The association between aortic arterial stiffness, carotid intima-media thickness and carotid plaques in community-dwelling older adults: A population-based study

Objective Information on the associations among arterial stiffness, carotid intima-media thickness (cIMT) and carotid plaques as biomarkers of atherosclerosis is limited in diverse populations. We aimed to assess whether aortic pulse wave velocity (aPWV) – as a surrogate of arterial stiffness – is associated with increased cIMT and the presence of carotid plaques in a cohort of older adults of Amerindian ancestry. Methods Atahualpa residents aged ≥60 years ( n = 320) underwent aPWV determinations, and carotid ultrasounds for cIMT and plaque assessment. Multivariate models were fitted to assess the independent association between the aPWV, and cIMT and carotid plaques, after adjusting for relevant confounders. Differences in risk factors across these biomarkers were investigated. Results Mean values of aPWV were 10.3 ± 1.8 m/s, and those of cIMT were 0.91 ± 0.21 mm (24% had a cIMT >1 mm). Carotid plaques were observed in 118 (37%) subjects. In univariate analyses, risk factors associated with an increased aPWV included age, female gender, poor physical activity and high blood pressure. An increased cIMT was associated with age, male gender, a poor diet, high blood pressure and severe tooth loss. The presence of carotid plaques was associated with increasing age, poor physical activity and high blood pressure. Multivariate models showed a significant association between aPWV and cIMT (β: 0.028; 95% C.I.: 0.001–0.056; p = 0.047) but not between aPWV and carotid plaques (OR: 1.14; 95% C.I.: 0.83–1.56; p = 0.423). Conclusions This study shows an independent association between aPWV and cIMT but not with carotid plaques. These biomarkers may indicate distinct phenotypes for atherosclerosis.

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Abstract WP173: The Association Between Aortic Arterial Stiffness, Carotid Intima-Media Thickness and Carotid Plaques in Community-Dwelling Older Adults. A Population-Based Study (the Atahualpa Project)

Stroke ◽

10.1161/str.51.suppl_1.wp173 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Victor J Del Brutto ◽

Oscar H Del Brutto ◽

Robertino M Mera ◽

Mark J Sedler ◽

Aldo F Costa ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Blood Pressure ◽

Older Adults ◽

Arterial Stiffness ◽

High Blood Pressure ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Carotid Plaques ◽

Independent Association

Background: Information on the associations among arterial stiffness, carotid intima-media thickness (cIMT) and carotid plaques as biomarkers of atherosclerosis is limited. We aimed to assess whether aortic pulse wave velocity (PWV) - as a surrogate of arterial stiffness - is associated with increased cIMT and the presence of carotid plaques in a cohort of older adults of Amerindian ancestry. Methods: Atahualpa residents aged ≥60 years (n=320) underwent aortic PWV determinations, and carotid ultrasound for cIMT and plaque assessment. Multivariate models were fitted to assess the independent association between the aortic PWV, and cIMT and carotid plaques (as dependent variables), after adjusting for relevant confounders. Differences in risk factors across these biomarkers were investigated. Results: Mean values of aortic PWV were 10.3±1.8 m/s, and those of cIMT were 0.91±0.21 mm (24% had a cIMT >1 mm). Carotid plaques were observed in 118 (37%) subjects. In univariate analyses, risk factors associated with an increased aortic PWV included age, female gender, poor physical activity and high blood pressure. An increased cIMT was associated with age, male gender, poor diet, high blood pressure and severe edentulism. The presence of carotid plaques was associated with increasing age, poor physical activity and high blood pressure. A fully-adjusted generalized linear model showed a significant association between aortic PWV and cIMT (β: 0.028; 95% C.I.: 0.001 - 0.056; p =0.047). In contrast, a logistic regression model showed no association between aortic PWV and carotid plaques (OR: 1.14; 95% C.I.: 0.83 - 1.56; p =0.423), after adjusting for relevant confounders. Conclusions: This study shows an independent association between aortic PWV and cIMT but not with carotid plaques. These biomarkers may indicate distinct phenotypes for atherosclerosis.

