The Steatocrit: A Simple Method for Monitoring Fat Malabsorption in Patients with Cystic Fibrosis C. COLUMBO, R. MAIAVACCA, M. RONCHI, E. CONSALVO, M. AMORETTI, AND A. GIUNTA The Laboratorio Malattie Metaboliche, ICP, Milan, Italy, and the Department of Pediatrics at the University of Milan, Milan, Italy

1988 ◽  
Vol 3 (4) ◽  
pp. 158-158
Author(s):  
Barbara Kellam
Keyword(s):  
Cystic Fibrosis ◽  
Simple Method ◽  
Fat Malabsorption ◽  
The University

INSULATION AGAINST ICE AT MEASURING WEIRS

1974 ◽  
Vol 5 (1) ◽  
pp. 32-49 ◽  
Author(s):  
JOHN TVEIT
Keyword(s):  
Hydraulic Engineering ◽  
Simple Method ◽  
Institute Of Technology ◽  
The University ◽  
Difficult Cases

This article deals with the problem of insulating measuring weirs to avoid ice disturbances. The development of a simple method for insulating a conventional V-weir is described. This method will serve its purpose in many cases. For more difficult cases a special type of a fully insulated weir is described. The experiments described were carried out by The Division of Hydraulic Engineering, The University of Trondheim, The Norwegian Institute of Technology, at the River and Harbour Laboratory of the University, and at the IHD representative basin Sagelva.

scholarly journals Persistent fat malabsorption in cystic fibrosis; lessons from patients and mice

2011 ◽  
Vol 10 (3) ◽  
pp. 150-158 ◽  
Author(s):  
M. Wouthuyzen-Bakker ◽  
F.A.J.A. Bodewes ◽  
H.J. Verkade
Keyword(s):  
Cystic Fibrosis ◽  
Fat Malabsorption

VITAMIN K SUPPLEMENTATION FOR INFANTS RECEIVING MILK SUBSTITUTE INFANT FORMULAS AND FOR THOSE WITH FAT MALABSORPTION

PEDIATRICS ◽  
1971 ◽  
Vol 48 (3) ◽  
pp. 483-487
Author(s):  
Lloyd J. Filer ◽  
Lewis A. Barness ◽  
Richard B. Goldbloom ◽  
Malcolm A. Holliday ◽  
Robert Miller ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Biliary Atresia ◽  
Vitamin K ◽  
Intramuscular Injection ◽  
Casein Hydrolysate ◽  
Vitamin K1 ◽  
Infant Formulas ◽  
Milk Substitute ◽  
Fat Malabsorption ◽  
Clinical Conditions

Certain milk substitute infant formulas, particularly meat-based and casein hydrolysate based formulas, may be low in vitamin K content in relation to the needs of the infants receiving them. Studies are reviewed of a few infants in which inadequate dietary supply of vitamin K from such sources may have been one factor in the development of hypoprothrombinemia, though this could not be established with certainty. On theoretical grounds it seems reasonable to increase the level of vitamin K1 in milk substitute formulas to 100 µg/l, particularly because these products are often used in treatment of clinical conditions which are associated with diminished absorption of this vitamin. Vitamin K1 (phylloquinone) would seem the most appropriate form to be used for supplementation of formulas. In clinical situations associated with malabsorption of fat, e.g., cystic fibrosis of the pancreas or biliary atresia, and prolonged diarrhea or starvation, vitamin K supplementation of feedings or periodic parenteral administration of vitamin K is recommended. When parenteral vitamin K is necessary, intravenous administration is rarely indicated. Subcutaneous or intramuscular injection is preferred.

scholarly journals Steatocrit: A Simple Method for Detection Fat Malabsorption

2019 ◽  
Vol 32 (11-12) ◽  
pp. 298-303
Author(s):  
Suharyono Suharyono ◽  
Hindra Irawan Satari ◽  
Agus Firmansyah
Keyword(s):  
Nutritional Status ◽  
Chronic Diarrhoea ◽  
Absorption Test ◽  
Technical Expertise ◽  
Simple Method ◽  
Female Patients ◽  
Alternative Method ◽  
Fat Malabsorption

