Association of IL10 gene promoter polymorphisms with risks of gastric cancer and atrophic gastritis

Objective To investigate the association between polymorphisms of the interleukin 10 ( IL10) gene and risk of gastric cancer (GC) and atrophic gastritis (AG). Methods This study enrolled patients with GC, patients with AG and healthy control subjects. Demographic data were collected and the IL10 gene –1082A/G, –819C/T and –592A/C polymorphisms were genotyped. An enzyme-linked immunosorbent assay was performed to detect Helicobacter pylori infection. Results The study enrolled 556 participants including 208 in the GC group, 116 in the AG group and 232 controls (CON group). In a recessive model of the IL10–819C/T polymorphism, a significantly decreased risk of GC was found compared with AG and non-cancer subjects, respectively (AG→GC: odds ratio OR 0.41; non-cancer→GC: OR 0.57). The CC genotype demonstrated a significantly increased risk of AG compared with CON. Similar significant results were detected in males and H. pylori-negative subgroups. The ACC haplotype was associated with a decreased risk of GC compared with AG. The ATC haplotype was associated with a decreased risk of AG compared with the CON group, but it was associated with an increased risk of GC compared with AG. Conclusion The IL10 gene promoter –819C/T (rs1800871) polymorphism was associated with the risk of GC and AG in a Chinese population.

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Interleukin-10 Gene Promoter Polymorphisms and Risk of Gastric Cancer in a Chinese Population: Single Nucleotide and Haplotype Analyses

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2013.14.4.2577 ◽

2013 ◽

Vol 14 (4) ◽

pp. 2577-2582 ◽

Cited By ~ 17

Author(s):

Xiong-Fei Pan ◽

Shu-Juan Yang ◽

Marie Loh ◽

Yao Xie ◽

Yuan-Yuan Wen ◽

...

Keyword(s):

Gastric Cancer ◽

Chinese Population ◽

Gene Promoter ◽

Interleukin 10 ◽

Promoter Polymorphisms ◽

Single Nucleotide

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Interleukin-10 (IL-10) 1082 promoter Polymorphisms and plasma IL-10 levels in patients with bacterial sepsis

Romanian Journal of Internal Medicine ◽

10.2478/rjim-2020-0033 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Monica Chavez Vivas ◽

Héctor Fabio Villamarín-Guerrero ◽

Carlos Alberto Sanchez

Keyword(s):

Gene Promoter ◽

Interleukin 10 ◽

High Plasma ◽

Promoter Polymorphism ◽

Gram Negative Bacteria ◽

Promoter Polymorphisms ◽

Gram Negative ◽

Homozygous Genotype ◽

Increased Risk ◽

Relevant Role

AbstractBackground. Interleukin-10 (IL-10) is a multifunctional cytokine has been seen to play a relevant role in the pathogenesis of sepsis. We examined the association between a single nucleotide polymorphism (SNP) in IL-10 -1082G/A in patients with sepsis in Cali city.Methods A total of 100 patients with sepsis and 50 control subjects were enrolled in this study. Blood samples were collected from all patients in EDTA containing tubes. IL-10-1082G/A gene promoter polymorphism was analyzed by Sequence Specific Polymerase Chain Reaction (SS-PCR), while levels of serum IL-10 were measured by Enzyme Linked Immunoassay Assay (ELISA) in patients with sepsis and healthy controls.Results. AA homozygous genotype was found more frequently in patients (32%), compared with controls (18%). AA homozygous patients showed had a increased risk of developing infection by Gram-negative bacteria (OR=2,875; 95% CI = 1.162-7.113; p = 0.020), and significantly high plasma levels of IL-10 (OR= 4.800, 95% CI 1.652–13.944; p=0.002). AA homozygous patients high plasma IL-10 levels have greater risk of developing sepsis (63.6%; OR = 4,894; 95% CI: 1,337-17,909; p = 0.002). In this group, Afro-Colombian individuals were overrepresented among the sepsis patients with high plasma IL-10 levels (OR=1.661; 95% CI: 1.408-1.959; p=0.036).Conclusion Our study concluded that AA genotype of IL-10 -1082G/A polymorphism is a risk factor for high IL-10 production and development of sepsis by Gram negative bacteria, especially, Afro-Colombian patients.

