Comparison of two intramuscular sedation protocols on sedation, recovery and ease of venipuncture for cats undergoing blood donation

2018 ◽  
Vol 21 (2) ◽  
pp. 95-102 ◽  
Author(s):  
Rebecca C Reader ◽  
Bruce A Barton ◽  
Amanda L Abelson
Keyword(s):  
Blood Donation ◽  
Muscle Relaxation ◽  
Blood Collection ◽  
Blood Draw ◽  
Suitable Alternative ◽  
Treatment Groups ◽  
Sedation Protocol ◽  
Significant Difference ◽  
Lateral Recumbency

Objectives The aim of this study was to compare the quality of sedation and recovery, and ease of venipuncture following sedation for feline blood donation using two intramuscular (IM) sedation protocols: alfaxalone/butorphanol (AB) and dexmedetomidine/butorphanol (DB). Methods This was an experimental randomized, blinded, crossover study. Ten client-owned healthy cats were recruited to participate in the study. Cats were sedated with AB (alfaxalone 2 mg/kg and butorphanol 0.2 mg/kg) for one donation and DB (dexmedetomidine 10 μg/kg and butorphanol 0.2 mg/kg) for another. Reaction to injection, quality of sedation and quality of recovery were assessed by a blinded observer. Time to lateral recumbency, number of venipuncture attempts, time required for blood collection and time to return to sternal recumbency were recorded. Cats were monitored for evidence of gastrointestinal distress. Each donation consisted of a maximum of 53 ml whole blood drawn over 3–22 mins. Donors received 100 ml subcutaneous lactated Ringer’s solution in recovery. Owners, unaware of sedation protocol, were asked to complete a questionnaire evaluating their cat’s behavior following sedation. Results IM injections were well tolerated by both treatment groups. There was no significant difference between treatment groups in sedation scores for posture ( P = 0.30) or behavior ( P = 0.06). Cats sedated with DB had significantly higher muscle relaxation scores ( P = 0.03) compared with AB. There was no significant difference between treatment groups in time to lateral recumbency ( P = 0.12), number of venipuncture attempts ( P = 0.91) and time for blood draw ( P = 0.29). There was no difference in quality of recoveries between treatment groups based on simple descriptive scores ( P = 0.18) and owner evaluation 24 h following sedation. One cat vomited following administration of DB. Conclusions and relevance Alfaxalone is a suitable alternative to dexmedetomidine when combined with butorphanol and used as part of an IM sedation protocol for cats undergoing blood donation.

scholarly journals Effect of heat stress on carcass and meat quality of indigenous sheep of Bangladesh

2014 ◽  
Vol 43 (2) ◽  
pp. 147-153 ◽  
Author(s):  
MS Rana ◽  
MA Hashem ◽  
S Akhter ◽  
M Habibullah ◽  
MH Islam ◽  
...  
Keyword(s):  
Heat Stress ◽  
Meat Quality ◽  
Carcass Characteristics ◽  
Muscle Area ◽  
Eye Muscle ◽  
Treatment Groups ◽  
Indigenous Sheep ◽  
Heat Treated ◽  
Significant Difference

The research was conducted to study the effect of heat stress on carcass characteristics and meat quality in indigenous sheep. Nine sheep were divided into three groups which were almost similar in age, sex and weight. Three groups were divided as zero hour (T0), four hours (T4) and eight hours (T8) heat exposure to direct sunlight. During experimental period temperature–humidity index (THI) value was calculated as 27.09 which indicated T4 and T8 groups were subjected to heat stress condition for at least four hours and eight hours respectively every day. Slaughter weight, body length and heart girth had no significant difference among the treatment groups. Dry matter, ash and ether extract had no significant difference (p>0.05) among the treatment groups but crude protein were increased with the increase of heat stress from T0 to T8 group (p<0.05). Drip loss was increased (p<0.05) in non-exposure group than treated groups but there is no significant result (p>0.05) found in pH and cooking loss. Carcass weight and eye muscle area had no significant difference (p>0.05) among the treatment groups but dressing percentage was decreased with the increase of time in heat treated groups (p<0.01). Significant difference (p<0.05) were found in weight of heart, kidney, lung + trachea and pluck between control and heat treated groups. The significant difference (p>0.05) in empty gut was found in gut with content and gut fill in heat treated groups. It can be concluded that heat stress had significant changes on carcass characteristics and meat quality of indigenous sheep.DOI: http://dx.doi.org/10.3329/bjas.v43i2.20717 Bang. J. Anim. Sci. 2014. 43 (2): 147-153

scholarly journals Quality of life in an adolescent orthodontic population: Invisalign versus fixed appliances

