Treatment of Neuroleptic-Induced Leukopenia with Lithium Carbonate

1981 ◽  
Vol 26 (7) ◽  
pp. 487-489 ◽  
Author(s):  
R. Yassa ◽  
J. Ananth
Keyword(s):  
Neutrophil Count ◽  
Leukocyte Count ◽  
Lithium Carbonate ◽  
Lithium Therapy ◽  
The Other ◽  
Total Leukocyte Count ◽  
Drug Induced ◽  
Other Hand ◽  
Wbc Count

Based on the finding that lithium carbonate administration can stimulate leukocyte production, six patients were treated with neuroleptic and other drug-induced granulocytopenia with lithium carbonate. The average total leukocyte count of 2500/mm3 increased to 4566/mm3. Similarly the average neutrophil count of 1028/mm3 increased to 2893/mm3 after lithium therapy. In all six patients, neutrophils decreased upon discontinuation of lithium. On the other hand, total WBC count of 4566/mm3 decreased to 2650/mm3, and the total neutrophil count of 2893/mm3 decreased to 966/mm3 after four weeks without lithium. The results suggest that lithium carbonate is effective in the treatment of drug-induced leukopenia.

A Review and Controlled Study of Cutaneous Conditions associated with Lithium Carbonate

1983 ◽  
Vol 143 (1) ◽  
pp. 42-50 ◽  
Author(s):  
Dimocritos Sarantidis ◽  
Brent Waters
Keyword(s):  
Demographic Data ◽  
Lithium Carbonate ◽  
Lithium Therapy ◽  
The Other ◽  
Controlled Study ◽  
Structured Interviews ◽  
Male And Female ◽  
Other Hand ◽  
Family Histories ◽  
First Time

SummaryThis study compares the incidence of a variety of cutaneous conditions among 91 patients treated with lithium carbonate with the incidence of such conditions among 44 patients treated with other non-neuroleptic, maintenance medications. Data on cutaneous conditions and allergies were obtained using structured interviews, demographic data, medication histories and personal and family histories.A significantly greater proportion of the lithium-treated patients than the comparison patients reported a cutaneous condition which may have been secondary to treatment in that it developed for the first time after the medication or appeared to have been exacerbated by the medication. Among the lithium-treated patients, females were found to be significantly more likely to report a secondary cutaneous condition. This effect was found across the whole range of cutaneous conditions. Male lithium-treated patients on the other hand reported approximately the same rate of secondary cutaneous conditions as both male and female comparison patients. Possible reasons for this sexual effect on incidence are discussed.The literature on cutaneous conditions which have been associated with lithium therapy is also reviewed.

scholarly journals Effects of Coronary Angioplasty on Inflammatory Markers and Lipid Profile in Patients with Cardiovascular Disease

2020 ◽  
Vol 10 (1) ◽  
pp. 1-7
Author(s):  
Tathiane Tanajura da Silva ◽  
Roque A. Junior ◽  
Daniel Lima de Moura ◽  
Júlio C. A. Santos ◽  
Álvaro L. Müller da Fonseca ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Coronary Angioplasty ◽  
Inflammatory Markers ◽  
Leukocyte Count ◽  
Wire Mesh ◽  
The Other ◽  
Total Leukocyte Count ◽  
Apolipoprotein A ◽  
Other Hand ◽  
Tnf Α

Background: Although atherosclerosis is a major cause of mortality, little is known about the role of inflammation, and mediators of disease progression. In this study, serum levels of inflammatory markers were evaluated in stable atherosclerotic disease patients before and by 24 hours after coronary angioplasty and stenting. Methods: The study included 12 patients (eight women and four men) who underwent coronary angioplasty to implant a conventional wire-mesh cobalt-chromium stent. Changes in the lipid profile were investigated. The pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukine-17 (IL-17) were measured by enzyme immunoassays. All patients received statins and reported being hypercholesterolemic, hypertensive, and sedentary. Results: TNF-α and IL-17 levels did not differ significantly before and after angioplasty. The total leukocyte count had a significant reduction when compared before (7.6; 6.5-10.6cells/µL) and after (6.78;5.2-8.2cells/µL) angioplasty, although, on the other hand, the CRP levels increased from 2.5 (0.0-14.75) to 8.0 (0.75-31mg/dL) (p<0.05). Patients had significantly higher average total cholesterol before (160; 148-193) then after (155; 122-172mg/dL) (p=0.0038), as well as HDL-cholesterol, before (41; 30-49) and after (33; 32-42mg/dL) (p=0.0192), and apolipoprotein-A levels, before (159;133-169) and after, (143; 115-150 mg/dL) (p<0.05) procedure. On the other hand, no significant differences were noticed on LDL-cholesterol, triglycerides, and apolipoprotein-B concentrations. Conclusion: The angioplasty procedure with stent implantation influenced lipoprotein metabolism specifically that of HDL, by leading to HDL-c and apolipoprotein-A reductions, as well as total leukocyte count, and CRP elevations by 24 hours after procedure.

