scholarly journals The Role of Diagnosis and Treatment of Underlying Liver Disease for the Prognosis of Primary Liver Cancer

2017 ◽  
Vol 24 (3) ◽  
pp. 107327481772924 ◽  
Author(s):  
Ashok Shiani ◽  
Shreya Narayanan ◽  
Luis Pena ◽  
Mark Friedman
Keyword(s):  
Liver Disease ◽  
Liver Cancer ◽  
Primary Liver Cancer ◽  
Diagnosis And Treatment ◽  
Underlying Liver Disease

scholarly journals Increased Porphyrins in Primary Liver Cancer Mainly Reflect a Parallel Liver Disease

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Jerzy Kaczynski ◽  
Göran Hansson ◽  
Sven Wallerstedt
Keyword(s):  
Liver Disease ◽  
Liver Cancer ◽  
Aminolevulinic Acid ◽  
Primary Liver Cancer ◽  
Clinical Signs ◽  
Liver Disorder ◽  
Liver Disorders ◽  
Increased Risk ◽  
History Of

Hepatic porphyries have been associated with an increased risk of primary liver cancer (PLC), which on the other hand may cause an increased porphyrin production. To evaluate the role of an underlying liver disorder we analyzed porphyrins in patients with hepatocellular carcinoma (HCC)(n=65), cholangiocellular carcinoma(n=3), or suspected PLC, which turned out to be metastases(n=18)or a benign disorder(n=11). None of the patients had a family history of porphyry or clinical signs of porphyry. Increased aminolevulinic acid or porphyrin values were common not only in patients with PLC (43%) but also in metastatic (50%) and benign (64%) liver disorders. The corresponding proportion for HCC patients with liver cirrhosis (55%) was higher(P<.05)than in those without cirrhosis (17%). We conclude that symptomatic porphyries are unusual in PLC, whereas elevated urinary and/or faecal porphyrins are common, primarily reflecting a parallel liver disease and not the PLC.

scholarly journals Natural Killer–Dendritic Cell Interactions in Liver Cancer: Implications for Immunotherapy

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2184
Author(s):  
Valentina Cazzetta ◽  
Sara Franzese ◽  
Claudia Carenza ◽  
Silvia Della Bella ◽  
Joanna Mikulak ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Immune Responses ◽  
Nk Cells ◽  
Natural Killer ◽  
Tumor Cells ◽  
Primary Liver Cancer ◽  
Circulating Antigens ◽  
Direct Cytotoxicity ◽  
Immune Changes

Natural killer (NK) and dendritic cells (DCs) are innate immune cells that play a crucial role in anti-tumor immunity. NK cells kill tumor cells through direct cytotoxicity and cytokine secretion. DCs are needed for the activation of adaptive immune responses against tumor cells. Both NK cells and DCs are subdivided in several subsets endowed with specialized effector functions. Crosstalk between NK cells and DCs leads to the reciprocal control of their activation and polarization of immune responses. In this review, we describe the role of NK cells and DCs in liver cancer, focusing on the mechanisms involved in their reciprocal control and activation. In this context, intrahepatic NK cells and DCs present unique immunological features, due to the constant exposure to non-self-circulating antigens. These interactions might play a fundamental role in the pathology of primary liver cancer, namely hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Additionally, the implications of these immune changes are relevant from the perspective of improving the cancer immunotherapy strategies in HCC and ICC patients.

scholarly journals Oncogenic role of the Notch pathway in primary liver cancer

2016 ◽  
Vol 12 (1) ◽  
pp. 3-10 ◽  
Author(s):  
JIE LU ◽  
YUJING XIA ◽  
KAN CHEN ◽  
YUANYUAN ZHENG ◽  
JIANRONG WANG ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Primary Liver Cancer ◽  
Notch Pathway

THU-473-Role of intracellular lysyl oxidase in progression of primary liver cancer

2019 ◽  
Vol 70 (1) ◽  
pp. e368
Author(s):  
Monika Lewinska ◽  
Deepak Kumar Bhatt ◽  
Letizia Satriano ◽  
Douglas VNP Oliveira ◽  
Friederike Mahn ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Lysyl Oxidase ◽  
Primary Liver Cancer

scholarly journals Neutrophils in liver diseases: pathogenesis and therapeutic targets

2020 ◽  
Vol 18 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Kai Liu ◽  
Fu-Sheng Wang ◽  
Ruonan Xu
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Liver Cancer ◽  
Immune Regulation ◽  
Liver Diseases ◽  
Immune Modulation ◽  
Functional Plasticity ◽  
Homogeneous Population ◽  
Patients With Cancer

AbstractPreviously, it was assumed that peripheral neutrophils are a homogeneous population that displays antimicrobial functions. However, recent data have revealed that neutrophils are heterogeneous and are additionally involved in tissue damage and immune regulation. The phenotypic and functional plasticity of neutrophils has been identified in patients with cancer, inflammatory disorders, infections, and other diseases. Currently, neutrophils, with their autocrine, paracrine, and immune modulation functions, have been shown to be involved in liver diseases, including viral hepatitis, nonalcoholic steatohepatitis, alcoholic liver disease, liver fibrosis, cirrhosis, liver failure, and liver cancer. Accordingly, this review summarizes the role of neutrophils in liver diseases.

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