2021 ◽  
Author(s):  
Richa Sharma ◽  
Robert Drummond ◽  
William Wiltshire ◽  
Robert Schroth ◽  
Milos Lekic ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Health Impact ◽  
Fixed Appliance ◽  
Treatment Groups ◽  
Significant Difference ◽  
Orthodontic Patients ◽  
Fixed Appliances ◽  
Domain Scores

ABSTRACT Objectives To investigate adolescent orthodontic patient experiences and quality of life with fixed appliances compared to Invisalign. Materials and Methods Adolescent patients in active treatment with Invisalign or fixed appliances for a minimum of 6 months were provided with the Child Oral Health Impact Profile-Short Form 19 questionnaire, along with additional items of interest that were assessed separately. Pearson's χ2 test was used to compare responses (P &lt; .05), and unpaired t-tests (P &lt; .05) were used to test for differences in mean satisfaction, quality of life, and domain scores. Results In total, 74 patients (37 in each treatment group) participated. Overall, no significant differences were noted in the mean quality of life, satisfaction, or domain scores between the two groups. A significant difference was noted in the time taken to adjust to appliances, with the Invisalign group demonstrating faster adaptation. Additionally, the fixed appliance group was 3.8 times more likely to report missing school because of their appliance (95% confidence interval [CI]: 1.2, 12.5) and 2.7 times more likely to report having difficulty eating certain foods (95% CI: 1.1, 7.1). When the sample of females between the ages of 14 and 18 was analyzed, the Invisalign group reported feeling attractive more often than the fixed appliance group. Conclusions Both treatment groups were generally very satisfied with their treatment modality. The overall quality of life of adolescent orthodontic patients undergoing treatment with fixed appliances and Invisalign for a minimum of 6 months was similar.

Comparison of a closed system and an open system for blood collection in feline donors

2020 ◽  
Vol 22 (12) ◽  
pp. 1121-1128
Author(s):  
Marie Binvel ◽  
Julie-Hélène Fairbrother ◽  
Valérie Lévesque ◽  
Marie-Claude Blais
Keyword(s):  
Open System ◽  
Closed System ◽  
Bacterial Contamination ◽  
Blood Donors ◽  
Blood Collection ◽  
Significant Difference ◽  
The Mean ◽  
Collection Methods ◽  
Time Point

Objectives This research aimed to evaluate the performance of a closed blood collection system and to compare it with an open system in terms of feasibility, tolerability by the donor, quality of blood collected and bacterial contamination. Methods Eight feline blood donors were prospectively and randomly subjected to both collection methods. Heart rate (HR), respiratory rate (RR) and blood pressure (BP) were evaluated before sedation, after sedation and after blood collection. The duration of the donation, the formation of a hematoma, and the degree of hemolysis and packed cell volume (PCV) of each blood unit were evaluated. Aliquot samples were aseptically collected from each unit and tested for bacterial contamination by culture and PCR on days 0, 14 and 28 of storage. Results There was no significant difference between collection methods for HR and RR at any time point. Before sedation, the mean systolic BP was significantly higher with the closed system (closed 169 mmHg, open 137 mmHg; P = 0.003). The average duration of collection was significantly shorter with the closed system (closed 3 mins 10 s, open 8 mins; P = 0.035); however, the prevalence of a successful blood collection with a single venipuncture and hematoma formation were not significantly different between systems. The mean unit PCV was significantly higher with the open system (closed 31%, open 34%; P = 0.026). On bacterial culture, 15/16 units were negative at all time points (closed 7; open 8). Using PCR, 5/16 units were positive for Ralstonia species for at least one time point (closed 3; open 2). Conclusions and relevance Our designed closed system appears to be well adapted to feline blood collection and was well tolerated by the donors, performing similarly to an open system, and could represent a valuable clinical device for the development of a feline blood bank, namely feline blood storage.

