Sedative effects of alfaxalone and hydromorphone with or without midazolam in cats: a pilot study

2021 ◽  
pp. 1098612X2199615
Author(s):  
Emily P Wheeler ◽  
Amanda L Abelson ◽  
Jane C Lindsey ◽  
Lois A Wetmore
Keyword(s):  
Pilot Study ◽  
Significant Positive Correlation ◽  
Time Correlation ◽  
Catheter Placement ◽  
Blinded Study ◽  
Sedative Effects ◽  
Sedation Scores ◽  
Adult Cats ◽  
To Receive

Objectives The aim of this pilot study was to compare the quality of sedation and ease of intravenous (IV) catheter placement following sedation using two intramuscular (IM) sedation protocols in cats: hydromorphone, alfaxalone and midazolam vs hydromorphone and alfaxalone. Methods This was a prospective, randomized and blinded study. Cats were randomly assigned to receive an IM injection of hydromorphone (0.1 mg/kg), alfaxalone (1.5 mg/kg) and midazolam (0.2 mg/kg; HAM group), or hydromorphone (0.1 mg/kg) and alfaxalone (1.5 mg/kg; HA group). Sedation scoring (0–9, where 9 indicated maximum sedation) was performed at 0, 5, 10, 15 and 20 mins from the time of injection. At 20 mins, an IV catheter placement score (0–10, where 10 indicated least resistance) was performed. Results Twenty-one client-owned adult cats were included in this study. Sedation and IV catheter placement scores were compared between groups using Wilcoxon rank sum tests. Peak sedation was significantly higher ( P = 0.002) in the HAM group (median 9; range 7–9) than in the HA group (median 7; range 3–9), and IV catheter placement scores were significantly higher ( P = 0.001) in the HAM group (median 9.5; range 7–10) compared with the HA group (median 7; range 4–9). Spearman correlations were calculated between IV catheter placement score and sedation scores. There was a significant positive correlation of average sedation over time (correlation 0.83; P <0.001) and sedation at 20 mins (correlation 0.76; P <0.001) with a higher, more favorable IV catheter placement score. Conclusions and relevance These preliminary results suggest that the addition of midazolam to IM alfaxalone and hydromorphone produced more profound sedation and greater ease of IV catheter placement than IM alfaxalone and hydromorphone alone.

scholarly journals Effects of combined midazolam and propofol in anesthesia induction and recovery of cats undergoing ovariohisterectomy

2015 ◽  
Vol 36 (6Supl2) ◽  
pp. 4269 ◽  
Author(s):  
Diogo Gorayeb de Castro ◽  
Juliana De Araújo Caldeira ◽  
Fernanda Corrêa Devito ◽  
Samanta Rios Melo ◽  
Silvia Renata Gaido Cortopassi
Keyword(s):  
Tracheal Intubation ◽  
Saline Solution ◽  
Healthy Adult ◽  
The Other ◽  
Anesthesia Induction ◽  
Nacl Solution ◽  
Blinded Study ◽  
Adult Cats ◽  
Solution Volume

<p>The objective of this study was to determine the effects of propofol and midazolam on induction of anesthesia in cats undergoing ovariohysterectomy, measured in terms of the quality of tracheal intubation, anesthesia induction, cardiorespiratory effects, and recuperation period. Thirty healthy adult cats were pretreated with acepromazine and morphine. After 30 min, they were divided into three groups: PG (n = 10), in which induction was performed with only intravenous propofol at doses required for intubation; MPG (n = 8), in which animals received intravenous midazolam (0.3 mg kg-1) administered over 30 s, followed by administration of propofol as in PG; and PMG (n = 9), in which propofol was first administered at a rate of 4 mg kg-1 min-1, after which midazolam was administered (0.3 mg/kg), followed by re-administration of propofol. In order to perform a blinded study, the PG and PMG received a 0.9% NaCl solution volume similar to the midazolam dose before induction (0.06 mL/kg). Similar to the other groups, the PG and MPG received (0.06 mL kg-1) saline 30 s after administration of propofol. In order to mimic the administration of midazolam, the saline solution was administered for 30s. The PG received 11.0 ± 1.38 mg kg-1 propofol, a greater dose than that administered to the PMG (p &lt; 0.001) and MPG (p &lt; 0.01), which received 7.9 ± 1.92 and 9.1 ± 2.20 mg kg-1, respectively. There were no differences in the intubation scores between groups. Previous use of midazolam did not affect agitation or excitement in cats; both sequences of propofol-midazolam administration are feasible, but the propofol-midazolam sequence was superior due to the lower propofol dose.</p>

Comparison of intramuscular butorphanol and buprenorphine combined with dexmedetomidine for sedation in cats

2017 ◽  
Vol 20 (4) ◽  
pp. 325-331 ◽  
Author(s):  
Rebecca J Bhalla ◽  
Toby A Trimble ◽  
Elizabeth A Leece ◽  
Enzo Vettorato
Keyword(s):  
Adverse Events ◽  
Sedative Effect ◽  
Intravenous Catheter ◽  
Exact Test ◽  
Composite Scale ◽  
Fisher’S Exact Test ◽  
Sedation Scores ◽  
Adult Cats ◽  
To Receive ◽  
Over Time

