Globalizing the Scientific Bandwagon: Trajectories of Precision Medicine in China and Brazil

2020 ◽  
Vol 46 (1) ◽  
pp. 192-225 ◽  
Author(s):  
Larry Au ◽  
Renan Gonçalves Leonel da Silva
Keyword(s):  
Precision Medicine ◽  
Large Scale ◽  
Dynamic Network ◽  
The United States ◽  
Biomedical Sciences ◽  
Biomedical Knowledge ◽  
Strong State ◽  
Institutional Void ◽  
History Of ◽  
Private Actors

Precision medicine (PM) is emerging as a scientific bandwagon within the contemporary biomedical sciences in the United States. PM brings together concepts and tools from genomics and bioinformatics to develop better diagnostics and therapies based on individualized information. Developing countries like China and Brazil have also begun pursuing PM projects, motivated by a desire to claim genomic sovereignty over its population. In spite of commonalities, institutional arrangements produced by the history of genomics research in China and Brazil are ushering PM along different trajectories. In the Chinese case, we identify a strong state-backed push for PM combined with a dynamic network of international academic and private actors along the lines of networked technonationalism that has made large-scale, speculative PM projects possible. The Brazilian case is characterized by an institutional void at the federal level in which PM is driven by domestic academic actors in universities in the regional level, resulting in smaller scale, needs-driven PM projects. Through these cases, this paper shows how a scientific bandwagon adapts to national histories and institutions. Through this peripheral translation of the scientific bandwagon, the global infrastructure of biomedical knowledge has the potential to be transformed.

The Decline and Rise of Democracy

2020 ◽  
Author(s):  
David Stasavage
Keyword(s):  
Political Institutions ◽  
The United States ◽  
Modern Democracy ◽  
Central State ◽  
Weak State ◽  
State Institutions ◽  
Strong State ◽  
The World ◽  
History Of ◽  
Historical Accounts

Historical accounts of democracy's rise tend to focus on ancient Greece and pre-Renaissance Europe. This book draws from global evidence to show that the story is much richer—democratic practices were present in many places, at many other times, from the Americas before European conquest, to ancient Mesopotamia, to precolonial Africa. Delving into the prevalence of early democracy throughout the world, the book makes the case that understanding how and where these democracies flourished—and when and why they declined—can provide crucial information not just about the history of governance, but also about the ways modern democracies work and where they could manifest in the future. Drawing from examples spanning several millennia, the book first considers why states developed either democratic or autocratic styles of governance and argues that early democracy tended to develop in small places with a weak state and, counterintuitively, simple technologies. When central state institutions (such as a tax bureaucracy) were absent—as in medieval Europe—rulers needed consent from their populace to govern. When central institutions were strong—as in China or the Middle East—consent was less necessary and autocracy more likely. The book then explores the transition from early to modern democracy, which first took shape in England and then the United States, illustrating that modern democracy arose as an effort to combine popular control with a strong state over a large territory. Democracy has been an experiment that has unfolded over time and across the world—and its transformation is ongoing. Amidst rising democratic anxieties, the book widens the historical lens on the growth of political institutions and offers surprising lessons for all who care about governance.

DO WE NEED PRIVATE UNIVERSITIES?

2020 ◽  
pp. 264-268
Author(s):  
Irina Podoynitsyna
Keyword(s):  
Large Scale ◽  
Success Factors ◽  
Private Universities ◽  
The United States ◽  
Educational Process ◽  
Educational Institutions ◽  
Sociological Study ◽  
History Of Development ◽  
History Of ◽  
Pros And Cons

The theses of the report are devoted to the problem of functioning of private universities in society, deter-mining their place in the educational process. A parallel is drawn with the work of private educational institutions in the United States, which have a glorious history of development dating back to the XVII century. The author of the theses relies on the analysis of special literature on this issue, formulates the success factors of American universities and the «failure factors» of Yakut private universities, and also refers to a large-scale sociological study of graduates of the Yakut Institute of Economics conducted under her leadership (Yakutsk, 469 respondents, 2016, 2017, 2018). The Author of the theses of the report con-cludes that in Russia the history of private universities began in the 90s of the twentieth century, it is quite dramatic. Branches of the capital's private universities operating in the province are at the greatest disad-vantage today. At the same time, sociologists should work on mistakes, study in detail the pros and cons of non-state universities and suggest ways to correct the situation.

scholarly journals Beyond ICS: How Should We Govern Complex Disasters in the United States?