scholarly journals The Study on Dorsal Venous Arch of Upper Limb Among Nepalese Medical Students at Tertiary Level Teaching Institute

2019 ◽  
Vol 18 (2) ◽  
pp. 48-52
Author(s):  
Nripendra Tiwari ◽  
Deepesh Budhathoki ◽  
Krishna Banshi Malla
Keyword(s):  
Upper Limb ◽  
Blood Donation ◽  
Hypovolemic Shock ◽  
Invasive Procedure ◽  
Male Students ◽  
Blood Collection ◽  
Cross Sectional ◽  
Medical College ◽  
Right Hand ◽  
Significant Difference

Introduction: Dorsal venous arch of upper limb is the beginning site for cephalic and basilic veins. The superficial veins are clinically important for venipuncture, blood collection and blood donation as well as for health screening and testing, intravenous transfusion for the emergency treatment of hypovolemic shock. Veins of the upper limb are also used for total parental nutrition, therapeutic invasive procedure and blood samples. The Dorsal Venous Arch is superficially placed and can be easily made prominent by putting a tourniquet at the wrist for any such surgical and therapeutic purposes. Methods: It was a cross-sectional observational study conducted in 200 hands among 100 individuals from MBBS first and second year students studying at a Medical College. Body Mass Index (BMI) of individuals was calculated to observe the correlation between length of the dorsal venous arch and BMI. Results: The mean±s.d. length of dorsal venous arch in male on right hand (20.7±2.4 cm) was significantly greater than in female on right hand (19.4±2.1 cm).There was no significant difference in length of dorsal venous arch on left side between male (20.1±2.2 cm.) and female (19.3±1.8 cm). Conclusions: The length of the dorsal venous arch on right hand was found significantly greater in male than in female. Also the length of dorsal venous arch on right side was found to be more than on left side in both sexes. The male students are significantly older, heavier and taller than females.  

scholarly journals Quality of Life in Uveal Melanoma Patients in Ireland: A Single-Centre Survey

2019 ◽  
Vol 6 (2) ◽  
pp. 99-106
Author(s):  
Olya Scannell ◽  
Valerie O’Neill ◽  
Mary Dunne ◽  
Caroline Baily ◽  
Amira Salih ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Uveal Melanoma ◽  
Psychosocial Support ◽  
Well Being ◽  
Disease Recurrence ◽  
The Body ◽  
Treatment Groups ◽  
Significant Difference ◽  
Melanoma Patients

Background: Uveal melanoma and its treatment can influence the physical and psychological well-being of patients in a way that differs from other cancers. Factors influencing quality of life (QOL) include visual impairment, changes in appearance, day-to-day functioning, ocular discomfort, and worry regarding disease recurrence. Objective: We aimed to study both general and disease-specific QOL in uveal melanoma patients in Ireland and compare QOL between a plaque radiotherapy group and an enucleation treatment group. This information was sought to enhance our understanding of QOL issues for uveal melanoma patients, in the context of improving care and providing appropriate psychosocial support. Method: The European Organisation for Research and Treatment of Cancer (EORTC) QOL questionnaires QLQ-C30 and QLQ-OPT30 were completed by patients with uveal melanoma treated by enucleation or brachytherapy. Results: 138 of 206 patients completed the questionnaires. There was no significant difference in QOL scores between treatment groups. Thirty-two percent of patients reported concerns about tumour recurrence elsewhere in the body. The brachytherapy group had a significantly higher “role functioning” score (p = 0.030). Enucleation patients were more likely to have problems with appearance (p < 0.0005). Younger patients (12–54 years of age) were more likely to report headaches (p < 0.0005) and problems with reading (p = 0.042), and they had a lower cognitive functioning score (p = 0.003) than those aged ≥55 years. Conclusions: There was no significant difference in reported QOL between treatment groups. Our data identified a number of vulnerable patient subgroups. By anticipating which patients are more likely to suffer in terms of certain aspects of their QOL, we are better able to provide appropriate and timely psychosocial support.

scholarly journals Is Telephysiotherapy an Option for Improved Quality of Life in Patients with Osteoarthritis of the Knee?

