Undifferentiated Carcinoma of the Nose and Paranasal Sinuses

1993 ◽  
Vol 72 (9) ◽  
pp. 588-595 ◽  
Author(s):  
Oreste Gallo ◽  
Paola Graziani ◽  
Omero Fini-Storchi
Keyword(s):  
Survival Rate ◽  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
High Growth ◽  
Clinical Analysis ◽  
Undifferentiated Carcinoma ◽  
Average Delay ◽  
Neck Metastases ◽  
Undifferentiated Tumors ◽  
Nose And Paranasal Sinuses

Among twenty-six “undifferentiated” tumors of the nasal cavity and paranasal sinuses treated from 1970 to 1990 at the Institute of Otolaryngology of Florence University, 13 were ultimately diagnosed as true undifferentiated sinusonasal carcinoma (SNUC) by conventional light microscopy and use of monoclonal antibodies to epithelial membrane antigen and cytokeratins. SNUC patients, who ranged in age from 20 to 82 years, often had multiple sinonasal symptoms due to very large tumors (nine of 13 tumors were staged as T3–T4) with short average delay of 4 months between onset of symptoms and diagnosis. Both data suggest the high growth capacity and aggressiveness of such a tumor. In our series, follow-up evidenced an overall crude 5-year survival rate of 15.5%. Worse prognostic factors are neck metastases and orbital invasion, according to the behavior of more common carcinomas of the nose and paranasal sinuses. We also found a better prognosis for SNUC primarily arisen in the nasal cavity than in paranasal sinuses (crude 5-year survival rate of 66% vs. 10%, respectively). The histopathological and clinical analysis of our series shows that SNUC is a highly aggressive, uncommon tumor of the nose paranasal sinuses, which should be recognized in advance for a more aggressive treatment by combined multiple therapy.

scholarly journals Inverted Papilloma against a Background of Bilateral Rhinosinusitis Polyposa with Viscous Mucin (Clinical Case)

2018 ◽  
Vol 8 (2) ◽  
pp. 70-74
Author(s):  
R. M. Pestova ◽  
E. E. Savel’eva ◽  
L. F. Aznabaeva ◽  
R. A. Sharipov
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Clinical Case ◽  
Diagnostic Algorithm ◽  
Inverted Papilloma ◽  
Benign Tumour ◽  
Initial Growth ◽  
Biopsy Material ◽  
Accurate Performance ◽  
Nose And Paranasal Sinuses

Introduction. Rhinosinusitis polyposa consists in a chronic inflammation of the mucous membrane of the nose and paranasal sinuses, followed by recurrent growth of polyps and characterised by a high prevalence. Nasal polyps may be associated with the presence of viscous mucin; their characteristic CT signs are hyperostosis of the walls of the affected sinuses and thinning cavity walls until the bone is destroyed, this being a sign of aseptic osteomyelitis. The same sign is typical for inverted papilloma, the most common benign tumour of the nose and sinuses.Materials and methods. The present article presents a clinical observation. What makes it interesting is that a benign tumour was diagnosed against the background of bilateral rhinosinusitis polyposa. The clinical picture did not have nasal bleeding, which is typical for inverted papilloma; this was most likely due to the initial growth of the tumour. Thickening bone structures (hyperostosis) was balanced due to the pathogenetic peculiarities of the rhinosinusitis polyposa development with viscous mucin. Inverted papilloma was suspected during rhinoscopy, which revealed asymmetric growth of polyps. Final verification of the clinical diagnosis was carried out following computerised tomography of the nose and paranasal sinuses and histological examination of biopsy material.Results and discussion. This clinical case is of interest due to rhinocytogram data suggesting a viral and inflammatory etiology of the development of inverted papilloma. Therefore, the observed nucleoli of the nuclei of the columnar epithelium are characteristic of intracellular infection — in particular, viral. Remodelling of cells of the cylindrical epithelium is a sign of chronic inflammatory process.Conclusion. Thus, accurate performance of the diagnostic algorithm with histological verification of all removed material allows the identification of a neoplasm of the nasal cavity even in difficult cases, along with other diseases of the nasal cavity. Rhinocytogram data can help suggest the etiology of the intracellular type of infection in the epithelial cell and pathogenesis of inverted papilloma in a particular case.

Sinonasal Undifferentiated Carcinoma: Case Series and Review of the Literature

Neurosurgery ◽  
2000 ◽  
Vol 47 (3) ◽  
pp. 750-755 ◽  
Author(s):  
Judith Gorelick ◽  
Donald Ross ◽  
Lawrence Marentette ◽  
Mila Blaivas
Keyword(s):  
Nasal Cavity ◽  
Surgical Resection ◽  
Paranasal Sinuses ◽  
Locally Advanced ◽  
Case Series ◽  
Undifferentiated Carcinoma ◽  
Intracranial Extension ◽  
System Response ◽  
Review Of The Literature ◽  
Sinonasal Undifferentiated Carcinoma

