scholarly journals Herbal Medicine for Dumping Syndrome: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 18 ◽  
pp. 153473541987340 ◽  
Author(s):  
Seungcheol Hong ◽  
Bongki Park ◽  
Hyeonseok Noh ◽  
Dong-Jun Choi
Keyword(s):  
Herbal Medicine ◽  
Clinical Evidence ◽  
Small Sample Size ◽  
Meta Analysis ◽  
Small Sample ◽  
Dumping Syndrome ◽  
Improvement Rate ◽  
Randomized Controlled ◽  
Symptom Response

Background: Dumping syndrome is a common complication of surgical treatment of gastric cancer, but conventional therapy has limitations related to symptom care due to its structural cause and the decreased quality of life. Objectives: The objective of this review was to assess the clinical evidence for the effectiveness of herbal medicine as a treatment for dumping syndrome. Methods: A literature review was conducted using 16 databases from their inceptions to March 2018. All randomized controlled trials (RCTs) of herbal medicine used to treat dumping syndrome patients were included and meta-analyzed. Methodological quality was assessed using the Cochrane Handbook for Systematic Reviews of Interventions. Results: A total of 174 dumping syndrome patients of 3 trials met all inclusion criteria. Two trials assessed the effectiveness of herbal medicine on the symptom response rate compared with conventional pharmacotherapy. Their results suggested significant effects in favor of herbal medicine (risk ratio [RR] = 1.37, 95% confidence interval [CI] = 1.16-1.63, P = .0003, heterogeneity τ2 = 0, χ2 = 0.02, P = .88, I2 = 0%). One trial assessed its effectiveness on the improvement rate of overall symptoms compared with conventional conservative complex therapy, such as postural management, diet regulation, and counseling (RR = 1.23, 95% CI = 0.96-1.58). Conclusions: Due to the small sample size, scarcity of reported articles, and lack of quality of the current RCTs, it was concluded that the effectiveness of herbal medicine in treating dumping syndrome is unclear.

scholarly journals A Systematic Review and Meta-Analysis of Mindfulness-Based (Baduanjin) Exercise for the Rehabilitation of Stroke Patients

2021 ◽  
Author(s):  
Xiyan Xie
Keyword(s):  
Conventional Treatment ◽  
Functional Performance ◽  
Small Sample Size ◽  
Meta Analysis ◽  
Small Sample ◽  
Cochrane Library ◽  
Stroke Patients ◽  
Chinese Journal ◽  
Randomized Controlled

Abstract Background: Baduanjin is a fitness routine that has been developed in accordance with the appeal of the General Administration of Sport of China and promoted both in China and abroad. This paper aims to systematically evaluate the effect of Baduanjin on the rehabilitation of stroke patients.Methods: We searched the Web of Science, Cochrane Library, Wanfang Database, Pubmed, Embase, CNKI, and VIP Chinese Journal Database for randomized controlled trials (RCTs) evaluating the rehabilitation effect of Baduanjin exercise on stroke patients. All manuscripts published before October 30, 2021 were considered. Results: A total of 1332 stroke patients were included in the 14 selected RCTs. Results of the meta-analysis showed that Baduanjin effectively improved the lower extremity balance function [MD = 9.74, 95% CI (5.32, 14.15), P < 0.0001], sensory-motor function [MD = 5.37, 95% CI (1.59, 9.16), P = 0.005], neurological function [MD = -2.41, 95% CI (-3.07, -1.75), P < 0.00001], the ability to perform daily activities [MD = 14.00, 95% CI (6.17, 21.83), P = 0.0005], sleep quality [MD = -3.08, 95% CI (-3.90, -2.25), P < 0.00001], and quality of life [MD = 31.71, 95% CI (13.68, 49.73), P = 0.06]. Compared to conventional treatment, the rehabilitation effect was greater with Baduanjin combined with conventional treatment. Conclusions: Baduanjin is an effective method to treat stroke patients and improve their functional performance. However, due to the small sample size and low data quality, further multicenter RCTs with large sample sizes are required to verify the results.