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Adesola C. Odole ◽  
Oluwatobi D. Ojo
Keyword(s):  
Quality Of Life ◽  
Physical Health ◽  
Osteoarthritis Of The Knee ◽  
Group Comparison ◽  
Treatment Groups ◽  
Knee Oa ◽  
Significant Difference ◽  
Environment Domain ◽  
Telephone Monitoring

This study investigated effect of a 6-week telephysiotherapy programme on quality of life (QoL) of patients with knee osteoarthritis (OA). Fifty patients with knee OA were randomly and equally assigned into two treatment groups: clinic group (CG) and telephysiotherapy group (TG). The CG received physiotherapist-administered osteoarthritis-specific exercises in the clinic thrice weekly for 6 weeks while the TG received structured telephone monitoring with self-administered osteoarthritis-specific exercises for the same duration at home. Participants’ QoL was assessed using WHOQoL-Bref at baseline, second, fourth, and sixth week of intervention. Data were analyzed using ANOVA and independent Student’st-test. Within-group comparison showed significant improvements in physical health domain (P=0.00*for TG and CG) and psychological domain (P=0.02*for TG;P=0.00*for CG) of WHOQoL following six-week intervention. However, there were no significant differences (P>0.05) in TG and CG’s social relationship and environment domains. Between-group comparison showed no significant differences (P>0.05) between CG and TG’s physical health, psychological, and social relationships domains of WHOQoL following 6-week intervention. However, there was significant difference in the environment domain (P<0.05). Telephysiotherapy using telephone medium improved QoL in patients with knee OA comparable to clinic based treatment.

Prospective evaluation of epoetin-alfa (EA) vs epoetin-beta (EB) vs darbepoetin (DE) in anemic cancer patients (pts) receiving chemotherapy (CT): Early results of an independent observational survey by the Italian ReVERTO network

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 18548-18548
Author(s):  
C. F. Pollera ◽  
F. Nelli ◽  
T. Gamucci ◽  
I. Sperduti ◽  
A. M. Giampaolo ◽  
...  
Keyword(s):  
Treatment Schedule ◽  
Weekly Schedule ◽  
Severe Anemia ◽  
Treatment Groups ◽  
Therapy Efficacy ◽  
Early Results ◽  
Significant Difference ◽  
To Receive ◽  
Major Data

18548 Background: Direct comparison of EA vs EB vs DE has never been performed. In order to define the efficacy, impact on quality of life (QL) and pt’s preference, a prospective observational comparison of erythropoietic agents has been carried out. Methods: Anemic pts (hgb <11 gr/dL) scheduled to receive at least 3 cycles of CT were stratified according to 5 factors (platinum-based CT vs non-platinum; hgb ≤9,5 vs >9,5; PS ≤0–1 vs >1; previous CT vs upfront CT; and previous antianemic therapy vs not) and were autonomously assigned by 15 investigators to EA (3 times a week) or EB (3 times a week and only in pts receiving platinum-based CT) or DE (once a week) therapy. Efficacy by hgb level changes and transfusion needing was evaluated after each cycle of CT, QL by Fact-An questionnaire after 1 and 3 cycles of CT, and pt’s preference for standard vs weekly schedule at least once thereafter. Results: From 09/04 to 12/05 177 pts were recruited: 41%, 39% and 20% were assigned to DE, EA and EB, respectively. Severe anemia at baseline (≤9,5) was reported in 29% of pts, whereas 47% received platinum-based CT. Stratifying categories were well balanced among the treatment groups. Baseline mean hgb values were 9.7, 9.9, and 10 for DE, EA and EB, respectively. As of the general population, DE produced higher subsequent mean hgb increase in respect to EA and EB (Mean increase [gr/dL] for DE: 0.84, 1.58, 2.03; EA: 0.34, 0.84, 1.68; EB: 0.76, 1.54, 1.17). No difference was observed neither among pts receiving platinum-based CT, (mean increase: DE: 0.34, 1.76, 2.8; EA: 0.7, 1.27, 2.14; EB: 0.76, 1.54, 1.71) nor among pts with severe anemia at baseline (DE: 0.98, 2, 2.6; EA: 1.24, 1.94, 3.13; EB: 1.25, 2.25, 2.75). Transfusion needing ranged from 7% for DE to 3% for EB without any significant difference. To date 67% of pts completed at least one subsequent QL valuation, whereas 62% gave their preference for treatment schedule. Conclusions: Early results of our prospective analysis show that antianemic therapy with D is at least as effective as standard schedule of EA or EB. Efficacy of DE seems confirmed in pts with bad prognostic categories for anemia. Major data on QL and pt’s preference will be presented. No significant financial relationships to disclose.

