Validation of the RUDAS in Patients With a Middle-Level Education in Lima, Peru

Objectives: To assess the psychometric properties of the Peruvian version of the Rowland Universal Dementia Assessment Scale (RUDAS-PE) to discriminate controls from patients with mild cognitive impairment (MCI) and early dementia (ED) in a population with a mid-level education. Methods: A total of 133 patients from a memory clinic were administered the RUDAS-PE, INECO Frontal Screening, Addenbrooke’s Cognitive Examination, and Mini-Mental State Examination. Results were compared against a neuropsychological evaluation (gold standard). Validity measures, internal consistency, and concurrent validity were calculated. Results: Cronbach’s α was 0.68; Pearson’s ratio was 0.79 ( P < .01). The area under the receiver–operating characteristics curve of the RUDAS to discriminate between ED and MCI was 89.0% (optimal cutoff at <21), whereas between MCI and controls, it was 99.0% (optimal cutoff at <24). Conclusions: The RUDAS-PE has acceptable psychometric properties performing well in its ability to discriminate controls from patients with MCI and ED.

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The use of the Digit Span Test in screening for cognitive impairment in acute medical inpatients

International Psychogeriatrics ◽

10.1017/s1041610211000792 ◽

2011 ◽

Vol 23 (10) ◽

pp. 1569-1574 ◽

Cited By ~ 31

Author(s):

Jess L. M. Leung ◽

Gary T. H. Lee ◽

Y. H. Lam ◽

Ray C. C. Chan ◽

Jimmy Y. M. Wu

Keyword(s):

Cognitive Impairment ◽

Digit Span ◽

Operating Characteristics ◽

Digit Span Test ◽

Span Test ◽

Acute Medical Unit ◽

Receiver Operating Characteristics Curve ◽

Medical Inpatients ◽

Valid Instrument ◽

State Examination

ABSTRACTBackground: There is no valid instrument currently in use at acute-care hospitals in Hong Kong to aid the detection of cognitive impairment. The objectives of this study were to (1) validate the Digit Span Test (DST) in the identification and differentiation of dementia and delirium; and (2) determine the prevalence of major cognitive impairment in elderly people in an acute medical unit.Methods:During the study period from January to February 2010, 144 patients aged 75 years or more who had had unplanned medical admissions were assessed by nurses, using the Digit Span Forwards (DSF) and the Digit Span Backwards (DSB) tests. The DST scores were compared with the psychiatrists’ DSM-IV-based diagnoses. Receiver Operating Characteristics curve (ROC) was used in conjunction with sensitivity and specificity measures to assess the performance of DST.Results: The prevalence rates of dementia alone, delirium alone and delirium superimposed on dementia were 21.5%, 9% and 9% respectively. The prior case-note documentation rate was 13.2% for dementia and 2.8% for delirium. Regarding the detection of major cognitive impairment, the ROC curve of DSB showed a sensitivity of 0.77 and specificity of 0.78 at the optimal cutoff of <3. A significant association between scores on the DST and the Cantonese version of the Mini-Mental State Examination (CMMSE) was found in this study (p < 0.05 for DSF, p = 0.00 for DSB).Conclusions: Dementia and delirium were prevalent, yet under-recognized, in acute medical geriatric inpatients. The DSB is an effective tool in identifying patients with major cognitive impairment.

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Performance of the Rowland Universal Dementia Assessment Scale for the Detection of Mild Cognitive Impairment and Dementia in a Diverse Cohort of Illiterate Persons From Rural Communities in Peru

Frontiers in Neurology ◽

10.3389/fneur.2021.629325 ◽

2021 ◽

Vol 12 ◽

Author(s):

Nilton Custodio ◽

Rosa Montesinos ◽

Monica M. Diaz ◽

Eder Herrera-Perez ◽

Kristhy Chavez ◽

...

