Effects of Amino Acid Dialysis Solution on the Nutrition of Continuous Ambulatory Peritoneal Dialysis Patients

1999 ◽  
Vol 19 (5) ◽  
pp. 462-470 ◽  
Author(s):  
Alicja E. Grzegorzewska ◽  
Irena Mariak ◽  
Agnieszka Dobrowolska–Zachwieja ◽  
Lech Szajdak
Keyword(s):  
Amino Acids ◽  
Peritoneal Dialysis ◽  
Amino Acid ◽  
Nutritional Status ◽  
Body Mass ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Nitrogen Balance ◽  
Control Group ◽  
Dialysis Solution ◽  
Dialysis Solutions

Objective To evaluate the influence of 1.1% amino acid dialysis solution (AADS) on parameters of nutrition in continuous ambulatory peritoneal dialysis (CAPD) patients. Study Design Studies were performed in 8 men, using AADS for the overnight exchange. Before starting AADS, food intake, nutritional status, and laboratory indices were evaluated and compared to the respective parameters obtained after 3 and 6 months of treatment with AADS, as well as after 3 months of AADS withdrawal. With the start of AADS, doses of antacids were increased and modified during AADS administration; the modified doses were continued through 3 months after cessation of AADS. Another group of CAPD patients using standard dialysis solutions served as controls. In these patients the same parameters were evaluated four times at 3-month intervals. Results Administration of AADS resulted in: (1) 91% absorption of amino acids and improvement of serum amino acid pattern; (2) no change in nutritional intake during the treatment, but after the 3 months of AADS therapy, levels of nutrient intake were lower than those 3 months after withdrawal of AADS with correction of metabolic acidosis; (3) no change in indices of nutritional status, but 3 months after AADS discontinuation, total body weight, lean body mass, and body mass index were significantly higher than those shown after 3 months of treatment; (4) an increase in hemoglobin concentration, hematocrit, BUN, and blood H+. The examined parameters were not significantly changed in patients treated for 9 months with standard dialysis solutions exclusively. The values of nitrogen balance obtained during AADS administration and after 3 months of AADS withdrawal were significantly higher than those obtained in the respective periods in the control group. The blood pH, pCO2, and HCO3– in the last period of the study were higher in the AADS group than in the control group. Conclusion In relatively well-nourished CAPD patients, overnight AADS administration results in increased serum concentration of amino acids without changes in other nutritional parameters. The use of AADS should be associated with increased doses of antacid medication, which abolishes the metabolic effects of acidosis that develop during AADS administration and facilitates positive nitrogen balance.

Intraperitoneal Amino Acids: A Therapy Whose Time Has Come?

1995 ◽  
Vol 15 (5_suppl) ◽  
pp. 67-74 ◽  
Author(s):  
Michael R. Jones
Keyword(s):  
United States ◽  
Amino Acids ◽  
Amino Acid ◽  
Nutritional Status ◽  
The United States ◽  
European Countries ◽  
Dialysis Solution ◽  
Limited Basis

In regard to the question posed in the title of this review, the answer is mixed. IPN is possible today but only on a limited basis and at high cost with uncertain benefit. A 1.1% amino acid dialysis solution for IPAA therapy is available in several European countries but has not yet been approved for use in the United States. When it becomes more widely available, IP AA should become an important tool, along with other types of therapy, for use in the maintenance of good nutritional status in PDpatients.

Continuous Ambulatory Peritoneal Dialysis (CAPD) of Children with Amino Acid Solutions: Technical and Metabolic Aspects

1990 ◽  
Vol 10 (3) ◽  
pp. 215-220 ◽  
Author(s):  
Alberto Canepa ◽  
Francesco Perfumo ◽  
Alba Carrea ◽  
Maria Teresa Piccardo ◽  
Maria Rosa Ciardi ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Plasma Concentration ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Acid Solutions ◽  
Glucose Load ◽  
Protein Meal ◽  
Dialysis Solution ◽  
Basal Plasma ◽  
Amino Acid Solutions ◽  
Dialysis Solutions

