Efficacy of corneal shape index in the evaluation of ocular hypertension, primary open-angle glaucoma and exfoliative glaucoma

2020 ◽  
pp. 112067212097202
Author(s):  
Maria J Vieira ◽  
Joana Pereira ◽  
Miguel Castro ◽  
Henrique Arruda ◽  
Joana Martins ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Staging System ◽  
Shape Index ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Deflection Amplitude ◽  
Exfoliative Glaucoma

Purpose: The aim of the present study is to calculate Concavity Shape Index (CSI) in patients with POAG and exfoliative glaucoma (XFG) and correlate CSI with the severity of glaucoma, comparing to control and ocular hypertension (OHT) patients. Methods: This was a cross‑sectional study with 146 eyes/146 subjects: 37 healthy eyes, 23 eyes with OHT and 86 glaucoma eyes (70 with POAG, 16 with XFG). The severity of glaucoma was scored with the Glaucoma Staging System 2 (GSS2). Corvis ST® was used to calculate CSI. Results: Central corneal thickness (CCT) was significantly thinner in POAG (526 ± 40.0 µm) and XFG (520 ± 38.2 µm) than control group (553 ± 28.8 µm). CSI had no significant differences between the groups. XFG had a higher mean of GSS 2 (2.42 ± 1.38) than POAG (1.87 ± 1.55) and OHT (1.87 ± 1.55). OHT had a significantly less deformable cornea than: control (higher A1 length, lower A1 velocity, higher A2 velocity), POAG (higher A1 length, lower A1 velocity, lower deflection amplitude at highest concavity), and XFG group (lower A1 velocity, lower deflection amplitude at highest concavity), which was independent of age and CCT. No significant correlation was found between GSS 2 and CSI. Discussion: OHT patients had stiffer corneas (less deformed by the air puff) when compared to control, POAG or XFG patients. A less deformable cornea could potentially be related to a more resistant LC/peripapillary sclera. As such, this would result in a lesser optic nerve susceptibility to IOP damage.

scholarly journals Pattern ERG as a predictor in ocular hypertensive

2016 ◽  
Vol 15 (2) ◽  
Author(s):  
Paaraj Dave ◽  
Jitendra Jethani
Keyword(s):  
Amplitude Ratio ◽  
Corneal Thickness ◽  
Visual Fields ◽  
Cross Sectional Study ◽  
Control Group ◽  
Study Group ◽  
Pattern Erg ◽  
Check Size ◽  
Cross Sectional ◽  
The Mean

Purpose: To report the repeatability of Pattern Electrotretinogram (PERG) and its findings in ocular hypertension (OHT) and normal eyes.Methods: A cross-sectional study where PERG responses were compared between the study group comprising of 80 eyes of 80 patients with intraocular pressure (IOP)>21 mmHg and the control group with 80 eyes of 80 normal individuals (IOP≤21mmHg). The optic disc and the visual fields were normal with a visual acuity of ≥ 0.8 in both groups. PERG was recorded twice for each individual in the control group by a single operator on 2 consecutive days to assess the repeatability.Results: The mean age in the study and control groups was 50.05±10.03 and 54.8±7.66 years(p=0.44) respectively. The mean IOP was 26.55±3.9 mmHg for the study group as opposed to 14.45±2.9 mmHg for the controls (p<0.001). The central corneal thickness and the cup-disc ratio was similar between the groups (p>.05). The P50-N95 amplitude (p=0.01) and the P50 latency (p<0.001) was statistically significantly different between both the groups. The intra-class correlation coefficient (ICC) showed poor agreement for all parameters except for N35-P50 0.8 to 16 degree check size amplitude ratio (PERG ratio).Conclusion:  Increase in P50 latency emerges as a new candidate for early glaucoma indicator in addition to reduction in P50-N95 amplitude. PERG parameters suffer from high test-retest variability. Deterioration in PERG recordings should be interpreted with caution. The variability is lesser for the PERG ratio which maybe more meaningful while monitoring for change over time.

scholarly journals Correlation between Corneal Elevation Topography and Perimetric Changes in Patients with Primary Open Angle Glaucoma

2020 ◽  
Vol 4 (2) ◽  
Keyword(s):  
Visual Field ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Cross Sectional Study ◽  
Visual Field Examination ◽  
Cross Sectional ◽  
Control Subjects ◽  
Scheimpflug Imaging ◽  
Average Maximum ◽  
Grading Scale