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Poor cardiovascular health is associated with subclinical atherosclerosis in apparently healthy sub-Saharan African populations: an H3Africa AWI-Gen study

BMC Medicine ◽

10.1186/s12916-021-01909-6 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Engelbert A. Nonterah ◽

◽

Nigel J. Crowther ◽

Abraham Oduro ◽

Godfred Agongo ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

South Africa ◽

Blood Pressure ◽

Cardiovascular Risk ◽

Cardiovascular Health ◽

Subclinical Atherosclerosis ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Sub Saharan

Abstract Background The cardiovascular health index (CVHI) introduced by the American Heart Association is a valid, accessible, simple, and translatable metric for monitoring cardiovascular health in a population. Components of the CVHI include the following seven cardiovascular risk factors (often captured as life’s simple 7): smoking, dietary intake, physical activity, body mass index, blood pressure, glucose, and total cholesterol. We sought to expand the evidence for its utility to under-studied populations in sub-Saharan Africa, by determining its association with common carotid intima-media thickness (CIMT). Methods We conducted a cross-sectional study involving 9011 participants drawn from Burkina Faso, Ghana, Kenya, and South Africa. We assessed established classical cardiovascular risk factors and measured carotid intima-media thickness of the left and right common carotid arteries using B-mode ultrasonography. Adjusted multilevel mixed-effect linear regression was used to determine the association of CVHI with common CIMT. In the combined population, an individual participant data meta-analyses random-effects was used to conduct pooled comparative sub-group analyses for differences between countries, sex, and socio-economic status. Results The mean age of the study population was 51 ± 7 years and 51% were women, with a mean common CIMT of 637 ± 117 μm and CVHI score of 10.3 ± 2.0. Inverse associations were found between CVHI and common CIMT (β-coefficients [95% confidence interval]: Burkina Faso, − 6.51 [− 9.83, − 3.20] μm; Ghana, − 5.42 [− 8.90, − 1.95]; Kenya, − 6.58 [− 9.05, − 4.10]; and South Africa, − 7.85 [− 9.65, − 6.05]). Inverse relations were observed for women (− 4.44 [− 6.23, − 2.65]) and men (− 6.27 [− 7.91, − 4.64]) in the pooled sample. Smoking (p < 0.001), physical activity (p < 0.001), and hyperglycemia (p < 0.001) were related to CIMT in women only, while blood pressure and obesity were related to CIMT in both women and men (p < 0.001). Conclusion This large pan-African population study demonstrates that CVHI is a strong marker of subclinical atherosclerosis, measured by common CIMT and importantly demonstrates that primary prevention of atherosclerotic cardiovascular disease in this understudied population should target physical activity, smoking, obesity, hypertension, and hyperglycemia.

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Rheumatoid Arthritis Impacts on the Independent Relationships between Circulating Adiponectin Concentrations and Cardiovascular Metabolic Risk

Mediators of Inflammation ◽

10.1155/2013/461849 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 5

Author(s):

Patrick H. Dessein ◽

Gavin R. Norton ◽

Margaret Badenhorst ◽

Angela J. Woodiwiss ◽

Ahmed Solomon

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Blood Pressure ◽

Cardiovascular Risk ◽

Hdl Cholesterol ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Metabolic Risk ◽

