scholarly journals Predictive modeling and in vivo assessment of cerebral blood flow in the management of complex cerebral aneurysms

2016 ◽  
Vol 36 (6) ◽  
pp. 998-1003 ◽  
Author(s):  
Brian P Walcott ◽  
Clemens Reinshagen ◽  
Christopher J Stapleton ◽  
Omar Choudhri ◽  
Vitaliy Rayz ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Aneurysms ◽  
Improve Risk Stratification ◽  
Complex Aneurysms ◽  
Aneurysm Treatment ◽  
Circulation Patterns ◽  
Recent Developments ◽  
Surgical Bypass ◽  
In Vivo Assessment

Cerebral aneurysms are weakened blood vessel dilatations that can result in spontaneous, devastating hemorrhage events. Aneurysm treatment aims to reduce hemorrhage events, and strategies for complex aneurysms often require surgical bypass or endovascular stenting for blood flow diversion. Interventions that divert blood flow from their normal circulation patterns have the potential to result in unintentional ischemia. Recent developments in computational modeling and in vivo assessment of hemodynamics for cerebral aneurysm treatment have entered into clinical practice. Herein, we review how these techniques are currently utilized to improve risk stratification and treatment planning.

Flow Diversion for Intracranial Aneurysm Treatment: Trials Involving Flow Diverters and Long-Term Outcomes

Neurosurgery ◽  
2019 ◽  
Vol 86 (Supplement_1) ◽  
pp. S36-S45 ◽  
Author(s):  
Bree Chancellor ◽  
Eytan Raz ◽  
Maksim Shapiro ◽  
Omar Tanweer ◽  
Erez Nossek ◽  
...  
Keyword(s):  
Cerebral Aneurysms ◽  
Flow Diversion ◽  
Long Term Outcomes ◽  
Complex Aneurysms ◽  
Aneurysm Treatment ◽  
Endovascular Methods ◽  
Cure Rates ◽  
Flow Diverters

Abstract Flow diverters (FDs) have changed the management of brain aneurysms; not only for complex aneurysms (giant, fusiform and blister) refractory to conventional therapies, but also for unruptured lesions previously managed by traditional surgical or coil-based endovascular methods. Since 2011 when the PipelineTM Embolization Device (Medtronic) was cleared by the Food and Drug Administration for adults with large or giant wide-neck intracranial aneurysms of the internal carotid artery proximal to the posterior communicating segment, the role of flow diversion for aneurysm treatment has expanded—supported by favorably low complication and high cure rates compared with alternative treatments. Here we review the key clinical trials and the long term outcomes that have demonstrated safety and efficacy of minimized porosity endoluminal devices in the treatment of cerebral aneurysms.

Hemorheologic Abnormalities Associated with HIV Infection: In Vivo Assessment of Retinal Microvascular Blood Flow

2006 ◽  
Vol 47 (9) ◽  
pp. 3933 ◽  
Author(s):  
Hajir Dadgostar ◽  
Gary N. Holland ◽  
Xin Huang ◽  
Adnan Tufail ◽  
Alisa Kim ◽  
...  
Keyword(s):  
Blood Flow ◽  
Hiv Infection ◽  
Microvascular Blood Flow ◽  
In Vivo Assessment

scholarly journals In vivo Assessment of Macrophage CNS Infiltration during Disruption of the Blood–Brain Barrier with Focused Ultrasound: A Magnetic Resonance Imaging Study

2010 ◽  
Vol 30 (3) ◽  
pp. 674-674 ◽  
Author(s):  
Hao-Li Liu ◽  
Yau-Yau Wai ◽  
Po-Hong Hsu ◽  
Lee-Ang Lyu ◽  
Jia-Shin Wu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Focused Ultrasound ◽  
Imaging Study ◽  
Magnetic Resonance Imaging Study ◽  
Resonance Imaging ◽  
In Vivo Assessment ◽  
Corrected Figure