The changes in plasma and dialysate amino acids (AA) in 7 continuous ambulatory peritoneal dialysis (CAPD) children after dialysis with a 1% AA solution were compared with a glucose-containing solution. During the AA exchange, the plasma levels of individual AA reached their peaks after 1 h, with their percentage increments significantly correlated (p < 0.001) with the ratio of the amount of AA in the bag to the basal plasma concentration. The plasma concentration of methionine, valine, phenylalanine, and isoleucine remained higher than the basal value at 4 h. The amount of AA absorbed was 66% after 1 h, and 86% after 4 h and 6 h, corresponding to 2574 ± 253 μmollkg body wt. During glucose-dialysis (1.36%), levels of histidine, methionine, valine, phenilal-anine, and isoleucine were significantly decreased in plasma after 1 h, and stayed low throughout the dialysis period. The loss of AA with the peritoneal effluent was 116 ± 69 μmol/kg/body wt. From this study, it seems that using an AA dialysis solution, with 1 exchange per day, might limit the daily glucose load and compensate for AA losses by supplying an extra amount of AA and by reducing the loss of other AA not contained in dialysis solutions. The AA pattern in plasma following AA-dialysis resembles that observed after a protein meal, with no signs of persistently high, nonphysiological levels.

The Use of Alternative Peritoneal Dialysis Solutions in Pediatric Patients

1993 ◽  
Vol 13 (2_suppl) ◽  
pp. 95-97 ◽  
Author(s):  
John Williamson Balfe ◽  
Izhar Qamar
Keyword(s):  
Amino Acids ◽  
Peritoneal Dialysis ◽  
Pediatric Patients ◽  
Dialysis Solution ◽  
Peritoneal Dialysis Solution ◽  
Calcium And Magnesium ◽  
Dialysis Solutions ◽  
Osmotic Solute ◽  
Peritoneal Dialysis Solutions

Changes in the formulation of peritoneal dialysis solutions will continue. For the present, dextrose dialysis will remain the osmotic solute of choice. How amino acids and glucose polymers as solute replace ments for glucose fit into the dialysis prescription remains to be seen. The lower concentration of calcium and magnesium appears to be gaining acceptance in many centers. It is feasible that in the next few years the challenge of adding bicarbonate to the peritoneal dialysis solution will be circumvented, because there appears to be a real clinical need for such an improvement. Pediatric modifications will be necessary, appreciating that such changes will have an economic penalty, and thus must have proven value.

Nutritional Aspects of CAPD and the Potential Use of Amino Acid Containing Dialysis Solutions

1983 ◽  
Vol 3 (1_suppl) ◽  
pp. 10-12 ◽  
Author(s):  
Oimitrios G. Oreopoulos ◽  
Errol Marliss G. Harvey ◽  
Anderson Arie Oren ◽  
Nicholas Oombros Paul ◽  
Williams Ramesh Khanna ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Plasma Amino Acid ◽  
Plasma Amino Acids ◽  
Effective Solution ◽  
Nutrient Losses ◽  
Protein Meal ◽  
Dialysis Solution ◽  
Dialysis Solutions ◽  
Potential Use

As a result of a combination of a decreased appetite with increased nutrient losses in the dialysate, a number of CAPO patients may develop malnutrition. A decrease in appetite is also observed in normal animals undergoing CAPO which suggests that some factors related to CAPO influence appetite so that these animals eat less. In addition to protein losses, CAPO patients are losing approximately two grams of amino acids a day, and they have plasma amino acid abnormalities similar to those produced by malnutrition and uremia. An amino acid-containing dialysis solution (2%) is an effective solution with respect to ultrafiltration and solute removal. Amino acids can be absorbed by the peritoneal route and produce an increase in plasma amino acids to levels similar to those observed after a protein meal. These observations indicate that administration of amino acids via the peritoneal route may prevent or correct malnutrition developed in patients on CAPO.

