Midfoot Arthritis in Children: Is There Any Relation With Malignancy?

Background: Musculoskeletal symptoms are a presenting manifestation in a number of lymphoproliferative disorders including leukemia, especially in children. Among these primary symptoms, midfoot arthritis seems to be an important alarm for malignancy in children. The aim of this study is evaluation association of midfoot arthritis with malignancy in children. Method: In this cross-sectional study, all medical records of patients with arthritis were identified and reviewed. All clinical and laboratory data were recorded in the information form and data were analyzed by SPSS 25 software. Results: A total of 557 cases of arthritis were evaluated, of which 18 (3.2%) cases have primary symptoms of midfoot arthritis. Four of 18 patients (22.2%) had B-cell precursor acute lymphoblastic leukemia, that midfoot arthritis was their first manifestation. Also, their laboratory findings confirmed that platelet, lactic acid dehydrogenesis, and uric acid values were significantly higher in these children. Based on statistical evaluation, there was no significant difference between age and sex in these patients. Conclusion: According to the findings of the present study, it can be concluded that “midfoot arthritis” may be the first manifestation of leukemia in children even with a near-normal hematologic values.

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A Cross-Sectional Study to Compare Differences on Clinical and Laboratory Findings in Children with Seropositive and Seronegative Lupus

10.21203/rs.3.rs-1113288/v1 ◽

2021 ◽

Author(s):

Shima Salehi ◽

Rozita Hosseini Shamsabadi ◽

Hassan Otukesh ◽

Reza Shiari ◽

Monir Sharafi

Keyword(s):

Autoimmune Disease ◽

Disease Diagnosis ◽

Cross Sectional Study ◽

Rapid Identification ◽

The Body ◽

Musculoskeletal Symptoms ◽

Laboratory Findings ◽

Cross Sectional ◽

Significant Difference ◽

History Of

Abstract Background: Lupus is an inflammatory and autoimmune disease that involves various tissues and organs of the body. Identification of diagnostic elements to rapid identification of seronegative lupus cases is very important in order to prevent morbidity and progression of disease. This study aimed to compare clinical and laboratory findings of seropositive cases with seronegative lupus patients. Methods: This cross-sectional analytic study was performed on 43 children (17 seronegative and 26 seropositive) with lupus who were admitted to Ali Asghar Hospital during 2007-2017. Seropositive patients had anti-nuclear antibody (ANA) titration >1/80, while seronegative patients had ANA titration <1/80 (at the time of disease diagnosis). Clinical and laboratory findings were compared between two groups.Results: Serositis in patients with ANA- was significantly higher than ANA+ (41.17% vs. 23.07%; p = 0.042). ANA- group had higher autoimmune disease history than ANA+ group (42.85% vs. 15.0%; p = 0.041). The family history of the disease in the ANA- group was greater than ANA+ group (50% vs. 23.52%). The percentage of hypertensive patients in ANA- group was higher than ANA+ group (52.94% vs. 26.92%; p = 0.037). Neurologic symptoms in ANA+ and ANA- groups were 38.46% and 17.64%, respectively (p = 0.043). The frequency of patients with thrombocytopenia in ANA+ group was significantly greater than ANA- group (32% vs. 12.5%; p=0.041). There was no significant difference in other clinical and laboratory findings between two groups. Conclusion: Seronegative lupus patients had higher percentage of musculoskeletal symptoms, autoimmune disease history, familial history of disease, and hypertension, while neurological and thrombocytopenia symptoms were higher in seropositive patients compared to seronegative cases. Therefore, evaluation of these factors can be helpful to diagnosis of seronegative patients.