Keyword(s):

Rural Communities ◽

Diagnostic Accuracy ◽

Psychometric Properties ◽

Gold Standard ◽

Area Under The Curve ◽

Assessment Scale ◽

Screening Tools ◽

Operating Characteristics ◽

Clinical Dementia Rating ◽

Optimal Cutoff

Background: The accurate diagnosis of neurocognitive disorders in illiterate Peruvian populations is challenging, largely owing to scarcity of brief cognitive screening tools (BCST) validated in these diverse populations. The Peruvian version of the Rowland Universal Dementia Assessment Scale (RUDAS-PE) is a BCST that relies minimally on educational attainment and has shown good diagnostic accuracy in an urban illiterate population in Peru, yet its psychometric properties in illiterate populations in rural settings of the country have not been previously investigated.Objectives: To establish the diagnostic accuracy of the RUDAS-PE compared to expert clinical diagnosis using the Clinical Dementia Rating (CDR) Scale in healthy and cognitively impaired illiterate persons living in two culturally and geographically distinct rural communities of Peru.Methods: A cross-sectional, population-based study of residents ≥ 50 years of age living in the Peruvian rural communities of Santa Clotilde and Chuquibambilla. A total of 129 subjects (76 from Santa Clotilde and 53 from Chuquibambilla) were included in this study. Gold standard diagnostic neurocognitive evaluation was based on expert neurological history and examination and administration of the CDR. Receiver operating characteristics, areas under the curve (AUC), and logistic regression analyses were conducted to determine the performance of RUDAS-PE compared to expert gold standard diagnosis.Results: Compared to gold standard diagnosis, the RUDAS-PE was better at correctly discriminating between MCI and dementia than discriminating between MCI and controls in both sites (97.0% vs. 76.2% correct classification in Chuquibambilla; 90.0% vs. 64.7% in Santa Clotilde). In Chuquibambilla, the area under the curve (AUC) of the RUDAS to discriminate between dementia and MCI was 99.4% (optimal cutoff at <18), whereas between MCI and controls it was 82.8% (optimal cutoff at <22). In Santa Clotilde, the area under the curve (AUC) of the RUDAS to discriminate between dementia and MCI was 99.1% (optimal cutoff at <17), whereas between MCI and controls it was 75.5% (optimal cutoff at <21).Conclusions: The RUDAS-PE has acceptable psychometric properties and performed well in its ability to discriminate MCI and dementia in two cohorts of illiterate older adults from two distinct rural Peruvian communities.

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A Comparison of the Greek ACE-III, M-ACE, ACE-R, MMSE, and ECAS in the Assessment and Identification of Alzheimer’s Disease

10.31234/osf.io/tx4mz ◽

2021 ◽

Author(s):

Panagiotis Kourtesis ◽

Eleni Margioti ◽

Christina Demenega ◽

Foteini Christidi ◽

Sharon Abrahams

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Psychometric Properties ◽

Convergent Validity ◽

Characteristic Curve ◽

Motor Impairments ◽

Duration Of Disease ◽

State Examination ◽

Addenbrooke’S Cognitive Examination ◽

Specific Score

Objective:This study aimed to adapt the Addenbrooke’s Cognitive Examination-III (ACE-III) and Mini-Addenbrooke’s CognitiveExamination (M-ACE) into Greek and then to examine the convergent validity against their predecessorsAddenbrooke’s Cognitive Examination-Revised (ACE-R) and Mini-Mental State Examination (MMSE) in a Greekpopulation. Moreover, a primary aim was to appraise the utility of each screen by conducting a comparison of thepsychometric properties of ACE-III, M-ACE, ACE-R, MMSE, and the Edinburgh Cognitive and Behavioural AmyotrophicLateral Sclerosis (ALS) Screen (ECAS) in detecting Alzheimer’s disease (AD).Methods:Forty patients with AD were recruited and matched with 38 controls. Bayesian Pearson’s correlation analysis wasconducted to examine the convergent validity. Receiver operating characteristic curve analysis was implemented toappraise the sensitivity and specificity of the tests in detecting AD.Results:The ACE-III, M-ACE, and the ECAS scores robustly correlated with ACE-R and MMSE. The ACE-III and the ECAS-ALSNon-Specific score were the most sensitive and specific tools in detecting AD, closely followed by ECAS Total scoreand M-ACE. Only ECAS Total score correlated with the duration of disease. The ECAS scores were more resilient toceiling effects than the other screens. M-ACE produced fewer ceiling effects than MMSE.Conclusion:The Greek ACE-III and M-ACE were successfully adapted and showed good convergent validity against theirpredecessors. They showed very good psychometric properties in detecting AD and may be considered in hecticclinical settings. ECAS Total score and ECAS-ALS Non-Specific showed comparable psychometric properties in thedetection of AD and may be considered in polypathological clinics where motor impairments are common.

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Etiological Work-Up for Adults with Bronchiectasis: A Predictive Diagnostic Score for Primary Ciliary Dyskinesia and Cystic Fibrosis

Journal of Clinical Medicine ◽

10.3390/jcm10163478 ◽

2021 ◽

Vol 10 (16) ◽

pp. 3478

Author(s):

Frederic Schlemmer ◽

Agnes Hamzaoui ◽

Sonia Zebachi ◽

Aurelie Le Thuaut ◽

Gilles Mangiapan ◽

...

