Mycobacterium Spindle Cell Pseudotumor Caused by Mycobacterium xenopi: A First Described Association of a Rare Entity Presenting in the Lung

2019 ◽  
Vol 28 (3) ◽  
pp. 316-320 ◽  
Author(s):  
Karina Furlan ◽  
Prih Rohra ◽  
Fatima Mir ◽  
Shenon Sethi ◽  
Abdullah Almajnooni ◽  
...  
Keyword(s):  
Spindle Cell ◽  
English Literature ◽  
Benign Lesion ◽  
Lower Lobe ◽  
Immunocompromised Patients ◽  
Rare Entity ◽  
Rare Form ◽  
Female Status ◽  
Mycobacterium Xenopi ◽  
Granulomatous Formation

Mycobacterial spindle cell pseudotumor (MSP) is a rare benign lesion characterized by a proliferation of bland spindle-shaped histiocytes with vague granulomatous formation, positive for acid-fast bacilli staining. This lesion is usually reported in the lymph nodes and skin of immunocompromised patients; only 6 cases primary in the lung have been reported in the English literature to this date. In this article, we present the case of a 42-year-old female status post failed kidney-pancreas transplant with subsequent multiple kidney transplants, on chronic immunosuppression, who developed a mass in the left lower lobe consistent with MSP. Mycobacterium xenopi was identified in lung tissue culture, an association never previously described in literature. This case report alerts for the possible association of this rare form of non-tuberculous mycobacteria in the pathogenesis of MSP and highlights the importance of this differential diagnosis in lung masses of immunocompromised patients.

Fetiform Teratoma (Homunculus)

2006 ◽  
Vol 130 (10) ◽  
pp. 1552-1556
Author(s):  
Jason R. Weiss ◽  
Jeanette R. Burgess ◽  
Keith J. Kaplan
Keyword(s):  
Ectopic Pregnancy ◽  
English Language ◽  
English Literature ◽  
Chief Complaint ◽  
Ovarian Teratoma ◽  
Rare Entity ◽  
Rare Form ◽  
Fetus In Fetu ◽  
Fetiform Teratoma ◽  
Language Literature

Abstract Fetiform teratoma (homunculus) is a term that has been given to a rare form of ovarian teratoma that resembles a malformed fetus. There are very few reported cases of this entity in the English language literature. In this report, we document a case of fetiform teratoma in a 23-year-old woman, gravida 0, who initially presented with a chief complaint of dyspareunia. The clinical and pathologic aspects of this rare entity are presented here, with a review of the English literature. Differentiating fetiform teratoma from the more highly developed fetus-in-fetu and ectopic pregnancy is also discussed.

scholarly journals Gastrointestinal Stromal Tumor of the Ampulla of Vater: A Narrative Review

2021 ◽  
pp. 1-6
Author(s):  
Bita Geramizadeh ◽  
Alireza Shojazadeh
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Spindle Cell ◽  
English Literature ◽  
Ampulla Of Vater ◽  
Good Prognosis ◽  
Stromal Tumor ◽  
Treatment Modalities ◽  
Histologic Diagnosis ◽  
Lower Gi Bleeding ◽  
Mitotic Figures

<b><i>Background:</i></b> Gastrointestinal stromal tumor (GIST) of the ampulla of Vater is a rare occurrence. To the best of our knowledge, there has been no published review on this rare tumor in the English literature so far. <b><i>Summary:</i></b> In this review, we will discuss all the reported details of the published cases, including demography, clinical presentation, imaging, gross pathology and histopathology, immunohistochemical findings, treatment modalities, and outcome of cases with the diagnosis GIST from the ampulla of Vater in the last 20 years. <b><i>Key Message:</i></b> Twenty-five cases of GIST in the ampulla of Vater have been reported in the last 20 years in the English literature. GIST in the ampulla of Vater are usually small tumors (&#x3c;5 cm) in middle-age patients. The majority of the patients present with lower GI bleeding and abdominal pain. Imaging findings are not characteristic, and most of the patients without biopsy and with no histologic diagnosis were operated with the primary impression of adenocarcinoma, neuroendocrine tumor, and GIST. Perioperative tissue biopsy has been accurate in &#x3c;70% of the cases. The majority of the reported cases of GISTs in the ampulla of Vater have been low risk with spindle-cell morphology, low mitotic figures, and minimal atypia; reactive for C-KIT and DOG-1; and nonreactive for SMA, desmin, and S100. In the majority of the cases, duodenectomy with or without Whipple’s operation has been performed, and most of the cases showed good prognosis.