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THE NEUROLOGICAL FACE OF CELIAC DISEASE

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032015000300002 ◽

2015 ◽

Vol 52 (3) ◽

pp. 167-170 ◽

Cited By ~ 11

Author(s):

Sedat IŞIKAY ◽

Halil KOCAMAZ

Keyword(s):

Celiac Disease ◽

Medical Records ◽

Laboratory Data ◽

Cross Sectional Study ◽

Breath Holding ◽

Neurological Manifestations ◽

Cross Sectional ◽

Hyperactivity Disorder ◽

Neurological Finding ◽

Significant Difference

BackgroundSeveral neurological disorders have also been widely described in celiac disease patients.ObjectiveThe aim of this study was to determine the incidence of accompanying different neurologic manifestations in children with celiac disease at the time of diagnosis and to discuss these manifestations in the light of the recent literature.MethodsThis prospective cross sectional study included 297 children diagnosed with celiac disease. The medical records of all patients were reviewed.ResultsIn neurological evaluation, totally 40 (13. 5%) of the 297 celiac patients had a neurological finding including headache, epilepsy, migraine, mental retardation, breath holding spells, ataxia, cerebral palsy, attention deficit hyperactivity disorder, Down syndrome and Turner syndrome in order of frequency. There was not any significant difference between the laboratory data of the patients with and without neurological manifestations. However; type 3a biopsy was statistically significantly more common among patients without neurological manifestations, while type 3b biopsy was statistically significantly more common among patients with neurological manifestations.ConclusionIt is important to keep in mind that in clinical course of celiac disease different neurological manifestations may be reported.

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The Role of Ischemia-modified Albumin as a Biomarker in Preeclampsia

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0040-1709662 ◽

2020 ◽

Vol 42 (03) ◽

pp. 133-139

Author(s):

Süleyman Serkan Karaşin ◽

Tayfur Çift

Keyword(s):

Pregnant Women ◽

Laboratory Data ◽

Cross Sectional Study ◽

Enzyme Linked Immunosorbent Assay ◽

Cross Sectional ◽

Ischemia Modified Albumin ◽

Significant Difference ◽

Gestational Week ◽

Severity Of The Disease

Abstract Objective Ischemia-modified albumin (IMA)is a modified type of albumin protein that is formed under oxidative stress. This study aims to compare the levels of serum IMA between normotensive and preeclamptic pregnancies and to evaluate the relationship between the severity of the disease. Methods A total of 90 pregnant women aged between 18 and 45 years participated in this cross-sectional study. The levels of serum IMA were measured by enzyme-linked immunosorbent assay in 30 preeclamptic pregnant women with the severe signs of the disease, 30 preeclamptic pregnant women, and 30 normotensive pregnant women.. The study was designed as a cross-sectional clinical study. Results When the demographic characteristics were examined, statistically significant differences were found between the groups in terms of age, gestational week at birth and blood pressure. Age was higher in the preeclampsia with signs of severity group than in the normotensive group (p = 0.033). Pregnancy week was significantly the lowest in the preeclampsia with the severity signs group (p = 0.004). In normotensive patients, IMA levels were lower than in the preeclampsia groups (p < 0.001) but there was no significant difference in terms of severity of disease (p = 0.191). According to laboratory data; only the creatinine level was significantly different between the groups. Conclusion The levels of serum IMA were higher in patients with preeclampsia than in healthy pregnancies. However, there was no significant correlation in terms of preeclampsia severity; more extensive, prospective and long-term studies are needed.

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Patient-reported complications associated with Campylobacter jejuni infection

Epidemiology and Infection ◽

10.1017/s0950268809991099 ◽

2009 ◽

Vol 138 (7) ◽

pp. 1004-1011 ◽

Cited By ~ 19

Author(s):

D. SCHÖNBERG-NORIO ◽

L. MATTILA ◽

A. LAUHIO ◽

M.-L. KATILA ◽

S.-S. KAUKORANTA ◽

...