Steatocrlt was determined through microcentrifugation of fecal hemogenate from 45 patients with chronic diarrhoea. In the same patients urine materials were collected to determine fat malabsorption using Lipiodol absorption test. There were 28 male and 17 female patients. Severe malabsorption using steatocrit was detected tn 31 patients (68;9%), while LAT determined severe malabsorption in 34 patients (75.5%). The overall sensitivity was 88.2%, and spesificity was 90.9%. Nutritional status did not influence the sensitivity and spesificity of steatocrit. We propose that this simple semiquantitative test can be used as an alternative method for detecting fat malabsorption particularly in laboratories with limited technical expertise.

scholarly journals Fat malabsorption in cystic fibrosis patients

1999 ◽  
Vol 70 (5) ◽  
pp. 943-944 ◽  
Author(s):  
Jane Murphy ◽  
Kirsi Laiho ◽  
Steve Wootton
Keyword(s):  
Cystic Fibrosis ◽  
Fat Malabsorption

scholarly journals 413. Differences in Inflammatory Mechanisms in Pseudomonas aeruginosa and Staphyloccoccus auereus Infections in Cystic Fibrosis

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S209-S209
Author(s):  
Melissa S Phuong ◽  
Rafael E Hernandez ◽  
Subash Sad
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Cell Death ◽  
Cytokine Production ◽  
Neutral Red ◽  
Chronic Infections ◽  
Neutral Red Assay ◽  
The One ◽  
The University

Abstract Background Chronic bacterial lung infections are the primary cause of morbidity and mortality in cystic fibrosis (CF). The most common CF pathogens, Pseudomonas aeruginosa (P. aeruginosa) or Staphylococcus aureus (S. aureus), are common commensal or environmental organisms that adapt to the CF lung. We sought to investigate whether adaptation from early lung colonizer to chronic pathogen alters the bacterial effects on host inflammation. Methods P. aeruginosa (n = 25) and S. aureus (n = 25) isolates from CF patients with early and chronic infections were acquired from Seattle Children’s CF. Environmental (n = 8) and clinical, non-CF P. aeruginosa (n = 8) isolates were obtained from the University of Ottawa. P. aeruginosa reference strain PA14 and PA14 transposon mutants for T3SS and flagellin were used to observe the relationship between cell death and cytokine production. We infected THP-1-derived macrophages (PMA differentiated) in vitro for 3 hours with various MOIs. We subsequently measured cell death of THP-1-derived macrophages using neutral red assay and cytokine production using ELISAs. Results Infections with PA14 mutants and non-CF P. aeruginosa isolates demonstrated that rapid cell death of THP-1-derived macrophages caused a reduction in cytokine production relative to strains that did not cause as much cell death. At 10 MOI, early P. aeruginosa isolates from CF patients induced more THP-1-derived macrophage cell death compared with chronic isolates (P < 0.0001). Chronic P. aeruginosa isolates induced greater production of TNF, IL-8, and IL-6 (P < 0.01, P < 0.0001, and P < 0.0001, respectively) compared with early strains. No difference in IL-1β production was observed. When controlling for cell death between the two groups by using heat-killed bacteria, the only difference maintained was in TNF production (P < 0.01). Between early and chronic S. aureus isolates, the one difference observed was greater IL-8 production among early isolates (P < 0.01). Conclusion Chronic P. aeruginosa isolates from CF patients induce less cell death but more TNF, IL-8, and IL-6 production compared with early isolates. This suggests that P. aeruginosa producing chronic infections induce inflammatory signals that may contribute to increased morbidity among CF patients. Disclosures All authors: No reported disclosures.

scholarly journals Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019

2020 ◽  
Vol 6 (4) ◽  
pp. 00123-2020
Author(s):  
Darcy E. Wagner ◽  
Laertis Ikonomou ◽  
Sarah E. Gilpin ◽  
Chelsea M. Magin ◽  
Fernanda Cruz ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Stem Cells ◽  
Progenitor Cells ◽  
Induced Pluripotent Stem Cell ◽  
Current Status ◽  
Future Research ◽  
Cell Therapies ◽  
Stem And Progenitor Cells ◽  
The University ◽  
University Of Vermont

