Successful Management of Massive Air Embolism During Cardiopulmonary Bypass Using Multimodal Neuroprotection Strategies

2018 ◽  
Vol 23 (3) ◽  
pp. 324-332 ◽  
Author(s):  
Olga L. Quintero ◽  
Juan C. Giraldo ◽  
Néstor F. Sandoval

Complications and critical events during cardiopulmonary bypass (CPB) are very challenging, difficult to manage, and in some instances have the potential to lead to fatal outcomes. Massive cerebral air embolism is undoubtedly a feared complication during CPB. If not diagnosed and managed early, its effects are devastating and even fatal. It is a catastrophic complication and its early diagnosis and intraoperative management are still controversial. This is why the decision-making process during a massive cerebral air embolism represents a challenge for the entire surgical, anesthetic, and perfusion team. All caregivers involved in this event must synchronize their responses quickly, harmoniously, and in such a way that all interventions lead to minimizing the impact of this complication. Its occurrence leaves important lessons to the surgical team that faces it. The best management strategy for a complication of this type is prevention. Nevertheless, a surgical team may ultimately be confronted with such an occurrence at some point despite all the prevention strategies, as was the case with our patient. That is why, in each institution, no effort should be spared to establish cost-effective strategies for early detection and a clear and concise management protocol to guide actions once this complication is detected. It is the duty of each surgical team to determine and clearly organize which strategies will be followed. The purpose of this case study was to demonstrate that a massive air embolism can be rapidly detected using near-infrared spectroscopy monitoring and can be successfully corrected with a multimodal neuroprotection strategy.

2006 ◽  
Vol 104 (4) ◽  
pp. 770-776 ◽  
Author(s):  
Bettina Jungwirth ◽  
M Lucia Gordan ◽  
Manfred Blobner ◽  
Wolfgang Schmehl ◽  
Eberhard F. Kochs ◽  
...  

Background The neuroprotective properties of xenon may improve cerebral outcome after cardiac surgery using cardiopulmonary bypass (CPB). However, its disposition to expand gaseous bubbles that during CPB present as cerebral air emboli (CAE) could abolish any beneficial effect or even worsen cerebral outcome. Therefore, the authors studied the impact of xenon on neurologic, cognitive, and histologic outcome after CPB combined with CAE in rats. Methods With institutional review board approval, 40 rats were assigned to four groups (n = 10). In two CPB-CAE groups, rats were subjected to 90 min of normothermic CPB with 10 repetitively administered CAEs (0.3 microl/bolus). Rats in two sham groups were not exposed to CPB and CAE. Groups were further subdivided into xenon (56%; 20 min before, during, and 30 min after CPB) and nitrogen groups. Neurologic and cognitive function was tested until postoperative day 14, when cerebral infarct volumes were determined. Results Animals of the CPB-CAE groups showed transient deficits in gross neurologic function. Further, rats of the CPB-CAE-xenon group demonstrated impaired fine motor and cognitive performance persisting until postoperative day 14. Consistently, infarct volumes were larger in the CPB-CAE-xenon group compared with the CPB-CAE-nitrogen group (P = 0.03). Conclusions This is the first demonstration in which the neurologic effects of CAE have been examined in a rat model of CPB. Xenon exposure aggravated the neurologic dysfunction that is produced by CAE during CPB; potential neuroprotective effects of xenon may have been masked by the effects of xenon on CAE.


2014 ◽  
Vol 05 (03) ◽  
pp. 114-115
Author(s):  
Ajay B. Jhaveri ◽  
Sharad C. Shah ◽  
Prasanna S. Shah

AbstractNeurological complications of gastrointestinal endoscopy are extremely rare; cerebral air embolism has been described and can be severe and fatal. A high index of suspicion for an air embolism is a must in case of procedural or periprocedural cardiopulmonary instability and neurologic symptoms, particularly in patients with recognized risk factors. The diagnosis of an air embolism is often difficult and is complicated by the fact that air may be rapidly absorbed from the circulation. Simple maneuvers to decrease the impact of a potential air embolism include; stopping the procedure, administering high flow 100% oxygen, placing the patient in Trendelenburg and left lateral decubitus position, and discontinuing nitrous oxide. C T Scan and 2 D ECHO are important diagnostic tests.