Keyword(s):

Campylobacter Jejuni ◽

Medical Records ◽

Joint Pain ◽

Cross Sectional Study ◽

Antimicrobial Treatment ◽

Musculoskeletal Symptoms ◽

Cross Sectional ◽

Positive Stool ◽

Patient Reported ◽

Stool Samples

SUMMARYThis study aimed to investigate the occurrence of complications, especially musculoskeletal symptoms, after sporadic Campylobacter jejuni enteritis of domestic origin in Finland. This multi-centre cross-sectional study was conducted during a seasonal peak in 2002. Questionnaires were sent to Campylobacter-positive patients, representing different geographical areas, 2 months after collection of positive stool samples. Medical records were viewed in several cases. Besides antimicrobial susceptibility testing C. jejuni isolates were serotyped. A total of 235 patients (58%) returned the questionnaire and 201 C. jejuni-positive patients were finally included in the study. Musculoskeletal symptoms associated with C. jejuni enteritis were frequent (39%); joint pain was most commonly reported (81%). The incidence of reactive arthritis was 4% and that of Achilles enthesopathy and/or heel pain was 9%. Stomach ache during enteritis was associated with the later development of joint pain. Antimicrobial treatment was common but did not prevent complications.

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Perfil de usuários e motivos da consulta de enfermagem em estomaterapia

Revista de Enfermagem UFPE on line ◽

10.5205/1981-8963.2020.245710 ◽

2020 ◽

Vol 14 ◽

Author(s):

Rosaura Soares Paczek ◽

Andreia Inês Engelmann ◽

Giulia Pedroso Perini ◽

Glória Pinto Soares de Aguiar ◽

Erica Rosalba Mallmann Duarte

Keyword(s):

Medical Records ◽

Self Care ◽

Cross Sectional Study ◽

Study Data ◽

Neoplastic Disease ◽

Age Group ◽

Cross Sectional ◽

Significant Difference ◽

Quantitative Descriptive ◽

Care Nursing

Objetivo: analisar o perfil de usuários e os motivos da consulta de enfermagem em estomaterapia. Método: trata-se de um estudo quantitativo, descritivo, exploratório e transversal. Coletaram-se os dados em prontuários de 252 usuários nos quais foram consultados em 1116 consultas de enfermagem. Analisaram-se os dados pelo programa SPSS versão 20, empregando-se a estatística descritiva. Resultados: revela-se, quanto ao sexo, que não houve diferença significativa; quanto à faixa etária, 53,6% dos participantes tinham 65 anos ou mais de idade; a causa do estoma foi a doença neoplásica maligna em 65,5% da amostra; o motivo da consulta, em 56%, foi a troca de bolsa de ostomia e 50,4% dos pacientes realizaram somente uma consulta no período analisado. Conclusão: mostrou-se, que o enfermeiro estomaterapeuta precisa refletir no planejamento e nas estratégias de cuidados prestados, contemplando a educação do autocuidado do usuário e educação permanente da equipe, enfatizando a sensibilidade do acolhimento, visto que a maioria dos pacientes tem neoplasia maligna, situação de grande impacto na vida do usuário e de sua família. Descritores: Estomia; Consulta de Enfermagem; Educação Permanente; Estomaterapia; Autocuidado; Cuidados de Enfermagem.AbstractObjective: to analyze the profile of users and the reasons for the nursing consultation in stomatherapy. Method: this is a quantitative, descriptive, exploratory and cross-sectional study. Data was collected from medical records of 252 users, who were consulted in 1116 nursing consultations. Data was analyzed using the SPSS version 20 program, using descriptive statistics. Results: it is revealed, as for sex, that there was no significant difference; as for the age group, 53.6% of the participants were 65 years old or older; the cause of the stoma was malignant neoplastic disease in 65.5% of the sample; the reason for the consultation, in 56%, was to change the ostomy bag and 50.4% of the patients had only one consultation during the analyzed period. Conclusion: it was shown that the stoma nurse needs to reflect on the planning and care strategies provided, contemplating the education of the user's self-care and permanent education of the team, emphasizing the sensitivity of the welcoming, since the majority of patients have malignancy, situation of great impact on the life of the user and their family. Descriptors: Ostomy; Nursing Consultation; Education Continuing; Stomatherapy; Self Care; Nursing Care.ResumenObjetivo: analizar el perfil de los usuarios y los motivos de la consulta de enfermería en estomaterapia. Método: se trata de un estudio cuantitativo, descriptivo, exploratorio y transversal. Se recopilaron datos de registros médicos de 252 usuarios, que fueron consultados en 1116 consultas de enfermería. Los datos se analizaron utilizando el programa SPSS versión 20, utilizando estadísticas descriptivas. Resultados: se revela, en cuanto al sexo, que no hubo diferencia significativa; en cuanto al grupo de edad, el 53,6% de los participantes tenían 65 años o más; la causa del estoma fue la enfermedad neoplásica maligna en el 65.5% de la muestra; el motivo de la consulta, en el 56%, fue cambiar la bolsa de ostomía y el 50,4% de los pacientes tuvieron una sola consulta durante el período analizado. Conclusión: se demostró que el enfermero de estomas necesita reflexionar sobre la planificación y las estrategias de atención provistas, contemplando la educación del autocuidado del usuario y la educación permanente del equipo, enfatizando la sensibilidad de la recepción, ya que la mayoría de los pacientes tienen neoplasia maligna, situación de gran impacto en la vida del usuario y su familia. Descriptores: Estomia; Consulta de Enfermería; Educación Permanente; Estomaterapia; Autocuidado; Cuidados de Enfermería.

