scholarly journals VIRAL EFFECT OF SARS-COV-2 ON MALE INFERTILITY

2021 ◽  
pp. 8-13
Author(s):  
Zh. Yu. Sapozhkova
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
Reproductive Medicine ◽  
Clinical Laboratory ◽  
Diagnostic Process ◽  
Laboratory Diagnostics ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Male Reproductive Health

Clinical laboratory diagnostics of male infertility is an integral part of the diagnostic process in the field of reproductive medicine. Studies conducted during the pandemia of novel coronavirus infection (COVID-19) indicate that RNA of SARS-CoV-2 can be detected in the testes, and that the possibility of disrupting spermatogenesis and the viral impact on male reproductive health has been predicted.

scholarly journals LABORATORY DIAGNOSTICS OF MALE INFERTILITY. BIOMARKERS. PART I

2021 ◽  
pp. 57-68
Author(s):  
Zh. Yu. Sapozhkova ◽  
G. A. Milovanova ◽  
O. I. Patsap
Keyword(s):  
Male Infertility ◽  
Reproductive Medicine ◽  
Laboratory Tests ◽  
Clinical Laboratory ◽  
Diagnostic Process ◽  
Laboratory Diagnostics ◽  
Human Semen ◽  
Male And Female ◽  
Depth Study ◽  
Diagnostic Approaches

Currently, clinical laboratory diagnostics of male infertility is an integral part of the diagnostic process in the field of reproductive medicine. This review provides information about novel and traditional immunological, cellular, biochemical and other markers of human semen, which are used in the complex laboratory diagnostics of male infertility. Unfortunately, at present, due to the lack of updated clinical guidelines for male and female infertility diagnostics, uninformative algorithms and incompatible assessment criteria are increasingly used. This situation leads to controversial discussions, where the diagnostic functions of laboratory tests and markers are questioned. That is why the constant search is needed for innovative diagnostic approaches aimed at in-depth study of the pathogenesis of male infertility and subfertility.

scholarly journals Aminodihydrophthalazinedione sodium in prevention, therapy and rehabilitation of patients with respiratory diseases

2021 ◽  
Vol 23 (3) ◽  
pp. 296-303
Author(s):  
Dmitry I. Trukhan ◽  
◽  
Natalya V. Bagisheva ◽  
Anna V. Mordyk ◽  
Ekaterina Yu. Nebesnaya ◽  
...  
Keyword(s):  
Viral Infections ◽  
Laboratory Diagnostics ◽  
The Novel ◽  
Modern Approach ◽  
Prevention Therapy ◽  
Prevention And Treatment ◽  
Respiratory Pathology ◽  
Coronavirus Infection ◽  
Respiratory Viral Infections ◽  
Novel Coronavirus

The modern approach to the prevention and treatment of acute respiratory viral infections consists in the use of drugs that increase the body’s defenses, helping to create a barrier to the penetration of the virus. Immunomodulators exhibit a nonspecific effect in acute respiratory viral infections, which makes it possible to use them against various types of respiratory viruses without accurate laboratory diagnostics and expands clinical capabilities. In the first part of the review, the features of sodium aminodihydrophthalazinedione and the experience of its use in respiratory pathology are considered. The pandemic of the novel coronavirus infection (COVID-19), spread by the novel coronavirus SARS-CoV-2, has become a challenge to health systems around the world. The second part of the review reviews the results of the first studies on the use of sodium aminodihydrophthalazinedione for the prevention and treatment of new coronavirus infection. Recently, much attention has been paid to the long-term consequences of the postponed coronavirus infection. In the final part of the review, various aspects of the “post-COVID syndrome” are discussed and the possibilities of aminodihydrophthalazinedione sodium at the stage of rehabilitation after a coronavirus infection are discussed.

scholarly journals Experience of international cooperation in developing epidemic control measures during COVID-19 spread in the Republic of Moldova

2021 ◽  
Vol 98 (4) ◽  
pp. 373-382
Author(s):  
A. Yu. Popova ◽  
T. A. Ruzhentsova ◽  
T. Yu. Krasovskaya ◽  
K. V. Аlbul ◽  
N. V. Beril ◽  
...  
Keyword(s):  
Lung Ventilation ◽  
Control Measures ◽  
Laboratory Diagnostics ◽  
The Novel ◽  
Healthcare Organizations ◽  
Epidemic Control ◽  
Republic Of Moldova ◽  
Coronavirus Infection ◽  
The Republic ◽  
Novel Coronavirus