2019 ◽  
Vol 3 (4) ◽  
pp. 1120-1136
Author(s):  
B Jewell Bohlinger

Over the past 30 years the U.S. prison population has exploded. With the impact of climate change already here, we are also seeing new critiques of mass incarceration emerge, namely their environmental impact. In response to these burgeoning critiques as well as calls to action by the Justice Department to implement more sustainable and cost-effective strategies in prisons, the United States is experiencing a surge in prison sustainability programs throughout the country. Although sustainability is an important challenge facing the world, this paper argues that while “greening” programs seem like attempts to reform current methods of imprisonment, sustainability programming is an extension of the neoliberalization of incarceration in the United States. By emphasizing cost cutting while individualizing rehabilitation, prisons mobilize sustainability programming to produce “green prisoners” who are willing to take responsibility for their rehabilitation and diminish their economically burdensome behaviors (i.e. excessive wastefulness). Using semi-structure journals and interviews at three Oregon prisons, this paper investigates these ideas through the lens of the Sustainability in Prisons Project.


2005 ◽  
Vol 22 (Supplement 36) ◽  
pp. 21-22
Author(s):  
B. Jungwirth ◽  
M. L. Gordan ◽  
M. Blobner ◽  
W. Schmehl ◽  
E. F. Kochs ◽  
...  

Materials ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 7758
Author(s):  
Susana Fernández ◽  
José Pablo González ◽  
Javier Grandal ◽  
Alejandro F. Braña ◽  
María Belén Gómez-Mancebo ◽  
...  

Different functionalities of materials based on indium tin oxide and fabricated at soft conditions were investigated with the goal of being used in a next generation of solar photovoltaic devices. These thin films were fabricated in a commercial UNIVEX 450B magnetron sputtering. The first studied functionality consisted of an effective n-type doped layer in an n-p heterojunction based on p-type crystalline silicon. At this point, the impact of the ITO film thickness (varied from 45 to 140 nm) and the substrate temperature (varied from room temperature to 250 °C) on the heterojunction parameters was evaluated separately. To avoid possible damages in the heterojunction interface, the applied ITO power was purposely set as low as 25 W; and to minimize the energy consumption, no heat treatment process was used. The second functionality consisted of indium-saving transparent conductive multicomponent materials for full spectrum applications. This was carried out by the doping of the ITO matrix with transition metals, as titanium and zinc. This action can reduce the production cost without sacrificing the optoelectronic film properties. The morphology, chemical, structural nature and optoelectronic properties were evaluated as function of the doping concentrations. The results revealed low manufactured and suitable films used successfully as conventional emitter, and near-infrared extended transparent conductive materials with superior performance that conventional ones, useful for full spectrum applications. Both can open interesting choices for cost-effective photovoltaic technologies.


Holzforschung ◽  
2019 ◽  
Vol 74 (1) ◽  
pp. 20-32
Author(s):  
Laurence R. Schimleck ◽  
Finto Antony ◽  
Christian Mora ◽  
Joseph Dahlen

AbstractNear-infrared (NIR) spectra or NIR-hyperspectral images obtained from radial strips or wood discs provide a cost-effective methodology for examining wood property variation within trees. The calibration used for wood property prediction is critical and can be obtained using two fundamentally different approaches. One involves using a spatial-specific model where wood property data and corresponding spectral data are measured at the same resolution for calibration and prediction, e.g. 10-mm radial increments. The other provides a spatial-interpolated model and involves measuring a property on a broad-scale, e.g. whole-tree, calibrating this data against NIR spectra representing the equivalent scale and then using the calibration to predict the property at higher resolution. To understand the impact of these approaches on subsequent patterns of within-tree variation, whole-tree air-dry density (ADD) and coarseness maps, based on data obtained using the two different approaches, were compared. Patterns of ADD and coarseness variation were comparable indicating that both approaches can be utilized to examine within-tree variation. Spatial-interpolated models have a distinct advantage; being based on whole-tree (or disc) samples, they greatly reduce the cost of wood property analysis and allow the development of maps for properties that are costly and difficult to measure, for example, pulp yield.


2014 ◽  
Vol 53 (4II) ◽  
pp. 531-549 ◽  
Author(s):  
Akbar Ullah . ◽  
Karim Khan ◽  
Munazza Akhtar

Since the recent energy crises, the research in this strand has increased considerably. A variety of its dimensions have been examined in the literature. For instance, higher energy prices; instability in the supplies of its various components; its rapid depletion and global warming are some of its dimensions, which have been the focus of discourse among both researchers and policy-makers. Equally, energy intensity measuring the energy consumption to GDP ratio has been an important component of energy policies [Ang (2004); Liu and Ang (2007); Jimenez and Mercado (2013)]. In particular, there is a special focus on sorting out the contribution of energy efficiency— ratio of sectoral specific energy consumption to sectoral GDP—to alienate the impact of efficiency on energy intensity from other relevant factors. This is because energy efficiency is recognised as one of the most cost-effective strategies to address crosscutting issues of energy security, climate change and competitiveness [IDB (2012)]. Consequently, the information regarding energy intensity, its efficiency or activity aspects are useful tools for policy decisions and evaluation and are regularly in practice in most of the advanced countries


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