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Perbedaan Rerata Rasio Kadar Natrium Kalium Maternal Antara Preeklamsia Berat Dan Eklamsia

JOURNAL OBGIN EMAS ◽

10.25077/aoj.4.1.48-52.2020 ◽

2020 ◽

Vol 4 (1) ◽

pp. 48-52

Author(s):

Gunawan Efri Syaputra ◽

Dovy Djanas

Keyword(s):

Medical Records ◽

Sampling Technique ◽

Endothelial Activation ◽

Cross Sectional Study ◽

Severe Preeclampsia ◽

Cross Sectional ◽

Sodium Potassium ◽

Specific Syndrome ◽

Significant Difference ◽

Sodium And Potassium

Background: Preeclampsia is a pregnancy-specific syndrome in the form of reduced organ perfusion due to vasospasm and endothelial activation that occurs after 20 weeks of gestational age. eclampsia is the occurrence of seizures in a woman with preeclampsia, Sodium (Na +) and Potassium (K +) play an important role in preeclampsia and eclampsia.Objective: To see the difference in mean sodium potassium ratio between pregnancy with severe preeclampsia and eclampsia.Methods: The study was analytic descriptive using a cross sectional study design by looking at the medical records of the subjects according to the time and place of the study. Samples are all medical records of pregnant women who suffer from pre-eclampsia and eclampsia in the obstetric and gynecology section of RSUP DR.M.Djamil padang in the period of 15 January 2016 to 31 December 2017, the values of which are sodium, potassium levels and sodium and potassium ratios. Samples were taken from populations that met the inclusion criteria and did not have exclusion criteria. Sampling using a consecuvite sampling technique which was taken from the medical records of RSUP DR. M. Djamil Padang Statistical analysis to assess significance using the T-test.Results: In the Severe preeclampsia and Eclampsia groups it was found that multipara parity had the highest respondents. This is in accordance with the literature where the incidence of preeclampsia is more often found at near term gestational age.Conclusion: There is no significant difference in the average sodium potassium ratio between Severe preeclampsia and EclampsiaKeywords: Severe preeclampsia, eclampsia, sodium and potassium

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CO-St (COVID 19- study): impact of the management of men versus women in the treatment of Covid 19. A Multi-Centric Observational study

10.20944/preprints202108.0119.v1 ◽

2021 ◽

Author(s):

Tiziana Ciarambino ◽

filomena pietrantonio ◽

Sara Rotunno ◽

Alessandra Fiorentini ◽

Rosalba Cipriani ◽

...