The purpose of the study — to identify the factors contributing to the spread of the novel coronavirus infection within the territory of the Republic of Moldova and to develop measures aimed at their elimination.Materials and methods. In May 2020, experts of Rospotrebnadzor (the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing), together with leading employees of institutions participating in planning and implementing measures aimed at prevention of COVID-19 spread, conducted a detailed analysis of epidemic control and curative measures in 10 healthcare organizations in the Republic of Moldova. They assessed the effectiveness of the undertaken actions in in-patient facilities, in laboratories, and in the country in general.Results. The existing approaches to treatment of patients with COVID-19 and to laboratory diagnostics were in line with the common practices; the adequacy of measures was evidenced by the hospital bed capacity and the stock of artificial lung ventilation machines. In the meantime, the experts came across the factors that obviously contributed to the infection spread. Their elimination could intercept some paths of infection and improve the situation.Conclusion. The analysis of the current measures and their results is important for planning and implementing actions aimed at improvement of the epidemic situation in different regions. The collaborative efforts helped slow down the outbreak in the Bender psychoneurological residential facility; outbreaks were prevented in other limited-access institutions; the incidence among healthcare workers decreased; the daily number of new COVID-19 cases decreased to 0–5 during the summer months in the Dniestrian Moldovan Republic. Presently, there is a clear picture of approaches that should be taken to decrease the incidence. Most likely, the experience obtained in the fight against the novel coronavirus infection will be of great use in future if any new variants of viruses emerge.

scholarly journals Varicocele as one of the causes of the decreased male infertility

2019 ◽  
Vol 20 (3) ◽  
pp. 27-35
Author(s):  
T. M. Sorokina ◽  
M. V. Andreeva ◽  
V. B. Chernykh ◽  
L. F. Kurilo
Keyword(s):  
Experimental Data ◽  
Reproductive Health ◽  
Male Infertility ◽  
Reproductive System ◽  
Male Fertility ◽  
Male Reproductive System ◽  
Review Of The Literature ◽  
High Prevalence ◽  
Male Reproductive Health ◽  
Methods Of Treatment

Varicocele is one of the most common diseases of the male reproductive system. Despite the high prevalence of this pathology, the effect of varicocele on male fertility is still a controversial issue. Opinions of experts about the possible effects of varicocele on the male reproductive health, the causes and methods of treatment are contradictory, and the experimental data obtained often show directly opposed results. This article presents a review of the literature on the effects of varicocele on the male reproductive system and fertility.

Analysis of the clinical manifestations of cerebral stroke in patients with the novel coronavirus infection (COVID-19)

2020 ◽  
pp. 30-45
Author(s):  
Vladislav V. Andreev ◽  
Alexander Y. Podunov ◽  
Daniil S. Lapin ◽  
Zarema L. Gilyaeva ◽  
Ekaterina N. Nikiforova ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Hemorrhagic Stroke ◽  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Community Acquired Pneumonia ◽  
Control Group ◽  
Cerebral Stroke ◽  
The Novel ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Objective: To improve the diagnosis and treatment of acute cerebrovascular accident in patients with community-acquired pneumonia caused by the novel coronavirus infection (COVID-19). Materials and methods: For the first time, clinical manifestations of strokes in patients with diagnosed new coronavirus infection (COVID-19) were analyzed in 130 patients. The study was conducted in two groups. The main group consisted of 69,2 % (n = 90) with a clinical and instrumental diagnosis: novel coronavirus infection in combination with stroke. The control group (30,8 %; n = 40) included the cases of ischemic and hemorrhagic stroke without signs of SARS-CoV-2. In both groups, the severity of the disease and pathogenetic subtypes were compared, and the features of the laboratory biochemical data were studied. Statistical analysis of the outcomes was carried out taking into account the severity of brain and lung tissue damage. Results: In patients with cerebral stroke against the background of the new coronavirus infection (COVID-19), the prevalence of ischemic stroke cases (86,4 %) was noted for undetermined (41,4 %) and cardioembolic (35,7 %) pathogenetic subtypes (according to TOAST) with localization in the carotid basin (89,7 %). In hemorrhagic stroke, parenchymal hemorrhage was observed with a greater frequency (54,5 %). The severity of the diagnosed strokes according to the NIHSS scale was up to 13,16 (8,80) points with less severe brain damage — Glasgow coma scale (14,0 (12,0 15,0). In the group of the patients, a widespread lesion of the lung tissue was diagnosed in 82,2 % of cases. No significant increase in the incidence of clinically significant manifestations of systemic and organ hypercoagulation was established. Conclusions: In stroke patients with COVID-19, ischemic manifestations with undetermined and cardioembolic subtypes without age and gender features prevail, with no differences in the severity of the course and a large number of favorable outcomes. A high activity of inflammatory and infectious changes was established by clinical laboratory.

