The Diet of Girls and Young Women at the Beginning of the Century

1993 ◽  
Vol 9 (1) ◽  
pp. 15-23 ◽  
Author(s):  
J. Fellague Ariouat ◽  
D.J.P. Barker

Recent research has shown that retarded growth during fetal life and infancy is linked to the development of cardiovascular disease (coronary heart disease and stroke) in adult life. Maternal nutrition has an important effect on early growth and the diets of young women may therefore influence cardiovascular disease in the next generation. Samples of women aged 80 years and over were interviewed in six areas of England and Wales with different cardiovascular death rates. The women, 281 in total, were asked about their diets when they were aged 10 to 15 years. Those who grew up in areas which now have low cardiovascular mortality tended to eat four meals a day rather than three, to live in households which had gardens, kept hens or livestock, and to go into domestic service, where diets were generally good. Those who grew up in areas which now have high cardiovascular mortality tended to eat less red meat, to live in houses without gardens, to enter industrial occupations and have higher fertility rates.

Author(s):  
Siti Rohaiza Ahmad

Maternal nutrition will not only affects pregnancy outcomes (such as birth weight) but will also affect the state of the fetus in their adult life in terms of diseases occurrence and also immune system development. Inadequate nutrition particularly will have a negative impact on the proliferation of the various cell populations responsible for the immune functions as well as the accumulation of high concentrations of inflammatory components. Maternal nutrition affects immunity ‘programming' during the period of pre-natal and post-natal life. Over the last decade, epidemiological and experimental studies have helped to expedite more understanding of immunity ‘programming.' External exposures such as smoking, alcohol and drugs during fetal life have also shown to have an impact on immunity ‘programming.' In this review, the relationship between fetal programming and the immune system, such as effects on the various immune-cellular components through some evidence from epidemiological and experimental models will be discussed.


2004 ◽  
Vol 63 (3) ◽  
pp. 405-412 ◽  
Author(s):  
I. C. McMillen ◽  
B. S. Muhlhausler ◽  
J. A. Duffield ◽  
B. S. J. Yuen

Exposure to either an increased or decreased level of intrauterine nutrition can result in an increase in adiposity and in circulating leptin concentrations in later life. In animals such as the sheep and pig in which fat is deposited before birth, leptin is synthesised in fetal adipose tissue and is present in the fetal circulation throughout late gestation. In the sheep a moderate increase or decrease in the level of maternal nutrition does not alter fetal plasma leptin concentrations, but there is evidence that chronic fetal hyperglycaemia and hyperinsulinaemia increase fetal fat mass and leptin synthesis within fetal fat depots. Importantly, there is a positive relationship between the relative mass of the ‘unilocular’ component of fetal perirenal and interscapular adipose tissue and circulating fetal leptin concentrations in the sheep. Thus, as in the neonate and adult, circulating leptin concentrations may be a signal of fat mass in fetal life. There is also evidence that leptin can act to regulate the lipid storage, leptin synthetic capacity and potential thermogenic functions of fat before birth. Thus, leptin may act as a signal of energy supply and have a ‘lipostatic’ role before birth. Future studies are clearly required to determine whether the intrauterine and early postnatal nutrient environment programme the endocrine feedback loop between adipose tissue and the central and peripheral neuroendocrine systems that regulate energy balance, resulting in an enhanced risk of obesity in adult life.


2008 ◽  
Vol 54 (8) ◽  
pp. 1325-1330 ◽  
Author(s):  
Peter G Scheffer ◽  
Tom Teerlink ◽  
Jacqueline M Dekker ◽  
Griët Bos ◽  
Giel Nijpels ◽  
...  

Abstract Background: Hypertriglyceridemia is a cardiovascular risk factor. Apolipoprotein C-III (apoC-III) is an important determinant of the catabolic rate of triglyceride-rich lipoproteins. The aim of this study was to investigate the prognostic value of plasma apoC-III concentrations for cardiovascular mortality. Methods: We performed this prospective study in 2244 subjects (ages 49–77 years) who participated in the Hoorn Study. During a mean follow-up of 15 years, 504 individuals died: 231 of cardiovascular disease, 180 of cancer, and 93 of other causes. Cardiovascular disease risk factors and plasma apoC-III concentrations were measured at baseline. Results: The age- and sex-adjusted plasma apoC-III concentration was prospectively associated with cardiovascular mortality (P < 0.001). After adjustment for traditional risk factors, including fasting triglycerides, the hazard ratio (95% CI) for cardiovascular death between the highest and the lowest quartile of apoC-III was 1.85 (1.02–3.38). High concentrations of apoC-III did not appear to be associated with noncardiovascular mortality. Conclusions: In this general population cohort, a high apoC-III concentration in plasma, independently of fasting triglycerides and other traditional risk factors, predicts cardiovascular mortality.