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TLR1 and PRKAA1 Gene Polymorphisms in the Development of Atrophic Gastritis and Gastric Cancer

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.274.tlr ◽

2018 ◽

Vol 27 (4) ◽

pp. 363-369 ◽

Cited By ~ 4

Author(s):

Gintare Dargiene ◽

Greta Streleckiene ◽

Jurgita Skieceviciene ◽

Marcis Leja ◽

Alexander Link ◽

...

Keyword(s):

Gastric Cancer ◽

Atrophic Gastritis ◽

Genetic Polymorphisms ◽

Association Studies ◽

Control Group ◽

Similar Distribution ◽

Genome Wide Association Studies ◽

Increased Risk ◽

Infection Susceptibility ◽

H Pylori

Background & Aims: Previous genome-wide association studies showed that genetic polymorphisms in toll-like receptor 1 (TLR1) and protein kinase AMP-activated alpha 1 catalytic subunit (PRKAA1) genes were associated with gastric cancer (GC) or increased Helicobacter pylori (H. pylori) infection susceptibility. The aim of this study was to evaluate the association between TLR1 and PRKAA1 genes polymorphisms and H.pylori infection, atrophic gastritis (AG) or GC in the European population.Methods: Single-nucleotide polymorphisms (SNPs) were analysed in 511 controls, 340 AG patients and 327 GC patients. TLR1 C>T (rs4833095) and PRKAA1 C>T (rs13361707) were genotyped by the real-time polymerase chain reaction. H. pylori status was determined by testing for anti-H. pylori IgG antibodies in the serum.Results: The study included 697 (59.2%) H. pylori positive and 481 (40.8%) H. pylori negative cases. We observed similar distribution of TLR1 and PRKAA1 alleles and genotypes in H. pylori positive and negative cases. TLR1 and PRKAA1 SNPs were not linked with the risk of AG. TC genotype of TLR1 gene was more prevalent in GC patients compared to the control group (29.7% and 22.3% respectively, p=0.002). Carriers of TC genotype had a higher risk of GC (aOR=1.89, 95% CI: 1.26–2.83, p=0.002). A similar association was observed in a dominant inheritance model for TLR1 gene SNP, where comparison of CC+TC vs. TT genotypes showed an increased risk of GC (aOR=1.86, 95% CI: 1.26–2.75, p=0.002). No association between genetic polymorphism in PRKAA1 gene and GC was observed.Conclusions: TLR1 rs4833095 SNP was associated with an increased risk of GC in a European population, while PRKAA1 rs13361707 genetic variant was not linked with GC. Both genetic polymorphisms were not associated with H. pylori infection susceptibility or the risk of AG.

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Interleukin-10 Gene Promoter Polymorphisms and Susceptibility to Asthma: Systematic Review and Meta-analysis

Biochemical Genetics ◽

10.1007/s10528-021-10056-9 ◽

2021 ◽

Author(s):

Danyal Imani ◽

Navid Dashti ◽

Arash Parvari ◽

Sajad Shafiekhani ◽

Fatemeh Alebrahim ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Gene Promoter ◽

Interleukin 10 ◽

Promoter Polymorphisms

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Correlations between Genetic Polymorphisms in Long Non-Coding RNA PRNCR1 and Gastric Cancer Risk in a Korean Population

International Journal of Molecular Sciences ◽

10.3390/ijms20133355 ◽

2019 ◽

Vol 20 (13) ◽

pp. 3355 ◽

Cited By ~ 5

Author(s):

Jang Hee Hong ◽

Eun-Heui Jin ◽

Hyojin Kang ◽

In Ae Chang ◽

Sang-Il Lee ◽

...

Keyword(s):

Gastric Cancer ◽

Binary Logistic Regression ◽

Tumor Stage ◽

Recessive Model ◽

Stage Iii ◽

Negative Results ◽

Non Coding Rna ◽

Increased Risk ◽

Gender And Age ◽

Chi Squared

We evaluated the association between prostate cancer non-coding RNA 1 (PRNCR1) polymorphisms and the risk of developing gastric cancer (GC) and GC subgroups in Korea. A case–control study was conducted with 437 GC patients and 357 healthy controls using a TaqMan genotyping assay. A chi-squared test, binary logistic regression, and genetic models were used to explore the association between five PRNCR1 polymorphisms and GC risk. After adjusting for gender and age, overall analyses using the recessive model indicated that the rs13252298 GG genotype was significantly associated with increased risk of intestinal-type gastric cancer (IGC). In the stratification analyses, the recessive model indicated that the rs1016343 TT genotype was significantly associated with decreased GC risk in individuals aged <60 years showing lymph node metastasis (LNM)-negative results. The rs13252298 GG genotype in the recessive model showed increased GC risk in subjects aged ≥60 years showing LNM-positive results and those aged ≥60 years in tumor stage III. In the dominant model, the rs16901946 combined genotype (AG/GG) was significantly associated with increased GC risk in subjects aged <60 years with tumor stage III. In the recessive model, the rs16901946 GG genotype was associated with decreased risk of GC and IGC in males aged ≥60 years. Thus, genetic variations in PRNCR1 may contribute to susceptibility to GC.

