Hepatic Lesions in Rabbits Infected with Encephalitozoon cuniculi Administered per Rectum

1992 ◽  
Vol 29 (6) ◽  
pp. 536-540 ◽  
Author(s):  
I. C. Fuentealba ◽  
N. T. Mahoney ◽  
J. A. Shadduck ◽  
J. Harvill ◽  
V. Wicher ◽  
...  
Keyword(s):  
New York ◽  
Plasma Cells ◽  
Inflammatory Cells ◽  
Giant Cells ◽  
Encephalitozoon Cuniculi ◽  
Acquired Immunodeficiency ◽  
Portal Veins ◽  
Hepatic Lesions ◽  
Hepatic Portal ◽  
Immunodeficiency Syndrome

Microsporidia have been recognized recently as opportunistic pathogens in acquired immunodeficiency syndrome patients. In an attempt to develop an animal model of enteric microsporidiosis, adult (5 to 6 months old) male Flemish Giant rabbits from a closed New York colony were administered 5 × 103, 5 × 105, and 5 × 107 Encephalitozoon cuniculi per rectum. Rabbits given 5 × 105 and 5 × 107 E. cuniculi had moderate granulomatous periportal infiltrates, characterized by the presence of numerous macrophages, epithelioid cells, and a few multinucleated giant cells, lymphocytes, and plasma cells. Inflammatory cells also were seen infiltrating the tunica adventitia and tunica media of hepatic portal veins and branches of the hepatic artery. This study demonstrates that administration of E. cuniculi per rectum to rabbits results in infection that is characterized by high frequency and severity of hepatic lesions.

Pediatric Acquired Immunodeficiency Syndrome: An Unusually High Incidence of Twinning

PEDIATRICS ◽  
1990 ◽  
Vol 86 (5) ◽  
pp. 774-777
Author(s):  
PAULINE A. THOMAS ◽  
STEVEN J. RALSTON ◽  
MARIE BERNARD ◽  
ROSALYN WILLIAMS ◽  
RITA O'DONNELL
Keyword(s):  
New York ◽  
New York City ◽  
Hiv Infection ◽  
York City ◽  
Acquired Immunodeficiency Syndrome ◽  
Early Years ◽  
Pediatric Aids ◽  
High Incidence ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Surveillance data on incidence of twins among reported cases of pediatric AIDS in New York City are presented. Most pairs are concordant for HIV infection. Three discordant pairs have been described elsewhere. Possible reasons for the association are discussed, including the most likely explanation that twins show symptoms early and are overrepresented in the early years of surveillance of pediatric AIDS.

Tuberculosis and the Acquired Immunodeficiency Syndrome at a New York City Hospital: 1978-1985

CHEST Journal ◽  
1987 ◽  
Vol 91 (2) ◽  
pp. 176-180 ◽  
Author(s):  
Sandra Handwerger ◽  
Donna Mildvan ◽  
Ruby Senie ◽  
F.W. McKinley
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Acquired Immunodeficiency Syndrome ◽  
City Hospital ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Survival and Mortality Patterns of an Acquired Immunodeficiency Syndrome (AIDS) Cohort in New York State

1993 ◽  
Vol 138 (5) ◽  
pp. 341-349 ◽  
Author(s):  
Hwa-Gan H. Chang ◽  
Dale L. Morse ◽  
Candace Noonan ◽  
Bruce Coles ◽  
Jaromir Mikl ◽  
...  
Keyword(s):  
New York ◽  
Acquired Immunodeficiency Syndrome ◽  
New York State ◽  
York State ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

scholarly journals Inflammatory Cells in Tissues of Gout Patients and Their Correlations with Comorbidities

2013 ◽  
Vol 7 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Syeling Lai ◽  
Xiaodong Zhou
Keyword(s):  
Diabetes Mellitus ◽  
T Cells ◽  
Uric Acid ◽  
B Cells ◽  
Uric Acid Level ◽  
Acid Level ◽  
Plasma Cells ◽  
Pathological Finding ◽  
Inflammatory Cells ◽  
Giant Cells

