Piroxicam in the Treatment of Acute Gout: A Multicentre Open Study in General Practice

1979 ◽  
Vol 7 (6) ◽  
pp. 507-510 ◽  
Author(s):  
J Eric Murphy
Keyword(s):  
General Practice ◽  
Uric Acid ◽  
General Practitioner ◽  
Side Effects ◽  
Pain Relief ◽  
Serum Uric Acid ◽  
Open Study ◽  
Acute Gout ◽  
Highly Effective

Twenty-nine patients with acute gout were treated with piroxicam (40 mg daily for 5 days) in a multicentre general practitioner study. Pain relief was noticeable within 4 hours of the first dose and thereafter proceeded steadily, together with the early relief of other sypmtoms associated with acute gout. The prompt relief of symptoms was accompanied by a fall in serum uric acid. Piroxicam was well tolerated, eight patients experiencing side-effects that were mainly mild and gastro-intestinal in nature. The drug seems to be highly effective and safe in the treatment of acute gout.

An Open Study of Two Dose Levels of ‘Vivalan’ (Viloxazine Hydrochloride ICI 58 834) in Depression in General Practice

1974 ◽  
Vol 2 (4) ◽  
pp. 253-259 ◽  
Author(s):  
P F C Bayliss ◽  
J W Harcup ◽  
M Mayer ◽  
R Million ◽  
J E Murphy ◽  
...  
Keyword(s):  
General Practice ◽  
Depressive Symptoms ◽  
Side Effects ◽  
Side Effect ◽  
Open Study ◽  
Anxiety Symptoms ◽  
High Dose ◽  
Dose Levels

Forty-eight mild to moderate depressives were treated by six genera practitioners with a chemically novel anti-depressant, ‘Vivalan’ (viloxazine hydrochloride, ICI 58 834). Twenty-five patients took 150 mg/day in three divided doses, and twenty-three took 200 mg/day in two divided doses, each for twenty-one days. The severity of both the depressive symptoms and the anxiety symptoms showed a statistically highly significant reduction over the duration of the study. There was no difference between the efficacy of the two dose levels. Viloxazine was generally well tolerated and there was no difference between the two dose levels as far as side-effects or withdrawals were concerned. The usual sedative and anti-cholinergic side-effects of the tricyclic anti-depressants were virtually absent. The only side-effect seen was a transient upper gastro-intestinal disturbance. It was commoner at the high dose but not significantly so. It is concluded that viloxazine hydrochloride appears to be an effective anti-depressant in this type of patient and produces little or no sedative or anti-cholinergic side-effects. Either 150 mg/day or 200 mg/day would seem a reasonable dose to use in general practice.

Tanderil®/Chloramphenicol Eye Ointment in the Treatment of the “Red Eye” Seen in General Practice

1978 ◽  
Vol 6 (2) ◽  
pp. 141-143 ◽  
Author(s):  
W A I Rushford ◽  
R M Holman ◽  
T B Pulvertaft
Keyword(s):  
General Practice ◽  
General Practitioner ◽  
Treatment Period ◽  
General Practitioners ◽  
Complete Resolution ◽  
Open Study ◽  
Allergic Conjunctivitis ◽  
Day Treatment ◽  
Red Eye

An open study is reported in which 35 general practitioners treated 128 patients suffering from ‘Red Eye’ with a new eye ointment containing 10% Tanderil (oxyphenbutazone) and 1% chloramphenicol. One hundred and seventeen patients completed the seven day treatment period, in which time 99 had complete resolution of the symptoms and were discharged, the remaining 18 patients needed a longer period of treatment. Eleven patients failed to complete the study period, of whom 5 patients were subsequently referred to a specialist and 6 had their treatment changed by the general practitioner. Six patients showed signs of allergy to the ointment, all of whom were being treated for allergic conjunctivitis. Seventeen per cent of patients had some difficulty in applying the eye ointment or complained of subsequent blurring of vision.

scholarly journals Effects of fecal microbiota transplantation on serum uric acid levels, symptoms and intestinal barrier function in patients with acute and recurrent gout: a pilot study

2020 ◽  
Author(s):  
Wenrui Xie ◽  
Xiaoya Yang ◽  
Zhihe Deng ◽  
Yamei Zheng ◽  
Ran Zhang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Lactic Acid ◽  
Pilot Study ◽  
Serum Uric Acid ◽  
Barrier Function ◽  
Fecal Microbiota Transplantation ◽  
Intestinal Barrier ◽  
Fecal Microbiota ◽  
Intestinal Barrier Function ◽  
Acute Gout