scholarly journals Effect of vitamins C and E supplementation onHelicobacter pylorieradication: a meta-analysis

2011 ◽  
Vol 106 (11) ◽  
pp. 1632-1637 ◽  
Author(s):  
Guogang Li ◽  
Lan Li ◽  
Chaohui Yu ◽  
Li Chen
Keyword(s):  
Methodological Quality ◽  
Eradication Rate ◽  
Small Sample Size ◽  
Meta Analysis ◽  
Small Sample ◽  
Cochrane Library ◽  
Significant Difference ◽  
H Pylori ◽  
Randomised Controlled

Vitamins C and E can act as potent antioxidants to reduce the damage caused by reactive oxygen species in gastric mucosa. Whether vitamin supplements forHelicobacter pylorieradication regimen could improve the rate of eradication remains uncertain. Therefore, we performed a meta-analysis to evaluate the efficacy of vitamins C and E supplementation for the eradication ofH. pylori. Searches were conducted in the databases PubMed, EMBASE and Cochrane Library. Randomised controlled trials (RCT) that fulfilled the inclusion criteria and addressed the clinical questions of this analysis were further assessed. Of the six RCT included, five had a low methodological quality. Of the six RCT, three compared the efficacy of the eradication regimenv.eradication regimen plus vitamins C and E. The result of the meta-analysis showed a non-significant difference in the eradication rate ofH. pyloribetween the two groups (risk ratio (RR) 0·93,P = 0·76). Another three RCT compared the eradication regimenv.eradication regimen plus vitamin C only, and there too there was no significant difference in the eradication rate (RR 0·83,P = 0·32). In conclusion, vitamins C and/or E supplements to theH. pylorieradication regimen could not improve the eradication rate. However, currently available data do not draw a definitive conclusion about the effectiveness of antioxidant vitamins onH. pylorieradication, owing to the small sample size and low-to-moderate methodological quality.

scholarly journals Analysis of Clinical Efficacy of Traditional Chinese Medicine in Recovery Stage of Stroke: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-35
Author(s):  
Xue Zhang ◽  
Xiao-Fei Zhang ◽  
Lin Wang ◽  
Dong-Yan Guo ◽  
Jia-Min Zhang ◽  
...  
Keyword(s):  
Large Scale ◽  
Clinical Symptoms ◽  
Small Sample Size ◽  
Meta Analysis ◽  
Recovery Period ◽  
Small Sample ◽  
Comprehensive Treatment ◽  
Neural Function ◽  
Routine Treatment

Background. We provide an updated meta-analysis with detailed information on a combination of TCM and routine treatment. Methods. Retrieve appropriate articles with no language restrictions on keywords until 8 July 2019 in an electronic database. All trajectories are screened according to certain criteria. The quality of certified research was also evaluated. We made a detailed record of the results of the measurement. Meta-analysis was carried out by using the Revman 5.3 software. Results. Sixty-seven RCTs were included, and 6594 subjects were analyzed. Compared with routine treatment, the total effective rate (TER) of TCM combined with routine treatment was improved, and the recovery of stroke was also significantly accelerated. Regulation of blood lipids by notably shrinking the contents of TC, TG, and LDL and enhancing the levels of HDL. The levels of serum hs-CRP, WHV, and WLV decreased significantly, indicating that the expression of thrombomodulin was decreased after the comprehensive treatment of traditional Chinese medicines (TCMs). The combination of TCM treatment could enhance the protection of neural function by decreasing the NIHSS scoring while increasing the BI scoring. Paeoniae Radix Rubra, Angeticae Sinensis Radix, etc., can effectively improve the clinical symptoms of stroke convalescent patients and promote the recovery of neurological function. ACU of Baihui, Renzhong, etc., can improve the clinical rehabilitation effect of patients. However, our findings must be handled with care because of the small sample size and low quality of clinic trials cited. Other rigorous and large-scale RCTs are in need to confirm these results. Conclusion. A combination of TCM and routine treatment in the treatment of stroke could improve TER, and it is beneficial to the rehabilitation of patients in the recovery period of apoplexy. These effects can be mediated by a combination of several mechanisms. Nevertheless, due to the limitations of this study, these results should be handled with caution.