Background: The major pathological finding of gout is the deposition of monosodium urate monohydrate (MSU) crystals with inflammatory infiltrate in the tissue. There have been many reports of in vitro analysis of inflammatory mechanism and comorbidities in gout. However, the associations of immune response cells and comorbidities of gout have not been well documented. Our studies aimed to examine the immune cell types and quantity in gout tissues, and to define the association of individual cell type with comorbidities. Methods: Surgically resected or biopsied tissues from 48 patients diagnosed as gout were used for this study. Cell count was performed on Hemotoxylin and Eosin stained sections for macrophages, plasma cells, neutrophils and on immunostained slides for T and B lymphocytes. Results: Hyperlipidemia, hypertension and diabetes mellitus were seen in 70.8%, 87.5% and 37.5% of patients, respectively. There were 35.6% and 37.8% of patients who admitted history of smoking and alcohol intake, respectively. Mean serum uric acid level was 8.5 mg/dl. The average body mass index was 30.1 kg/m2. H&E stained tissue sections demonstrated the crystalline deposits rimmed by palisading multinucleated giant cells, macrophages, neutrophils, plasma cells, T and B cells. Significant correlations between the clinical features and tissue inflammatory cells were observed in hyperlipidemia with number of T cells (p = 0.0363), hypertension with number of T cells and B cells (p = 0.0138 and 0.0033, respectively), diabetes mellitus with macrophages (p = 0.0016), and uric acid level with giant cells (p = 0.0088). Conclusion: Comorbidity factors including hyperlipidemia, hypertension and diabetes are significantly associated with the inflammatory cells in the tissues.

scholarly journals A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep

Animals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2869
Author(s):  
Verónica Molina-Hernández ◽  
María T. Ruiz-Campillo ◽  
Francisco J. Martínez-Moreno ◽  
Leandro Buffoni ◽  
Álvaro Martínez-Moreno ◽  
...  
Keyword(s):  
Bile Ducts ◽  
Plasma Cells ◽  
Fasciola Hepatica ◽  
Vaccine Trial ◽  
Granulomatous Inflammation ◽  
Giant Cells ◽  
Control Group ◽  
Infected Control Group ◽  
Hepatic Lesions ◽  
Host Parasite

Fasciolosis is an important economic disease of livestock. There is a global interest in the development of protective vaccines since current anthelmintic therapy is no longer sustainable. A better knowledge of the host-parasite interaction is needed for the design of effective vaccines. The present study evaluates the microscopical hepatic lesions in sheep immunized with a partially protective vaccine (VAC1), a non-protective vaccine (VAC2), and an infected control group (IC). The nature of granulomatous inflammation associated with degeneration of adult flukes found in the VAC1 group was characterized by immunohistochemistry. Hepatic lesions (fibrous perihepatitis, chronic tracts, bile duct hyperplasia, infiltration of eosinophils and lymphocytes and plasma cells) were significantly less severe in the VAC1 group than in the IC group. Dead adult flukes within bile ducts were observed only in the VAC1 group and were surrounded by a severe granulomatous inflammation composed by macrophages and multinucleate giant cells with a high expression of lysozyme, CD163 and S100 markers, and a low expression of CD68. Numerous CD3+ T lymphocytes and scarce infiltrate of FoxP3+ Treg and CD208+ dendritic cells were present. This is the first report describing degenerated flukes associated to a severe granulomatous inflammation in bile ducts in a F. hepatica vaccine trial.

Trends in AIDS Epidemic

PEDIATRICS ◽  
1993 ◽  
Vol 92 (4) ◽  
pp. 636-636
Author(s):  
ANDREW F. SHORR
Keyword(s):  
New York ◽  
Hiv And Aids ◽  
The Past ◽  
Aids Epidemic ◽  
Interesting Insight ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
The Impact ◽  
Insight Into

Futterman et al provide interesting insight into the spread of the human immunodeficiency virus (HIV) among adolescents in New York City and into the impact the acquired immunodeficiency syndrome (AIDS) has had on this population. In their conclusion, however, they misrepresent the data regarding HIV and AIDS among youth. More specifically, they write, "Reported AIDS cases among adolescents increased by over 77% over the past two years. . ." By using cumulative percent data for AIDS cases, they distort the true picture. The actual data reveal that the number of AIDS cases in this population has dropped during the past year.

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