A workshop entitled “Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Diseases” was hosted by the University of Vermont Larner College of Medicine in collaboration with the National Heart, Lung and Blood Institute, the Alpha-1 Foundation, the Cystic Fibrosis Foundation, the International Society for Cell and Gene Therapy and the Pulmonary Fibrosis Foundation. The event was held from July 15 to 18, 2019 at the University of Vermont, Burlington, Vermont. The objectives of the conference were to review and discuss the current status of the following active areas of research: 1) technological advancements in the analysis and visualisation of lung stem and progenitor cells; 2) evaluation of lung stem and progenitor cells in the context of their interactions with the niche; 3) progress toward the application and delivery of stem and progenitor cells for the treatment of lung diseases such as cystic fibrosis; 4) progress in induced pluripotent stem cell models and application for disease modelling; and 5) the emerging roles of cell therapy and extracellular vesicles in immunomodulation of the lung. This selection of topics represents some of the most dynamic research areas in which incredible progress continues to be made. The workshop also included active discussion on the regulation and commercialisation of regenerative medicine products and concluded with an open discussion to set priorities and recommendations for future research directions in basic and translation lung biology.

scholarly journals Analysis of Bone Metabolism in Children with Cystic Fibrosis

PRILOZI ◽  
2018 ◽  
Vol 39 (1) ◽  
pp. 151-155
Author(s):  
Tatjana Jakovska
Keyword(s):  
Cystic Fibrosis ◽  
Bone Formation ◽  
Bone Markers ◽  
Formation Rate ◽  
Serum Markers ◽  
Control Group ◽  
Healthy Children ◽  
Pediatric Clinic ◽  
Significant Difference ◽  
The University

Abstract One of the most important CF-related conditions is the bone disease, which is nowadays acknowledged as a significant clinical complication of CF. Imbalance between bone formation and degradation in cystic fibrosis (CF) has become an important issue for developing osteopenia. The aim of the study was to assess bone formation and resorption process with bone markers in children with cystic fibrosis (CF). Materials and methods: The study included 35 clinically stable children with CF who regularly attended the Cystic fibrosis center at the University Pediatric Clinic in Skopje, R. Macedonia. The control group was presented with 21 healthy children at the same age. Serum osteocalcin (OC), β cross laps, 25OHD and PTH were determined by ELISA assays in the CF group (mean age 8.25±SD1.9 y.) and in age-match controls (7.5±1.9 y.). Results: Vitamin D in the CF group was (23.83±10.9 ng/ml versus 25.6±11.53 in the control group, p=0.57), OC (70.88±34.24 ng/ml v.100.02±47.98, p=0.01) βcrosslaps (1.35±0.72 ng/ml v.1.54±0.73, p=0.37) and PTH (37.39±25.5 pg/ml v. 36.76±25.73, p=0.92). In the study, we did not find a significant difference for 25OHD between CF and healthy controls. OC in children with CF correlates significantly with the control and indicates a decreased formation rate whereas resorption rate is normal. Conclusion: Our results suggest that bone turnover in CF is impaired in childhood. Serum markers for bone formation can be used for predicting osteopenia in children with CF.

scholarly journals CF GLOBAL CARE: Collaboration Between Two CF Centers; University of Michigan, USA and Marmara University, Istanbul, Turkey before and during the COVID-19 Pandemic

2021 ◽  
Author(s):  
Samya Nasr ◽  
Yasemin Gokdemir ◽  
Ela Erdem Eralp ◽  
Fazilet Karakoc ◽  
Almala Ergenekon ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Quality Of Care ◽  
Middle East ◽  
Improve Quality ◽  
University Of Michigan ◽  
Middle Income ◽  
Middle Income Countries ◽  
Middle East Countries ◽  
The University

Solving the world’s health challenges requires multidisciplinary collaborations that bring together the talents, experiences, resources, and ideas from multiple sectors in low and middle-income countries (LMIC) and high -income countries (HIC). Cystic Fibrosis (CF) was thought to be a disease of Caucasian populations from European decent. However, it has been shown to affect people from all ethnic backgrounds. CF care varies significantly for people with CF (pw CF) from HIC with median survival approaching 50 years of age, to LMIC with pw CF dying in infancy or early childhood. To address the discrepancy in quality of care and outcomes, we report on a collaboration between our team at the University of Michigan cystic fibrosis center (UoM CFC), through support from the Middle East CF Association (MECFA) and the CF Foundation (CFF), and a CF center in Turkey (Marmara University CF Center, Istanbul) to address deficiencies and improve quality of care in that center. The collaboration has been successful in improving Ma CFC data and patient care. This partnership can be viewed as a model of collaboration to be duplicated in other Middle East Countries and LMIC to deliver optimal CF care.

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