Correction to: Journal of Cerebral Blood Flow & Metabolism (2009) 30, 168–177; doi: 10.1038/jcbfm.2009.179 Following the publication of this article, the authors noted errors in Figure 1 . The corrected figure appears below:

In vivo assessment of peripheral vascular function by tcpo2 and skin blood flow modelling

2011 ◽  
Vol 21 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Luis Monteiro Rodrigues ◽  
Pedro Contreiras Pinto ◽  
Joachim W. Fluhr
Keyword(s):  
Blood Flow ◽  
Skin Blood Flow ◽  
Vascular Function ◽  
Peripheral Vascular ◽  
Flow Modelling ◽  
In Vivo Assessment

Correlation Between Laminar Wall Shear Stress and Growth of Unruptured Cerebral Aneurysms: In Vivo Assessment

2019 ◽  
Vol 131 ◽  
pp. e599-e605 ◽  
Author(s):  
Denise Brunozzi ◽  
Peter Theiss ◽  
Amanda Andrews ◽  
Sepideh Amin-Hanjani ◽  
Fady T. Charbel ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Cerebral Aneurysms ◽  
Wall Shear ◽  
Unruptured Cerebral Aneurysms ◽  
In Vivo Assessment

scholarly journals Virtual Reality Visualization of CFD Simulated Blood Flow in Cerebral Aneurysms Treated with Flow Diverter Stents

2021 ◽  
Vol 11 (17) ◽  
pp. 8082
Author(s):  
Sima Baheri Islami ◽  
Mike Wesolowski ◽  
William Revell ◽  
Xiongbiao Chen
Keyword(s):  
Blood Flow ◽  
Virtual Reality ◽  
Flow Behavior ◽  
Cerebral Aneurysms ◽  
Point Clouds ◽  
Parent Artery ◽  
Time Varying ◽  
Head Mounted Display ◽  
Aneurysm Treatment ◽  
The Impact

Virtual reality (VR) has the potential to be a powerful tool for the visualization of simulated blood flow in cerebral aneurysms. This paper presents our study aimed at developing the VR visualization of computational fluid dynamics (CFD) simulations of cerebral aneurysms treated with flow-diverting (FD) stents. First, a spherical sidewall aneurysm located at a simplified internal carotid artery was considered for investigating the impact of stent deployment and positioning on the corresponding spatially time-varying blood flow behavior. The three-dimensional unsteady blood flow over a cardiac cycle was simulated numerically using the finite volume method, and the distributions of hemodynamic parameters inside the aneurysm sac, and on its wall, were presented with and without stent cases. Two stent positions, with and without a gap between the artery wall and stent, were considered to show the influence of correct stent position on aneurysm treatment. Second, a straightforward workflow was developed to import, process, and visualize the CFD analysis data in a VR environment by using open-source software with a high resolution. The Unity3D engine was used for displaying the processed animations in a VR environment operated on a head-mounted display (HMD). The refining process of each frame of time-varying CFD data was automated. The animated flow elements rendered in the VR environment were velocity vectors, velocity contours, streamlines, particle traces, and point clouds. CFD results showed that proper stenting facilitates thrombosis and occlusion of the aneurysm by modification of the flow patterns, which leads to lower inflow jet velocities into the aneurysm, longer turnover time, lower aneurysm-averaged kinetic energy, and lower wall shear stress. Additionally, the results indicated that a gap between the stent and the parent artery may lead to undesirable hemodynamic alterations. The VR visualization illustrated that the recognition of the potential in danger regions of aneurysms and the evaluation of the performance of FD stents in aneurysm treatment can be conducted without the need for several slices through the parent artery and aneurysm, as is required for traditional postprocessing methods. Through VR visualization, the details of the simulation results become readily available by navigating in the 3D animated flow elements using a high-degree-of-freedom headset.

Sign in / Sign up

Export Citation Format

Share Document