ABSTRACT OBJECTIVE AND IMPORTANCE We report on four cases of sinonasal undifferentiated carcinoma (SNUC), a relatively newly described clinicopathological entity of the nasal cavity and paranasal sinuses. SNUC tends to present with advanced-stage disease, often with intracranial invasion, and requires an aggressive treatment approach that includes surgical resection. A review of the literature identified several reports of SNUC in pathology and otolaryngology journals since its initial description in 1986, but no report has yet appeared in the neurosurgery literature. CLINICAL PRESENTATION Four patients presented with various symptoms related to the nose and/or orbit, including one or more of the following: obstruction, epistaxis, decreased visual acuity, diplopia, and pain. All patients were noted to have masses in the nasal cavity or paranasal sinuses, with or without intracranial extension. INTERVENTION All four patients underwent multimodal treatment with chemotherapy, radiotherapy (60–65 Gy), and aggressive surgical resection via a combined bifrontal craniotomy and a subcranial approach to the anterior cranial fossa. Three of four patients died as a result of their disease, an average of 15 months after diagnosis. Only one patient remains alive, although with metastatic intracranial disease, at 24 months after diagnosis. CONCLUSION SNUC is a rare neoplasm with a poor prognosis despite an aggressive multimodal approach to treatment. On the basis of our experience, we advocate radical resection as part of the initial combined therapy for patients who present with locally advanced, nonmetastatic disease but we suggest reserving surgery for patients with early brain invasion until there has been a radiographically proven central nervous system response to adjuvant therapy.

Nasal teeth

1992 ◽  
Vol 106 (4) ◽  
pp. 366-367 ◽  
Author(s):  
J. P. M. Pracy ◽  
H. O. L. Williams ◽  
P. Q. Montgomery
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Mandibular Condyle ◽  
Coronoid Process ◽  
Significant Morbidity ◽  
Supernumerary Teeth ◽  
Nose And Paranasal Sinuses ◽  
Nasal Teeth

AbstractEctopic and supernumerary teeth occur in a wide variety of sites. Those that have been reportedinclude the mandibular condyle, coronoid process, orbit, palate, nasal cavity and the maxillaryantrum. Eruption of teeth into these sites is rare, and easily overlooked. We present two casesin which eruption of teeth into the nose and paranasal sinuses was associated with significant morbidity and show how this was relieved by appropriate surgery.

scholarly journals Optimization of treatment methods for chronic diseases of the nose and paranasal sinuses combined with chronic dacryocystitis

2019 ◽  
Vol 3 ◽  
Author(s):  
N.J. Khushvakova ◽  
F.A. Nurmukhammedov ◽  
U.F.Davronov
Keyword(s):  
Nasal Cavity ◽  
Chronic Diseases ◽  
Paranasal Sinuses ◽  
Lacrimal Duct ◽  
Treatment Methods ◽  
Chronic Dacryocystitis ◽  
Silicone Stent ◽  
Nose And Paranasal Sinuses

The pathogenesis of the overgrowth of dacryorrhinostoma is based on many factors from the development of granulations and scars in the area of ​​the bone opening to the development of the commissural opening, mucositis in the nasal cavity to purulent persistent forms of rhinosinusitis in the area nose-lacrimal duct. To improve the reparative processes after the operation of endoscopic dacriocystomy with the installation of silicone stent-drainage (from the intubation tube), a zinc hyalrate solution was used.

scholarly journals Primary Neoplasms of the Nasal Cavity, Paranasal Sinuses and Nasopharynx in the Dog: A Report of 16 Cases from the Files of the AFIP

1978 ◽  
Vol 15 (1) ◽  
pp. 18-30 ◽  
Author(s):  
A. W. Confer ◽  
A. DePaoli
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Clinical Signs ◽  
Armed Forces ◽  
Undifferentiated Carcinoma ◽  
Nasal Discharge ◽  
Undifferentiated Sarcoma ◽  
Facial Swelling ◽  
Primary Neoplasms ◽  
Degree Of Differentiation

Sixteen cases of primary neoplasms of the nasal cavity, paranasal sinuses and nasopharynx in the dog were reviewed from the files of the Armed Forces Institute of Pathology (AFIP). The mean age of affected dogs was 9.5 years. The presenting clinical signs were epistaxis, nasal discharge or facial swelling. Eleven of the affected dogs were purebred. Three of these were Collies and two German Shepherds. The nasal cavity was involved most often. All neoplasms were malignant (11 carcinomas and five sarcomas), and there was invasion of the adjacent bony structures in most dogs. Tumors were classified according to prominent cell type and degree of differentiation into respiratory epithelial carcinoma (four), adenocarcinoma (one), squamous cell carcinoma (one), muco-epidermoid carcinoma (two), undifferentiated carcinoma (three), chondrosarcoma (three) and undifferentiated sarcoma (two).

scholarly journals A Rare Tumor of the Nasal Cavity: Hemangiopericytoma

2020 ◽  
Vol 6 (01) ◽  
pp. 38-40
Author(s):  
Kaustubh J. Kahane ◽  
Siddhartha Shrivastava ◽  
Apurva A. Jarandikar ◽  
Aishwarya S. Phatak
Keyword(s):  
Soft Tissue ◽  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Soft Tissue Sarcomas ◽  
Vascular Tumors ◽  
Preoperative Embolization ◽  
Rare Entity ◽  
Complete Surgical Resection ◽  
Nose And Paranasal Sinuses ◽  
Orbital Region

AbstractHemangiopericytomas (HPCs) are soft tissue neoplasms that account for 3 to 5% of all soft tissue sarcomas and 1% of all vascular tumors. The vascular tumors originate from pericytes in the head and neck. The most common sites are the nasal cavity, paranasal sinuses, orbital region, parotid gland, and neck. HPC arising from the nose and paranasal sinuses is a rare entity. Till now, less than 200 cases have been reported in the literature. The treatment of choice is complete surgical resection, if possible, combined with preoperative embolization. We are presenting a rare case of HPC of the nasal cavity for its rarity and for concerns in management. This case was managed by endoscopic resection, which gave complete clearance of the disease and achieved better cosmesis.

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