Real-life adherence in capecitabine therapy using two analysis methods and persistence after 6 months of treatment

2020 ◽  
pp. 107815522094963
Author(s):  
Fiorenzo Santoleri ◽  
Alessia Romagnoli ◽  
Alberto Costantini
Keyword(s):  
Adverse Reactions ◽  
Real Life ◽  
Study Drug ◽  
Cross Sectional Study ◽  
Perceived Quality ◽  
Sectional Study ◽  
Adherence To Treatment ◽  
Calculation Methods ◽  
Cross Sectional ◽  
Pharmacy Refill

Medication adherence in the field of Oncology is crucial in therapy management and can influence the probability of achieving and maintaining efficacy over time. We conducted a cross-sectional study to evaluate adherence and persistence to oral therapy with Capecitabine, using two different calculation methods: therapy diary and indirect prescription refilling patterns. The main objective of the study was to compare the two methods of analysis and to propose a reliable adherence datum, yielded by the application of two complementary methodologies. We consequently set out to verify if data collected from therapy diaries can be superimposed to those gathered from prescription refilling patterns. Furthermore, we included data on patient-perceived quality in relation to Capecitabine therapy, as well as adverse reactions and their duration. Of 594 patients who used the study drug as of January 1, 2012, 45 completed their therapy diary. Adherence to treatment was 0.93 ± 0.10 and 0.84 ± 0.15, calculated using therapy diaries and pharmacy refill data, respectively. In terms of persistence, 53% of patients continued with treatment after six months of therapy. On a 1 to 5 scale, perceived quality was 3.31. In conclusion, when it comes to calculating adherence, it is important to preserve the objectivity of the method, which must be unencumbered by any conditioning. Regardless of the method, also considering what has already been discussed in the available literature, adherence in patients under treatment with Capecitabine, unlike persistence, is good.

scholarly journals Perceived quality of surgical care in association with patient-related factors and correlation to reported postoperative complications in Finland: a cross-sectional study

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e037708
Author(s):  
Ira Helena Saarinen ◽  
Jaana-Maija Koivisto ◽  
Antti Kaipia ◽  
Elina Haavisto
Keyword(s):  
Quality Of Care ◽  
Postoperative Complications ◽  
Cross Sectional Study ◽  
Perceived Quality ◽  
Living Alone ◽  
Sectional Study ◽  
Related Factors ◽  
Cross Sectional ◽  
Perceived Quality Of Care

ObjectiveTo study if patient-related factors are associated with patient-evaluated quality of care in surgery. To examine if there is an association with postoperative complications and patient-evaluated low quality of care.DesignA correlation cross-sectional study, in addition, a phone call interview at 30 days postoperatively to examine complications.SettingThe data on patients admitted for non-cardiac general and orthopaedic surgery at a central hospital in Southwestern Finland were collected in two phases during an 8-month period.Participants436 consecutive consenting and eligible in-ward non-cardiac general surgery and orthopaedic surgery adult patients. Ambulatory, paediatric and memory disorder patients were excluded. 378 patients completed the questionnaire (Good Nursing Care Scale for Patients (GNCS-P)).MethodsPerceived quality of care was examined by the GNCS-P questionnaire. Patient-related factors were obtained from electronic patient records and questionnaire. A telephone interview related to postdischarge complications was conducted 30 days after discharge.Main outcome measuresPatient evaluation of quality of care at discharge, its association with patient-related factors and patient-reported postdischarge complications.ResultsThe overall quality was evaluated high or very high by the patients. The lowest overall quality of care rate was assessed by surgical patients living alone (p=0.0088) and patients who evaluated their state of health moderate or poor (p=0.0047). Surgical patients reporting postoperative complications after discharge evaluated lower overall quality of care (p=0.0105) than patients with no complications.ConclusionPatient demographic factors do not seem to influence the perceptions of the quality of care. Instead, subjective state of health and living conditions (living alone) may have an influence on the patient experience of quality of care. The perceived quality of care in healthcare staff technical and communication skills may have an association with reported postoperative complications.

Compliance and Adherence to Treatment in Hypertensive Patients in different Tertiary Care Hospitals in Lahore

2021 ◽  
Vol 15 (8) ◽  
pp. 1858-1860
Author(s):  
Junaid Mushtaq ◽  
Israr-Ul- Haq ◽  
Waqas Mahmood ◽  
Mujtaba H. Siddiqui ◽  
Atiq Ahmad ◽  
...  
Keyword(s):  
Medical Center ◽  
Tertiary Care ◽  
Educational Status ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Adherence To Treatment ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Hospital Doctors ◽  
Tertiary Care Hospitals

