scholarly journals Subjective Memory Complaints in White and African American Participants

2019 ◽  
Vol 33 (3) ◽  
pp. 135-143
Author(s):  
Samantha E. John ◽  
Sarah A. Evans ◽  
John Hanfelt ◽  
David W. Loring ◽  
Felicia C. Goldstein
Keyword(s):  
African American ◽  
Memory Performance ◽  
Matched Sample ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Memory Complaint ◽  
Cognitively Normal ◽  
Memory Complaints ◽  
African American Race ◽  
Over Time

Objective: Subjective memory complaints (SMCs) are associated with mild cognitive impairment and dementia but are understudied in African Americans (AAs). We compared SMC endorsement in white and AA participants and evaluated predictors of diagnostic progression. Methods: Initial visit variables, including SMC and memory performance, were compared within a cognitively normal race-matched sample of white and AA participants ( N total = 912; 456each race) to assess the presence and predictors of SMC, the predictors of future diagnostic progression, and the change in memory performance over time. Results: More white (32.9%) than AA (24.3%) participants reported SMC ( P < .01, ϕ = −.10). Subjective memory complaint was predicted by memory performance ( B = −0.03, standard error [SE] = 0.013, odds ratio [OR] = .968, P < .05) and race ( B = −0.99, SE = 0.080, OR = .373, P < .001). Subjective memory complaints and memory performance were associated with progression, χ2 (3, n = 912) = 102.37, P < .001. African American race (−2.05 ± 0.24 SE) and SMC (−0.45 ± 0.21 SE) were associated with worse memory performance at baseline and over time, χ 2(3) = 13.54, P < .01. Conclusions: In contrast to previous research, our study found that SMC is associated with diagnostic progression and objective memory declines in both white and AA participants.

Absence of a relationship between subjective memory complaint and objective memory impairment in mild cognitive impairment (MCI): is it time to abandon subjective memory complaint as an MCI diagnostic criterion?

2012 ◽  
Vol 24 (9) ◽  
pp. 1505-1514 ◽  
Author(s):  
Megan Elizabeth Lenehan ◽  
Shannon Zofia Klekociuk ◽  
Mathew James Summers
Keyword(s):  
Memory Impairment ◽  
Memory Performance ◽  
False Negative ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Memory Complaint ◽  
Subjective Memory Complaint ◽  
Memory Complaints ◽  
Diagnostic Criterion ◽  
The Relationship

ABSTRACTBackground:Subjective memory complaints are a requirement in the diagnosis of mild cognitive impairment (MCI) as they are thought to indicate a decline in objective memory performance. However, recent research suggests that the relationship between subjective memory complaint and objective memory impairment is less clear. Thus, it is possible that many people without subjective memory complaints who develop Alzheimer's disease are precluded from a diagnosis of MCI.Methods:The present study examined the relationship between subjective memory complaint assessed using the Multifactorial Memory Questionnaire (MMQ) and objective memory impairment assessed using standard neuropsychological measures in cases of amnestic MCI (n= 48), non-amnestic MCI (n= 27), and unimpaired healthy participants (n= 64).Results:Correlational and regression analyses indicated that subjective memory complaints displayed a poor relationship with objective memory performance. A subsequent discriminant function analysis indicated that subjective memory complaints failed to improve the diagnostic accuracy of MCI and resulted in increased rates of false negative and false positive diagnoses.Conclusion:The results of the present study suggest that a diagnostic criterion of subjective memory complaint reduces the accuracy of MCI diagnosis, resulting in an elevated rate of false positive and false negative diagnoses. The results of this study in conjunction with recent research indicate that a criterion of subjective memory complaint should be discarded from emerging diagnostic criteria for MCI.

scholarly journals Symptoms of Depression in a Large Healthy Population Cohort are related to Subjective Memory Complaints and Memory Performance in Negative Contexts

2017 ◽  
Author(s):  
Susanne Schweizer ◽  
Rogier A. Kievit ◽  
Tina Emery ◽  
Richard N. Henson ◽  
Keyword(s):  
Depressive Symptoms ◽  
General Population ◽  
Memory Performance ◽  
Large Population ◽  
Healthy Population ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Symptoms Of Depression ◽  
Memory Complaints ◽  
The Impact