Acupuncture for the Treatment of Gastro-Oesophageal Reflux Disease: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 35 (5) ◽  
pp. 316-323 ◽  
Author(s):  
Jiajie Zhu ◽  
Yu Guo ◽  
Shan Liu ◽  
Xiaolan Su ◽  
Yijie Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Reflux Disease ◽  
Small Sample Size ◽  
Meta Analysis ◽  
Small Sample ◽  
Oesophageal Reflux ◽  
Symptom Improvement ◽  
Significant Heterogeneity ◽  
Oesophageal Reflux Disease

Background Gastro-oesophageal reflux disease (GORD) is one of the most common diseases presenting to gastroenterology clinics. Acupuncture is widely used as a complementary and alternative treatment for patients with GORD. Objective To explore the effectiveness of acupuncture for the treatment of GORD. Methods Four English and four Chinese databases were searched through June 2016. Randomised controlled trials investigating the effectiveness of manual acupuncture or electroacupuncture (MA/EA) for GORD versus or as an adjunct to Western medicine (WM) were selected. Data extraction and quality evaluation were performed by two authors independently and RevMan 5.2.0 was used to analyse data. Results A total of 12 trials involving 1235 patients were included. Meta-analyses demonstrated that patients receiving MA/EA combined with WM had a superior global symptom improvement compared with those receiving WM alone (relative risk (RR) 1.17, 95% CI 1.09 to 1.26; p=0.03; six studies) with no significant heterogeneity (I2=0%, p=0.41). Recurrence rates of those receiving MA/EA alone were lower than those receiving WM (RR 0.42,95% CI 0.29 to 0.61; p<0.001; three studies) with low heterogeneity (I2=7%, p=0.34), while global symptom improvement (six studies) and symptom scores (three studies) were similar (both p>0.05). Descriptive analyses suggested that acupuncture also improves quality of life in patients with GORD. Conclusion This meta-analysis suggests that acupuncture is an effective and safe treatment for GORD. However, due to the small sample size and poor methodological quality of the included trials, further studies are required to validate our conclusions. Trial registration number PROSPERO Systematic review registration no. CRD42016041916.

scholarly journals Nasogastric Nutrition versus Nasojejunal Nutrition in Patients with Severe Acute Pancreatitis: A Meta-Analysis of Randomized Controlled Trials

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Youfeng Zhu ◽  
Haiyan Yin ◽  
Rui Zhang ◽  
Xiaoling Ye ◽  
Jianrui Wei
Keyword(s):  
Acute Pancreatitis ◽  
Randomized Controlled Trials ◽  
Severe Acute Pancreatitis ◽  
Small Sample Size ◽  
Meta Analysis ◽  
Small Sample ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
China National Knowledge Infrastructure ◽  
Randomized Controlled

Introduction.Previous studies have shown that the nasogastric (NG) route seems equivalent to the nasojejunal (NJ) route in patients with severe acute pancreatitis (SAP). However, these studies used a small sample size and old criteria for diagnosing SAP, which may include some patients with moderate SAP, according to the newly established SAP criteria (Atlanta 2012 classification). Based on the changes in the criteria for classifying SAP, we performed an up-to-date meta-analysis.Method.We reviewed the PubMed, EMbase, China National Knowledge Infrastructure, Wanfang Database, and Cochrane Central Register of Controlled Trials electronic databases. We included randomized controlled trials comparing NG and NJ nutrition in patients with SAP. We performed the meta-analysis using the Cochrane Collaborations’ RevMan 5.3 software.Results.We included four randomized controlled trials involving 237 patients with SAP. There were no significant differences in the incidence of mortality, infectious complications, digestive complications, achievement of energy balance, or length of hospital stay between the NG and NJ nutrition groups.Conclusions.NG nutrition was as safe and effective as NJ nutrition in patients with SAP. Further studies are needed to confirm our results.