scholarly journals The Comparison of the Effect of Repetitive Doses of Succinylcholine and Thiopental Sodium on the Duration and Severity of Seizure in Electro Convulsive Therapy: Randomized Clinical Trial

2019 ◽  
pp. 1-8
Author(s):  
Farhad Nanaei ◽  
Hadi Bahrami ◽  
Aziz Kasani
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Initial Dose ◽  
Psychiatric Ward ◽  
Convulsive Therapy ◽  
Treatment Groups ◽  
Significant Difference ◽  
Thiopental Sodium ◽  
Hypnotic Drugs

Background and Aim: Regarding the controversial results on the effects of anesthetics, especially thiopental sodium, on the duration and severity of seizure and the lack of adequate information on the use of doses of anesthetic and paralysing drugs during ECT, this study was designed to determine the effect of repetitive doses of succinylcholine and Thiopental sodium was administered on the duration and severity of seizure during ECT. Materials and Methods: The present study was a one-blind randomized clinical trial on patients admitted to the psychiatric ward of Dezful Ganjavian Hospital. The research samples were selected after informed consent and entry criteria. Then, the samples were randomly assigned to two groups. In one group, succinylcholine dose was repeated (one third of the initial dose), and in the other group, the dose of thiopental sodium was repeated (one third of the initial dose). In all patients, seizure duration based on EEG monitoring and severity of seizure was determined by the psychiatrist based on the symptoms of the patient during seizure. Results: There was a significant difference between the quality of seizure in the two treatment groups after the intervention. There was a strong and good seizure in the thiopental sodium group (p <0.0001). There was a significant difference between the variables of seizure status in comparison with the previous shock in the two treatment groups after the intervention (p <0.0001). The duration of seizure was higher in thiopental sodium treatment group, but no significant difference was observed (p = 0.82). Conclusion: The results of this study showed that the duration and quality of seizure was better in patients requiring repetitive doses of hypnotic drugs (Thiopental Sodium), which was used to repeat the dose of muscle relaxant (succinylcholine).

scholarly journals Comparative evaluation of isoflurane and sevoflurane in avian patients

2021 ◽  
pp. 1067-1073
Author(s):  
R. R. Anjana ◽  
P. V. Parikh ◽  
J. K. Mahla ◽  
D. N. Kelawala ◽  
K. P. Patel ◽  
...  
Keyword(s):  
Induction Time ◽  
Recovery Time ◽  
Muscle Relaxation ◽  
Complete Recovery ◽  
Versus Group ◽  
Quality Of Recovery ◽  
Anesthetic Agents ◽  
Group I ◽  
Significant Difference