AbstractDecades of research have investigated the impact of clinical depression on memory, which has revealed biases and in some cases impairments. However, little is understood about the effects of sub-clinical symptoms of depression on memory performance in the general population. Here we report the effects of symptoms of depression on memory problems in a large population-derived cohort (N = 2544), 87% of whom reported at least one symptom of depression. Specifically, we investigate the impact of depressive symptoms on subjective memory complaints, objective memory performance on a standard neuropsychological task and, in a subsample (n = 288), objective memory in affective contexts. There was a dissociation between subjective and objective memory performance, with depressive symptoms showing a robust relationship with self-reports of memory complaints, even after adjusting for age, gender, general cognitive ability and symptoms of anxiety, but not with performance on the standardised measure of verbal memory. Contrary to our expectations, hippocampal volume (assessed in a subsample, n = 592) did not account for significant variance in subjective memory, objective memory or depressive symptoms. Nonetheless, depressive symptoms were related to poorer memory for pictures presented in negative contexts, even after adjusting for memory for pictures in neutral contexts. Thus the symptoms of depression, associated with subjective memory complaints, appear better assessed by memory performance in affective contexts, rather than standardised memory measures. We discuss the implications of these findings for understanding the impact of depressive symptoms on memory functioning in the general population.

Executive Function Predicts the Validity of Subjective Memory Complaints in Older Adults beyond Demographic, Emotional, and Clinical Factors

2020 ◽  
pp. 1-8
Author(s):  
R.-Y. Chao ◽  
T.-F. Chen ◽  
Y.-L. Chang
Keyword(s):  
Older Adults ◽  
Executive Function ◽  
Group Membership ◽  
Memory Performance ◽  
Objective Measures ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Old Adults ◽  
Symptoms Of Depression ◽  
Memory Complaints

Background: Although evidence suggests that subjective memory complaints (SMCs) could be a risk factor for dementia, the relationship between SMCs and objective memory performance remains controversial. Old adults with or without mild cognitive impairment (MCI) may represent a highly heterogeneous group, based partly on the demonstrated variability in the level of executive function among those individuals. It is reasonable to speculate that the accuracy of the memory-monitoring ability could be affected by the level of executive function in old adults. Objective: This study investigated the effects of executive function level on the consistency between SMCs and objective memory performance while simultaneously considering demographic and clinical variables in nondemented older adults. Setting: Participants were recruited from both the memory clinics and local communities. Participants: Participants comprised 65 cognitively normal (CN) older adults and 54 patients with MCI. Measurements: Discrepancy scores between subjective memory evaluation and objective memory performance were calculated to determine the degree and directionality of the concordance between subjective and objective measures. Demographic, emotional, genetic, and clinical information as well as several executive function measurements were collected. Results: The CN and MCI groups exhibited similar degrees of SMC; however, the patients with MCI were more likely to overestimate their objective memory ability, whereas the CN adults were more likely to underestimate their objective memory ability. The results also revealed that symptoms of depression, group membership, and the executive function level together predicted the discrepancy between the subjective and objective measures of memory function; however, the executive function level retained its unique predictive ability even after the symptoms of depression, group membership, and other factors were controlled for. Conclusion: Although both noncognitive and cognitive factors were necessary for consideration, the level of executive function may play a unique role in understanding the equivocal relationship of the concurrence between subjective complaints and objective function measures. Through a comprehensive evaluation, high-risk individuals (i.e., CN individuals heightened self-awareness of memory changes) may possibly be identified or provided with the necessary intervention during stages at which objective cognitive impairment remains clinically unapparent.

A-101 PTSD and Personality Traits Influence the Relationship Between Memory Complaints and Memory Performance

2020 ◽  
Vol 35 (6) ◽  
pp. 894-894
Author(s):  
Armistead-Jehle P ◽  
Mattson E ◽  
Nelson N ◽  
Disner S
Keyword(s):  
Personality Assessment ◽  
Military Service ◽  
Memory Performance ◽  
Subjective Memory Complaints ◽  
Post Traumatic Stress ◽  
Subjective Memory ◽  
Memory Complaints ◽  
Neuropsychological Status ◽  
Mediational Role ◽  
Ptsd Severity

