scholarly journals Sampling and Evaluating the Peripheral Nervous System

2019 ◽  
Vol 48 (1) ◽  
pp. 10-18 ◽  
Author(s):  
Mark T. Butt
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Sciatic Nerve ◽  
Peripheral Nervous System ◽  
Morphological Changes ◽  
Sampling Strategy ◽  
Mechanisms Of Toxicity ◽  
Test Article ◽  
Ganglion Neurons ◽  
The Brain

Many preclinical investigations limit the evaluation of the peripheral nervous system (PNS) to paraffin-embedded sections/hematoxylin and eosin–stained sections of the sciatic nerve. This limitation ignores several key mechanisms of toxicity and anatomic differences that may interfere with an accurate assessment of test article effects on the neurons/neurites peripheral to the brain and spinal cord. Ganglion neurons may be exposed to higher concentrations of the test article as compared to neurons in the brain or spinal cord due to differences in capillary permeability. Many peripheral neuropathies are length-dependent, meaning distal nerves may show morphological changes before they are evident in the mid-sciatic nerve. Paraffin-embedded nerves are not optimal to assess myelin changes, notably those leading to demyelination. Differentiating between axonal or myelin degeneration may not be possible from the examination of paraffin-embedded sections. A sampling strategy more consistent with known mechanisms of toxicity, atraumatic harvest of tissues, optimized fixation, and the use of resin and paraffin-embedded sections will greatly enhance the pathologist’s ability to observe and characterize effects in the PNS.

Some Points in the Histology of Lymphogenous and Hæmatogenous Toxic Lesions of the Spinal Cord

1908 ◽  
Vol 54 (226) ◽  
pp. 560-561
Author(s):  
David Orr ◽  
R. G. Rows
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Sciatic Nerve ◽  
Morphological Type ◽  
Broth Culture ◽  
Anatomical Distribution ◽  
Tabes Dorsalis ◽  
The Central Nervous System ◽  
The Brain

At a quarterly meeting of this Association held last year at Nottingham, we showed the results of our experiments with toxins upon the spinal cord and brain of rabbits. Our main conclusion was, that the central nervous system could be infected by toxins passing up along the lymph channels of the perineural sheath. The method we employed in our experiments consisted in placing a celloidin capsule filled with a broth culture of an organism under the sciatic nerve or under the skin of the cheek; and we invariably found a resulting degeneration in the spinal cord or brain, according to the situation of the capsule. These lesions we found to be identical in morphological type and anatomical distribution with those found in the cord of early tabes dorsalis and in the brain and cord of general paralysis of the insane. The conclusion suggested by our work was that these two diseases, if toxic, were most probably infections of lymphogenous origin.

Iodoantipyrine and Rb86 Cl uptake by brain, cord, and sciatic nerve in the rat

1963 ◽  
Vol 204 (2) ◽  
pp. 327-329 ◽  
Author(s):  
Morris J. Mandel ◽  
Francesco Arcidiacono ◽  
Leo A. Sapirstein
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Nervous System ◽  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Anatomical Entity ◽  
Nerve Blood Flow ◽  
The Brain

Rb86 and Iodo131 antipyrine were injected together by vein in rats. The brain, spinal cord, and nerve contents of each label were measured 30 or 60 sec later. Iodoantipyrine values were used to calculate blood flow to these portions of the nervous system. The ratio of Rb86 to iodoantipyrine uptake was used as an index of the efficacy of the hematoneural barrier. The barrier is most complete in the brain, less complete in the spinal cord, and absent in peripheral nerve. Blood flow values per gram are: brain .41 ml/g min; cord .28 ml/g min, and nerve .11 ml/g min. It is suggested that the blood-brain barrier is an anatomical entity rather than a functional one.

scholarly journals Activity-Dependent Plasticity of Spinal Circuits in the Developing and Mature Spinal Cord

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Behdad Tahayori ◽  
David M. Koceja
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Developmental Stages ◽  
Morphological Changes ◽  
Large Diameter ◽  
Sensory Information ◽  
Ample Evidence ◽  
Plastic Changes ◽  
Activity Dependent ◽  
The Brain

Part of the development and maturation of the central nervous system (CNS) occurs through interactions with the environment. Through physical activities and interactions with the world, an animal receives considerable sensory information from various sources. These sources can be internally (proprioceptive) or externally (such as touch and pressure) generated senses. Ample evidence exists to demonstrate that the sensory information originating from large diameter afferents (Ia fibers) have an important role in inducing essential functional and morphological changes for the maturation of both the brain and the spinal cord. The Ia fibers transmit sensory information generated by muscle activity and movement. Such use or activity-dependent plastic changes occur throughout life and are one reason for the ability to acquire new skills and learn new movements. However, the extent and particularly the mechanisms of activity-dependent changes are markedly different between a developing nervous system and a mature nervous system. Understanding these mechanisms is an important step to develop strategies for regaining motor function after different injuries to the CNS. Plastic changes induced by activity occur both in the brain and spinal cord. This paper reviews the activity-dependent changes in the spinal cord neural circuits during both the developmental stages of the CNS and in adulthood.

scholarly journals Spinal cord pathways

2020 ◽  
pp. S40-S44
Author(s):  
M Dlamini
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
The Brain ◽  
System Knowledge

The spinal cord is the primary pathway of communication between the brain and peripheral nervous system. Knowledge of the spinal cord anatomy and recognition of typical common spinal cord syndromes are important as many of these diseases have a predilection for targeting specific areas or tracts within the spinal cord.

Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system

2016 ◽  
Vol 8 (337) ◽  
pp. 337rv5-337rv5 ◽  
Author(s):  
Kate L. Montgomery ◽  
Shrivats M. Iyer ◽  
Amelia J. Christensen ◽  
Karl Deisseroth ◽  
Scott L. Delp
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
The Brain ◽  
Optogenetic Control

scholarly journals Pathological and anatomical changes in the nervous system of dogs in case of arsenic poisoning

2020 ◽  
Vol VI (2) ◽  
pp. 139-154
Author(s):  
A. A. Tsvetaev
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
Positive Answer ◽  
Nerve Cells ◽  
Late Period ◽  
Anatomical Changes ◽  
Arsenic Poisoning ◽  
Complete Destruction ◽  
The Brain

A positive answer to this topic was given in 1882 by prof. N. M. Popov in his dissertation: "Materials for science on acute mellitic toxic origin". He asserts that, first of all, the nerve cells (of the spinal cord) come to a state of turbid swelling and vacuolization. Both of these processes can lead them to complete destruction: the first, through the transition to a bland, spreading formation, the second, through an increase in the vacuole. Finally, in the late period, there is a pigment atrophy, which destroys all the cells, the improvement from the previous changes. The intensity of the process is determined by the greater or lesser proximity of the vessel .... In all likelihood, the author says, the brain also changes here. With the same positivity, the suffering of the peripheral nervous system is excluded in this work.

Neuroembryology and Development of the Nervous System

2017 ◽  
pp. 9-46
Author(s):  
Eduardo E. Benarroch ◽  
Jeremy K. Cutsforth-Gregory ◽  
Kelly D. Flemming
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Embryonic Development ◽  
Peripheral Nervous System ◽  
System P ◽  
And Function ◽  
The Brain

The study of neuroscience begins with a survey of the embryonic development of the nervous system because it provides a framework and background for understanding the anatomy and function of the nervous system in the adult. The eventual location and connectivity of the structures in the brain, spinal cord, and peripheral nervous system reflect the orderly development of the nervous system.

scholarly journals Razi and his Concepts on Bone and Joint Disorders

2020 ◽  
Vol 23 (9) ◽  
pp. 624-628
Author(s):  
Ahmadreza Afshar ◽  
Ali Tabrizi
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
The Body ◽  
Necrotic Bone ◽  
Fracture Management ◽  
Painful Hip ◽  
The Brain ◽  
Large Vessels

This brief review presents Razi’s concepts of bone and joint disorders. Razi differentiated between ligaments, tendons, and nerves and recognized the role of the brain, spinal cord, and peripheral nervous system in the perception of senses and voluntary movements. He described paralysis and loss of sensation following brain, spinal cord, and peripheral nervous system injuries. Razi presented an early concept of compartment syndrome. Razi’s approach to fracture management is very similar to the current concept of functional bracing for some fractures. Razi mentioned suturing the wounds and ligation of bleeding large vessels. He cautioned about phlebotomy in the antecubital fossa as it may become complicated by the adjacent arterial and nerve injuries. Razi treated osteomyelitis by removing the infected and necrotic bone by sawing, cutting, and rasping. He also documented arthralgia, painful hip, and sciatic pain and made a sharp distinction between arthralgia and gout. He indicated the gout origin as the production of a waste substance that the body fails to expel. Razi’s basic concepts on the bone and joint disorders established a foundation for modern orthopedic science.

scholarly journals IX . Researches on the intimate structure of the brain.—Second series

1868 ◽  
Vol 158 ◽  
pp. 263-331 ◽  
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Medulla Oblongata ◽  
Morphological Changes ◽  
The Other ◽  
Other Hand ◽  
Close Study ◽  
The Subject ◽  
The One ◽  
The Brain

Before I begin to describe the parts which form the subject of this communication, and to show how some of them are merely modified portions or developments of others that belong to the medulla oblongata , it will be advisable to recur to those morphological changes in the medulla, which I formerly pointed out as themselves arising from modifications of the spinal cord . And while in unravelling structures so extremely complex, such a course seems almost necessary to facilitate their comprehension, and convey to the reader a just notion of their morphological changes, in relation on the one hand, to the remaining parts of the encephalon, and on the other hand, to the spinal cord, it will afford me an opportunity of adding to this recapitulation some new facts that have been elicited by subsequent observation and a more extended experience. It is gratifying to know that many of the results of my previous researches have been found to throw considerable light on certain diseases of the nervous system, especially on some forms of paralysis; and my own pathological investigations, as well as a close study of nervous disorders, have not only enabled me to shape my present researches as much as possible in accordance with the requirements of the pathologist, but, by pointing to the probability of certain anatomical connexions suggested by morbid symptoms, they have sometimes been the means of directing the course of my dissections in a very peculiar way.

Glucuronyl 3-sulfate occurs exclusively on distal unmyelinated terminals of selected sensory neurons in the peripheral nervous system

1995 ◽  
Vol 53 ◽  
pp. 958-959
Author(s):  
S.S. Spicer ◽  
B.A. Schulte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Peripheral Nervous System ◽  
Sensory Neurons ◽  
Sensory Nerves ◽  
Tissue Antigens ◽  
The Central Nervous System ◽  
The Brain ◽  
Leu 7

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

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