Black African ◽

Pressure Independent

Adiponectin and leptin are likely involved in the pathophysiology of rheumatoid arthritis (RA) and therefore potential new therapeutic targets. Adiponectin inhibition could be expected to enhance cardiovascular metabolic risk. However, it is unknown whether RA changes the influence of adipokines on cardiovascular metabolic risk. We determined whether RA impacts on the independent relationships of circulating leptin and adiponectin concentrations with cardiovascular risk factors and carotid intima-media thickness (cIMT) in 277 black African subjects from a developing population; 119 had RA. RA impacted on the relationships of adiponectin concentrations with lipid concentrations and blood pressure, independent of confounders including adiposity (interactionP<0.05). This translated into an association of adiponectin concentrations with more favorable lipid variables including HDL cholesterol (P=0.0005), non-HDL cholesterol (P=0.007), and triglyceride (P=0.005) concentrations, total cholesterol-HDL cholesterol (P=0.0002) and triglycerides-HDL cholesterol (P=0.0003) ratios, and higher systolic (P=0.0006), diastolic (P=0.0004), and mean blood pressure (P=0.0007) in RA but not non-RA subjects. Leptin was not associated with metabolic risk after adjustment for adiposity. The cIMT did not differ by RA status, and adipokine concentrations were unrelated to atherosclerosis. This study suggests that leptin and adiponectin inhibition may not alter overall cardiovascular risk and disease in RA.

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Use of physical activity and cardiorespiratory fitness in identifying cardiovascular risk factors in male brazilian adolescents

Brazilian Journal of Kinanthropometry and Human Performance ◽

10.5007/1980-0037.2016v18n6p678 ◽

2016 ◽

Vol 18 (6) ◽

pp. 678

Author(s):

Lilian Messias Sampaio Brito ◽

Luis Paulo Gomes Mascarenhas ◽

Deise Cristiane Moser ◽

Ana Cláudia Kapp Titski ◽

Monica Nunes Lima Cat ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Blood Pressure ◽

Body Mass ◽

Cardiorespiratory Fitness ◽

High Blood Pressure ◽

Abdominal Obesity ◽

Age Groups ◽

Cross Sectional ◽

The Impact

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n6p678 The aim of this study was to investigate the impact of physical activity (PA) and cardiorespiratory fitness (CRF) levels on the prevalence of overweight and high blood pressure levels in adolescents. In this observational, cross-sectional study, 614 boys aged 10-14 years were assessed for height, body mass, body mass index (BMI), waist circumference (WC) and blood pressure (BP). CRF was assessed using a run test (Léger Test) and subjects were then grouped according to their CRF level. PA level was assessed through a questionnaire (The Three Day Physical Activity Recall) and classified into two groups, namely > 300 minutes of PA/week and < 300 minutes of PA/week. Maturational stage was evaluated according to the development of pubic hair (self-assessment) as proposed by Tanner. We used statistical descriptive analysis, univariate and multivariate analyses in the total participants and subjects were divided by age. Fifty percent of the sample performed < 300 minutes of PA/week and 67.6% had unsatisfactory CRF levels. There was a higher prevalence of unsatisfactory CRF levels among subjects with altered BMI (overweight), WC (abdominal obesity) or BP (high blood pressure) for all age groups. PA history, however, did not show any significance. A total of 31% of participants were overweight, 24.8% had abdominal obesity and 15.4% had increased BP. Unsatisfactory CRF levels were found to be a better predictor for the diagnosis of cardiovascular diseases (CV) risk factors than PA history, regardless of age group.

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Prevalence and Determinants of High Blood Pressure among Adolescents: A School based Study in Rural Area of Hooghly District, West Bengal

International Journal of Research and Review ◽

10.52403/ijrr.20211127 ◽

2021 ◽

Vol 8 (11) ◽

pp. 205-210

Author(s):

