w and 24 w expressed in mean±SEM are 63.96±.90, 62.33±.88 and 61.20±.85 while in group B the values were 63.58±1.88, 62.26±1.74 and 60.86±1.65. In group A, the values for BMI at baseline, 12 w and 24 w were 26.45±.41, 25.78±.42 and 25.31±.40 while in group B the values were 26.09±.76, 25.53±.71 and 24.96±.68 respectively. In group A, WHR values were 0.79±.007, 0.78±.007 and 0.78±.007 while in group B 0.79±.010, 0.79±0.108, 0.79±.011 at baseline, 12 w and 24 w respectively. However, on comparing both the groups at 12 and 24 w, no statistically significant difference was observed in all the parameters.Conclusion: There was a definite improvement in anthropometric parameters with both metformin and myoinositol but on comparing these drugs, no significant difference was observed. Thus, myoinositol can also be used as an alternative to metformin for the treatment of PCOS.

scholarly journals AB0519 PHYSICAL ACTIVITY AND OBESITY IN PATIENTS WITH ANKYLOSING SPONDYLITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1286.2-1286
Author(s):  
R. Dhahri ◽  
S. Miri ◽  
M. Slouma ◽  
B. Louzir ◽  
L. Metoui ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cardiovascular Risk ◽  
Ankylosing Spondylitis ◽  
Waist Circumference ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Hip Circumference ◽  
Waist To Hip Ratio ◽  
The Mean

Background:Ankylosing Spondylitis (AS) is associated with an increased cardiovascular risk. Obesity and limited activity in patients with AS may contribute to this cardiovascular risk.Objectives:We aimed to evaluate physical Activity and obesity in patients with AS.Methods:We conducted a cross-sectional observational study of 40 patients with AS, over a period of 3 months. We evaluated the level of physical activity using the IPAQ (International Physical Activity Questionnaire). We also measured body mass index (BMI), body fat percentage, waist circumference, hip circumference and their ratio in all patients.Results:The mean age of our population was 44±10 years. A male predominance was noted with a sex ratio =11.1. The mean ASDAS-CRP and BASDAI levels were 2.1±0.95 and 2.25±1.33. The mean of IPAQ was 3900 MET minutes per week, with a median of 3069 and extremes of 339 and 11000. 45.5% of patients had moderate physical activity and 20% had low activity.The mean BMI was 26.5 + 4.7 kg/m2. Twenty percent of patients were obese. The mean body fat percentage was 25% with a median of 23.7% and extremes of 8-46%. Forty-five percent of the patients had a high fat mass. The mean waist circumference was 95±13 cm, hip circumference 104±9.5 cm. The mean waist to hip ratio was 0.9±0.07. Thirty-seven percent of patients had a high waist to hip ratio. BMI and body fat percentage were negatively correlated with HDL level; (r=-0.365,p=0.024)and(r=-0.393,p=0.015) respectively.Conclusion:The majority of our patients have moderate or low levels of physical activity. The increase in BMI and fat mass appear to be associated with disturbance of the lipid balance, with low HDL values.Disclosure of Interests:None declared.

scholarly journals Vitamin D does not have any Impact on Ovarian Reserve Markers in Infertile Women

2017 ◽  
pp. 1
Author(s):  
Ümit Görkem ◽  
Ferit Kerim Küçükler ◽  
Cihan Toğrul ◽  
Şebnem Gülen
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Waist Circumference ◽  
Body Mass ◽  
Ovarian Reserve ◽  
Hip Circumference ◽  
Infertile Women ◽  
Significant Difference ◽  
Ovarian Reserve Markers ◽  
Ovarian Syndrome

<p><strong>Objective:</strong> To evaluate the potential role of vitamin D on ovarian reserve markers in infertile women with different reserve patterns.</p><p><strong>Study design:</strong> This prospective cross-sectional study included the infertile women attending the Hitit University Hospital. The initial examination included the measurements of waist circumference and hip circumference, body mass index, and waist/hip ratio. A total of 171 women were divided into three groups according to ovarian reserve patterns: (i) adequate ovarian reserve pattern (AOR, n=77), (ii) high ovarian reserve pattern (polycystic ovarian syndrome, n=62), and (iii) diminished ovarian reserve pattern (DOR, n=32). The serum estradiol (E2), follicle stimulating hormone, total testosterone, 17-hydroxy-progesterone (17(OH) P), dehydroepiandrosterone sulfate, anti-mullerian hormone, and hydroxycholecalciferol (25(OH) D) levels were analyzed. </p><p><strong>Results:</strong> No significant difference between three different groups was detected in terms of body mass index, waist circumference, hip circumference, waist/hip ratio, E2 and 17OHP levels (p&gt;0.05, for all). One-hundred-sixty-nine (98.2%) women in all groups had vitamin D concentration below 30 ng/mL as a cut-off value. The circulating 25 (OH) D levels did not show a significant difference between all ovarian reserve groups (p=0.804). No correlation between 25(OH) D and anti-mullerian hormone levels was documented in women with AOR, polycystic ovarian syndrome and DOR patterns (r=-0.099 p=0.393, r=0.034 p=0.794 and r=0.157 p=0.390 respectively). 25 (OH) D levels were significantly correlated with body mass index, waist circumference and hip circumference parameters only in AOR group (r=-0.355 p=0.002, r=-0.305 p=0.007 and r=-0.322 p=0.004 respectively).</p><p><strong>Conclusions:</strong> There is no association between 25 (OH) D and ovarian reserve markers. 25 (OH) D levels were significantly correlated with body mass index, waist circumference and hip circumference parameters only in AOR group.</p>

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