Aim: To determine the factors that affect compliance and adherence to medications of hypertensive patients visiting OPD clinics. Study design: Descriptive-cross sectional study. Place and duration of study: Department of Medicine, Unit 1, Lahore General Hospital, Doctors Hospital & Medical Center and Farooq Hospital Lahore from 1st January 2019 to 31st December 2019. Methodology: One hundred and sixty five patients with hypertension were handed over questionnaire socio-demographic, compliance and adherence were recorded. Results: Patients who maintained BP charting were only 13(7.9%) and those without BP charting were 152(92.1%). Patients taking regular medications were only 20(12.1%). Forgetfulness in taking medications was found in 47.3% of patients. 20.6% of patients were unable to purchase medicines because of financial reasons. Thirty two patients (19.4%) thought that they should not take medicines as they were not having any symptoms. Conclusion: Major causes of non-adherence were expense of medications, lack of symptoms, lack of money, forgetfulness, lack of awareness due to poor educational status and nature of job. Keywords: Compliance, Adherence, Medications, Hypertension, Forgetfulness

scholarly journals Compliance to albendazole therapy under national deworming day programme at schools in Goa: a questionnaire survey

2017 ◽  
Vol 4 (9) ◽  
pp. 3302
Author(s):  
Nitin Y. Dhupdale ◽  
Jagdish A. Cacodcar ◽  
Purushottam A. Giri ◽  
Vijay S. ◽  
Akshaya Naik
Keyword(s):  
Side Effects ◽  
School Children ◽  
Questionnaire Survey ◽  
Adverse Reactions ◽  
Cross Sectional Study ◽  
Family Welfare ◽  
Sectional Study ◽  
Ministry Of Health ◽  
Cross Sectional ◽  
Self Administered Questionnaire

Background: Ministry of Health and Family Welfare, Government of India observed National Deworming Day (NDD) on February 10, 2016 and second round on August 10, 2016 in all 36 States/UTs of the country. The same initiative was implemented in the state of Goa; the present study was aimed at evaluating this initiative. The objectives of the study were to find the compliance of school children to albendazole tablets and also to find any side effects encountered by the students.Methods: A cross-sectional study was conducted in month of Ocober 2016 amongst total of 266 parents completed a self-administered questionnaire. The Data retrieved from completed questionnaires was entered in EpiDATA and analysed by SPSS version 23. Results: Of the total 65.8% of students received albendazole tablets. The overall compliance to the albendazole was 61.3%. Only 4.1% of students developed minor adverse reactions. Overall 78.9% of the parents were willing to participate in the next round of NDD.Conclusions: The compliance to the albendazole was less than expected. There is a greater need to involve parents and teachers to improve the compliance of students towards albendazole to achieve desired outcomes. 

Clinical Profile of Young Patients with Erectile Dysfunction: Preliminary Findings of a Real-life Cross-sectional Study

2020 ◽  
Vol 6 (1) ◽  
pp. 184-189 ◽  
Author(s):  
Edoardo Pozzi ◽  
Paolo Capogrosso ◽  
Francesco Chierigo ◽  
Filippo Pederzoli ◽  
Eugenio Ventimiglia ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Real Life ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Clinical Profile ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Cross-sectional study of internalised stigma and medication adherence in patients with obsessive compulsive disorder

2020 ◽  
Vol 33 (2) ◽  
pp. e100180
Author(s):  
Eram Ansari ◽  
Sudha Mishra ◽  
Adarsh Tripathi ◽  
Sujita Kumar Kar ◽  
Pronob Kumar Dalal
Keyword(s):  
Medication Adherence ◽  
Obsessive Compulsive Disorder ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Adherence To Treatment ◽  
Obsessive Compulsive ◽  
Cross Sectional ◽  
Compulsive Disorder ◽  
Current Medication

BackgroundPatients suffering from psychiatric disorders tend to stigmatise themselves which had been linked to poor adherence to treatment.AimsThe aim of the present study was to study internalised stigma and medication adherence and to assess the relationship between them in patients with obsessive compulsive disorder (OCD).MethodsA cross-sectional study was conducted on 112 patients diagnosed with OCD who were attending the Out-patient's department at Department of Psychiatry of a tertiary care hospital in North India. Internalised stigma and current medication adherence were assessed with Internalized Stigma of Mental Illness Scale (ISMI) and Medication Adherence Rating Scale, respectively. Yale-Brown Obsessive Compulsive Scale was used to assess the current severity of OCD symptoms. Sociodemographic and clinical details were also obtained from the patients by using a semistructured sociodemographic proforma.ResultsMost of the patients reported moderate level of internalised stigma with a mean ISMI score of 77.98 (10.82). Most of the patients were compliant while 41.96% reported poor medication adherence. Internalised stigma was negatively correlated with the current medication adherence. Current severity of OCD symptoms also showed a significant positive correlation with internalised stigma and a significant negative correlation with medication adherence.ConclusionHigh levels of internalised stigma were associated with lower adherence to treatment which suggests that internalised stigma may be a very important factor influencing medication adherence in patients with OCD.