scholarly journals Chinese herbal medicine for the treatment of chronic rhinosinusitis: protocol for a systematic review and meta-analysis

2020 ◽  
Author(s):  
Shouliang Hu ◽  
Lu Li ◽  
Xin Zhu ◽  
Yijie Fu ◽  
Hui Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Herbal Medicine ◽  
Confidence Interval ◽  
Chronic Rhinosinusitis ◽  
Chinese Herbal Medicine ◽  
Meta Analysis ◽  
Biomedical Literature ◽  
Randomized Controlled ◽  
Chinese Herbal

Abstract Background: In east Asian countries, the traditional treatment is to treat chronic rhinosinusitis(CRS) with some herbal formulas. However, there is a lack of clinical evidence to support the effect of the drug. Here, we describe a randomized controlled trial to investigate the efficacy and safety of herbal formulations for the treatment of CRS.Methods: We will search electronic databases including the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biomedical Literature Database (CBM), PubMed, Embase, Chinese Science and Technology Periodical Database (VIP), China National Knowledge Infrastructure (CNKI), and Wanfang database using keywords related to CRS and Chinese herbal medicine. Extensive database search was carried out for CRS related randomized controlled trials.Two reviewers(SH and LL) will independently filter the search results to determine eligible articles, complete data collection.The quality of individual trials will be assessed by(XZ and YF) using the Cochrane collaborative bias risk assessment tool. We will calculate the relative risk and 95% confidence interval(CI) of the dichotomy results and the weighted average difference, as well as the corresponding 95% confidence interval of the continuous results. Statistical methods such as subgroup analysis and sensitivity analysis will be used to investigate the sources of heterogeneity.Discussion: The systematic review and meta-analysis will provide evidence for the quality of life and the safety of traditional Chinese medicine in CRS patients.This study will provide a high quality research method for the therapeutic effect of Chinese herbal medicine on CRS, and will also help broaden research horizons for the complementary and alternative therapy of CRS.Systematic review registrationPROSPERO registration number: CRD42019123047(https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42019123047).

scholarly journals Acupotomy for Osteoarthritis of the Knee; A Systematic Review and Meta-Analysis

2021 ◽  
Vol 38 (2) ◽  
pp. 96-109
Author(s):  
Seung Min Lee ◽  
Cham Kyul Lee ◽  
Kyung Ho Kim ◽  
Eun Jung Kim ◽  
Chan Yung Jung ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Western Medicine ◽  
Small Sample Size ◽  
Meta Analysis ◽  
Intervention Group ◽  
Effective Rate ◽  
Small Sample ◽  
Control Group ◽  
Osteoarthritis Of The Knee ◽  
Randomized Controlled

The purpose of this study was to evaluate the effectiveness and safety of acupotomy for the treatment of patients with knee osteoarthritis. There were 9 databases searched to retrieve randomized controlled trials until August 3, 2019 regarding acupotomy versus conventional Western medicine, conventional Western medicine treatment with and without acupotomy, and Korean medicine treatment with and without acupotomy, and meta-analysis was performed. Of 303 potentially relevant studies retrieved, 43 were systematically reviewed. All studies were conducted in China. Effective rate, visual analogue scale, and Western Ontario and McMaster Universities Osteoarthritis index were used as the evaluation scales. The Ashi point was selected most frequently. In all studies, the intervention group was more effective than the control group. Meta-analysis revealed that acupotomy showed statistically significant beneficial results. Although acupotomy had a beneficial effect on knee osteoarthritis, the risk of bias of the included studies was not low. The majority of the results from the evaluation scales used were highly heterogeneous (> 50%) which reduced confidence in the estimation of effect, or had a small sample size. Further clinical research and development is required in the future.