Objectives The objective of this study was to compare the sedative effect of butorphanol–dexmedetomidine with buprenorphine–dexmedetomidine following intramuscular (IM) administration in cats. Methods Using a prospective, randomised, blinded design, 40 client-owned adult cats were assigned to receive IM dexmedetomidine (10 µg/kg) combined with either butorphanol (0.4 mg/kg) (‘BUT’ group) or buprenorphine (20 µg/kg) (‘BUP’ group). Sedation was scored using a previously published multidimensional composite scale before administration (T0) and 5, 10, 15 and 20 mins afterwards (T5, T10, T15 and T20, respectively). Alfaxalone (1.5 mg/kg) was administered IM at T20 if the cat was not deemed adequately sedated to place an intravenous catheter. Adverse events were recorded. Friedman two-way ANOVA analysed sedation scores within groups. Mann–Whitney Rank Sum test compared sedation scores between groups; Fisher’s exact test analysed the frequency of alfaxalone administration and adverse events. P <0.05 was considered statistically significant. Results Sedation scores between groups were similar at baseline, but at T5, T10, T15 and T20 scores were higher in the BUT group ( P <0.01). Within both groups, sedation scores changed over time and the highest sedation scores were reached at T10. Requirement for additional sedation was similar between groups: two cats in the BUT group and five cats in the BUP group. One cat and 11 cats vomited ( P = 0.002) in the BUT and BUP groups, respectively. No other adverse events were recorded. Conclusions and relevance At these doses, IM buprenorphine–dexmedetomidine provides inferior sedation and a higher incidence of vomiting than butorphanol–dexmedetomidine in cats. Butorphanol–dexmedetomidine may be preferred for feline sedation, especially where vomiting is contraindicated.

Evaluation of an intramuscular butorphanol and alfaxalone protocol for feline blood donation: a pilot study

2017 ◽  
Vol 20 (8) ◽  
pp. 793-798 ◽  
Author(s):  
Marcella C Granfone ◽  
Julie M Walker ◽  
Lesley J Smith
Keyword(s):  
Heart Rate ◽  
Pilot Study ◽  
Healthy Adult ◽  
Blood Donation ◽  
Jugular Vein ◽  
Target Volume ◽  
Sedation Scores ◽  
Baseline Values ◽  
Significant Change ◽  
Adult Cats

Objectives The purpose of this pilot study was to evaluate the use of an intramuscular (IM) sedation protocol with butorphanol and alfaxalone in cats undergoing blood donation. We hypothesized that this drug combination would provide sufficient sedation to perform phlebotomy without causing hypotension or significant changes in heart rate. Methods Six purpose-bred, healthy adult cats were sedated using IM butorphanol (0.4 mg/kg) and alfaxalone (2–3 mg/kg). Pulse and Doppler blood pressure (BP) were recorded at baseline, after sedation and immediately following phlebotomy. Once laterally recumbent, 12 ml/kg blood was collected from the jugular vein. Sedation scores, duration of lateral recumbency and the ability to successfully perform phlebotomy were recorded. Results There was no significant change in heart rate post-sedation (median 190 beats per min [bpm], range 160–224 bpm) or post-phlebotomy (median 200 bpm, range 180–220 bpm) compared with baseline values (median 200 bpm, range 180–220 bpm) ( P = 0.395). A statistically significant change in BP was detected ( P = 0.029), attributed to a difference between post-sedation (median 113.3 mmHg, range 110.7–130.0) and baseline (median 133.3 mmHg, range 130.0–183.3) measurements. Hypotension was not observed in any cat. Collection of at least 80% of the target volume was achieved in 5/6 cats, although all were adequately sedated to allow jugular venous phlebotomy. Median recumbency time was 53 mins (range 43–83 mins). Phlebotomy duration lasted a median of 13 mins (range 5–21 mins). Conclusions and relevance The administration of IM alfaxalone and butorphanol provided sufficient restraint for blood donation without causing hypotension or significant changes in heart rate before or after phlebotomy.

scholarly journals Effects of combined midazolam and propofol in anesthesia induction and recovery of cats undergoing ovariohisterectomy

2015 ◽  
Vol 36 (6Supl2) ◽  
pp. 4269
Author(s):  
Diogo Gorayeb de Castro ◽  
Juliana De Araújo Caldeira ◽  
Fernanda Corrêa Devito ◽  
Samanta Rios Melo ◽  
Silvia Renata Gaido Cortopassi
Keyword(s):  
Tracheal Intubation ◽  
Saline Solution ◽  
Healthy Adult ◽  
The Other ◽  
Anesthesia Induction ◽  
Nacl Solution ◽  
Blinded Study ◽  
Adult Cats ◽  
Solution Volume