Aim: The aim of this study is to assess Scheimpflug topographic elevation maps in patients with POAG and correlate the results with their perimetric changes. Methods: This was an analytical observational cross-sectional study. The study included 130 eyes of 70 subjects which were divided into 78 eyes of 44 patients diagnosed with POAG and 52 eyes of 26 control subjects. Measurement of IOP, visual field examination in patients with POAG using Humphrey Field Analyzer (2003 Carl Zeiss Meditec), Germany were done. Subjects were scanned using TMS-5 topographer (Topographic Modeling System, version 5. Tomey Corp. Nagoya, Japan) to measure central corneal thickness, mean anterior keratometry, maximum anterior and posterior topographic elevation maps in the central 3, 5, and 7 mm. Results: 78 patients with POAG classified according to visual field deterioration using Hodapp-Anderson-Parrish grading scale into mild glaucoma 33 eyes, moderate glaucoma 19 eyes, severe glaucoma 26 eyes, and 52 eyes control were included in the study. The mean age of the patients with POAG was 57.82 ± 7.78 years; 22 eyes (50%) were male and 22 eyes (50%) were female. The average age of control subjects was 56.62 ± 8.48 years; 12 eyes (46.2%) were male and 14 eyes (53.8%) were female, average CCT was 530.3 ± 23.58 µm, average mean anterior keratometry (MAK) was 42.97 ± 1.42 D, average maximum anterior elevation (MAE) in 3,5 and 7mm zone was 5.31 ± 2.28, 12.10 ± 6.94 and 44.04 ± 21.99 µm respectively and average maximum posterior elevation (MPE) in 3,5 and 7mm zone was 8.46 ± 2.10, 19.90 ± 9.39 and 62.72 ± 28.82 µm respectively in patients with POAG, whereas average CCT was 543.0 ± 31.02µm, average MAK was 43.11 ± 1.73 D, average MAE in 3,5 and 7mm zone was 4.52 ± 1.97, 5.90 ± 2.71 and 27.19 ± 8.55 µm respectively. Conclusion: Evaluation of corneal elevation topography by scheimpflug imaging showed forward shifting of the anterior and posterior corneal surfaces in POAG.

scholarly journals Corneal Segmentation Analysis Increases Glaucoma Diagnostic Ability of Optic Nerve Head Examination, Heidelberg Retina Tomograph’s Moorfield’s Regression Analysis, and Glaucoma Probability Score

2015 ◽  
Vol 2015 ◽  
pp. 1-8
Author(s):  
F. Saenz-Frances ◽  
L. Jañez ◽  
C. Berrozpe-Villabona ◽  
L. Borrego-Sanz ◽  
L. Morales-Fernández ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Open Angle Glaucoma ◽  
Characteristic Curve ◽  
Corneal Thickness ◽  
Cross Sectional Study ◽  
Receiver Operator Characteristic Curve ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Segmentation Analysis

Purpose. To study whether a corneal thickness segmentation model, consisting in a central circular zone of 1 mm radius centered at the corneal apex (zone I) and five concentric rings of 1 mm width (moving outwards: zones II to VI), could boost the diagnostic accuracy of Heidelberg Retina Tomograph’s (HRT’s) MRA and GPS.Material and Methods. Cross-sectional study. 121 healthy volunteers and 125 patients with primary open-angle glaucoma. Six binary multivariate logistic regression models were constructed (MOD-A1, MOD-A2, MOD-B1, MOD-B2, MOD-C1, and MOD-C2). The dependent variable was the presence of glaucoma. In MOD-A1, the predictor was the result (presence of glaucoma) of the analysis of the stereophotography of the optic nerve head (ONH). In MOD-B1 and MOD-C1, the predictor was the result of the MRA and GPS, respectively. In MOD-B2 and MOD-C2, the predictors were the same along with corneal variables: central, overall, and zones I to VI thicknesses. This scheme was reproduced for model MOD-A2 (stereophotography along with corneal variables). Models were compared using the area under the receiver operator characteristic curve (AUC).Results. MOD-A1-AUC: 0.771; MOD-A2-AUC: 0.88; MOD-B1-AUC: 0.736; MOD-B2-AUC: 0.845; MOD-C1-AUC: 0.712; MOD-C2-AUC: 0.838.Conclusion. Corneal thickness variables enhance ONH assessment and HRT’s MRA and GPS diagnostic capacity.

