Syntheses and Antibacterial Activities of Tizoxanide, an N-(Nitrothiazolyl)salicylamide, and its O-Aryl Glucuronide
Keyword(s):
Mild hydrolysis of the broad-spectrum anaerobic antibacterial and antiparasitic agent nitazoxanide 1 affords tizoxanide 2, which is a major metabolite of 1 retaining most of its activity; further metabolism of 2 leads to the O-aryl glucuronide 3, efficiently synthesised in four steps from benzyl salicylate and showing slight antibacterial activity.
2010 ◽
Vol 53
(9)
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pp. 3626-3631
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2019 ◽
Vol 2019
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pp. 1-10
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Keyword(s):
2020 ◽
Vol 23
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Keyword(s):
2015 ◽
Vol 2015
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pp. 1-10
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