Abstract Background: Gut dysbiosis has been reported to be closely associated with gout. Fecal microbiota transplantation (FMT) has been considered as an effective way to restore the balance of gut microbiota. We aimed to evaluate the effects of FMT on serum uric acid levels, gout symptoms and the intestinal barrier function in patients with acute and recurrent gout. Methods: We performed a pilot study of FMT for acute and recurrent gout. The primary outcome was the changes in serum uric acid level on day 28 post-FMT and in gout symptoms by one year. The secondary outcomes included the changes in levels of urine uric acid, diamine oxidase (DAO), D-lactic acid and endotoxin on day 28 post-FMT. The levels of DAO, D-lactic acid and endotoxin were assessed by enzyme assay. Results: Eleven patients received FMT treatment. All the patients had a reduction in serum uric acid levels after FMT treatment ( P < 0.05), accompanied with a decrease in the frequency and duration time of acute gout flares. The levels of DAO, D-lactic acid and endotoxin, reflecting the intestinal barrier function, were higher in patients with gout than in healthy donors ( P < 0.05). After FMT treatment, the levels of DAO and endotoxin decreased ( P < 0.05). Conclusions: Our findings demonstrate that FMT is effective for reducing serum uric acid levels and improving gout symptoms in patients with gout; FMT contributes to improve the impaired intestinal barrier function of the patients.

Effects of washed microbiota transplantation on serum uric acid levels, symptoms and intestinal barrier function in patients with acute and recurrent gout: a pilot study

2021 ◽  
Author(s):  
Wen-Rui Xie ◽  
Xiao-Ya Yang ◽  
Zhi-He Deng ◽  
Ya-Mei Zheng ◽  
Ran Zhang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Lactic Acid ◽  
Pilot Study ◽  
Serum Uric Acid ◽  
Barrier Function ◽  
Fecal Microbiota Transplantation ◽  
Serum Uric Acid Level ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Acute Gout

Introduction: Gut dysbiosis has been reported to be closely associated with gout. Washed microbiota transplantation (WMT) is considered as an effective way to restore a healthy gut microbiota with less adverse events than the conventional fecal microbiota transplantation. In this study, we aimed to evaluate the effects of WMT on serum uric acid levels, symptoms and the intestinal barrier function in patients with acute and recurrent gout. Methods: We performed a pilot study of WMT for acute and recurrent gout. The primary outcome was the changes in serum uric acid level and gout symptoms. The secondary outcomes included the changes in levels of diamine oxidase (DAO), D-lactic acid and endotoxin. Results: Eleven patients received WMT treatment. The averaged serum uric acid levels in patients with gout reduced after WMT (P = 0.031), accompanied with a decrease in the frequency and duration time of acute gout flares (P < 0.01). The levels of DAO, D-lactic acid and endotoxin were higher in patients than in healthy donors (P < 0.05). After WMT treatment, the levels of DAO and endotoxin decreased (P < 0.05). Conclusions: WMT is effective for reducing serum uric acid levels and improving gout symptoms in patients with gout, and contributes to improve their impaired intestinal barrier function.

scholarly journals The pattern of allopurinol prescription in a university hospital practice

2020 ◽  
Vol 47 (1) ◽  
Author(s):  
Sahar Ahmed Saad ◽  
Maha Mahmoud Sabkar
Keyword(s):  
Uric Acid ◽  
Side Effects ◽  
Adverse Effects ◽  
Serum Uric Acid ◽  
Research Work ◽  
University Hospital ◽  
Hospital Practice ◽  
Inappropriate Use ◽  
The Cost

Abstract Background Allopurinol as a drug is commonly used to treat gout and its complications. The aim usually is to lower the level of serum uric acid. Also, it was found to be prescribed in cases of asymptomatic hyperuricemia. However, this medication has serious side effects and some of these are fatal. So the aim of the current research work is to look at its use, whether properly indicated or not, in a university hospital. Results A total of 427 patients were included in this study. Only 3.7% (16) of the patients had the drug for significant hyperuricemia. Gout was confirmed in 40 (9.4%) patients. Conclusion It is clear that most patients received allopurinol without proper indications. The inappropriate use of allopurinol should be looked at to reduce the cost of medication and more importantly to avoid possible adverse effects.