scholarly journals The impact of semen infections over sperm parameters in primary infertile men - results from a real life, cross-sectional study

2018 ◽  
Vol 110 (4) ◽  
pp. e299
Author(s):  
F. Pederzoli ◽  
E. Ventimiglia ◽  
P. Capogrosso ◽  
L. Boeri ◽  
W. Cazzaniga ◽  
...  
Keyword(s):  
Real Life ◽  
Cross Sectional Study ◽  
Sperm Parameters ◽  
Sectional Study ◽  
Cross Sectional ◽  
Infertile Men ◽  
The Impact

Factors Associated With the Quality of Life of Patients With Venous Leg Ulcers in Primary Care: Cross-Sectional Study

2020 ◽  
pp. 153473462096756
Author(s):  
Carmen Folguera-Álvarez ◽  
Sofia Garrido-Elustondo ◽  
Milagros Rico-Blázquez ◽  
José Verdú-Soriano
Keyword(s):  
Quality Of Life ◽  
Primary Care ◽  
Cross Sectional Study ◽  
Perceived Quality ◽  
T Test ◽  
Leg Ulcers ◽  
Sectional Study ◽  
Cross Sectional ◽  
Perceived Quality Of Life

The presence of venous leg ulcers (VLU) is associated with emotional disorders in individuals who have conditions, such as depression, anxiety, and sleeping problems, which result in a reduced perceived quality of life by these individuals. The study aim was to describe the perceived quality of life and associated factors for individuals with VLU. We conducted a cross-sectional study in 22 primary care health centers with a sample of 93 individuals with VLU. The variables collected were the following: perceived quality of life measured with Spanish version of the Charing Cross Venous Ulcer Questionnaire (CCVUQ-e), ulcer severity measured with the RESVECH 2.0 Score, demographic variables, and those related to the healing process. The results showed a mean CCVUQ-e score of 47.4 ± 11.8 points (Mean ± SD), with the most affected dimension being the emotional status, followed by cosmesis, social interaction, and domestic activities. The mean RESVECH 2.0 score was 11.1 ± 3.7 points. An association was found between ulcer-related pain and poorer quality of life ( P < .05, t test) and between erythema in perilesional skin and poorer quality life ( P < .05, t test). The signs of infection and inflammation in the VLUs were as follows: increasing exudate, friable tissue, and biofilm-compatible tissue, which were associated with a poorer quality of life ( P < .05, t test). The multivariate model was statistically significant and explained a variability of 26% in the CCVUQ-e score. This study confirms that wound severity, pain, and signs of infection in VLU decrease the perceived quality of life of individuals with these wounds.

Self-Stigma and adherence to medication in patients with psychotic disorders – cross-sectional study

2016 ◽  
Vol 33 (S1) ◽  
pp. s265-s265 ◽  
Author(s):  
K. Vrbova ◽  
D. Kamaradova ◽  
K. Latalova ◽  
M. Ociskova ◽  
J. Prasko ◽  
...  
Keyword(s):  
Psychotic Disorders ◽  
Demographic Data ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
Social Adaptation ◽  
Sectional Study ◽  
Adherence To Treatment ◽  
Cross Sectional ◽  
Illness Onset ◽  
Adherence To Medication

IntroductionAdherence to treatment of mental disorders is one of the key factors influencing its success and, secondarily, the patients’ quality of life and social adaptation.AimsThe cross-sectional study of 90 outpatients diagnosed with psychotic disorders aimed at determining if there was a relationship between discontinuation of medication in the past, current adherence to treatment and self-stigma.MethodsThe assessment was made with the objective and subjective Clinical Global Impression – Severity scale, Drug Attitude Inventory, Internalized Stigma of Mental Illness (ISMI) scale and demographic data.ResultsThe questionnaires were filled out by 79 patients, of whom 5 handed in incomplete questionnaires. Complete sets of data were obtained from 74 patients. The data analysis showed that the levels of self-stigma as assessed by the total ISMI scores was not statistically significantly correlated with most of the demographic factors (age, age of illness onset, gender, education, marital status, employment, duration of the illness, number of hospitalizations and antipsychotic dosage). However, there was a significant negative correlation with current adherence to treatment.ConclusionsAdherence to treatment is one of the most important prerequisites for successful therapy. Adherence may be enhanced through better motivation and education of patients on the necessity of adhering to treatment recommendations and the consequences of non-adherent behavior. Important factors in adherence also seem to be patients’ stigmatization and self-stigma. Adherence may be increased by promising self-stigma-reducing strategies performed by systematic psychoeducation of patients or as a part of psychotherapeutic counseling.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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