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Tumor necrosis factor-alpha and Interleukin-10 gene promoter polymorphisms in Turkish rheumatoid arthritis patients

Clinical Rheumatology ◽

10.1007/s10067-008-0893-1 ◽

2008 ◽

Vol 27 (10) ◽

pp. 1243-1248 ◽

Cited By ~ 25

Author(s):

Omer Ates ◽

Gulen Hatemi ◽

Vedat Hamuryudan ◽

Aysegul Topal-Sarikaya

Keyword(s):

Rheumatoid Arthritis ◽

Tumor Necrosis Factor ◽

Tumor Necrosis Factor Alpha ◽

Tumor Necrosis ◽

Gene Promoter ◽

Interleukin 10 ◽

Promoter Polymorphisms ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Necrosis Factor

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934 Association between chronic hepatitis B virus infection and interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) gene promoter polymorphisms

Hepatology ◽

10.1016/s0270-9139(03)80972-2 ◽

2003 ◽

Vol 38 ◽

pp. 607-607

Author(s):

J CHEONG ◽

S HONG ◽

K LEE ◽

S YOON ◽

D KIM ◽

...

Keyword(s):

Tumor Necrosis ◽

Gene Promoter ◽

Interleukin 10 ◽

Hepatitis B Virus Infection ◽

Promoter Polymorphisms ◽

Tnf Α ◽

Chronic Hepatitis B Virus ◽

B Virus ◽

Factor Α ◽

Necrosis Factor

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Association of Long Non-Coding RNA Polymorphisms with Gastric Cancer and Atrophic Gastritis

Genes ◽

10.3390/genes11121505 ◽

2020 ◽

Vol 11 (12) ◽

pp. 1505

Author(s):

Vytenis Petkevicius ◽

Greta Streleckiene ◽

Kotryna Balciute ◽

Alexander Link ◽

Marcis Leja ◽

...

Keyword(s):

Gastric Cancer ◽

Atrophic Gastritis ◽

Recessive Model ◽

Nucleotide Polymorphisms ◽

Blood Leukocytes ◽

Significance Threshold ◽

Non Coding Rna ◽

Premalignant Condition ◽

Gastric Cancer Patients ◽

Long Non Coding Rna

Long non-coding RNAs (lncRNA) play an important role in the carcinogenesis of various tumours, including gastric cancer. This study aimed to assess the associations of lncRNA ANRIL, H19, MALAT1, MEG3, HOTAIR single-nucleotide polymorphisms (SNPs) with gastric cancer and atrophic gastritis. SNPs were analyzed in 613 gastric cancer patients, 118 patients with atrophic gastritis and 476 controls from three tertiary centers in Germany, Lithuania and Latvia. Genomic DNA was extracted from peripheral blood leukocytes. SNPs were genotyped by the real-time polymerase chain reaction. Results showed that carriers of MALAT1 rs3200401 CT genotype had the significantly higher odds of atrophic gastritis than those with CC genotype (OR-1.81; 95% CI 1.17–2.80, p = 0.0066). Higher odds of AG were found in a recessive model (CC vs. TT + CT) for ANRIL rs1333045 (OR-1.88; 95% CI 1.19–2.95, p = 0.0066). Carriers of ANRIL (rs17694493) GG genotype had higher odds of gastric cancer (OR-4.93; 95% CI 1.28–19.00) and atrophic gastritis (OR-5.11; 95% CI 1.10–23.80) compared with the CC genotype, and carriers of HOTAIR rs17840857 TG genotype had higher odds of atrophic gastritis (OR-1.61 95% CI 1.04–2.50) compared with the TT genotype; however, the ORs did not reach the adjusted significance threshold (p < 0.007). In summary, our data provide novel evidence for a possible link between lncRNA SNPs and premalignant condition of gastric cancer, suggesting the involvement of lncRNAs in gastric cancer development.

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