Keyword(s):

Oxygen Therapy ◽

Signs And Symptoms ◽

Epidemiological Data ◽

Cross Sectional Study ◽

Antiviral Drugs ◽

Laboratory Findings ◽

Cross Sectional ◽

Significant Difference ◽

Rehabilitation Ward ◽

Epidemiological Link

Background: from December 2019 and the spreading of syndemics, a lot of medical centers reg-istered data about their patients. In Italy, the most relevant quantity of patients was hospitalized in internal medicine wards. Methods: In this observational, retrospective cross-sectional study, all data of the COVID-19 patients, admitted Latio hospitals, from March 01 to December 31, 2020, were collected and their Epidemiological data, demographics, signs and symptoms on admission, comorbidities, laboratory findings, chest radiography and CT findings, treatment received and mortality rate were analyzed by gender to find any differences of gravity of disease. Clinician details were registered on database (one for every hospital). Cost analysis was performed by length of stay and antiviral drugs use, using point of view of Italian Healthcare System. Results: 2256 patients with mean age of 71.01 ± 28.02 years were included. For men, frequency of hyper-tension, COPD, use of oxygen therapy, Tocilizumab were significantly higher and epidemiolog-ical link was related to rehabilitation ward and community. The gender difference about hospi-talization was one day more for man. No strong significant difference by gender in the death rate was observed. Considering antiviral drugs and hospitalization, a man costs €1000 more than woman. Conclusions: In male patients, hypertension and COPD were observed more frequently and the epidemiological link was related to rehabilitation ward and community. In female sub-jects, the epidemiological link was related to Hospital and we observed significantly higher atypical chest-X ray. Tocilizumab, oxygen therapy and antiviral drugs were prescribed more in male subjects. No differences by gender we report in other treatments and outcomes. Future studies should be analyzed to get a more comprehensive understanding of COVID-19 by gender.

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Evaluation of Neurological Complications in Hospitalized COVID-19 Patients: A Cross-Sectional Study 2020

10.21203/rs.3.rs-360768/v1 ◽

2021 ◽

Author(s):

Mojtaba Khazaei ◽

Fatemeh Feizy ◽

Salman Khazaei

Keyword(s):

Electronic Medical Records ◽

Medical Records ◽

Neurological Complications ◽

Cross Sectional Study ◽

Neurological Symptoms ◽

Medical Sciences ◽

Laboratory Findings ◽

Cross Sectional ◽

Effective Interventions ◽

Brain Tissue Damage

Abstract Objective: The coronavirus (COVID-19) has been spreading around the world since December 2019. Neurological symptoms have been reported as a part of the clinical spectrum of the disease. This study aimed to determine the frequency of neurological complications in hospitalized patients with COVID-19.Methods: Electronic medical records in the hospital information system, laboratory findings, and radiological examinations were evaluated for all patients with laboratory-confirmed SARS-CoV-2 infection. The cases were referred to Shahid Beheshti Hospital affiliated to Hamadan University of Medical Sciences from February 20, 2020 to the end of the same year.Results: A total of 477 hospitalized COVID-19 patients were included in the analyses. Based on our results, 105 (22.02%) patients showed neurological manifestations. Ischemic stroke, decreased consciousness, and headache were the most frequent reported neurological symptoms with the rate of 34 (7.13%), 28 (5.88%), and13 (2.72%), respectively. Moreover, 54 (51.43%) cases were male, and the vast majority of the patients (66; 62.86%) had more than 60 years of age. Conclusions: SARS-CoV-2 may involve nervous system and cause brain tissue damage. The findings of this study provide more information on coronavirus disease, contributing to effective interventions for the control of the disease

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What do we know about covid-19 critically ill patients receiving enteral nutrition? a crosssectional study

Medical & Clinical Research ◽

10.33140/mcr.06.035 ◽

2020 ◽

Vol 5 ◽

Keyword(s):