Spindle Cell Carcinoma in a Young Man: A Case Report of a Rare Entity

2015 ◽  
Vol 120 (2) ◽  
pp. e27
Author(s):  
ROSEANE CARVALHO VASCONCELOS ◽  
LUCIANA ELOISA DA SILVA CASTRO NÓBREGA ◽  
VIVIANE ALVES DE OLIVEIRA MAIA ◽  
EDILMAR DE MOURA SANTOS ◽  
VICTOR DINIZ BORBOREMA DOS SANTOS ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Rare Entity

Sarcomatoid Carcinoma of the Small Intestine: A Case Report and Review of the Literature

2004 ◽  
Vol 128 (8) ◽  
pp. 918-921
Author(s):  
Michelle Reid-Nicholson ◽  
Muhammed Idrees ◽  
Giorgio Perino ◽  
Prodromos Hytiroglou
Keyword(s):  
Small Bowel ◽  
Epithelial Membrane Antigen ◽  
Spindle Cell ◽  
English Literature ◽  
Sarcomatoid Carcinoma ◽  
Giant Cells ◽  
Intestinal Wall ◽  
Cytokeratin 20 ◽  
Spindle Cells ◽  
Immunohistochemical Stains

Abstract Sarcomatoid carcinoma of the small bowel is rare; to our knowledge, 19 cases have been reported to date in the English literature under several names. We report an additional case occurring in the jejunum of a 55-year-old man. The tumor was a polypoid 7.5-cm mass, which infiltrated the full thickness of the intestinal wall and the serosa of an adhesed loop of small bowel. On microscopic examination, the neoplasm was composed of sheets of spindle cells; focally, an anaplastic component was present, including tumor giant cells with bizarre nuclei. On immunohistochemical stains, tumor cells were positive for cytokeratin 7, cytokeratin AE1/AE3, vimentin, and focally, epithelial membrane antigen. No staining for cytokeratin 20 was found. Sarcomatoid carcinoma must be kept in mind in the differential diagnosis of malignant spindle cell tumors of the small bowel. As consensus regarding the terminology of these rare tumors is being reached, immunohistochemical stains are essential for accurate diagnosis.

Pancreatic Carcinosarcoma with a Rare Presentation

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S65-S66
Author(s):  
J Khan ◽  
S Guo
Keyword(s):  
Spindle Cell ◽  
Sarcomatoid Carcinoma ◽  
World Health ◽  
Rare Entity ◽  
Cell Component ◽  
Rare Presentation ◽  
Term Survival ◽  
Cytoplasmic Staining ◽  
Spindle Cell Component ◽  
Head Of The Pancreas

