How to Handle Lymphadenectomy Specimens to Identify Metastasis More Accurately in Gynecologic Pathology

2018 ◽  
Vol 27 (3) ◽  
pp. 244-250
Author(s):  
Gunsu Kimyon Comert ◽  
Nazmiye Dincer ◽  
Alp Usubutun
Keyword(s):  
Retrospective Study ◽  
Lymph Nodes ◽  
Detection Rate ◽  
Gynecologic Cancer ◽  
Processing Technique ◽  
Cancer Surgery ◽  
Test Results ◽  
Single Section

Aim. To identify the value of processing multiple sections to detect metastasis in lymph nodes (LNs) dissected during gynecologic cancer surgery, and to evaluate the sizes of metastatic LNs in each region to compare with the largest one. Materials and Methods. This retrospective study included 362 patients who had gynecologic cancer with at least one metastatic LN. Slides of 627 metastatic LN specimens were categorized according to the processing technique into single and more than one section (MOS) groups. In the MOS group, the LNs were cut into 2 or 3 parallel slices because their greatest dimensions exceeded 0.5 cm. Sizes of LN metastatic foci (MF) were measured and defined as follows: MF ⩽2 mm as micrometastasis and MF >2 mm as macrometastasis. The largest LN diameters among the metastatic LNs and the largest LNs in those regions were measured. Groups were compared using the Kruskal-Wallis test. Results. Sixty-five (10.3%) of the metastatic LNs included in this study had micrometastases and 40 (6.3%) of them had MF ⩽1 mm. The rate of micrometastasis was higher in the MOS group than in the single-section group (11.8% vs 8.5%, respectively). Twenty-eight percent (n = 175) of metastatic LNs were not the largest, and 55.5% of those were less than 1 cm in diameter. Conclusion. Methods of LN processing and macroscopic evaluation are not standardized, and processing single sections from LNs may overlook micrometastases. The detection rate of micrometastases can be improved by processing multiple sections from LNs.

scholarly journals Major Vascular Injury During Gynecologic Cancer Surgery

2021 ◽  
pp. 100815
Author(s):  
Andrea L Buras ◽  
Jing Yi Chern ◽  
Hye Sook Chon ◽  
Mian M Shahzad ◽  
Robert M Wenham ◽  
...  
Keyword(s):  
Vascular Injury ◽  
Gynecologic Cancer ◽  
Cancer Surgery ◽  
Major Vascular Injury

scholarly journals The Findings of SPECT/CT Concerning Bypass Lymph Circulation in Lymphedema Following Breast Cancer Surgery

Healthcare ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 471
Author(s):  
Min Young Lee ◽  
Eunjung Kong ◽  
Dong Gyu Lee
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymphatic Drainage ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Node Dissection ◽  
Positive Group

This study aimed to determine whether bypass circulation was present in lymphedema and its effect. This was a retrospective, cross-sectional study. Patients who underwent unilateral breast cancer surgery with axillary lymph node dissection were recruited and underwent single-photon emission tomography/computed tomography (SPECT/CT). SPECT/CT was performed to detect the three-dimensional locations of radio-activated lymph nodes. Patients with radioactivity in anatomical locations other than axillary lymph nodes were classified into a positive group. All patients received complete decongestive therapy (CDT). Exclusion criteria were as follows: History of bilateral breast cancer surgery, cervical lymph node dissection history, and upper extremity amputation. The difference in the upper extremity circumference (cm) was measured at four points: Mid-point of the upper arm, elbow, and 10 and 15 cm below the elbow. Twenty-nine patients were included in this study. Fifteen patients (51.7%) had bypass lymphatic systems on the affected side, six (20.7%) had a bypass lymphatic system with axillary lymph nodes on the unaffected side, and 11 (37.9%) showed new lymphatic drainage. The positive group showed significantly less swelling than the negative group at the mid-arm, elbow, and 15 cm below the elbow. Bypass lymphatic circulation had two patterns: Infraclavicular lymph nodes and supraclavicular and/or cervical lymph nodes. Changes in lymph drainage caused by surgery triggered the activation of the superficial lymphatic drainage system to relieve lymphedema. Superficial lymphatic drainage has a connection through the deltopectoral groove.

scholarly journals Nanoparticles can improve the positive rate of metastatic lymph node in thyroid cancer surgery

2020 ◽  
Author(s):  
Xindi Su ◽  
Fang Chai ◽  
Benrui Lin ◽  
Lu Qu ◽  
Keyi Liu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Metastatic Lymph Node ◽  
Cancer Surgery ◽  
Control Group ◽  
Blood Calcium ◽  
Metastatic Lymph ◽  
Positive Rate ◽  
Experimental Group

Abstract Objective. To investigate the application of carbon nanoparticles in lymph node dissection and parathyroid gland protection during thyroid cancer surgery. Subjects and Methods. Retrospective analysis was performed on 282 cases of thyroid cancer surgery in our hospital from 2018 to 2019. All patients underwent total thyroidectomy and cervical central lymph node dissection. Nanocarbon was not used in the control group, but was used in the experimental group. The general situation of the patients, the number of postoperative lymph nodes and the number of metastasis were collected, and the differences between serum parathyroid hormone and blood calcium were compared before and on the 3rd and 30th day after surgery. Results. There was no difference in age, sex and TNM stage between the two groups (P > 0.05). The number of metastatic lymph nodes in the experimental group (9.80 ± 4.80) was different from that in the control group (6.95 ± 3.86) (P < 0.05), and the number of metastatic lymph nodes in the experimental group was different from that in the control group (χ2 = 14.968, P < 0.05). There was no difference in blood calcium and PTH between the two groups before and at 3 and 30 days after surgery (P > 0. 05). Conclusion. The application of carbon nanoparticles in thyroid cancer surgery can significantly increase the number of lymph nodes seized and the positive rate of metastatic lymph node removal, but the protection of parathyroid gland is not obvious.