Malay Kumar Das ◽

Rabindranath Sinha ◽

Aparajita Dasgupta

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Blood Pressure ◽

Body Mass Index ◽

Food Intake ◽

Alcohol Consumption ◽

Body Mass ◽

High Blood Pressure ◽

Fast Food ◽

Non Communicable Diseases

Introduction: The World Health Organization has already warned of increasing non-communicable diseases among adolescents as a major public health problem. The importance of this age group also lies in the fact that many serious diseases in adulthood have their roots in adolescence. Method: A pre-designed and pre-tested questionnaire was used in class-room setting to collect information from students regarding presence of risk factors of non-communicable diseases. The respondents were also subjected to anthropometric measurements and blood pressure examination using standard operating procedures. Results: A total of 761 students of class VI-XII participated in the study of which 61.4% were boys and rests were girls. High blood pressure among boys and girls were 19.9% and 22.1% were respectively. In Bivariate analysis age > 15 years (median) (OR= 2.11), fast food intake (>3 times/week) (OR= 1.66), Alcohol consumption (OR= 2.22), less physical activity (OR=1.54), increased body mass index (OR=2.53), significantly associated with high blood pressure. In Multivariate analysis age (AOR= 2.25), fast food intake (AOR= 1.50), Alcohol consumption (OR= 2.23), less physical activity (AOR=1.71), increased body mass index (AOR=2.42) remains significant predictor. Conclusion: Detecting the risk factors of high blood pressure prevalent in the population is of utmost importance to achieve a healthy population. Formulation and dissemination of need--based, culturally acceptable and age appropriate scientific messages for school students should be conducted more proactively. Keywords: Adolescents, Blood pressure, Risk factor, Rural school.

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AN EMBEDDED MICROPROCESSOR UNIT-BASED PORTABLE NONINVASIVE ARTERIOSCLEROSIS DETECTING SYSTEM AND ITS EXPERIMENTAL STUDY

Biomedical Engineering Applications Basis and Communications ◽

10.4015/s1016237213500518 ◽

2013 ◽

Vol 25 (06) ◽

pp. 1350051

Author(s):

Wei He ◽

Songnong Li ◽

Hanguang Xiao ◽

Chuanxiang Yu ◽

Haitao Lin

Keyword(s):

Risk Factors ◽

Clinical Trial ◽

Arterial Stiffness ◽

Doppler Ultrasonography ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Stiffness Index ◽

Cardiovascular Morbidity And Mortality ◽

Embedded Microprocessor ◽

Arterial Stiffness Index

Pulse wave velocity (PWV) and arterial stiffness index (ASI) are considered as the independent predictors of cardiovascular morbidity and mortality — the effective methods to assess arterial stiffness. A portable noninvasive arterial elasticity detecting system (PNAEDS) was developed based on embedded microprocessor unit. This system can simultaneously measure PWV, ASI and other arteriosclerosis critical risk factors. Algorithm of main critical risk factors and design of the system were described in detail. To verify the performance of the PNAEDS, laboratory prospective validation and clinical trial were launched. Reliability of the system and superiority of improved PWV algorithm were validated in laboratory prospective validation. Subsequently, the authors implemented a comparative clinical trial (60 subjects) between measured values obtained by the PNAEDS and carotid intima-media thickness (IMT) value that Doppler ultrasonography measured. Clinical testing results revealed that the measurement with the PNAEDS was consistent with the measurement with the Doppler ultrasonography. In summary, the system may be used to reliably determine the arteriosclerosis critical risk factors and to the early diagnosis and prevention of cardiovascular disease.

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Arterial stiffness changes in patients with cardiovascular risk factors but normal carotid intima–media thickness

Journal of Cardiovascular Medicine ◽

10.2459/jcm.0b013e3283639721 ◽

2013 ◽

Vol 14 (9) ◽

pp. 622-628 ◽

Cited By ~ 10

Author(s):

Moemen Mohammed ◽

Concetta Zito ◽

Maurizio Cusmà-Piccione ◽

Gianluca Di Bella ◽

Francesco Antonini-Canterin ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Arterial Stiffness ◽

Cardiovascular Risk Factors ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Media Thickness

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Prevalence of Stroke Risk Factors in an Urban Community at Parakou (Northern Benin) in 2016

10.21203/rs.3.rs-809956/v1 ◽

2021 ◽

Author(s):

Yèssito Corine Nadège Houehanou ◽

Mendinatou Agbetou ◽

Oyéné Kossi ◽

Maurice Agonnoudé ◽

Hospice Hountada ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Blood Pressure ◽

