The Afterlife of Breast Cancer: Exploring the Digital Performativity of Post-Treatment Patienthood

2021 ◽  
pp. 097325862110482
Author(s):  
Neha Gupta
Keyword(s):  
Breast Cancer ◽  
Chronic Illness ◽  
Side Effects ◽  
Gender Identity ◽  
Post Treatment ◽  
Temporal Experience ◽  
Treatment Regimes ◽  
Social Mediation ◽  
It Impacts ◽  
The Everyday

This article looks at the practices of digital performativity of bodies-in-remission on Instagram to detail the affective and temporal experience of post-treatment patienthood. To explore these performativities, I use the images and narratives of the post-treatment breast-cancer body to have a conversation about the vicarious ‘re-experience’ of the malady—now in abeyance—through the discursive register of fear and the clinical haunting of the everyday in trying to offset the side-effects of the treatment regimes. I further argue that these techno-digital enactments of post-treatment patienthood co-emerge through complex ‘intra-actions’ of and within entanglements of materialities, networks, discourses, affect, and multiple registers of techno-social mediation that shape and constrict them. Accordingly, this article is an effort to make sense of how people ‘memorise’ chronic illness and prolonged suffering—especially when it impacts key sources of their gender identity—through negotiations with the temporal-discursive processes of networked communications.

Management of side effects during and post-treatment in breast cancer survivors

2017 ◽  
Vol 24 (2) ◽  
pp. 167-175 ◽  
Author(s):  
Oxana Palesh ◽  
Caroline Scheiber ◽  
Shelli Kesler ◽  
Karen Mustian ◽  
Cheryl Koopman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Post Treatment

Complementary medicine use during adjuvant radiotherapy of breast cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e12088-e12088
Author(s):  
Rebecca Buecker ◽  
Ulrich Schafer
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Disease Progression ◽  
Complementary Medicine ◽  
Adjuvant Radiotherapy ◽  
Postoperative Radiotherapy ◽  
Treatment Regimes ◽  
Curative Radiotherapy ◽  
Significant Difference ◽  
Grade Ii

e12088 Background: Complementary medicine (CM) is used widely in cancer patients, mostly in palliative treatment regimes or during chemotherapy. In contrast, the use of CM during curative Radiotherapy (RT) is less frequent.The aim of this study was to evaluate the influence of CM with regard to toxicity and recurrence during postoperative radiotherapy for breast cancer. Methods: Between 2010 and 2013 all patients intended for adjuvant radiotherapy for breast cancer received a questionnaire concerning the use of CM e.g. Vitamins, trace elements, enzymes, natural herbs etc. (yes / no) and if yes what kinds. Radiotherapy was applied with 50.4 Gy to the whole breast and a Boost of 10.8 Gy in 6.5 weeks.6 weeks after radiotherapy the side effects were analyzed. Follow up for progression rates was done yearly. Results: A total number of 879 patients with breast cancer completed the questionnaire, 641 (73%) did not take any CM and 238 (27%) took CM. There were almost 40 different products mentioned and the most common were magnesium (n=71) and selenium (n=38). The RT side effects (Dermatitis RTOG grade 0, I, II, III/IV) 6 weeks after completion of RT were as follow: in the non CM group 53% grade 0, 41% grade I, and 6% grade II, 0% grade III/IV. And in the CM group 54%, 39%, 9%, and 0% respectively. The corresponding side effects for the group taking magnesium were 35% 42%, 6% and 1% and for the selenium group 47%, 47%, 5% and 0%. There was no significant difference in side effects between the non CM and CM patients, respectively magnesium and selenium group . The sum of all registered disease progression (0 years – 5 years) were in the non CM group 6.4%, in the CM group 6.3%, in the magnesium group 5.6% and in the selenium group 7.9%, no significant difference could be detected between all groups. Conclusions: In this cohort, 27 % of patients used CM during adjuvant radiotherapy of breast cancer. The most commonly product is magnesium followed by selenium. A measurable influence of CM on RT side effects or disease progression could not be identified.