1993 ◽  
Vol 9 (2) ◽  
pp. 99-106 ◽  
Author(s):  
D.J.P. Barker

This paper presents evidence that restraint of growth and development during critical periods of fetal life and infancy have an important effect on the development of cardiovascular disease.


2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
D E Rebellon-Sanchez ◽  
A Robledo-Colonia ◽  
L Lopez-Erazo ◽  
S Cuenca-Velez ◽  
M A Recio-Gomez ◽  
...  

Abstract Introduction Cardiovascular disease is the leading cause of morbidity and mortality worldwide. In Colombia, a Latin-American country, cardiovascular disease accounts for nearly 30% of total deaths. The country has a high heterogeneity in social conditions, health services and ethnicity across the regions. Health is coverage by two main insurances as subsidized for the poor and contributive for formal workers. Purpose The aim of this study was to identify factors related with cardiovascular mortality Methodology A cross-sectional study using data from the official mortality registries of the National Administrative Department of Statistics of Colombia (DANE). Cardiovascular mortality was defined using the International Classification of Diseases 10 (ICD-10) I00–I09, I10–I15, I20–I25, I26–I45, I47–I49, I51, I46, I50, I60–I69, I70, I71–I99 and the corresponding ICD-9. Measures of frequency by region was estimated. Factors related to cardiovascular death were explored using a multilevel mixed-effects logistic regression. Results There were 2,073,275 deaths in Colombia between 2008 and 2017. 74.0% of them was due to noncommunicable diseases, 14.7% to injuries, and 11.2% to communicable, maternal, neonatal, and nutritional diseases. Of total 30.7% (636,987 deaths) were due to cardiovascular causes and 43.3% (897,502 deaths) to other non-communicable diseases. 29.6% of cardiovascular deaths were in people under 70 years of age. The highest proportion of premature deaths was in the San Andrés Island with 36.5%, following by the Orinoquía (34.8%), the Amazonía (34.1%) and the Caribe region (31.3%). Male had higher cardiovascular mortality (OR=1.11, 95% CI: 1.10–1:12) related to women. Compared with people between 15 and 44 years of age, the chance of cardiovascular death increased in the categories of 45–70 years (OR=1.91, 95% CI: 1.87–1.95) and 70 years or older (OR=2.98, 95% CI: 2.92–3.04). Those with African-Colombian ethnicity were more likely to die from cardiovascular disease (OR=1.13, 95% CI: 1.11–1.15) related to those without ethnic recognition and similarly the raizal ethnic group from San Andrés island, OR=1.35 (95% CI: 1.19–1.52). Illiteracy was related with a 32% (95% CI: 1.29–1.36) higher chance of cardiovascular death compared to having a professional degree. Those affiliated to subsidized were more likely to die from cardiovascular disease than those to the contributive insurance OR 1.26 (95% CI: 1.25–1.27) Conclusion Cardiovascular disease is the leading cause of death in Colombia with little reduction in the proportion of premature deaths over the period. Moreover, in the least wealthy regions the proportion was higher than the national average. Health inequalities was identified related to education, ethnic origin, and type of insurance. A region approach is needed to tackle the determinants of cardiovascular mortality. FUNDunding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The researcher David Rebellόn was supported by the Fogarty International Center of the National Institutes of Health under Award Number D43TW006589. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.


2005 ◽  
Vol 17 (9) ◽  
pp. 71
Author(s):  
C. McMillen ◽  
J. A. Duffield ◽  
B. S. Muhlhausler

During the past decade there has been a world-wide series of epidemiological and clinical studies, which have demonstrated that there are associations between prenatal growth restriction and the risk of insulin resistance, central obesity, hypertension, type 2 diabetes and cardiovascular disease in adult life. More recently there has also been increasing interest in the consequences of exposure of the fetus to increased levels of maternal nutrition and whether maternal ‘overnutrition’ may program an ‘intergenerational cycle of obesity’. In this presentation, we review recent experimental evidence that highlights the impact of varying levels of fetal nutrition on the structural and functional development of the adipocyte, and on expression of a range of appetite regulatory peptides within the developing brain. The importance of the timing of nutritional perturbations and the different consequences of fetal undernutrition and overnutrition on subsequent gene expression within different fat depots and on the expression of appetite stimulatory and inhibitory neuropeptides will be reviewed. The importance of defining those critical windows during an individual’s lifespan when nutritional or other intervention strategies will have the maximum benefit in preventing the development of obesity and cardiovascular disease will also be considered.