Agreement between the newly developed OCT glaucoma staging system and the standardized visual field glaucoma staging system 2

2021 ◽  
pp. 112067212110143
Author(s):  
Elshimaa A Mateen Mossa ◽  
Heba Khallaf ◽  
Khulood Muhammad Sayed
Keyword(s):  
Visual Field ◽  
Open Angle Glaucoma ◽  
Staging System ◽  
Control Group ◽  
Ganglion Cell Complex ◽  
Automated Perimetry ◽  
Cross Sectional ◽  
Stage 4 ◽  
Staging Systems ◽  
Stage 1

Purpose: The purpose of this research was to assess the agreement between the new optical coherence tomography (OCT) glaucoma staging system (GSS) and the visual field (VF) GSS 2 (GSS2). Methods: This is a cross-sectional study of 161 eyes of 110 patients with controlled primary open-angle glaucoma (POAG). All eyes were subjected to VF examination using standard automated perimetry and Humphrey field analyzer II 750. GSS2 was used for the classification of the VF defects’ severity. OCT of the optic disc and the macular ganglion cell complex (GCC) was performed using RTVue. Patients were classified by OCT GSS into six stages. Results: The study examined 161 eyes of 110 patients with controlled POAG. The staging according to VF GSS2 was as follows: stage 0 (12.42%), border stage (12.42%), stage 1 (13.04%), stage 2 (14.29%), stage 3 (14.28%), stage 4 (14.28%), and stage 5 (19.25%). The staging by OCT GSS was as follows: stage 0 (18.6 %), border stage (17.3%), stage 1 (6.8%), stage 2 (9.31%), stage 3 (6%), stage 4 (11.8%), and stage 5 (30.43%). The sensitivity of the new OCT GSS was different in different stages of glaucoma. In this study, no normal control group was considered; thus, the specificity could not be calculated. There was moderate agreement between the two staging systems. Conclusions: OCT GSS is a reliable and objective method for diagnosing and monitoring glaucoma. Correlations were found between GSS2, inferior and total macular GCC thickness values, and cup-to-disc ratios, so considering these items as additional parameters may make this new classification even more sensitive than VF GSS2.

scholarly journals Evidence of a Down Syndrome Keratopathy: A Three-Dimensional (3-D) Morphogeometric and Volumetric Analysis

2021 ◽  
Vol 11 (2) ◽  
pp. 82
Author(s):  
Ibrahim Toprak ◽  
Francisco Cavas ◽  
Alfredo Vega ◽  
José S. Velázquez ◽  
Jorge L. Alio del Barrio ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Corneal Thickness ◽  
Three Dimensional ◽  
Normal Karyotype ◽  
Volumetric Analysis ◽  
Cross Sectional Study ◽  
High Order ◽  
Control Group ◽  
Cross Sectional ◽  
Anterior Posterior

The aim of this study was to investigate whether a different and abnormal corneal profile is present in Down syndrome (DS) by personalized three-dimensional (3D) modelling. This single-centre cross-sectional study included 43 patients with DS (43 eyes) and 58 age-sex-matched control subjects (58 eyes) with normal karyotype and topography. Refraction, central corneal thickness (CCT), aberrations (high-order, coma and spherical), asphericity and morphogeometric/volumetric parameters based on a 3D corneal model that was generated from raw topographical data were evaluated. Deviation of anterior/posterior apex (Dapexant/Dapexpost) and thinnest point (Dmctant/Dmctpost) from corneal vertex, anterior/posterior surface area (Aant/Apost), sagittal area passing through the anterior/posterior apex (Aapexant/Aapexpost) and thinnest point (Amctpost), total corneal volume (Vtotal) and volumetric progression for each 0.05 mm step of the radius value centred to the thinnest point (VOLMCT) and anterior/posterior apex (VOLAAP/VOLPAP) comprised the morphogeometric/volumetric parameters. In the DS group, 58.1% of the eyes presented abnormal topography. High-order and coma aberrations, asphericity, Dapexant, Aant, Apost and Aapexant were significantly higher, whereas CCT, Aapexpost, Amctpost, Vtotal, VOLAAP, VOLPAP and VOLMCT were lower in the DS group than in the control group (p < 0.05). Dapexpost did not differ between the groups (p > 0.05). This study demonstrates that corneas of the subjects with DS are different and more aberrated than those of normal age- and sex-matched non-DS controls. Anterior corneal apex appears to be displaced in DS even with normal topography, while posterior apex seems stable although topography is abnormal. These findings may help to modify our approach in the diagnosis of keratopathy in subjects with DS.

scholarly journals Glaucoma Profile at the Tertiary Ophthalmic Centers in Ankara, Turkey

2021 ◽  
Author(s):  
Atilla Bayer ◽  
Ufuk Elgin ◽  
Oya Tekeli ◽  
Tamer Takmaz ◽  
Ümit Ekşioğlu ◽  
...  
Keyword(s):  
Open Angle Glaucoma ◽  
Cross Sectional Study ◽  
Clinical Findings ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Cross Sectional ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Predominant Type ◽  
Exfoliative Glaucoma