scholarly journals Analysis rates of drunk driving accidents and temporal distribution between 2012 and 2016 and risk factors

2019 ◽  
Author(s):  
Mei Shen ◽  
Yue Du ◽  
Hua sheng Zhou
Keyword(s):  
Detection Rate ◽  
Road Traffic ◽  
Temporal Distribution ◽  
Drunk Driving ◽  
Test Results ◽  
Occurrence Time ◽  
Guangzhou City ◽  
The Government ◽  
Medical University ◽  
The Relationship

Abstract Background: This study aimed to understand the temporal distribution characteristics of road traffic collisions and the drunk driving collisions and casualty rates in some districts of Guangzhou city to develop suggestions for prevention of drunk driving. Methods: Data such as test results, casualties, and occurrence time from a total of 4986 traffic collisions reports issued by the Health Laboratory Centre of Southern Medical University between 2012 and 2016 were retrospectively analyzed. Results: Outcome measures included the relationship between the temporal distribution and rate of drunkdriving collisions and casualties. Data from the recent five years indicated that the number of collisions declined yearly, and the detection detection rate of drunk driving increased yearly. Drunk driving collisions mainly occurred during the period from 22:00-04:00 every day. The number of traffic collisions and the detection rate of drunk driving were significantly higher in the nighttime than that in the daytime. Most collisions occurred on Wednesday. The detection rate of drunk driving collisions was high in February, October, November and December, all with a percentage of more than 63%. The casualty rate of collisions that did not involve drunk driving was significantly higher than that of drunk driving collisions. Conclusion: Through the analysis of drunk driving in some districts of Guangzhou, we can control the intensity of drunk driving inspection so as to prevent road traffic collisions caused by drunk driving. At the same time, the government should step up publicity and education on the hazards of drunk driving to reduce the occurrence of drunk driving Road traffic collisions.

scholarly journals Manifestations of Tuberculosis in Ear, Nose, Throat, Head and Neck Region – A Retrospective Study

2020 ◽  
Vol 28 (2) ◽  
pp. 144-150
Author(s):  
Vandana P Thorawade ◽  
S A Jaiswal ◽  
Seema Ramlakhan Gupta
Keyword(s):  
Retrospective Study ◽  
Early Diagnosis ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Salivary Glands ◽  
Neck Region ◽  
Pulmonary Medicine ◽  
Cervical Lymph Nodes ◽  
Head And Neck Region ◽  
Variable Nature

Introduction  Tuberculosis can involve any organ or site. Otorhinolaryngologist may encounter tuberculosis affecting lymph nodes, ear, larynx, deep neck spaces, salivary glands etc. which can mimic other chronic granulomatous conditions or malignancy. To ensure early diagnosis, it is important to recognize its cardinal signs and symptoms and to be aware of potential pitfalls in diagnosis. This study was done to learn the clinical presentation of tuberculosis in ear, nose, throat and head and neck region, and to assess the effectiveness of various investigations and treatment done for the same. Materials and Methods  A retrospective study done in our institution involving 120 patients suffering from tuberculosis in ear, nose, throat and head and neck region who attended pulmonary medicine or ENT OPD or ward between January 2008 to December 2017 that is, 10 years. Study period for data collection and analysis was 1 month. Results Total 120 patients-69 males and 51 females. Most common site was cervical lymph nodes(77.5% patients), followed by larynx(8.3%),middle ear(7.5%),deep neck spaces(2.5%) and salivary glands and nose(1.7% each). Histopathology was highly sensitive(99. 1%).All except one patient responded to first-line antitubercular drugs, the other patient was given treatment for MDR-TB to which he responded. Conclusion Tuberculosis can involve any site in the head and neck region, most common being cervical lymph nodes mainly presenting as neck swelling. Variable nature of manifestations of tuberculosis makes it essential to have high degree of suspicion for early diagnosis.

Radiographic Characterization of Enlarged Sternal Lymph Nodes in 71 Dogs and 13 Cats

2012 ◽  
Vol 48 (3) ◽  
pp. 176-181 ◽  
Author(s):  
Kelli Smith ◽  
Robert O'Brien
Keyword(s):  
Retrospective Study ◽  
Lymph Nodes ◽  
Statistical Difference ◽  
Inflammatory Diseases ◽  
Wide Spectrum ◽  
Etiologic Agent ◽  
Neoplastic Disease ◽  
Clinical Diagnoses ◽  
Average Size

In this retrospective study, radiographically enlarged sternal lymph nodes (LNs) were evaluated in 71 dogs and 13 cats for average size, location, and most representative radiographic view. Concurrent clinical diagnoses were also noted and grouped into one of three following categories: neoplastic, inflammatory, or hematologic. There were no statistically significant differences in LN size between lateral views within each species. Enlarged sternal LNs were more cranially positioned in dogs than cats. No statistical difference was noted between right and left laterals, as to on which projection the enlarged sterna lymph nodes was seen best. Neoplastic disease (78.9%) was the most prevalent condition seen in association with LN enlargement in dogs, followed by primary infectious or inflammatory diseases (14.1%) and various hematologic conditions (7.0%). In cats, neoplasia was also most common (69.2%), followed by inflammatory diseases (30.8%). No hematologic conditions were noted in cats. The most common etiologic agent seen concurrently with enlarged sternal LNs in both dogs (33.8%) and cats (38.5%) was malignant lymphoma. The results of this study provide a clinically useful representation of the average size and location of radiographically enlarged sternal LNs for dogs and cats. The diseases represented demonstrate the wide spectrum of potential causes of sternal lymphadenopathy.

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