The objective of this study was to determine the effects of propofol and midazolam on induction of anesthesia in cats undergoing ovariohysterectomy, measured in terms of the quality of tracheal intubation, anesthesia induction, cardiorespiratory effects, and recuperation period. Thirty healthy adult cats were pretreated with acepromazine and morphine. After 30 min, they were divided into three groups: PG (n = 10), in which induction was performed with only intravenous propofol at doses required for intubation; MPG (n = 8), in which animals received intravenous midazolam (0.3 mg kg-1) administered over 30 s, followed by administration of propofol as in PG; and PMG (n = 9), in which propofol was first administered at a rate of 4 mg kg-1 min-1, after which midazolam was administered (0.3 mg/kg), followed by re-administration of propofol. In order to perform a blinded study, the PG and PMG received a 0.9% NaCl solution volume similar to the midazolam dose before induction (0.06 mL/kg). Similar to the other groups, the PG and MPG received (0.06 mL kg-1) saline 30 s after administration of propofol. In order to mimic the administration of midazolam, the saline solution was administered for 30s. The PG received 11.0 ± 1.38 mg kg-1 propofol, a greater dose than that administered to the PMG (p < 0.001) and MPG (p < 0.01), which received 7.9 ± 1.92 and 9.1 ± 2.20 mg kg-1, respectively. There were no differences in the intubation scores between groups. Previous use of midazolam did not affect agitation or excitement in cats; both sequences of propofol-midazolam administration are feasible, but the propofol-midazolam sequence was superior due to the lower propofol dose.

A Pilot Study of Mobile Telephone Message Interventions with Suicide Attempters in China

Crisis ◽  
2010 ◽  
Vol 31 (2) ◽  
pp. 109-112 ◽  
Author(s):  
Hui Chen ◽  
Brian L. Mishara ◽  
Xiao Xian Liu
Keyword(s):  
Pilot Study ◽  
Effective Means ◽  
Text Message ◽  
Text Messages ◽  
Mobile Telephone ◽  
Future Research ◽  
Quick Method ◽  
Suicide Attempters ◽  
To Receive

Background: In China, where follow-up with hospitalized attempters is generally lacking, there is a great need for inexpensive and effective means of maintaining contact and decreasing recidivism. Aims: Our objective was to test whether mobile telephone message contacts after discharge would be feasible and acceptable to suicide attempters in China. Methods: Fifteen participants were recruited from suicide attempters seen in the Emergency Department in Wuhan, China, to participate in a pilot study to receive mobile telephone messages after discharge. All participants have access to a mobile telephone, and there is no charge for the user to receive text messages. Results: Most participants (12) considered the text message contacts an acceptable and useful form of help and would like to continue to receive them for a longer period of time. Conclusions: This suggests that, as a low-cost and quick method of intervention in areas where more intensive follow-up is not practical or available, telephone messages contacts are accessible, feasible, and acceptable to suicide attempters. We hope that this will inspire future research on regular and long-term message interventions to prevent recidivism in suicide attempters.

Using Photovoice as a method for assessing the quality of life of individuals impacted by gynecologic malignancies: A pilot study

2010 ◽  
Author(s):  
Megan Lipe ◽  
Deidre Pereira ◽  
Stacy Dodd ◽  
Tim Sannes ◽  
Michelle Bishop ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pilot Study ◽  
Gynecologic Malignancies

Lesson Study dan Implikasinya Terhadap Pembelajaran Berbasis Kurikulum Tingkat Satuan Pendidikan

2016 ◽  
Vol 1 ◽  
pp. 189-196
Author(s):  
Vian Harsution
Keyword(s):  
Learning Environment ◽  
Learning Process ◽  
Lesson Study ◽  
Learning Difficulties ◽  
Learning Needs ◽  
Democratic Leadership ◽  
Entrepreneurial Spirit ◽  
To Receive

Lesson study is a systematic, collaborative, and sustainable method of improving the quality of learning. Lesson study emphasizes the exploration of students’ learning needs; teacher openness towards learning difficulties encountered; the willingness of teachers to receive and provide advice and solutions to the difficulties encountered; and the consistency of the various parties to follow up the suggestions and solutions. Implementation of lesson study involving teachers, principals, and experts in the field of education. Kurikulum tingkat satuan pendidikan or abbreviated KTSP is operational curriculum formulated and implemented by each educational unit. KTSP has the characteristics, namely: giving broad autonomy to the educational unit, involving the community and parent participation, involving the democratic leadership of the principal, and require the support of a working team that is synergistic and transparent. KTSP based on the learning process, needs to be supported by a conducive learning environment and fun to be created by teachers.Teachers and principals in a professional, systematic and collaborative create an atmosphere that fosters independence, tenacity, entrepreneurial spirit, adaptive and proactive nature of the learning process. Thus, the learning needs of students who fulfilled optimally and professional ability of teacher who have increased on an ongoing basis, may usher in success – based learning KTSP. It means that the lesson study provides positive implications for the KTSP – based learning.

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