Abstract Purpose: This study aimed to investigate the demographic and clinical characteristics of the patients with glaucoma, who presented at the tertiary ophthalmology clinics in Ankara, Turkey.Patients and Methods: This cross-sectional study included all of the consecutive glaucoma patients or glaucoma suspects who presented at ten different tertiary ophthalmology clinics in Ankara between March 2015 and May 2015. The demographic characteristics and clinical findings of the patients were evaluated. Glaucoma was diagnosed according to the International Society for Geographical and Epidemiological Ophthalmology Classification. In the patients with binocular glaucoma, only the data of the worse eye was included for statistical analyses. Results: A total of 4604 eyes of 2541 patients fulfilled the inclusion criteria and were classified as having glaucoma. Binocular involvement was present in 2063 (81.2%) patients. Primary open angle glaucoma (POAG) was the most common glaucoma type (38.8%), followed by exfoliative glaucoma (XFG; 26.2%), and primary angle-closure glaucoma (PACG; 7.7%). The distribution of the sexes was significantly different among the diagnosis groups (P < 0.001). The cup/disk ratio was the highest among the patients with secondary angle-closure glaucoma (SACG; P < 0.001). The visual field MD parameter was significantly higher in the patients with SACG and XFG (P < 0.001). Monocular and binocular blindness ratios were 21% and 2.8%, respectively.Conclusions: The predominant type of glaucoma in Turkish clinic patients was found to be POAG, followed by XFG and PACG.

scholarly journals Study of corneal biomechanical properties in patients with childhood glaucoma

2020 ◽  
Vol 13 (12) ◽  
pp. 1922-1927
Author(s):  
Sara Garcia Caride ◽  
Federico Sáenz Francés ◽  
Julián García Feijoo
Keyword(s):  
Pearson Correlation ◽  
Corneal Thickness ◽  
Intraclass Correlation ◽  
Clinical History ◽  
Biomechanical Properties ◽  
Cross Sectional Study ◽  
Control Group ◽  
Ophthalmological Examination ◽  
Cross Sectional ◽  
Corneal Biomechanical Properties

AIM: To study of corneal biomechanical properties and intraocular pressure (IOP) measured with Corvis Scheimpflug Technology (ST) in patients with childhood glaucoma (CG). METHODS: Cross-sectional study in which 89 eyes were included 56 of them with CG. Only one eye per patient was included. The following variables were obtained from the clinical history and the ophthalmological examination: age, sex, IOP, number of surgeries, and the cup/disc ratio (CDR). The following parameters were recorded using Corvis ST: corrected by biomechanics IOP (bIOP), not corrected IOP (nctIOP), central corneal thickness (CCT), maximum concavity [radius, peak distance (PD) and deformation amplitude], applanation 1 and 2 (length and velocity). The mean age was 23±14.55 and 33±19.5 years old for the control group and CG group, respectively. Totally 36 were males and 53 were females. In the CG group, 7 patients were controlled only with medical treatment. Sixteen had at least one previous goniotomy, 19 had at least one trabeculectomy, and 11 had an Ahmed implant. RESULTS: A significant and positive intraclass correlation coefficient was found between Goldman IOP and the IOP measured by Corvis in both groups. No differences were found between the IOP measured with Corvis and Goldman using a student t-test. Regarding biomechanical parameters, there were differences in the applanation length 2 (A-L2), in the applanation velocity 2 (A-V2) and in the PD. By sex, only the applanation length 1 (A-L1) was found to be different in control group. A positive and significant Pearson correlation was found between CDR and the A-L1. CONCLUSION: Corneal biomechanical properties have shown differences between CG and healthy subjects and also between men and women.

scholarly journals Effect of Posture in Intraocular Pressure, Comparison between Normal and Glaucomatous Subjects

2013 ◽  
Vol 11 (2) ◽  
pp. 21-23
Author(s):  
Ram Shrestha ◽  
Sagarika Patyal ◽  
Ramesh Bista ◽  
Sagar Rajkarnikar ◽  
Anu Gurung
Keyword(s):  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Armed Forces ◽  
Normal Tension Glaucoma ◽  
Cross Sectional Study ◽  
Control Group ◽  
Open Angle ◽  
Cross Sectional ◽  
Postural Changes