Abstract Introduction/Objective Carcino-sarcoma of the pancreas is a rare tumor and very limited clinical and pathologic data have been reported in the literature. As per World Health Organization (WHO) classification of tumors of the digestive system, the carcinosarcoma of the pancreas is classified together with sarcomatoid carcinoma and anaplastic giant cell carcinomas in undifferentiated carcinoma of pancreas. Carcinosarcoma is a rare entity with very poor prognosis. Methods/Case Report Here we report a rare case of pancreatic carcinosarcoma in a 68 year old male patient who underwent a pancreatoduodenectomy for unilocular cystic mass in the head of the pancreas. The mass grossly replaces the whole head of the pancreas. Histologically, the lesion showed a high-grade spindle cell component and adjacent moderately differentiated adenocarcinoma. On immunohistochemical examination, the carcinomatous component was positive for epithelial markers, and the sarcomatous component was positive for DOG1 and had a focal cytoplasmic staining for S-100. The diagnosis of pancreatic carcinosarcoma was rendered. Treatment options are same as of pancreatic carcinoma. Surgical resection is the best option available for patients. Systemic chemotherapy is indicated for patients with distant metastasis or patients with other contraindications. Despite surgery and adjuvant chemotherapy, recurrence rates are high, and prognosis is poor. However, there are no relevant standard chemotherapies available. Based on the limited number of reported cases, the prognosis of carcinosarcoma of the pancreas appears to be poor. But some cases with long term survival have been reported. There are very few primary pancreatic neoplasms with carcinomatous and sarcomatous components reported in the current literature. Results (if a Case Study enter NA) NA Conclusion This case highlights the importance of familiarity with histopathology of this rare entity, and to order proper immunohistochemical and molecular work-up when there is a suspicious abnormal spindle cell component.

scholarly journals Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Ryan Leibrandt ◽  
Kenneth Angelino ◽  
Monique Vizel-Schwartz ◽  
Ilan Shapira
Keyword(s):  
Respiratory Syncytial Virus ◽  
Upper Respiratory Tract ◽  
Rare Entity ◽  
Rare Form ◽  
Cold Temperatures ◽  
Tertiary Syphilis ◽  
Life Threatening ◽  
Upper Respiratory ◽  
Syncytial Virus ◽  
Paroxysmal Cold Hemoglobinuria

Paroxysmal cold hemoglobinuria (PCH) is a rare form of cold autoimmune hemolytic anemia first discovered in the early 20th century in adults with tertiary syphilis. Today, it is more commonly seen in children as a life-threatening anemia during a viral upper respiratory tract infection (URI). Although respiratory syncytial virus (RSV) has previously been reported to cause PCH in a child, herein we present the first documented case in an adult. The Donath–Landsteiner (DL) test, the diagnostic test for PCH, was positive on two separate occasions. The patient was treated successfully with warming and avoidance of cold temperatures. To facilitate identification of this rare entity by clinicians, we include a discussion about the pathophysiology, diagnosis, and treatment of PCH.

scholarly journals Acquired smooth muscle hamartoma: A case report on the lower extremity with hidrosis

2019 ◽  
Vol 7 ◽  
pp. 2050313X1989383
Author(s):  
Malika A Ladha ◽  
Todd Remington
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Lower Extremity ◽  
Smooth Muscle Cells ◽  
English Literature ◽  
Surgical Excision ◽  
Muscle Cells ◽  
Clinical Spectrum ◽  
Rare Entity ◽  
First Case

Smooth muscle hamartomas are benign dermal proliferations of smooth muscle cells. Smooth muscle hamartomas are sub-divided into congenital or acquired; the latter is a rare entity with less than 20 cases being reported in the English literature. Most often asymptomatic, acquired smooth muscle hamartomas follow an indolent course. Treatment in the form of surgical excision can be utilized for symptomatic or cosmetic purposes. Here, we report the first case of an acquired smooth muscle hamartomas of the shin which also uniquely presented with hidrosis. This case highlights the varied clinical spectrum of acquired smooth muscle hamartomas.