Localization of Spontaneous Respiratory Neuronal Activities in the Medulla Oblongata of the Cat: A New Location of the Expiratory Center

1957 ◽  
Vol 190 (2) ◽  
pp. 350-355 ◽  
Author(s):  
Edgar Haber ◽  
Kurt W. Kohn ◽  
S. H. Ngai ◽  
D. A. Holaday ◽  
S. C. Wang
Keyword(s):  
Vagus Nerve ◽  
Reticular Formation ◽  
Medulla Oblongata ◽  
Electric Stimulation ◽  
The Other ◽  
Drug Induced ◽  
Other Hand ◽  
Twin Beam ◽  
New Location ◽  
Stimulation Of

Medulla oblongata of 80 vagotomized cats was explored with microelectrodes. Spontaneous respiratory neuronal activities and chest movements were recorded simultaneously with a twin beam cathode ray oscilloscope. It was found that inspiratory discharges are concentrated in the reticular formation between 3 mm rostral and 1 mm caudal to the level of the obex, which corresponds approximately to the inspiratory region of Pitts, Magoun and Ranson. On the other hand, expiratory discharges are not obtained in Pitts' expiratory area, but are found in a circumscribed region in the reticular formation from the level of the obex to 3 mm caudally. Electric stimulation of this region has been found recently by Ngai and Wang to yield marked expiratory spasm. It is concluded that the expiratory center is located caudally to the inspiratory center in the cat. The spontaneous respiratory neuronal discharges continue with no alterations of pattern of firing during drug-induced respiratory paralysis, and are increased both in number and in frequency during CO2 inhalation. Stimulation of the vagus nerve with 50 shocks/sec. reduces inspiratory discharges and prolongs the duration of expiratory discharges.

scholarly journals Bacterial infection in wheezy children.

2021 ◽  
Vol 28 (02) ◽  
pp. 176-180
Author(s):  
Maria Saleem ◽  
Asim Khurshid ◽  
Waqas Imran Khan ◽  
Amna Wajdan
Keyword(s):  
Bacterial Infection ◽  
Absolute Neutrophil Count ◽  
Neutrophil Count ◽  
Leukocyte Count ◽  
Tertiary Care ◽  
Case Series ◽  
Total Leukocyte Count ◽  
X Rays ◽  
Differential Leukocyte Count ◽  
Case Series Study

Objective: To determine the frequency of bacterial infection in children less than five years of age presenting with respiratory wheeze to Tertiary care centre. Study Design: Descriptive Case Series study. Setting: Department of Pediatrics, The Children’s Hospital and The Institute of Child Health, Multan. Period: November 2019 to April 2020. Material & Methods: A total of 130 children, presenting with respiratory symptoms were examined for presence of respiratory wheeze. After confirmation of chest auscultation, patients were enrolled. Information regarding duration of wheeze, axillary temperature, presence of chest in drawing and respiratory rate were recorded. Appropriate blood sample were drawn for total leukocyte count and differential leukocyte count from which absolute neutrophils count was calculated. Children were evaluated for the presence of bacterial infection as per operational definition. Results: There were 38 (29.23%) female and 92 (70.76%) male patients. Overall, mean age was13.17±5.49 with age range of 1-57 months. Bacterial infection was noted in 33 (25.38%) patients. Out of 130 patients presenting with wheeze, 50 patients (38.46%) had temperature range of 98.1-990F. Absolute neutrophil count was more than 5000/dl in 42(32.30%) patients, out of these 33(78.6%) had bacterial infection. Chest X-rays were showing infiltrates in 110 (84.6%) patients. Conclusion: Children suffering from wheeze have bacterial infection if age is less than five years and there is fever, crepitations, elevated absolute neutrophil count and radiographic evidence of pneumonia.

scholarly journals Immunometabolic response in Egyptian water buffalo cows during the transition period

2021 ◽  
pp. 2678-2685
Author(s):  
Naglaa A. Gomaa ◽  
Samy A. Darwish ◽  
Mahmoud A. Aly
Keyword(s):  
Neutrophil Count ◽  
Water Buffalo ◽  
Transition Period ◽  
Complete Blood Count ◽  
Leukocyte Count ◽  
Density Lipoprotein ◽  
Physiological Adaptation ◽  
Total Leukocyte Count ◽  
Gamma Glutamyl Transferase ◽  
Glutamyl Transferase