2009 ◽  
Vol 87 (3) ◽  
pp. 161-179 ◽  
Author(s):  
Caroline Le Clair ◽  
Tina Abbi ◽  
Heather Sandhu ◽  
Paramjit S. Tappia

Epidemiological, clinical, and experimental observations have led to the hypothesis that the risk of developing chronic diseases in adulthood is influenced not only by genetic and adult lifestyle factors, but also by environmental factors during early life. Low birth weight, a marker of intrauterine stress, has been linked to predisposition to cardiovascular disease (CVD) and diabetes. The compelling animal evidence and significant human data to support this conclusion are reviewed. Specifically, the review discusses the role of maternal nutrition before and during pregnancy, placental insufficiencies and epigenetic changes in the increased predisposition to diabetes and CVD in adult life. The impact of low birth weight and catch-up growth as they pertain to risk of disease in adult life is also discussed. In addition, adult disease risk in the overnourished fetus is also mentioned. Reference is made to some of the mechanisms of the induction of diabetes and CVD phenotype. It is proposed that fetal nutrition, growth and development through efficient maternal nutrition before and during pregnancy could constitute the basis for nutritional strategies for the primary prevention of diabetes and CVD.


Author(s):  
Jeong‐Hun Shin ◽  
Mi‐Hyang Jung ◽  
Chang Hee Kwon ◽  
Chan Joo Lee ◽  
Dae‐Hee Kim ◽  
...  

Background Socioeconomic status is associated with differences in risk factors of cardiovascular disease and increased risks of cardiovascular disease and mortality. However, it is unclear whether an association exists between cardiovascular disease and income, a common measure of socioeconomic status, among patients with hypertension. Methods and Results This population‐based longitudinal study comprised 479 359 patients aged ≥19 years diagnosed with essential hypertension. Participants were categorized by income and blood pressure levels. Primary end point was all‐cause and cardiovascular mortality and secondary end points were cardiovascular events, a composite of cardiovascular death, myocardial infarction, and stroke. Low income was significantly associated with high all‐cause (hazard ratio [HR], 1.26; 95% CI, 1.23–1.29, lowest versus highest income) and cardiovascular mortality (HR, 1.31; 95% CI, 1.25–1.38) as well as cardiovascular events (HR, 1.07; 95% CI, 1.05–1.10) in patients with hypertension after adjusting for age, sex, systolic blood pressure, body mass index, smoking status, alcohol consumption, physical activity, fasting glucose, total cholesterol, and the use of aspirin or statins. In each blood pressure category, low‐income levels were associated with high all‐cause and cardiovascular mortality and cardiovascular events. The excess risks of all‐cause and cardiovascular mortality and cardiovascular events associated with uncontrolled blood pressure were more prominent in the lowest income group. Conclusions Low income and uncontrolled blood pressure are associated with increased all‐cause and cardiovascular mortality and cardiovascular events in patients with hypertension. These findings suggest that income is an important aspect of social determinants of health that has an impact on cardiovascular outcomes in the care of hypertension.


Life ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 467
Author(s):  
Shaikha Alabduljabbar ◽  
Sara Al Zaidan ◽  
Arun Prasath Lakshmanan ◽  
Annalisa Terranegra

The development of childhood and adult non-communicable diseases (NCD) is associated with environmental factors, starting from intrauterine life. A new theory finds the roots of epigenetic programming in parental gametogenesis, continuing during embryo development, fetal life, and finally in post-natal life. Maternal health status and poor nutrition are widely recognized as implications in the onset of childhood and adult diseases. Early nutrition, particularly breastfeeding, also plays a primary role in affecting the health status of an individual later in life. A poor maternal diet during pregnancy and lack of breastfeeding can cause a nutrient deficiency that affects the gut microbiota, and acts as a cofactor for many pathways, impacting the epigenetic controls and transcription of genes involved in the metabolism, angiogenesis, and other pathways, leading to NCDs in adult life. Both maternal and fetal genetic backgrounds also affect nutrient adsorption and functioning at the cellular level. This review discusses the most recent evidence on maternal nutrition and breastfeeding in the development of NCD, the potentiality of the omics technologies in uncovering the molecular mechanisms underlying it, with the future prospective of applying a personalized nutrition approach to prevent and treat NCD from the beginning of fetal life.


2017 ◽  
Vol 12 (S 01) ◽  
pp. S1-S84
Author(s):  
B Zinman ◽  
SE Inzucchi ◽  
JM Lachin ◽  
J George ◽  
M Mattheus ◽  
...  

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