scholarly journals Likely clinical depression and HIV-related decline in antiretroviral therapy untreated women who seroconverted during participation in microbicide trials in sub-Saharan Africa

2021 ◽  
pp. 095646242097593
Author(s):  
Christine T Rael ◽  
Sarah Roberts ◽  
Mbolaji Ibitoye ◽  
Pamina M Gorbach ◽  
Thesla Palanee-Phillips ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Alcohol Use ◽  
Male Partner ◽  
Hiv Disclosure ◽  
Clinical Depression ◽  
Sub Saharan Africa ◽  
Hiv Viral Load ◽  
Cross Sectional ◽  
Hopkins Symptom Checklist ◽  
Sub Saharan

Depression worsens HIV outcomes in populations treated with antiretroviral therapy (ART) medications. Data are limited on the relationship between depression and HIV in untreated populations in sub-Saharan Africa. We aimed to identify associations between likely clinical depression, alcohol use, social support by partners, and HIV viral load (VL) among ART untreated women who recently became HIV positive and enrolled in the Microbicide Trials Network (MTN)-015 study. Analyses used cross-sectional data collected at baseline in MTN-015. Participants in this analysis ( N = 190) enrolled from other MTN trials were not receiving ART and provided data on their HIV disclosure status to their husband or male partner and alcohol use behavior. The dependent variable, VL, was categorized as: low (≤400 RNA copies/mL; 9.1% of participants), medium (401–20,000 RNA copies/mL; 48.8%), and high (>20,000 RNA copies/mL; 42.0%). Depression was assessed using eight items from Hopkins Symptom Checklist; a cutoff of ≥1.75 indicated likely clinical depression. Independent variables with a significance of p ≤ 0.05 in unadjusted regressions were included in a regression adjusted for age, education, and time since seroconversion. Depressive symptoms were positively associated with high VL, in the adjusted regression (OR = 1.80; 95% CI = 1.07–3.01). Results suggest that likely having clinical depression may have a biological relationship with HIV disease progression.

Factors Affecting Adherence to Pediatrics Antiretroviral Therapy in Mekelle Hospital, Tigray Ethiopia

2015 ◽  
Vol 4 (1) ◽  
pp. 1 ◽  
Author(s):  
Teklemariam Gultie ◽  
Tesfay G/Amlak ◽  
Girum Sebsibie
Keyword(s):  
Antiretroviral Therapy ◽  
Cross Sectional Study ◽  
Hiv Treatment ◽  
Sub Saharan Africa ◽  
Hospital Data ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Care Givers ◽  
Male Care ◽  
Sub Saharan

The most important factor in the success of HIV treatment is adherence to antiretroviral therapy (ART).The challenge to adherence to ART is particularly serious in Sub-Saharan Africa as the high rates of HIV/AIDS lead to greater numbers of affected individuals. Although long-term good ART adherence has been observed in certain settings of public sectors the magnitude of this challenge in Sub-Saharan Africa remains large and there is evidence for high rates of patient’s poor adherence. Study aimed to assess the factors affecting adherence to pediatrics antiretroviral therapy (ART) among children in Mekelle hospital, Tigray, Ethiopia. A Hospital based cross-sectional study was conducted on 226 children on antiretroviral therapy from May 01 to 30/2014 at Mekelle hospital. Data was collected from care givers of children under 15 years old who are on ART. Of the 226 children under 15 years, 90.3 % reported complete adherence to antiretroviral therapy medications at the regular schedule over the past 7 days. Factors associated with adherence were having male care giver (AOR=2.10[1.01, 7.22]), age of the child (AOR=1.43[1.16, 3.98]) below 5 years and use of first line ART drugs (AOR=2.86[1.54, 3.67]). Over all the adherence of children on ART to their medication in this study is relatively higher as compared to others. However, complete adherence is expected in order to make the drugs effective. Different strategies have to be designed to improve the adherence level.

scholarly journals Alcohol Use and Antiretroviral Therapy Non-Adherence Among Adults Living with HIV/AIDS in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 24 (6) ◽  
pp. 1727-1742 ◽  
Author(s):  
Jennifer Velloza ◽  
Christopher G. Kemp ◽  
Frances M. Aunon ◽  
Megan K. Ramaiya ◽  
Emma Creegan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Antiretroviral Therapy ◽  
Alcohol Use ◽  
Meta Analysis ◽  
Sub Saharan Africa ◽  
Sub Saharan ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals The impact of the availability of antiretroviral therapy on personal and community fear of HIV/AIDS, and HIV prevention practices in Rwimi, Uganda: A mixed-method study