High Blood Pressure ◽

Stroke Risk ◽

Demographic Data ◽

Metabolic Risk Factors ◽

Sub Saharan Africa ◽

Metabolic Risk ◽

Stroke Risk Factors

Abstract Background: Sub-Saharan Africa faces a high burden of stroke due to growing of their risk factors. We aimed to estimate the prevalence of stroke risk factors and to identify associated factors in the district of Titirou in Parakou (northern Benin), in 2016.Methods: It was a cross-sectional study. It included adults living in Titirou and having given their consent. A door-to-door survey was performed from 15 march to 15 July 2016 in each neighbourhood or village until the expected number reached. We recorded the socio-demographic data, medical histories, anthropometric and blood pressure measures using WHO steps approach. Prevalences of stroke risk factors were calculated and a logistic regression was done to identify factors associated with metabolic risk factors.Results: A total of 4671 participants was included with a mean age of 27.7±12.9 years and a sex ratio of 0.97. Prevalences of behavioural risk factors were estimated at: 17.2% of alcohol consumption, 21.5% of low fruits and vegetables consumption, 51.1% of low physical activity practice, and 3.5% of smoking. Metabolic risk factors prevalence’s amounted to: 8.7% of obesity, 7.1% of high blood pressure, 1.7% of self-reported diabetes and 2.2% of dyslipidaemia. Age (p<0.001), sex (p<0.001), marital status (p<0.001) and professional occupation (p=0.010) were associated with obesity. Age was also associated with high blood pressure (p<0.001) and diabetes (p<0.001). Dyslipidaemia varied according to smoking (p=0.033) and low physical activity practice (p=0.003). Conclusion: The study showed high prevalences of low physical activity practice and obesity. Targeted local interventions focused on these factors should be conducted for primary prevention of stroke in this community, or even beyond in Benin.

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Abstract WP241: Prevalence of Subclinical Extracranial Carotid Atherosclerosis Detected by Ultrasound Among Amerindians: A Population Study in Rural Ecuador

Stroke ◽

10.1161/str.51.suppl_1.wp241 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Victor J Del Brutto ◽

Jose G Romano ◽

Robertino M Mera ◽

Jonathan P Amodio ◽

Tatjana Rundek ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

High Blood Pressure ◽

Carotid Atherosclerosis ◽

Male Gender ◽

Rural Setting ◽

Carotid Plaques ◽

The Mean

Background: Epidemiological information on extracranial carotid atherosclerosis (ECA) among Amerindians is limited. We aim to determine the prevalence of subclinical ECA and its correlation with cardiovascular risk factors in community-dwelling adults of Amerindian ancestry living in a rural Ecuadorian village. Methods: Utilizing a population-based design, stroke-free individuals aged ≥40 years were invited to undergo carotid ultrasound. Subclinical ECA was defined as an intima-media thickness (cIMT) >1mm and/or the presence of carotid plaques (focal intima thickening >1.5mm that protrudes into the lumen). Degree of luminal stenosis was calculated and considered significant if >50%. We investigated the association between these biomarkers and cardiovascular risk factors. Results: Of 728 candidates, 559 (77%) stroke-free individuals underwent carotid sonographic evaluation and were included. The mean age was 62.3 ±12.5 and 238 (43%) were men. The mean value of the cIMT was 0.85 ± 0.17mm (median cIMT: 0.83mm; IQ range: 0.74-0.92 mm). The prevalence of increased cIMT, carotid plaques, and increased cIMT and/or carotid plaques were 14%, 23.8%, and 26.1%, respectively. Table depicts the association of these biomarkers with cardiovascular risk factors. A multinomial logistic regression model, using individuals with normal carotids as the referent category, showed significant associations of ECA with increasing age, male gender, smoking and high blood pressure. Significant carotid stenosis was found in 19 subjects (3.4%). Conclusions: About one-fourth of Amerindians living in a rural setting have subclinical ECA. Increasing age, male gender, smoking and high blood pressure were independent determinants of the burden of ECA, while elevated glucose and total cholesterol showed no significant association. Obesity was inversely associated with ECA in univariate analysis, but such association disappeared in the multivariate model.

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