Abstract Objective Previous research has shown that post-traumatic stress disorder (PTSD) symptomatology may mediate the association between subjective cognitive complaints and objective cognitive performance, however, the precise nature of this mediation is not well understood. The present study aims to expand on these findings by focusing on memory processes and exploring the influence that personality variables may have on the mediational role of PTSD symptoms. Methods In a sample of 196 U.S. military service members and veterans, we administered the PTSD checklist (PCL), Personality Assessment Inventory (PAI), Memory Complaints Inventory (MCI), and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Results Overall MCI score (reflecting subjective memory complaints) was associated with both RBANS immediate (β= −0.15, SE = 0.06, p = 0.01) and delayed memory performance (β= −0.13, SE = 0.06, p = 0.02), but PTSD severity mediated both of these relationships (95% CI -0.14, −0.01; 95% CI -0.14, −0.02, respectively). Trait depression moderated the mediation path between subjective memory complaints and PTSD severity (β= −0.02, SE = 0.004, p &lt; .001), but not the path between PTSD and either immediate or delayed memory performance (all p &gt; .05). Conclusion Results suggest that targeting PTSD and depressive symptoms may be a promising treatment for those with subjective memory complaints.

scholarly journals Age and sex impact plasma NFL and t-Tau trajectories in individuals with subjective memory complaints: a 3-year follow-up study

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Filippo Baldacci ◽  
◽  
Simone Lista ◽  
Maria Laura Manca ◽  
Patrizia A. Chiesa ◽  
...  
Keyword(s):  
Plasma Vitamin ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Memory Complaints ◽  
Apoe Ε4 ◽  
Biological Variables ◽  
T Tau ◽  
The Impact ◽  
Over Time

Abstract Background Plasma neurofilament light (NFL) and total Tau (t-Tau) proteins are candidate biomarkers for early stages of Alzheimer’s disease (AD). The impact of biological factors on their plasma concentrations in individuals with subjective memory complaints (SMC) has been poorly explored. We longitudinally investigate the effect of sex, age, APOE ε4 allele, comorbidities, brain amyloid-β (Aβ) burden, and cognitive scores on plasma NFL and t-Tau concentrations in cognitively healthy individuals with SMC, a condition associated with AD development. Methods Three hundred sixteen and 79 individuals, respectively, have baseline and three-time point assessments (at baseline, 1-year, and 3-year follow-up) of the two biomarkers. Plasma biomarkers were measured with an ultrasensitive assay in a mono-center cohort (INSIGHT-preAD study). Results We show an effect of age on plasma NFL, with women having a higher increase of plasma t-Tau concentrations compared to men, over time. The APOE ε4 allele does not affect the biomarker concentrations while plasma vitamin B12 deficiency is associated with higher plasma t-Tau concentrations. Both biomarkers are correlated and increase over time. Baseline NFL is related to the rate of Aβ deposition at 2-year follow-up in the left-posterior cingulate and the inferior parietal gyri. Baseline plasma NFL and the rate of change of plasma t-Tau are inversely associated with cognitive score. Conclusion We find that plasma NFL and t-Tau longitudinal trajectories are affected by age and female sex, respectively, in SMC individuals. Exploring the influence of biological variables on AD biomarkers is crucial for their clinical validation in blood.

Are depressive symptomatology and self-focused attention associated with subjective memory impairment in older adults?

2014 ◽  
Vol 26 (4) ◽  
pp. 573-580 ◽  
Author(s):  
Juhee Chin ◽  
Kyung Ja Oh ◽  
Sang Won Seo ◽  
Duk L. Na
Keyword(s):  
Test Performance ◽  
Memory Impairment ◽  
Depressive Symptomatology ◽  
Memory Performance ◽  
Neuropsychological Test ◽  
Focused Attention ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
Memory Complaints

ABSTRACTBackground:Subjective memory impairment (SMI) refers to conditions in which people complain of memory problems despite intact cognition. The primary purpose of the present study was to examine the roles of self-focused attention and depressive symptomatology in subjective memory complaints.Methods:One hundred and eight patients who visited a memory disorder clinic with complaints of memory decline, but who were found on subsequent neuropsychological assessment to have normal cognitive function, were recruited to participate in the study. The severity of subjective memory complaints was measured with the modified Multifactorial Memory Questionnaire. In addition, neuropsychological functions, self-focused attention, and depressive symptomatology were also assessed.Results:The results showed that the severity of SMI was not significantly correlated with any of the neuropsychological test scores except for the complex figure copy. The severity of SMI, however, was significantly correlated with self-focused attention and depressive symptomatology. Hierarchical regression analysis revealed that self-focused attention and depressive symptomatology significantly contributed to the severity of subjective memory complaints over and above the neuropsychological test performance. The interaction effects between self-focused attention/depressive symptomatology and objective memory performance on the severity of SMI were not significant.Conclusions:In conclusion, self-focused attention and depressive symptomatology appear to play important roles in the severity of SMI, even though it is not clear how these factors interact with objective memory performance. Clinical implications as well as limitations of the present study were discussed.

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