2018 ◽  
Vol 1 (1) ◽  
pp. 1-14
Author(s):  
Nicole Naadu Ofosu ◽  
L. Duncan Saunders ◽  
Gian Jhangri ◽  
Afif Alibhai
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Prevention ◽  
Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Sub Saharan Africa ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Sub Saharan ◽  
The Impact ◽  
Hiv Aids

The impact of the widespread availability of antiretroviral therapy (ART) on the human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) related attitudes, behaviours and practices of the general population in Sub-Saharan Africa is understudied. We assessed the impact of ART availability on the fear of HIV/ AIDS (measured at both community and personal levels) and HIV prevention practices in Rwimi, Uganda using a cross-sectional survey. The fear of HIV/AIDS was described as a perceived threat to either self and/or community regarding the risk of contracting the disease, whereby the higher the perception of the threat, the greater the fear. We assessed associations between the outcomes of the dependent variables on both the community and personal fear of HIV/AIDS, and the independent variables of HIV/AIDS-related knowledge and demographics. Qualitative data was also generated from focus group discussions (FGD) on the context of the fear of HIV/AIDS and HIV pre- vention practices. The majority of participants (89.4%; males - 86.8%; females - 90.8%) felt that ART availability has reduced the fear of HIV/AIDS in the community. In contrast, fewer participants (22.4%; males - 24.4%; females – 21.2%) mentioned that their personal fear of HIV/AIDS has been reduced with the availability of ART. From the qualitative study, factors identified as influencing the fear of HIV/AIDS included stigma, fear of infection, and the inconvenience of being on ART. Although fear of HIV/AIDS persists, the fear is reduced because of the availability of life-prolonging ART. HIV prevention practices are influenced by socio-cultural norms (gender roles, relationship dynamics, power and trust), which, we argue, should be considered when de-signing sustainable HIV/AIDS prevention programs.

scholarly journals Alcohol use and intimate partner violence among women and their partners in sub-Saharan Africa

2017 ◽  
Vol 4 ◽  
Author(s):  
M. C. Greene ◽  
J. C. Kane ◽  
W. A. Tol
Keyword(s):  
Intimate Partner Violence ◽  
Risk Factor ◽  
Alcohol Use ◽  
Partner Violence ◽  
Male Partner ◽  
Intimate Partner ◽  
Sub Saharan Africa ◽  
Demographic And Health Surveys ◽  
Sub Saharan ◽  
The Relationship

Background:Alcohol use is a well-documented risk factor for intimate partner violence (IPV); however, the majority of research comes from high-income countries.Methods:Using nationally representative data from 86 024 women that participated in the Demographic and Health Surveys, we evaluated the relationship between male partner alcohol use and experiencing IPV in 14 countries in sub-Saharan Africa (SSA). Using multilevel mixed-effects models, we calculated the within-country, between-country, and contextual effects of alcohol use on IPV.Results:Prevalence of partner alcohol use and IPV ranged substantially across countries (3–62 and 11–60%, respectively). Partner alcohol use was associated with a significant increase in the odds of reporting IPV for all 14 countries included in this analysis. Furthermore, the relationship between alcohol use and IPV, although largely explained by partner alcohol use, was also attributable to overall prevalence of alcohol use in a given country. The partner alcohol use–IPV relationship was moderated by socioeconomic status (SES): among women with a partner who used alcohol those with lower SES had higher odds of experiencing IPV than women with higher SES.Conclusions:Results of this study suggest that partner alcohol use is a robust correlate of IPV in SSA; however, drinking norms may independently relate to IPV and confound the relationship between partner alcohol use and IPV. These findings motivate future research employing experimental and longitudinal designs to examine alcohol use as a modifiable risk factor of IPV and as a novel target for treatment and prevention research to reduce IPV in SSA.

scholarly journals Relationship between depressive symptoms, alcohol use, and antiretroviral therapy adherence among HIV-infected, clinic-attending patients in South Africa