Introduction: Intraocular pressure (IOP) increases when changing from sitting to supine position with an average difference of 0.3 to 6.0mm of Hg. These postural changes of IOP have been found in normal persons, patients with ocular hypertension and normal tension glaucoma. The eye is relatively non-distensible, even small changes in the volume of aqueous humor may significantly change IOP. The increase in resistance in aqueous flow is thought to be the reason for higher IOP in supine compared to sitting position. The aim of this study was to analyze the effects of posture in intraocular pressure in normal and primary open angle glaucoma subjects. Methods: It was a prospective cross sectional study done in Armed Forces Medical College, Pune, between May, 2007 to May, 2009 with sample sized of 60 people (30 controls and 30 Primary open angle glaucoma). Patients underwent complete ocular examination. Two drops of Topical 4% lignocaine were instilled. IOP measurements were taken by Rebound tonometer in sitting and supine positions at 10 min and 30 min interval respectively. Results: Control group (40-76 yrs) and POAG group (40-78 yrs) were found to have a mean rise of IOP of 1.65 and 2 mm of Hg respectively from sitting to lying for 10min, and  a mean rise of 2.52 and 5.36 mm of Hg respectively from sitting to lying for 30min. Conclusions: The rise in IOP due to change of posture from sitting to supine positions was significantly higher in glaucomatous patients.Medical Journal of Shree Birendra Hospital; July-December 2012/vol.11/Issue2/21-23 DOI: http://dx.doi.org/10.3126/mjsbh.v11i2.7904 

DYSLIPIDEMIA IN THYROID DISORDERS

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Kashish Narula ◽  
Narendra Kumar Dara ◽  
Shyam Lal Meena
Keyword(s):  
Lipid Metabolism ◽  
Thyroid Dysfunction ◽  
Cross Sectional Study ◽  
Control Group ◽  
Thyroid Disorders ◽  
Cross Sectional ◽  
Carbohydrate And Lipid Metabolism ◽  
History Of ◽  
Thyroid Profile ◽  
Basal Energy Expenditure

Background: Thyroid hormones influence nearly all major metabolic pathways. Their most obvious and well-known action is the increase in basal energy expenditure obtained by acting on protein, carbohydrate and lipid metabolism. The lipid metabolism is more influenced by the thyroid hormone. Methods: A cross-sectional study was conducted on 100 patients with suspicion of thyroid disorders were taken as cases. One hundred patients with normal thyroid profile and no history of other chronic diseases were taken as control group. Results: The serum TC, TG and LDL levels in hypothyroid individuals (both overt and subclinical) were significantly higher than euthyroid subjects but the levels were comparable between hyperthyroid and euthyroid group. Conclusion: Dyslipidemias are associated with thyroid disorders, so biochemical screening for thyroid dysfunction in all dyslipidemic patients. Therefore, patients presenting with dyslipidemia are recommended for investigation to explore thyroid dysfunction. Keywords: Thyroid profile, Total cholesterol, Triglycerides and LDL

Pengaruh bising lalu lintas terhadap penurunan fungsi pendengaran pada juru parkir di kota Denpasar

2013 ◽  
Vol 40 (2) ◽  
Author(s):  
Ni Ketut Susilawati ◽  
Wayan Sudana ◽  
Eka Putra Setiawan
Keyword(s):  
Hearing Impairment ◽  
Noise Exposure ◽  
Traffic Noise ◽  
Hearing Threshold ◽  
Noise Pollution ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Hearing Function

Background: Noise pollution or noise is an unwanted sound which is disturbing to human beings.However small or soft the sound, if it is undesirable it is considered as noise. Noise induced hearingloss is a sensorineural hearing loss that is commonly encountered second to presbycusis. Purpose: Toknow the effect of traffic noise exposure on hearing impairment to the employees of the Parking DistrictCompany of the Denpasar city and to improve diagnostic detection on hearing impairment caused bynoise. Method: A cross sectional study was conducted at the Parking District Company office. Thepopulations of this study were the employees of the Parking District Company. Samples of this study were the employees who were exposed to traffic noise and control samples were an employee who was unexposed. Samples were selected by simple random sampling. Results: From 40 parking attendants,27 persons (67.5%) aged above 35 years old. The parking attendants who had been working for ten to fifteen years were 36 persons (90%) and no history using ear protection when working. Seven persons(17.5%) had referred DPOAE upon examination with increase hearing threshold on audiogram result.In this study the parking attendants who had hearing deficit induced by noise were 7 persons (17.5%)and only one person (2.5%) in control group. There was a statistically significant effect of traffic noiseto hearing function deficit (p<0.05). Conclusion: Traffic noise has effect in hearing function deficit onthe parking attendants.ORLI Vol. 40 No. 2 Tahun 2010Key words: NIHL, parking attendant, audiometry, DPOAE.

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