Keyword(s):

Cystic Fibrosis ◽

Primary Ciliary Dyskinesia ◽

Clinical Score ◽

Adult Patients ◽

Operating Characteristics ◽

Diagnostic Score ◽

Receiver Operating Characteristics Curve ◽

Diagnostic Work ◽

Work Up ◽

Ciliary Dyskinesia

Background: etiological investigations are not done for all adult patients with bronchiectasis because of the availability and interpretation of tests. The aim of the study was to elaborate a score to identify patients at high risk of having cystic fibrosis or primary ciliary dyskinesia (CF/PCD), which require appropriate management. Methods: diagnostic work-ups were carried out on a French monocenter cohort, and results were subjected to logistic-regression analyses to identify the independent factors associated with CF/PCD diagnosis and, thereby, elaborate a score to validate in a second cohort. Results: among 188 patients, 158 had no obvious diagnosis and were enrolled in the algorithm-construction group. In multivariate analyses, age at symptom onset (8.69 (2.10–35.99); p = 0.003), chronic ENT symptoms or diagnosed sinusitis (10.53 (1.26–87.57); p = 0.03), digestive symptoms or situs inversus (5.10 (1.23–21.14); p = 0.025), and Pseudomonas. aeruginosa and/or Staphylococcus aureus isolated from sputum (11.13 (1.34–92.21); p = 0.02) are associated with CF or PCD. Receiver operating characteristics curve analysis, using a validation group of 167 patients with bronchiectasis, confirmed the score’s performance with AUC 0.92 (95% CI: 0.84–0.98). Conclusions: a clinical score may help identify adult patients with bronchiectasis at higher risk of having CF or PCD.

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Cooperative Learning and Literacy Instruction in Middle Level Education

The Teacher’s Role in Implementing Cooperative Learning in the Classroom ◽

10.1007/978-0-387-70892-8_5 ◽

2008 ◽

pp. 92-109 ◽

Cited By ~ 2

Author(s):

Robert J. Stevens

Keyword(s):

Cooperative Learning ◽

Literacy Instruction ◽

Middle Level ◽

Middle Level Education

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Evaluating the Risk of Tumors Diseases Based on Measurement of Urinary and Serumal Antioxidants Using the New Agar Diffusion Methods

Oxidative Medicine and Cellular Longevity ◽

10.1155/2017/6578453 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Ying Zhou ◽

Jing Chen ◽

Zhen Wang ◽

Hui Liu

Keyword(s):

Antioxidant Capacity ◽

Healthy People ◽

Healthy Individuals ◽

Operating Characteristics ◽

Tumor Patients ◽

Tumor Diseases ◽

Receiver Operating Characteristics Curve ◽

Age Range ◽

Urine And Serum ◽

Effect Of Age

Objectives. To discuss the characteristics of the amount of urinary total antioxidants in tumor diseases and the possibility of utilizing the changing regulation of urinary antioxidants to diagnose tumor diseases.Method. Urine and serum specimens from 130 healthy people were used to investigate the variation of antioxidant capacity against age. Urine and serum specimens from 44 unselected patients with tumors and 44 healthy people with same age background were used to explore the significance of urinary antioxidant capacity in clinic to diagnose tumor diseases. Potassium permanganate agar method and iodine starch method were used to determine the amount of total antioxidants.Results. In healthy people, more antioxidants in urine were measured in older people, while the results were opposite in serum. More antioxidants were found in urine of tumor patients than in healthy people with same age-range.Conclusions. According to the results of 130 measurements, the amount of antioxidants in urine varies by age. By using agar methods to measure antioxidants, the effect of age is required to be considered. Antioxidants levels from tumor patients were significantly higher than healthy individuals in urine. The combination of urine and serum to determine total antioxidants can better diagnose tumor diseases based on iodine starch method, with area under the receiver operating characteristics curve at 0.787.

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The Association between Serum Sodium Levels and Febrile Seizures Recurrence: Is the Degree of Hyponatremia a Risk Factor?