2016 ◽  
Vol 22 (11) ◽  
pp. 1426-1433 ◽  
Author(s):  
Jessica F Magidson ◽  
Wylene Saal ◽  
Adriaan Nel ◽  
Jocelyn E Remmert ◽  
Ashraf Kagee
Keyword(s):  
South Africa ◽  
Depressive Symptoms ◽  
Antiretroviral Therapy ◽  
Alcohol Use ◽  
Sub Saharan Africa ◽  
Level Measurement ◽  
Antiretroviral Therapy Adherence ◽  
Prevalence Of Depression ◽  
Sub Saharan ◽  
Independent Association

Despite the prevalence of depression and alcohol use among HIV-infected individuals, few studies have examined their association together in relation to nonadherence to antiretroviral therapy in sub-Saharan Africa. This study examined depressive symptoms, alcohol use, and other psychosocial factors (stigma, demographic characteristics) in relation to nonadherence to antiretroviral therapy among clinic-attending, HIV-infected individuals in South Africa ( n = 101). Nonadherence was assessed using event-level measurement (missed doses over the past weekend). Multivariable logistic regression analyses revealed that only alcohol use, over and above depressive symptoms and education level, was associated with antiretroviral therapy nonadherence(AOR = 1.15; 95%CI = 1.02–1.29; p < .05). Findings point to the independent association of alcohol use and nonadherence to antiretroviral therapy above and beyond depressive symptoms.

scholarly journals Pooled analysis of the association between alcohol use and violence against women: evidence from four violence prevention studies in Africa

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e049282
Author(s):  
Leane Ramsoomar ◽  
Andrew Gibbs ◽  
Esnat D Chirwa ◽  
Kristin Dunkle ◽  
Rachel Jewkes
Keyword(s):  
Alcohol Use ◽  
Violence Against Women ◽  
Partner Violence ◽  
Pooled Analysis ◽  
Sub Saharan Africa ◽  
Data Sets ◽  
Cross Sectional ◽  
Harmful Alcohol ◽  
Prevention Studies ◽  
Sub Saharan

ObjectivesTo test associations between men’s past year alcohol use and patterns of drinking, and their perpetration of intimate partner violence (IPV) and non-partner sexual violence (NPSV). To test the associations between women’s reports of partner alcohol use and their experience of IPV, in three countries in Africa.DesignPooled analysis of cross-sectional baseline data from men and women participating in four IPV prevention studies across Africa and Asia.SettingData from five data sets generated by four violence against women and girls prevention studies in three countries in sub-Saharan Africa, South Africa, Ghana and Rwanda.Participants8104 men 18+ years old and 5613 women 18+ years old from a mix of volunteer and randomly selected samples.Main outcome measuresStudies employed comparable measures of past year alcohol use, harmful alcohol use (Alcohol Use Disorder Identification Test scale) and items from modified WHO Women’s Health and Domestic Violence to measure physical IPV and NPSV perpetration among men and IPV experience among women.FindingsOverall harmful alcohol use among men was associated with a substantially increased odds of perpetrating physical IPV (adjusted OR (aOR)=3.45 (95% CI 2.56 to 4.64)) and NPSV (aOR=2.64 (95% CI 1.85 to 3.76)) compared with non-drinkers. Women who had seen their partner occasionally drunk (aOR=2.68 (95% CI 2.13 to 3.36)) or frequently drunk (aOR=5.94 (95% CI 4.19 to 8.41)) in the past 12 months had an increased odds of experiencing physical IPV.ConclusionsAlcohol use is associated with increased IPV and NPSV perpetration for men and (physical) IPV experience for women. Reported frequency of IPV and NPSV increase with increasing levels and frequency of alcohol use. Interventions aimed at reducing alcohol may also lead to reductions in IPV and NPSV perpetration and experience.

scholarly journals HIV Viral Load Monitoring Among Patients Receiving Antiretroviral Therapy — Eight Sub-Saharan Africa Countries, 2013–2018