scholarly journals Clinical Efficacy and Safety of Shashen Maidong Decoction in the Treatment of Pediatric Mycoplasma Pneumonia: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Jiawei Wang ◽  
Xiao Ma ◽  
Shizhang Wei ◽  
Tao Yang ◽  
Yuling Tong ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Small Sample Size ◽  
Meta Analysis ◽  
Lymphocyte Subpopulation ◽  
Small Sample ◽  
Systematic Evaluation ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Mycoplasma Pneumonia ◽  
Factor Α

Objective: This study was intended to provide data to support the effect of Shashen Maidong Decoction in improving mycoplasma pneumonia in pediatric patients through systematic evaluation.Methods: PubMed, the Web of Science, EMbase, CNKI, CQVIP, Wan-Fang, and CBM databases were comprehensively searched from established in June 2021. Randomized controlled trials of TRQI were selected by screening the literature and extracting information. The Cochrane RCT Evaluation Manual was used to evaluate the methodological quality of all included studies, and Meta-analysis was performed using Stata 14.0 and Review Manager 5.4 software.Results: A total of 1,127 patients from 12 clinical studies met the inclusion criteria. Meta-analysis results showed that the treatment group of Shashen Maidong Decoction was able to significantly increase the overall efficiency level and significantly reduce the incidence of adverse reactions, time for disappearance of cough, time for relief of cough, time for defervescence, time for disappearance of lung rales, time for return to normal of chest X-ray, T lymphocyte subpopulation (CD3+) and tumor necrosis factor-α (TNF-α) and other index levels (p &lt; 0.05).Conclusion: Shashen Maidong Decoction has a significant improvement in the levels of relevant indexes in pediatric mycoplasma pneumonia, which provides a basis for the safety and efficacy of pediatric mycoplasma pneumonia. However, due to the small sample size included in the study, the study quality was not high, and more randomized controlled trials of high quality are required for further validation.

scholarly journals Acupoint Injection for Alleviating Side Effects of Chemotherapy in People with Cancer: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yulan Yang ◽  
Hairong Su ◽  
Jian Wen ◽  
Jianyun Hong
Keyword(s):  
Side Effects ◽  
Adverse Reactions ◽  
Small Sample Size ◽  
Meta Analysis ◽  
Small Sample ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Randomized Controlled ◽  
Acupoint Injection ◽  
Review Manager

Objective. This study aimed to investigate the efficacy of acupoint injection for alleviating side effects of chemotherapy in people with cancer. Methods. PubMed, EMBASE, Cochrane library databases, CNKI, VIP, WanFang Date, and CBM were searched for randomized controlled trials (RCTs) from inception through December 28, 2020. This meta-analysis was performed using Review Manager 5.3. Results. A total of 8 RCTs including 557 participants were eligible and included in the meta-analysis. The selected RCTs studied acupoint injection for alleviating side effects of chemotherapy in people with cancer. Statistically significant improvements were observed for the incidence of nausea and vomiting (RR = 0.39; 95% CI 0.26, 0.58; P  < 0.00001), the number of leukocyte (MD = 1.89; 95%CI 0.74, 3.03; P  = 0.001), and the number of platelet (MD = 28.82; 95%CI 19.33, 38.30; P  < 0.00001). Two of these studies suggested that acupoint injection can also reduce some other adverse reactions, which showed a statistical difference (RR = 0.29; 95% CI 0.11, 0.75; P  = 0.01). Conclusion. The analysis indicated that acupoint injection can alleviate side effects of chemotherapy in people with cancer. However, due to the high risk of bias and small sample size in the included studies, the results need to be further confirmed by further large, rigorously designed trials.

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