scholarly journals Serum uric acid in acute gout

1997 ◽  
Vol 56 (11) ◽  
pp. 696-697 ◽  
Author(s):  
J A LOGAN ◽  
E MORRISON ◽  
P E McGILL
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Acute Gout

scholarly journals Estimation of Serum Uric Acid in Cases of Hyperuriceamia and Gout

2011 ◽  
Vol 51 (181) ◽  
Author(s):  
R K Pokharel ◽  
BK Yadav ◽  
B Jha ◽  
K Parajuli
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Relevant Information ◽  
University Teaching ◽  
Acute Gout ◽  
College Hospital ◽  
The Mean

Introduction: Gout is crystal deposit arthritis and is an ancient disease. The biologic precursor to gout is hyperuricaemia. The prevalence of hyperuricaemia and gout has an increasing trend all over the world including the developing countries. The purpose of this study is to estimate serum uric acid level in hyperuricaemic and gout patients attending a medical college hospital. Methods: A consecutive 150 hyperuricaemics and 150 gout patients attending Tribhuwan University Teaching Hospital from June to September 2005 were included in this study. The serum uric acid level was measured by the enzymatic (PAP- Uricase) method. The patients with acute gout were interviewed and relevant information was obtained. Results: Males comprised 84 % of gout cases. Hyperuricaemia was common in both sexes. The mean age for gout was 47.49 and 56.65 years in males and females respectively. The mean age for the first gout attack was 42.1 ± 14.0 years. Family history was positive in 22 % of cases. The overall mean serum uric acid level in hyperuricaemics was 7.2 ± 0.7 mg/dL and 8.4 ± 1.1 mg/dL in acute gout (p 0.0001). The mean serum uric acid level was signifi cantly (p 0.0001) high among males both at the asymptomatic phase and at acute gout. Gout was more common in non-vegetarians (95 %) and alcoholics (65.3 %). Serum uric acid level was inversely related with the amount of daily water intake (p 0.0001). Conclusions: Serum uric acid level is signifi cantly high among the male gouty arthritic patients. However, it is also high among asymptomatic hyperuricaemic cases of both sexes.  Keywords: asymptomatic hyperuricaemia, gout, serum uric acid level.

Evaluation of Intravenous Tramadol for Use in the Prehospital Situation by Ambulance Paramedics

1997 ◽  
Vol 12 (2) ◽  
pp. 87-91 ◽  
Author(s):  
Michael E. Ward ◽  
John Radburn ◽  
Steve Morant
Keyword(s):  
Logistic Regression ◽  
Side Effects ◽  
Pain Relief ◽  
Open Study ◽  
Severe Pain ◽  
Statistical Tests ◽  
Opioid Analgesic ◽  
Regression Analyses ◽  
Pain Scores ◽  
Control Study

AbstractIntroduction:An evaluation of the opioid analgesic tramadol (Zydol, Searle United Kingdom) was carried-out by ambulance paramedics to assess its efficacy in providing pain relief in the prehospital situation.Methods:Type of subjects—Patients suffering severe pain from any cause uncontrolled by other simple methods.Number of subjects—101 patients received tramadol and 41 patients served as a control. Study design—Random, open study.Statistical tests—Pain score at scene and on arrival at hospital were compared using Fisher's exact tests (2 sides). Logistic regression analyses also were applied to other factors.Results:Pain scores improved for 93.1% of the tramadol treated patients and for 44.0% of the controls. A total of 30.7% of patients treated with tramadol complained of nausea after treatment compared with 17.1% before treatment and with 12.2% of the control patients.Conclusion:Pain was significantly decreased by the administration of tramadol. It was safe with only minimal side effects, the major one being nausea. Suggestions are made for areas of further study.

A Trial of Benorylate Tablets in the Symptomatic Relief of Osteoarthritis

1977 ◽  
Vol 5 (2) ◽  
pp. 120-123
Author(s):  
P J Cosgrove
Keyword(s):  
General Practice ◽  
Pain Relief ◽  
Joint Pain ◽  
Open Study ◽  
Symptomatic Relief ◽  
Moderate Pain

The effectiveness of Benoral Tablets in controlling joint pain and stiffness in osteoarthritis was assessed over a two-week period in a multicentre general practice open study. In this trial it has been demonstrated that a correlation exists between pain relief and relief from stiffness for patients suffering from osteoarthritis taking Benoral Tablets over this period. It way also found that patients with initially mild to moderate pain benefited most from their treatment.

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