2019 ◽  
Vol 16 (2) ◽  
Author(s):  
Branda Nowell ◽  
Toddi Steelman
Keyword(s):  
Disaster Response ◽  
Large Scale ◽  
National Policy ◽  
The United States ◽  
Network Governance ◽  
Governance Structures ◽  
Incident Command System ◽  
Incident Command ◽  
Complex Disasters ◽  
Private Actors

Abstract The complexity of large-scale disasters requires governance structures that can integrate numerous responders quickly under often chaotic conditions. Complex disasters – by definition – span multiple jurisdictions and activate numerous response functions carried out by numerous legally autonomous public, nonprofit, and private actors. The command operating structure of the Incident Command System (ICS) is a hierarchical structure used to manage complex incidents. Increasingly, complex disasters are seen as networks of multiple actors. Improving our capacity to respond to large-scale, complex disasters requires moving beyond the “hierarchy versus networks” debate to understand the conditions under which governance structures can best serve disaster response goals. Understanding the capabilities and limitations of the governance structures embedded in our national policy tools and frameworks can enhance our ability to govern effectively in networked contexts. In this article, we suggest the need to shift focus to build greater capacity for hybrid and network governance approaches, including a more sophisticated understanding of the conditions under which these governance forms are most effective.

scholarly journals Application of Artificial Intelligence Technology in Oncology: Towards the Establishment of Precision Medicine

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3532 ◽  
Author(s):  
Ryuji Hamamoto ◽  
Kruthi Suvarna ◽  
Masayoshi Yamada ◽  
Kazuma Kobayashi ◽  
Norio Shinkai ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Precision Medicine ◽  
Medical Devices ◽  
The United States ◽  
Medical Data ◽  
Clinical Implementation ◽  
Medical Field ◽  
Core Technology ◽  
Artificial Intelligence Technology ◽  
History Of

In recent years, advances in artificial intelligence (AI) technology have led to the rapid clinical implementation of devices with AI technology in the medical field. More than 60 AI-equipped medical devices have already been approved by the Food and Drug Administration (FDA) in the United States, and the active introduction of AI technology is considered to be an inevitable trend in the future of medicine. In the field of oncology, clinical applications of medical devices using AI technology are already underway, mainly in radiology, and AI technology is expected to be positioned as an important core technology. In particular, “precision medicine,” a medical treatment that selects the most appropriate treatment for each patient based on a vast amount of medical data such as genome information, has become a worldwide trend; AI technology is expected to be utilized in the process of extracting truly useful information from a large amount of medical data and applying it to diagnosis and treatment. In this review, we would like to introduce the history of AI technology and the current state of medical AI, especially in the oncology field, as well as discuss the possibilities and challenges of AI technology in the medical field.

Private universities and elite formation in Russia: Yakut case

2020 ◽  
Vol 1 (RL. 2020. vol.1. no. 2) ◽  
Author(s):  
Irina Podoynitsyna
Keyword(s):  
Large Scale ◽  
Success Factors ◽  
Private Universities ◽  
The United States ◽  
Educational Process ◽  
Sociological Study ◽  
Public And Private ◽  
North Eastern ◽  
History Of ◽  
Pros And Cons

The article is devoted to the problem of functioning of private universities in society, determining their place in the educational process. A parallel is drawn with the work of private educational institutions in the United States, which have a glorious history of development dating back to the XVII century. The author of the article relies on the analysis of special literature on this issue, identifies success factors of American universities and “failure factors” of private universities in Yakutia, and also refers to a large-scale sociological study of graduates of the M. K. Ammosov North-Eastern Federal University. Research conducted under his leadership (Yakutsk, 469 respondents, 2016, 2017, 2018). The Author concludes that the history of private universities in Russia, which began in the 90s of the twentieth century, is quite dramatic. Branches of the capital's private universities operating in the province are at the greatest disadvantage today. The current situation requires a detailed sociological analysis, a comparative analysis of the performance of public and private universities and identification of the pros and cons of non-state universities on this basis, in order to develop recommendations for correcting the situation.

Natural History of T1N0M0 Hepatocellular carcinoma: Large scale study in the United States.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e15120-e15120
Author(s):  
Humaid Obaid Al-Shamsi ◽  
Reham Abdel-Wahab ◽  
Manal Hassan ◽  
Gehan Botrus ◽  
Ahmed S Shalaby ◽  
...  
Keyword(s):  
United States ◽  
Hepatocellular Carcinoma ◽  
Natural History ◽  
Large Scale ◽  
The United States ◽  
Large Scale Study ◽  
History Of

scholarly journals Virulence Characterization of Puccinia striiformis f. sp. tritici Using a New Set of Yr Single-Gene Line Differentials in the United States in 2010

Plant Disease ◽  
2014 ◽  
Vol 98 (11) ◽  
pp. 1534-1542 ◽  
Author(s):  
Anmin Wan ◽  
Xianming Chen
Keyword(s):  
United States ◽  
Stripe Rust ◽  
Large Scale ◽  
Puccinia Striiformis ◽  
Yellow Rust ◽  
Single Gene ◽  
The United States ◽  
The Past ◽  
History Of