Enteral Nutrition ◽

Critically Ill ◽

Medical Records ◽

Statistical Significance ◽

Invasive Mechanical Ventilation ◽

Laboratory Data ◽

Prevalence Ratio ◽

Simplified Acute Physiology Score ◽

Cross Sectional Study ◽

Cross Sectional

Background and Aims: Given the need to nourish critically ill COVID-19 patients, whose specific issues may hinder their nutritional supply, this research aimed to evaluate individuals who fed enteral nutrition (EN) and compare them with patients fed orally (ON), in order to assess their profile and find significant differences between both groups. Methods: This is a cross-sectional study in which demographic, medical and laboratory data of EN and ON severe patients with COVID-19 were collected from electronic medical records. Univariate and multivariate analysis inferred and confirmed Prevalence Ratio (PR) of these variables, respectively. Results: A total of 211 medical records were assessed (EN=123). EN patients were mostly male, over 50 years old, overweight or obese, using invasive mechanical ventilation (IMV) and vasopressor drugs (VD). They presented high levels of SAP3 (Simplified Acute Physiology Score 3), d-dimer and brain natriuretic peptide (BNP), as well as low lymphocyte counts. Death rate was 44,71%. In significant comparisons between EN and ON groups, IMV (PR=7.06, p<0.001), hemodialysis (PR=1.57, p<0.001), VD (PR=2. 16, p<0.001), CT lung injury>50% (PR=1. 31, p=0.039), high BNP (p=0.001) and SAPS3 (p<0.001), lymphopenia (p<0.001) and death (PR=2. 19, p<0.001) prevailed in the former. Logistic regression supported statistical significance for IMV (z=7.027, p<0.001), VD (z=3.473, p=0.001), low lymphocytes count (z=-3.785, p=0.001), and death (z=2.692 and p=0.007). Conclusion: 1) EN patients were more severely ill than those ON. 2) When correlated with ON, EN group had higher rates of IMV, VD, lymphopenia and death.

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Pediatric Logistic Organ Dysfunction (PELOD) Score as prognosis of multiple organ failure in sepsis

Paediatrica Indonesiana ◽

10.14238/pi50.4.2010.226-31 ◽

2010 ◽

Vol 50 (4) ◽

pp. 226

Author(s):

Hendra Hendra ◽

Ari Lukas Runtunuwu ◽

Jeanette Irene Chistie Manoppo

Keyword(s):

Multiple Organ Failure ◽

Organ Failure ◽

Cross Sectional Study ◽

Multiple Organ ◽

Laboratory Findings ◽

Cross Sectional ◽

Logistic Organ Dysfunction ◽

Emergency Event ◽

Significant Difference ◽

Pelod Score

Background Sepsis is an emergency event that often found inpediatric intensive care unit. If this condition is not early detectedand promptly treated, severe complications including septic shockand multiple organ failure may result that can end up as death.Objective To discover alternative measurement as a prognosis ofmultiple organ failure in sepsis.Methods This cross sectional study was conducted in 37 patientsdiagnosed as sepsis. The age of the patients were 1 month until 13years and the patients were hospitalized in child health departmentof R. D. Kandou Hospital during June 2009 – September 2009.Result Bronchopneumonia (18) was the most commoninfection source, followed by gastroenteritis (11), encephalitis(6) and meningitis (2). The bacteria which is found was Proteusmirabilis (5), Citrobacter difersus (5), Staphylococcus aureus (3),Escherichia coli (2) and Acinetobacter baumannii (1). There wasno significant difference in gender distribution, nutrition statusand blood culture between both groups. Laboratory findings andclinical manifestations which included white blood cell (WBC)> 10.000/μL (34), platelet count > 150.000 (27) and bodytemperature 38oC – 39oC (20). There was a correlation betweenPELOD score and multiple organ failure (P=0.02). A higherPELOD score will increase opportunity to get multiple organfailure. In patient with organ failure more than two, PELODscore 0-10 (9 patients), score 11-20 (7 patients), score 21-30 (8patients), and score 31-40 (1 patient).Conclusion There was a correlation between PELOD score andmultiple organ failure in patient with sepsis. A higher PELODscore will increase opportunity to get multiple organ failure.

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