Regulatory Functions of MicroRNAs in Male Reproductive Health: A New Approach to Understanding Male Infertility

2018 ◽  
pp. 193371911876597 ◽  
Author(s):  
Asghar Beigi Harchegani ◽  
Hossein Shafaghatian ◽  
Eisa Tahmasbpour ◽  
Alireza Shahriary
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
New Approach ◽  
Regulatory Functions ◽  
Male Reproductive Health

scholarly journals Varicocele as one of the causes of the decreased male infertility

2019 ◽  
Vol 20 (3) ◽  
pp. 27-35
Author(s):  
T. M. Sorokina ◽  
M. V. Andreeva ◽  
V. B. Chernykh ◽  
L. F. Kurilo
Keyword(s):  
Experimental Data ◽  
Reproductive Health ◽  
Male Infertility ◽  
Reproductive System ◽  
Male Fertility ◽  
Male Reproductive System ◽  
Review Of The Literature ◽  
High Prevalence ◽  
Male Reproductive Health ◽  
Methods Of Treatment

Varicocele is one of the most common diseases of the male reproductive system. Despite the high prevalence of this pathology, the effect of varicocele on male fertility is still a controversial issue. Opinions of experts about the possible effects of varicocele on the male reproductive health, the causes and methods of treatment are contradictory, and the experimental data obtained often show directly opposed results. This article presents a review of the literature on the effects of varicocele on the male reproductive system and fertility.

scholarly journals Endocrine Disruption of Androgenic Activity by Perfluoroalkyl Substances: Clinical and Experimental Evidence

2018 ◽  
Vol 104 (4) ◽  
pp. 1259-1271 ◽  
Author(s):  
Andrea Di Nisio ◽  
Iva Sabovic ◽  
Umberto Valente ◽  
Simone Tescari ◽  
Maria Santa Rocca ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
Experimental Evidence ◽  
Molecular Mechanisms ◽  
Nuclear Translocation ◽  
Seminal Fluid ◽  
Semen Quality ◽  
Substantial Impact ◽  
Gene Reporter Assay ◽  
Male Reproductive Health

Abstract Background Considerable attention has been paid to perfluoroalkyl compounds (PFCs) because of their worldwide presence in humans, wildlife, and environment. A wide variety of toxicological effects is well supported in animals, including testicular toxicity and male infertility. For these reasons, the understanding of epidemiological associations and of the molecular mechanisms involved in the endocrine-disrupting properties of PFCs on human reproductive health is a major concern. Objective To investigate the relationship between PFC exposure and male reproductive health. Design This study was performed within a screening protocol to evaluate male reproductive health in high schools. Patients This is a cross-sectional study on 212 exposed males from the Veneto region, one of the four areas worldwide heavily polluted with PFCs, and 171 nonexposed controls. Main Outcome Measures Anthropometrics, seminal parameters, and sex hormones were measured in young males from exposed areas compared with age-matched controls. We also performed biochemical studies in established experimental models. Results We found that increased levels of PFCs in plasma and seminal fluid positively correlate with circulating testosterone (T) and with a reduction of semen quality, testicular volume, penile length, and anogenital distance. Experimental evidence points toward an antagonistic action of perfluorooctanoic acid on the binding of T to androgen receptor (AR) in a gene reporter assay, a competition assay on an AR-coated surface plasmon resonance chip, and an AR nuclear translocation assay. Discussion This study documents that PFCs have a substantial impact on human health as they interfere with hormonal pathways, potentially leading to male infertility.

scholarly journals VIRAL EFFECT OF SARS-COV-2 ON MALE INFERTILITY

2021 ◽  
pp. 8-13
Author(s):  
Zh. Yu. Sapozhkova
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
Reproductive Medicine ◽  
Clinical Laboratory ◽  
Diagnostic Process ◽  
Laboratory Diagnostics ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Male Reproductive Health

Clinical laboratory diagnostics of male infertility is an integral part of the diagnostic process in the field of reproductive medicine. Studies conducted during the pandemia of novel coronavirus infection (COVID-19) indicate that RNA of SARS-CoV-2 can be detected in the testes, and that the possibility of disrupting spermatogenesis and the viral impact on male reproductive health has been predicted.

scholarly journals Research Funding for Male Reproductive Health and Infertility in the UK and USA [2016 to 2019]

2021 ◽  
Author(s):  
Eva Gumerova ◽  
Christopher J. De Jonge ◽  
Christopher LR Barratt
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
Research Funding ◽  
Open Data ◽  
Research Groups ◽  
Research Activity ◽  
Significant Difference ◽  
The Us ◽  
The Uk ◽  
Male Reproductive Health