Puccinia striiformis f. sp. tritici causes stripe rust (yellow rust) of wheat and is highly variable in virulence toward wheat with race-specific resistance. During 2010, wheat stripe rust was the most widespread in the recorded history of the United States, resulting in large-scale application of fungicides and substantial yield loss. A new differential set with 18 yellow rust (Yr) single-gene lines was established and used to differentiate races of P. striiformis f. sp. tritici, which were named as race PSTv in distinction from the PST races identified in the past. An octal system was used to describe the virulence and avirulence patterns of the PSTv races. From 348 viable P. striiformis f. sp. tritici isolates recovered from a total of 381 wheat and grass stripe rust samples collected in 24 states, 41 races, named PSTv-1 to PSTv-41, were identified using the new set of 18 Yr single-gene differentials, and their equivalent PST race names were determined on the previous set of 20 wheat cultivar differentials. The frequencies and distributions of the races and their virulences were determined. The five most predominant races were PSTv-37 (34.5%), PSTv-11 (17.5%), PSTv-14 (7.2%), PSTv-36 (5.2%), and PSTv-34 (4.9%). PSTv-37 was distributed throughout the country while PSTv-11 and PSTv-14 were almost restricted to states west of the Rocky Mountains. The races had virulence to 0 to 13 of the 18 Yr genes. Frequencies of virulences toward resistance genes Yr6, Yr7, Yr8, Yr9, Yr17, Yr27, Yr43, Yr44, YrTr1, and YrExp2 were high (67.0 to 93.7%); those to Yr1 (32.8%) and YrTye (31.3%) were moderate; and those to Yr10, Yr24, Yr32, and YrSP were low (3.4 to 5.7%). All of the isolates were avirulent to Yr5 and Yr15.

Iraq's Burgeoning Judiciary: Current Issues and the Best Way Forward

2008 ◽  
Vol 4 ◽  
Author(s):  
Justin Charles Roberts
Keyword(s):  
National Security ◽  
Large Scale ◽  
Due Process ◽  
The United States ◽  
Sustainable Growth ◽  
Department Of Justice ◽  
History Of ◽  
The Rich ◽  
And Training

Following the United States takeover of Iraq in 2003, the Department of Justice released an assessment of Iraq’s fractured judiciary. Corruption, public distrust of the courts, and other roadblocks provided a bleak outlook on the rebuilding of the Iraqi judiciary. Nevertheless, recent large-scale judicial reforms have been moderately successful, including the separation of executive and judicial power, guarantee of due process, and efforts to protect the system from corruption, bribery, and political pressure. Now, during a period of relative stability, the Iraqi government must focus the improvement of the judiciary on four major areas: judicial independence, the debate between transparency and national security, the ability to prosecute high-ranking officials, issues with Kurdish autonomy, and international assistance and training. While each of these issues is deeply complex, this research asserts that there are six crucial improvements that will best enhance the Iraqi judiciary going forward. These improvements include increased courthouse rehabilitation to provide security for judges, a policy of erring on the side of transparency instead of worry over national security, a focus on promoting judges by merit instead of removing them through review, the rolling back of the ministerial protection law, a movement toward the election of judges instead of appointment, and an initiative to educate the Iraqi people and judiciary on the rich history of Iraqi law, as Iraq was the birthplace of codified law. If these improvements begin to be implemented now, they will ensure solid and sustainable growth of the Iraqi society and economy in the long-term.

Maritime Boundaries on National Ocean Service Nautical Charts

1993 ◽  
pp. 9-15
Author(s):  
Charles Harrington
Keyword(s):  
United States ◽  
United States Of America ◽  
Coastal Waters ◽  
Large Scale ◽  
Geneva Convention ◽  
The United States ◽  
Lead Agency ◽  
Technical Aspects ◽  
History Of ◽  
Definition Of

The National Ocean Service (NOS) is responsible for charting the Nation's coastal waters and, therefore, is the lead Agency for the portrayal of maritime limits of the United States of America. The 1958 Geneva Convention on the Territorial Sea and the Contiguous Zone states " ... the normal baseline for measuring the breadth of the territorial sea is the low waterline along the coast as marked on large-scale charts officially recognized by the coastal state." In 1976, NOS was requested to show various maritime limits on its regular issue of nautical charts. The paper presents the history of maritime boundaries on National Ocean Service (NOS) charts, methods used in constructing the various maritime limits, the definition of the limits, the push for lateral seaward boundaries, and the technical aspects of maritime limits.

Science and Medicine in the United States of America

2012 ◽  
Author(s):  
Edmund Ramsden
Keyword(s):  
Public Health ◽  
United States ◽  
Health Care ◽  
United States Of America ◽  
Rapid Growth ◽  
Large Scale ◽  
Medical Science ◽  
The United States ◽  
Biomedical Sciences ◽  
Democratic State

This article begins with great optimism expressed by Tocqueville for America's future as the embodiment of the democratic state. It discusses the opportunity to express the liberal political ideals, arguing that its success was based on a community of common sensibility. An understanding of society and politics endowed the historian with the power to help remake health care. This article explores and compares the ways in which medicine is developed and applied in a number of different social, cultural, and physical contexts. It shows rapid growth, from a period in which European ideas, methods, and structures were adapted to the American context, to one in which the United States is at the forefront of large-scale initiatives in public health, disease control, and innovation in the biomedical sciences. Finally, it mentions the contradiction, most notably between profound faith in the technical capacities of medical science and equally profound dissatisfaction with the provision of health care.

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