Background and Aim: The transition period is extremely critical for pregnant producing animals. However, there is very limited research on the metabolic and immunological changes in Egyptian water buffalo cows during the transition period. Therefore, this study was conducted to investigate the immunometabolic changes occurring during the transition period in Egyptian water buffalo cows. Materials and Methods: A total of 50 multiparous pregnant Egyptian water buffalo cows were subjected to weekly blood sampling 3 weeks before calving and 3 weeks after calving and on the day of parturition to determine the complete blood count, including red blood cell count, total leukocyte count (TLC), differential leukocyte count, hemoglobin level, and packed cell volume (PCV). Some selected serum biochemical and immunological parameters were analyzed, including serum glucose, beta-hydroxybutyric acid (BHBA), non-esterified fatty acids, triglycerides, high-density lipoprotein, low-density lipoprotein (LDL), very LDL (VLDL), cholesterol, total protein, albumin, globulin, creatinine, blood urea nitrogen (BUN), aspartate aminotransferase, alkaline phosphatase, alanine transaminase, gamma-glutamyl transferase, Haptoglobin, and C-reactive protein and the pro-inflammatory cytokines interleukin β1, interleukin 6 (IL-6), and tumor necrosis factor-alpha. All data were statistically analyzed using the IBM Statistical Package for the Social Sciences statistics software. Results: The neutrophil count showed a statistically significant increase at 2 weeks preparturition. There was also a significant increase in PCV, TLC, neutrophil count, and IL-6 and TNF-α level at the time of parturition and even at 2 weeks post parturition, except PCV that returned to normal levels in the 1st week post parturition. BHBA and BUN levels were increased significantly in the 2nd and 3rd weeks postcalving. Serum creatinine and VLDL levels were decreased significantly at the time of parturition, and VLDL levels showed a significant decrease even till the 3rd week postcalving, whereas creatinine levels gradually returned to the pre-calving levels in the 3rd week postcalving. Other parameters showed no significant changes. Conclusion: The most important immunometabolic changes occur in the first 2 weeks post parturition in Egyptian water buffalo cows, which exhibit a potent, remarkable physiological adaptation achieved by their functional liver, which can help the animal overcome the stressful conditions during the transition period.

Lithium Carbonate in the Treatment of Drug-Induced Leukopenia in Patients with Solid Tumors

1980 ◽  
Vol 66 (6) ◽  
pp. 729-737 ◽  
Author(s):  
Alberto Scanni ◽  
Maurizio Tomirotti ◽  
Sergio Berra ◽  
Luciano Licciardello ◽  
Irene Felicetta ◽  
...  
Keyword(s):  
Side Effects ◽  
Solid Tumors ◽  
Leukocyte Count ◽  
Controlled Trial ◽  
Lithium Carbonate ◽  
Neutrophil Granulocytes ◽  
Significant Extent ◽  
Drug Induced

The authors report on the first part of an ongoing: controlled trial (52 cases) on the evaluation of the effectiveness of Li2CO3 treatment of drug-induced leukopenia in patients with solid tumors. The results indicate that treatment with 750 mg/day per os of Li2CO3 for 7 days is capable of raising the leukocyte count to a highly significant extent, without serious side effects. The leukocytosis is due to an increase in neutrophil granulocytes.

scholarly journals STUDIES ON THE MECHANISM OF PENICILLIN-INDUCED FEVER

1972 ◽  
Vol 136 (2) ◽  
pp. 227-240 ◽  
Author(s):  
Michael J. Chusid ◽  
Elisha Atkins
Keyword(s):  
Serum Protein ◽  
The Other ◽  
Endogenous Pyrogen ◽  
Spleen Cells ◽  
Drug Induced ◽  
Blood Leukocytes ◽  
Protein Conjugate ◽  
Other Hand

Rabbits immunized to benzylpenicillin G responded with fever when challenged with a penicillin-serum protein conjugate, but not with penicillin itself. After one or two challenges with conjugate, the rabbits became unresponsive (tolerant) to further injections. This form of hypersensitivity was transferable with plasma of immunized donors to normal rabbits. Blood leukocytes of immunized rabbits incubated with penicillin-protein conjugate and hypersensitive serum released endogenous pyrogen in vitro. Spleen cells from the same animals, on the other hand, were inactive when incubated with this antigen in vitro. These experiments appear to be the first to demonstrate in vitro a possible mechanism of drug-induced fever.

scholarly journals Combined Diagnostic Accuracy of Total Leukocyte Count, Neutrophil Count, and Ultrasonography for the Diagnosis of Acute Appendicitis

Cureus ◽  
2021 ◽  
Author(s):  
Shehzadi Rimsha Fatima ◽  
Farhan Zaheer ◽  
Foad Ali Moosa ◽  
Shehanshah Muhammed Arqam ◽  
Raja Muhammad Mussab ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Diagnostic Accuracy ◽  
Neutrophil Count ◽  
Leukocyte Count ◽  
Total Leukocyte Count

scholarly journals Lithium therapy of canine cyclic hematopoiesis

Blood ◽  
1980 ◽  
Vol 55 (1) ◽  
pp. 26-28 ◽  
Author(s):  
WP Hammond ◽  
DC Dale
Keyword(s):  
Blood Cell ◽  
Lithium Carbonate ◽  
Precursor Cells ◽  
Lithium Therapy ◽  
The Other ◽  
Regulatory Mechanisms ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Hematopoietic Precursor ◽  
Cyclic Hematopoiesis

Abstract Treatment of cyclic hematopoiesis in the grey collie dog with lithium carbonate eliminated the recurrent neutropenia and normalized the other blood cell counts. These findings suggest that human cyclic hematopoiesis may be successfully treated with lithium. The effects of lithium on the monocytes, platelets, and reticulocytes, as well as the neutrophils, suggest that lithium operates on basic regulatory mechanisms affecting the most primitive hematopoietic precursor cells.

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