Spindle Cell Lipomas of the Respiratory Tract: A Case Report and Comprehensive Literature Review

2019 ◽  
Vol 128 (11) ◽  
pp. 1086-1091 ◽  
Author(s):  
Jonathan Reid ◽  
Bret Wehrli ◽  
Leigh J. Sowerby
Keyword(s):  
Literature Review ◽  
Oral Cavity ◽  
Respiratory Tract ◽  
Spindle Cell ◽  
Case Reports ◽  
English Literature ◽  
Good Prognosis ◽  
Benign Tumors ◽  
Common Location ◽  
Literature Reviews

Background: Spindle cell lipomas (SCLs) are benign tumors that are characteristically present on the upper back and neck, but in rare cases present throughout the respiratory mucosa, causing hoarseness, stridor, dyspnea, and obstruction. Objective: To highlight the importance of considering SCL in the diagnosis of benign respiratory tract tumors, a literature review identified all published cases of respiratory tract SCLs, including 2 from our institution: one case in the nasopharynx and 1 in the nasal valve. Methods: All case reports, series and literature reviews from the English literature from 1975 through March 2018 were systematically identified for review in the MEDLINE, EMBASE, and Scopus databases. Two additional cases from our institution were described. Results: In total, 24 cases of SCL in the respiratory tract were identified for review. Two cases from our institution are described here, bringing the total of reported cases to 26. Extensive analyses of oral cavity SCLs already exist, so we excluded this site from our review and focused on sites where SCLs may present with respiratory symptoms. Excluding the oral cavity and oropharynx, the most common location described is the larynx. All 26 cases were treated with excision. One tumor required a second surgery, but there were no other complications nor recurrences. Conclusion: Although rare, SCLs may arise from throughout the respiratory tract and cause dyspnea, hoarseness and stridor. Spindle cell lipoma should be considered in the differential diagnosis of a respiratory tract mass. This diagnosis confers a good prognosis and patients may be reassured that surgery is almost always curative.

Solitary Fibrous Tumor of the Parapharyngeal Space: A Case Report and Review of the Literature

1996 ◽  
Vol 75 (10) ◽  
pp. 681-684 ◽  
Author(s):  
Kunal Gangopadhyay ◽  
Khalid Taibah ◽  
M. Babu Manohar ◽  
Hala Kfoury
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Solitary Fibrous Tumor ◽  
Spindle Cell ◽  
Parapharyngeal Space ◽  
English Literature ◽  
Review Of The Literature ◽  
Solitary Fibrous Tumors ◽  
Rare Location ◽  
Fibrous Tumor

Solitary fibrous tumors are uncommon spindle cell neoplasms generally associated with serosal surfaces, especially the pleura. Recently, these tumors have been documented in a number of extrapleural sites including the head and neck. So far only two cases of parapharyngeal solitary fibrous tumor have been reported in the English literature. Rare location of an uncommon lesion often gives rise to difficulty in diagnosis or to misdiagnosis. In both the previously reported cases, as well as in our case, the diagnosis of solitary fibrous tumor was not made until the excised tumor was subjected to histopathology and immunohistochemistry.

scholarly journals Primary Pulmonary Malignant Melanoma: Report of an Important Entity and Literature Review

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Christos Kyriakopoulos ◽  
George Zarkavelis ◽  
Artemis Andrianopoulou ◽  
Alexandra Papoudou-Bai ◽  
Dimitrios Stefanou ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
English Literature ◽  
Detailed Examination ◽  
Published Data ◽  
Radiographic Imaging ◽  
Rare Entity ◽  
Extensive Review ◽  
Review Of The Literature ◽  
Primary Tumors ◽  
Intracranial Metastases

Malignant melanoma involving the respiratory tract is nearly always metastatic in origin, and primary tumors are extremely rare. Published data on primary pulmonary malignant melanomas are limited. Up to now 40 relevant cases have been reported in the English literature. Herein, we report a case of a 56-year-old female patient who presented with intracranial metastases due to primary pulmonary melanoma. She underwent bronchoscopy and died 5 months after the initial diagnosis despite the administered biochemotherapy and subsequent immunotherapy. To establish the diagnosis of primary pulmonary malignant melanoma, any extrapulmonary origin was excluded by detailed examination and radiographic imaging. Moreover, an extensive review of the literature regarding this rare entity has been performed.

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