There is a paucity of data on research funding for male reproductive health. We investigated the research funding for male reproductive health and infertility by examining publicly accessible databases from the UK and US government funding agencies. Information on the funding provided to male–based and 40 female–based research was collected using public accessed web databases from the UKRI–GTR, the NIHR's Open Data Summary, and the US' NIH RePORT. Funded projects that began research activity between January 2016 to December 2019 were recorded, along with their grant and project details. Strict inclusion–exclusion criteria were followed for both UK and US data with a primary research focus on male infertility, reproductive health and disorders, and contraception development. Funding support was divided into three research groups: male–based, female–based, and not–specified research. Between the 4–year period, the UK is divided into 5 funding periods, starting from 2015/16 to 2019/20, and the US is divided into 5 fiscal years, from 2016 to 2020. Between January 2016 to December 2019, UK agencies awarded a total of 11,767,190 GBP to 18 projects for male–based research and 29,850,945 GBP to 40 projects for female–based research. There was no statistically significant difference in funding average between the two research groups. The US NIH funded 76 projects totaling 59,257,746 US dollars for male–based research and 99 projects totaling 83,272,898 US dollars for female–based research. There was no statistically significant difference in funding average between the two groups. The findings of this study cannot be used to generalize and reflect global funding trends towards infertility and reproductive health as the data collected followed a narrow funding timeframe from government agencies and only two countries. Other funding sources such as charities, industry and major philanthropic organizations were not evaluated. This is the first study examining funding granted by main government research agencies from the UK and US for male reproductive health. This study should stimulate further discussion of the challenges of tackling male infertility and reproductive health disorders and formulate appropriate investment strategies.

scholarly journals Role of Herbal Medicines on Male Infertility - A Review

2021 ◽  
pp. 289-293
Author(s):  
B. Ashwinidevi ◽  
S. Kavitha ◽  
R. Yasodai
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
Histological Study ◽  
Sperm Concentration ◽  
Herbal Medicines ◽  
Testicular Tissue ◽  
Protective Mechanisms ◽  
Tissue Samples ◽  
Holistic Approaches ◽  
Male Reproductive Health

Infertility is one of the most serious social problems are caused by many Factors such as genetic, environmental factors about 70% of cases remain unknown, Protective Mechanisms of the Sperm is called Spermatogenesis. The formation of the sperm from a germ cell precursor, its maturation, transport, viability, and the final steps, any changes happens in this series which causes infertility condition. The clinical detection of infertility is identified by analysis of semen. The main parameters are sperm concentration, morphology and viability of sperm .the origin of infertility in men happened by a lot of factors are hormonal disorders, mental stress, physical abnormalities, lifestyle problems, obesity , sexual issues, genetic abnormalities and deficiency of single-genes. This article aimed on the histological study testicular tissue samples, the structure of male reproductive, causes for male infertility, procedures available to find the genes engaged in infertility, the current remedial measures for male infertility. Whereas, the herbal therapies, are better positioned to offer more holistic approaches to improve male reproductive health. In traditional medicine which helps to nourishes and stimulates the sexual tissues and ameliorate male reproductive health issues.

scholarly journals Was Henry VIII Infertile? Miscarriages and Male Infertility in Tudor England

2021 ◽  
Vol 52 (2) ◽  
pp. 155-176
Author(s):  
Valerie Shrimplin ◽  
Channa N. Jayasena
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Sperm Function ◽  
Henry Viii ◽  
Tudor England ◽  
History Of ◽  
Fertility Problems ◽  
Male Reproductive Health

Abstract Although fertility has traditionally been viewed as the responsibility of women, recent studies suggest that reduced sperm function is a major cause of the recurrent pregnancy loss that affects 1 to 2 percent of couples. The reproductive and nutritional history of King Henry VIII indicates that 70 percent of the legitimate pregnancies attributed to Henry and his six wives resulted in miscarriage or stillbirth. By comparison, only 10 percent of the recorded pregnancies of the thirty-one noblemen closely associated with Henry had the same outcomes. Henry’s reproductive health likely contributed to the fertility problems for which his wives took the blame. The disregard of male infertility in Henry’s case may offer a clue to the reasons for the under-reporting of male reproductive health, then and now, to the detriment of both men and women.

scholarly journals EAU-verslag Andrologie

2020 ◽  
Vol 10 (S2) ◽  
pp. 20-22
Author(s):  
Marij Dinkelman-Smit
Keyword(s):  
Sexual Dysfunction ◽  
Reproductive Health ◽  
Male Infertility ◽  
Sexual And Reproductive Health ◽  
Male Hypogonadism ◽  
Male Sexual Dysfunction

Samenvatting De EAU guidelines ‘Male infertility, male sexual dysfunction en male hypogonadism’ zijn ondergebracht onder een nieuw panel dat dit jaar de eerste ‘Sexual and Reproductive Health’ richtlijn presenteerde: zeer de moeite waard om te bekijken. Hierna volgt een samenvatting ‘Andrologie en testiculaire kiemceltumor’ uit de EAU20 Virtual.

scholarly journals Impact of the SARS‐CoV‐2 Virus on Male Reproductive Health

2021 ◽  
Author(s):  
Daniel E. Nassau ◽  
Jordan C. Best ◽  
Eliyahu Kresch ◽  
Daniel C Gonzalez ◽  
Kajal Khodamoradi ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Male Reproductive Health
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