Evaluation of Local Injection of Bevacizumab against Triple-Negative Breast Cancer Xenograft Tumors

2019 ◽  
Vol 25 (8) ◽  
pp. 862-870
Author(s):  
Xin Jiang ◽  
Qiao-Li Zhang ◽  
Tie-Gang Liu ◽  
Wei-Peng Zhao ◽  
Ming Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Matrix Metalloproteinase ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Local Delivery ◽  
Local Injection ◽  
Vegf Receptor ◽  
Protein Protein Interaction ◽  
Local Injections

Background and objective:Bevacizumab (BVZ) is a recombinant humanized antibody that inhibits the vascular endothelial growth factor A (VEGFA) and is used for the treatment of various types of cancer. BVZ is primarily given by the intravenous drip (I.V.), which often leads to low efficacy and various side effects. Therefore, the present study was to evaluate the effect of local delivery of BVZ against triple-negative breast cancer (TNBC) xenograft tumors.Methods:Mice 4T1 TNBC cells were engrafted in female BALB/c mice. After the tumors reached about 5 mm (diameter), animals were treated with BVZ through the local injection from four directions around the tumors. The tumor growth, survival and potential mechanisms of action were evaluated.Results:The growth and microvessel density of engrafted tumors were dramatically reduced with the tumor inhibition rate of 32.8 ± 3%. No obvious side effects were observed. The expression of VEGFA, VEGF receptor (VEGFR), matrix metalloproteinase (MMP)-2, MMP-9, Delta-like ligand 4 (DLL4) and Integrin-5 was significantly reduced in TNBC tumor tissues. In contrast, tissue inhibitor of matrix metalloproteinase (TIMP)-2 was significantly upregulated in xenograft tumors. Additionally, local delivery of BVZ led to the reduction of VEGFA and tumor necrosis factor (TNF)-alpha in the serum. Protein-protein interaction (PPI) analysis revealed that the proteins altered by the local delivery of BVZ were associated with angiogenesis and regulation of cell migration.Conclusion:This study provided evidence associated with local delivery of BVZ against TNBC tumors supporting the use of BVZ local injections to overcome some of the disadvantages associated with I.V. therapy with BVZ.

Molecular Studies on Novel Antitumor Bis 1,4-Dihydropyridine Derivatives Against Lung Carcinoma and their Limited Side Effects on Normal Melanocytes

2019 ◽  
Vol 18 (15) ◽  
pp. 2156-2168 ◽  
Author(s):  
Magda F. Mohamed ◽  
Nada S. Ibrahim ◽  
Ahmed H.M. Elwahy ◽  
Ismail A. Abdelhamid
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Cells ◽  
Cell Line ◽  
Lung Carcinoma ◽  
Carcinoma Cell ◽  
Normal Cells ◽  
Lung Carcinoma Cell Line ◽  
Molecular Studies ◽  
Dihydropyridine Derivatives

Background: Cancer is a complex genetic disease which is characterized by an abnormal cell growth, invasion and spreading to other parts of the body. There are several factors that lead to cancer by causing DNA damage and the impairment of its repair. Treatment of cancer using the chemotherapeutic drugs have adverse side effects such as toxicity as they lose their specificity toward cancer cells and affect also normal cells. Moreover, the cancer cells can resist the chemotherapeutic agents and make them ineffective. For these reasons, much attentions have been paid to develop new drugs with limited side effects on normal cells and to diminish cancer resistance to drug chemotherapy. Recently, some 1,4-dihydropyridine derivatives were reported to act as Multi-Drug Resistance (MDR) modulators that inhibit p-glycoprotein which is responsible for the inability of drugs to enter the cancer cells. Also 1,4-DHPs have antimutagenic properties against chemicals via modulating DNA repair when studied on drosophila. Objective: The objective of this study is the synthesis of bis 1,4-DHPs incorporating ester as well as ether linkages and evaluate the anticancer activity of new compounds for synergistic purpose. Different genetic tools were used in an attempt to know the mechanism of action of this compound against lung cancer. Method: An efficient one pot synthesis of bis 1,4-DHPs using 3-aminocrotononitrile and bis(aldehydes) has been developed. The cytotoxic effect against human cell lines MCF7, and A549 cell lines was evaluated. Results: All compounds exhibited better cytotoxicity toward lung carcinoma cells than breast cancer cells. With respect to lung carcinoma cell line (A549), compound 10 was the most active compound and the three other compounds 7, 8, and 9 showed comparable IC50 values. In case of breast cancer cell line (MCF7), the most active one was compound 7, while compound 8 recorded the least activity. Conclusion: we have developed an efficient method for the synthesis of novel bis 1,4-dihydropyridine derivatives incorporating ester or ether linkage. All compounds showed better cytotoxicity results against A549 than MCF7, so that lung carcinoma cell line was chosen to perform the molecular studies on it. The results showed that all compounds (7, 8, 9 and 10) caused cell cycle arrest at G1 phase. The molecular docking study on CDK2 confirmed the results of cell cycle assay which showed good binding energy between the compounds and the active site of enzyme indicating the inhibition of the enzyme.