Background and Aim: Literature comparing the use of isoflurane and sevoflurane inhalation anesthetic agents in birds is scarce. This study aimed to evaluate the comparison of isoflurane and sevoflurane during induction, maintenance, and recovery of anesthesia in avian patients. Materials and Methods: In this study, 24 injured avian patients (n=24) were selected randomly and divided into four groups during kite flying festival. In the present study, isoflurane and sevoflurane were used as induction and maintenance anesthetic agents, with and without butorphanol tartrate premedication agent in all the birds. Different physiological parameters were evaluated, namely, cloacal temperature (°F), heart rate (beats/min), respiratory rate (breaths/min), and SpO2 (%) were recorded at 0, 10, 20 min, and at recovery time. The quality of anesthesia was assessed on the basis of induction time, quality of induction, production of analgesia, muscle relaxation, body reflexes, recovery time, quality of recovery, sitting, standing, and complete recovery time (CRT). Results: The mean±standard error value of induction time was 230.00±32.55, 280.00±25.29, 180.00±21.90, and 260.00±36.87 s, respectively, in Groups I, II, III, and IV. The feather plucking, pharyngeal, and toe pinching reflexes were noticed, when the birds were passing through the light plane of anesthesia during induction. Comparison of cloacal temperature at the time of recovery between Group-I versus Group-III revealed a significant difference (p<0.05). Comparison of mean respiratory rates at the time of recovery between Group-II versus Group-IV revealed a significant difference (p<0.05). Excellent quality of recovery was observed in all the groups of anesthetic protocols. Sitting, standing, and CRT were observed shortest in avian patients maintained with sevoflurane as compared to isoflurane. Conclusion: The quality of induction of anesthesia was rapid in avian patients when induced with sevoflurane as compared to isoflurane. Rapid onset of induction and recovery of anesthesia were found with sevoflurane followed by isoflurane. Induction and maintenance of anesthesia in avian patients with sevoflurane resulted in the lowest time required for sitting, standing, and CRT.

Comparison of emergence times and quality between isoflurane and sevoflurane in rhesus macaque (Macaca mulatta) undergoing neurosurgical procedure

2017 ◽  
Vol 51 (5) ◽  
pp. 518-525 ◽  
Author(s):  
Henri G M J Bertrand ◽  
Svenja Springer ◽  
Wesley Burnside ◽  
Charlotte Sandersen ◽  
Paul A Flecknell
Keyword(s):  
Rhesus Macaques ◽  
Neurosurgical Procedures ◽  
Mechanically Ventilated ◽  
Treatment Groups ◽  
Sevoflurane Anaesthesia ◽  
Quality Of Recovery ◽  
Quality Profile ◽  
Significant Difference ◽  
Volatile Agents

Volatile agents for anaesthesia are widely used for anaesthetizing laboratory primates, and isoflurane is one of the most frequently used agents. Sevoflurane has been shown to offer a more rapid recovery than isoflurane in a number of species, but no comparisons have been made in non-human primates. This study compared the recovery characteristics of isoflurane and sevoflurane in rhesus macaques undergoing experimental neurosurgery. Twelve primates (7 males and 5 females) were randomly allocated to the treatment groups. They were sedated with ketamine (10 mg/kg) and anaesthesia was induced with propofol (usually 8 mg/kg intravenously [IV]). Anaesthesia was maintained with either sevoflurane (SEVO) (2.2 ± 0.4%) or isoflurane (ISO) (1.2 ± 0.2%) and alfentanil (0.2–0.5 µg/kg/min IV) for 332–592 min. Animals were mechanically ventilated. Meloxicam (0.3 mg/kg) and methylprednisolone infusion (5.4 mg/kg/h) were also administered. Time to extubation after cessation of anaesthesia was significantly shorter with sevoflurane (ISO: 7.0 ± 1.8 min; SEVO: 3.6 ± 1.5; *P = 0.005) as was the time to the animal sitting unaided (ISO: 15.7 ± 8.2 min; SEVO: 7.1 ± 1.7 min; *P = 0.004) . No significant difference in the quality of recovery following isoflurane or sevoflurane anaesthesia was found. In conclusion, isoflurane and sevoflurane are both suitable volatile agents for the maintenance of general anaesthesia in rhesus macaques undergoing experimental neurosurgical procedures. The two volatile agents presented a similar emergence quality profile, however sevoflurane anaesthesia was associated with a faster recovery, offering the possibility of conducting earlier post-operative neurological assessment.

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