Osmotic Agents for Peritoneal Dialysis

1986 ◽  
Vol 9 (6) ◽  
pp. 387-390 ◽  
Author(s):  
R. Khanna ◽  
Z. J. Twardowski ◽  
D.G. Oreopoulos
Keyword(s):  
Amino Acids ◽  
Peritoneal Dialysis ◽  
Sole Agent ◽  
Dialysis Solution ◽  
Osmotic Agent ◽  
Peritoneal Dialysis Solution ◽  
Osmotic Agents ◽  
Near Future ◽  
Dialysis Solutions

Glucose has more advantages than drawbacks and is now the sole agent used in clinical practice. Yet there is interest in finding a substitute for glucose as an osmotic agent in peritoneal dialysis solution. Work has identified several promising agents such as albumin, amino acids, gelatin and glycerol but it appears that every one of them, including glucose, would be useful for a short-dwell or for a long-dwell exchange but not for both. Some of them, such as albumin and the amino acids, are close to being an ideal osmotic agent but are prohibitively costly to manufacture. We predict that interest in the future will focus on dialysis solutions containing a mixture of osmotic agents. Such a solution would be acceptable for both short and long-dwell exchanges. It will have a sufficiently low concentration of different agents to minimize toxicity and long-term undesirable side effects. We expect that solutions will be available to better meet patients needs in the near future.

Continuous ambulatory peritoneal dialysis using self-made, ultrafiltration-sterilized, L-lactate-based dialysis solution

1994 ◽  
Vol 17 (9) ◽  
pp. 488-491 ◽  
Author(s):  
T.S. Ing ◽  
A.W. Yu ◽  
B. Agrawal ◽  
P.K. Tiwari ◽  
A.P. McShane ◽  
...  
Keyword(s):  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
End Stage Renal Failure ◽  
Plastic Bags ◽  
Dialysis Solution ◽  
Sterile Plastic ◽  
End Stage ◽  
Dialysis Solutions

Continuous ambulatory peritoneal dialysis was successfully carried out in 6 end-stage renal failure patients using self-made, ultrafiltration-sterilized dialysis solutions. A Y-set was used to deliver the above solutions to sterile plastic bags.

scholarly journals PERAN EDUKASI GIZI TERHADAP ASUPAN ENERGI-PROTEIN DAN INDEKS MASSA TUBUH PASIEN GAGAL GINJAL KRONIS DENGAN TERAPI CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD)

2021 ◽  
Vol 9 (1) ◽  
pp. 53-58
Author(s):  
Yudhi Adrianto ◽  
Diah Mulyawati Utari ◽  
Fitri Hudayani ◽  
Triyani Kresnawan
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Peritoneal Dialysis ◽  
Food Intake ◽  
Nutritional Status ◽  
Nutrition Education ◽  
Body Mass ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Protein Intake ◽  
Normal Body Mass Index

Background: Nutrition are the essential factor to maintain body weight, body mass index and food intake in CAPD patients. Dialysis could increase nutrients lost and had to be replaced by adequate intake. Nutrition education should be needed to increase patient’s knowledge, food intake and body mass index.Objectives: To determine the role of nutrition education towards energy-protein intake and body mass index in patient with continuous ambulatory peritoneal dialysis (CAPD)Method: A cross-sectional study design with total sampling technique to obtains thirthy CAPD outpatient at RSUPN Dr. Cipto Mangunkusumo. Energy and protein intake were assessed by 3-days-food records (weekday and weekend). Nutritional status were obtained with BMI by dry body weight. Data were analyzed with independent t-test.Results: Most of subject are male outpatients, 25 – 55 years old (76.7%), had hypertension (83.3%) and normal BMI (50%). Most of subject had been undergoing peritoneal dialysis more than a year (67%), and had less than two times education per year. Energy intake were categorized as sufficient (80%) but protein intake were categorized as insufficient. There were no differences between frequency of nutrition education with energy-protein intake and nutritional status (p0.05)Conclusion: There are no differences between energy-protein intake and nutritional status with the frequency of nutrition education. Nutritional education by nutritionist and/or dietitian according to the recommendations help to maintain normal body mass index.

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