2021 ◽  
Vol 70 (21) ◽  
pp. 775-778
Author(s):  
Shirley Lee Lecher ◽  
Peter Fonjungo ◽  
Dennis Ellenberger ◽  
Christiane Adje Toure ◽  
George Alemnji ◽  
...  
Keyword(s):  
Viral Load ◽  
Antiretroviral Therapy ◽  
Sub Saharan Africa ◽  
Hiv Viral Load ◽  
Viral Load Monitoring ◽  
Load Monitoring ◽  
Sub Saharan

scholarly journals Alcohol use during pregnancy in Rakai, Uganda

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256434
Author(s):  
Adriane Wynn ◽  
Dorean Nabukalu ◽  
Tom Lutalo ◽  
Maria Wawer ◽  
Larry W. Chang ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Pregnant Women ◽  
Partner Violence ◽  
Sub Saharan Africa ◽  
Hiv Status ◽  
Cross Sectional ◽  
The Past ◽  
Catholic Religion ◽  
Sub Saharan ◽  
Living With Hiv

Introduction Antenatal alcohol use is linked to adverse maternal and neonatal outcomes. Uganda has one of the highest rates of alcohol use in sub-Saharan Africa, but the prevalence of antenatal alcohol use has not been reported in the Rakai region. Methods We used cross-sectional data from pregnant women in the Rakai Community Cohort Study between March 2017 and September 2018. Using bivariate and multivariable analyses, we assessed associations between self-reported antenatal alcohol use and sociodemographic characteristics, intimate partner violence (IPV), and HIV status. Results Among 960 pregnant women, the median age was 26 years, 35% experienced IPV in the past 12 months, 13% were living with HIV, and 33% reported alcohol use during their current pregnancy. After adjusting for marital status, education, smoking, and HIV status; Catholic religion (AOR: 3.54; 95% CI: 1.89–6.64; compared to other), bar/restaurant work (AOR: 2.40; 95% CI: 1.17–4.92; compared to agriculture), >one sex partner in past year (AOR: 1.92; 95% CI: 1.17–3.16), a partner that drank before sex in past year (AOR: 2.01; 95% CI: 1.48–2.74), and past year IPV (AOR: 1.55; 95% CI: 1.14–2.11) were associated with antenatal alcohol use. Conclusion We found that alcohol use during pregnancy was common and associated with religion, occupation, higher numbers of past year sex partners, having a partner who drank before sex in the past 12 months, and IPV experience. More research is needed to understand the quantity, frequency, and timing of antenatal alcohol use; and potential impacts on neonates; and to identify services that are acceptable and effective among pregnant women.

scholarly journals Burden of depressive symptoms and non-alcohol substance abuse; and their association with alcohol use and partner violence: a cross-sectional study in four sub-Saharan Africa countries

2018 ◽  
Vol 5 ◽  
Author(s):  
F. Bajunirwe ◽  
S. Maling ◽  
H.-O. Adami ◽  
I. O. Ajayi ◽  
J. Volmink ◽  
...  
Keyword(s):  
Risk Factors ◽  
Substance Abuse ◽  
Depressive Symptoms ◽  
Alcohol Use ◽  
Partner Violence ◽  
Cross Sectional Study ◽  
Sub Saharan Africa ◽  
Sectional Study ◽  
Cross Sectional ◽  
Sub Saharan

In sub-Saharan Africa, there are limited data on burden of non-alcohol substance abuse (NAS) and depressive symptoms (DS), yet potential risk factors such as alcohol and intimate partner violence (IPV) are common and NAS abuse may be the rise. The aim of this study was to measure the burden of DS and NAS abuse, and determine whether alcohol use and IPV are associated with DS and/or NAS abuse. We conducted a cross-sectional study at five sites in four countries: Nigeria (nurses), South Africa (teachers), Tanzania (teachers) and two sites in Uganda (rural and peri-urban residents). Participants were selected by simple random sampling from a sampling frame at each of the study sites. We used a standardized tool to collect data on demographics, alcohol use and NAS use, IPV and DS and calculated prevalence ratios (PR). We enrolled 1415 respondents and of these 34.6% were male. DS occurred among 383 (32.3%) and NAS use among 52 (4.3%). In the multivariable analysis, being female (PR  =  1.49, p  =  0.008), NAS abuse (PR  =  2.06, p  =  0.02) and IPV (PR  =  2.93, p < 0.001) were significantly associated with DS. Older age [odds ratio (OR) = 0.31, p < 0.001)], female (OR = 0.48, p  =  0.036) were protective of NAS but current smokers (OR = 2.98, p < 0.001) and those reporting IPV (OR  =  2.16, p  =  0.024) were more likely to use NAS. Longitudinal studies should be done to establish temporal relationships with these risk factors to provide basis for interventions.

Sign in / Sign up

Export Citation Format

Share Document