Journal of Pediatric Neurology ◽

10.1055/s-0041-1722851 ◽

2021 ◽

Author(s):

Esma Keleş Alp ◽

Ahmet Midhat Elmacı

Keyword(s):

Serum Sodium ◽

Medical Records ◽

Febrile Seizure ◽

Serum Sodium Level ◽

Febrile Seizures ◽

Lower Sensitivity ◽

Operating Characteristics ◽

Serum Electrolyte ◽

Optimal Cutoff ◽

Characteristics Analysis

AbstractFebrile seizures are common disorders in childhood. We evaluated the serum electrolyte levels and the associated factors in children with single and recurrent febrile seizures in 24 hours period of hospitalization. The medical records of children who were clinically diagnosed with febrile seizures and hospitalized were retrospectively revealed and analyzed. Data were collected for children aged 1 to 6 years including demographic parameters and serum electrolyte levels. A total of 244 children were enrolled in the study in which 209 were diagnosed with single febrile seizures and 35 of them with recurrent febrile seizures. Serum sodium levels were significantly lower in children with recurrent febrile seizure (138.5 ± 2.38 and 134.2 ± 3.55, p < 0.001). Correlation analysis revealed that mild hyponatremia is associated with recurrence of febrile seizure within 24 hours. However, receiver-operating characteristics analysis for hyponatremia showed lower sensitivity (50.3%) and specificity (43.1%) values for optimal cutoff value of 133.5 mmol/L of serum sodium level. Our study suggested that serum sodium levels were significantly lower in children with recurrent febrile seizures. However, because of its lower sensitivity and specificity values, mild hyponatremia cannot be used as an indicator for febrile seizure recurrence.

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Examining the Psychometric Properties of Maximally Efficient Items From the Social Skills Improvement System–Teacher Rating Scale

Journal of Psychoeducational Assessment ◽

10.1177/0734282917743335 ◽

2017 ◽

Vol 37 (3) ◽

pp. 307-319 ◽

Cited By ~ 1

Author(s):

Christopher James Anthony ◽

James Clyde DiPerna

Keyword(s):

Social Skills ◽

Psychometric Properties ◽

Rating Scale ◽

Teacher Rating ◽

Psychological Research ◽

Teacher Rating Scale ◽

The Social ◽

Validity Measures ◽

Initial Support ◽

Social Skills Improvement System

The current study examined the psychometric properties of a set of maximally efficient items (SMIs) from the Social Skills Improvement System–Teacher Rating Scale (SSIS-TRS). Sixty-three teachers rated 302 second through sixth graders on these SMIs, and several concurrent validity measures were administered. Results provided initial support for the validity of scores from the SMIs. Implications for practice and psychological research are discussed.

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DeepIsoFun: a deep domain adaptation approach to predict isoform functions

Bioinformatics ◽

10.1093/bioinformatics/bty1017 ◽

2018 ◽

Vol 35 (15) ◽

pp. 2535-2544 ◽

Cited By ~ 4

Author(s):

Dipan Shaw ◽

Hao Chen ◽

Tao Jiang

Keyword(s):

Network Architecture ◽

Domain Adaptation ◽

Multiple Instance Learning ◽

Training Data ◽

Supplementary Information ◽

Operating Characteristics ◽

Neural Network Architecture ◽

Receiver Operating Characteristics Curve ◽

Gene Functions ◽

Better Than

AbstractMotivationIsoforms are mRNAs produced from the same gene locus by alternative splicing and may have different functions. Although gene functions have been studied extensively, little is known about the specific functions of isoforms. Recently, some computational approaches based on multiple instance learning have been proposed to predict isoform functions from annotated gene functions and expression data, but their performance is far from being desirable primarily due to the lack of labeled training data. To improve the performance on this problem, we propose a novel deep learning method, DeepIsoFun, that combines multiple instance learning with domain adaptation. The latter technique helps to transfer the knowledge of gene functions to the prediction of isoform functions and provides additional labeled training data. Our model is trained on a deep neural network architecture so that it can adapt to different expression distributions associated with different gene ontology terms.ResultsWe evaluated the performance of DeepIsoFun on three expression datasets of human and mouse collected from SRA studies at different times. On each dataset, DeepIsoFun performed significantly better than the existing methods. In terms of area under the receiver operating characteristics curve, our method acquired at least 26% improvement and in terms of area under the precision-recall curve, it acquired at least 10% improvement over the state-of-the-art methods. In addition, we also study the divergence of the functions predicted by our method for isoforms from the same gene and the overall correlation between expression similarity and the similarity of predicted functions.Availability and implementationhttps://github.com/dls03/DeepIsoFun/Supplementary informationSupplementary data are available at Bioinformatics online.

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