Preliminary Pre-Clinical studies on the side effects of breast cancer treatment

2021 ◽  
pp. 1-41
Author(s):  
Camila Salata ◽  
Carlos E. deAlmeida ◽  
Samara C. Ferreira-Machado ◽  
Regina C. Barroso ◽  
Liebert P Nogueira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Treatment ◽  
Clinical Studies ◽  
Breast Cancer Treatment

scholarly journals Patient Preferences: Results of a German Adaptive Choice-Based Conjoint Analysis (Market Research Study Sponsored by Eli Lilly and Company) in Patients on Palliative Treatment for Advanced Breast Cancer

Breast Care ◽  
2021 ◽  
pp. 1-9
Author(s):  
Mattea Reinisch ◽  
Norbert Marschner ◽  
Thorsten Otto ◽  
Agnieszka Korfel ◽  
Clemens Stoffregen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Advanced Breast Cancer ◽  
Patient Preferences ◽  
Advanced Breast ◽  
Line Treatment ◽  
Second Line ◽  
Quantitative Survey ◽  
Therapy Assessment ◽  
Adaptive Choice

<b><i>Introduction:</i></b> Integration of patient preferences into shared decision making improves disease-related outcomes, but such data from patients with advanced breast cancer (aBC) are limited. The objective of this study was to demonstrate the relative importance of overall survival (OS) and progression-free survival (PFS) in relation to quality of life (QoL) and therapy-associated side effects from the perspective of patients with aBC. <b><i>Methods:</i></b> Postmenopausal patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative aBC receiving first- or second-line treatment were recruited throughout Germany. Patient-relevant attributes for aBC therapy assessment were collected using a stepwise multimodal approach. A conjoint matrix was developed, resulting in 2 attributes for therapy goals (OS and PFS), 4 for QoL, and 6 for side effects. An online quantitative survey was then performed using adaptive choice-based conjoint (ACBC) methodology. <b><i>Results:</i></b> The quantitative survey included 104 patients: 67 (64.4%) receiving first-line treatment and 37 (35.6%) receiving second-line treatment. The QoL attribute “physical agility and mobility” received the highest utility score (19.4 of 100%), reflecting the greatest importance to patients, followed by treatment goals (OS [15.2%] and PFS [14.4%]). Therapy-related side effects were less important, with nausea/vomiting being the most important (9.3%), followed by infection (6.4%) and hair loss (5.0%). The McFadden pseudo <i>R</i><sup>2</sup> (0.805), the root likelihood (0.864), and the χ<sup>2</sup> test (2,809.041; <i>p</i> &#x3c; 0.0001) indicated a very good fit of the statistical model. <b><i>Conclusion:</i></b> Using ACBC analysis, it appears that QoL, OS, and PFS are most important to postmenopausal patients with aBC in relation to cancer treatment. Side effects seem to be less important if OS or PFS are prolonged and the QoL is maintained. Thus, QoL, OS, and PFS should be considered equally when making treatment decisions in aBC.

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