Regulatory Functions of MicroRNAs in Male Reproductive Health: A New Approach to Understanding Male Infertility

2018 ◽  
pp. 193371911876597 ◽  
Author(s):  
Asghar Beigi Harchegani ◽  
Hossein Shafaghatian ◽  
Eisa Tahmasbpour ◽  
Alireza Shahriary
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
New Approach ◽  
Regulatory Functions ◽  
Male Reproductive Health

scholarly journals Effectiveness of immobilized probiotics for complex therapy of novel coronavirus infection COVID-19 in hospital settings

2020 ◽  
Author(s):  
NG Bomshteyn ◽  
YuV Bolotov ◽  
IA Kim ◽  
DV Trukhin
Keyword(s):  
Prospective Observational Study ◽  
Clinical Laboratory ◽  
The Novel ◽  
Complex Treatment ◽  
Open Label ◽  
Probiotic Treatment ◽  
Complex Therapy ◽  
Coronavirus Infection ◽  
The Russian Federation ◽  
Novel Coronavirus

Taking into account the gut–lung microbiota axis, the new probiotic treatment methods for COVID-19 are currently being discussed. There are effective medicinal preparations of domestic manufacture in the Russian Federation, the immobilized probiotics. The study was aimed to determine the effectiveness of the mixed immobilized probiotic containing the immobilized B. bifidum and lactobacilli L. plantarum (100 million CFU per dose) or the simple immobilized probiotic containing the immobilized B. bifidum (500 million CFU per dose) in the complex therapy of patients with COVID-19. During the open-label, prospective, observational study 70 patients with confirmed diagnosis of COVID-19 received complex treatment which included the immobilized probiotics. All patients were discharged from the hospital with imporoved health status, as well as with improved instrumental and laboratory indicators: body temperature returned to normal in all patients; shortness of breath, cough, feeling of chest tightening, myalgia and headache disappeared; the patients regained sense of smell and taste; the weakness decreased or disappeared (pathognomic symptom for COVID-19). The dynamics of clinical, laboratory and instrumental indicators reflecting the course of the novel coronavirus infection demonstrates the effectiveness of the used complex therapy. The immobilized probiotics may be recommended for the complex treatment of patients with COVID-19.

scholarly journals Endocrine Disruption of Androgenic Activity by Perfluoroalkyl Substances: Clinical and Experimental Evidence

2018 ◽  
Vol 104 (4) ◽  
pp. 1259-1271 ◽  
Author(s):  
Andrea Di Nisio ◽  
Iva Sabovic ◽  
Umberto Valente ◽  
Simone Tescari ◽  
Maria Santa Rocca ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
Experimental Evidence ◽  
Molecular Mechanisms ◽  
Nuclear Translocation ◽  
Seminal Fluid ◽  
Semen Quality ◽  
Substantial Impact ◽  
Gene Reporter Assay ◽  
Male Reproductive Health

Abstract Background Considerable attention has been paid to perfluoroalkyl compounds (PFCs) because of their worldwide presence in humans, wildlife, and environment. A wide variety of toxicological effects is well supported in animals, including testicular toxicity and male infertility. For these reasons, the understanding of epidemiological associations and of the molecular mechanisms involved in the endocrine-disrupting properties of PFCs on human reproductive health is a major concern. Objective To investigate the relationship between PFC exposure and male reproductive health. Design This study was performed within a screening protocol to evaluate male reproductive health in high schools. Patients This is a cross-sectional study on 212 exposed males from the Veneto region, one of the four areas worldwide heavily polluted with PFCs, and 171 nonexposed controls. Main Outcome Measures Anthropometrics, seminal parameters, and sex hormones were measured in young males from exposed areas compared with age-matched controls. We also performed biochemical studies in established experimental models. Results We found that increased levels of PFCs in plasma and seminal fluid positively correlate with circulating testosterone (T) and with a reduction of semen quality, testicular volume, penile length, and anogenital distance. Experimental evidence points toward an antagonistic action of perfluorooctanoic acid on the binding of T to androgen receptor (AR) in a gene reporter assay, a competition assay on an AR-coated surface plasmon resonance chip, and an AR nuclear translocation assay. Discussion This study documents that PFCs have a substantial impact on human health as they interfere with hormonal pathways, potentially leading to male infertility.

The features of the course of acute stroke associated with the novel coronavirus infection COVID-19

2021 ◽  
pp. 496 (569)-503 (576)
Author(s):  
Nataliya Vasilievna Nozdryukhina ◽  
Ekaterina Nikolaevna Kabaeva ◽  
Evgeniy Vladimirovich Kirilyuk ◽  
Kristina Andreevna Tushova ◽  
Ilsiyar Ildarovna Salikhova
Keyword(s):  
Acute Stroke ◽  
Clinical Laboratory ◽  
The Novel ◽  
English Version ◽  
Leading Role ◽  
Results Of Treatment ◽  
Specialized Hospital ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
The City

Despite the modern advances of medicine, the incidence and death rate of COVID-19 remains quite high. The data about complications associated with the infection caused by SARS-CoV-2 are constantly updated. There is more and more information about complications from the nervous system, where stroke plays a leading role. The desire to more accurately understand the mechanisms of stroke development in patients with the novel coronavirus infection and the search for ways to improve the results of treatment of this pathology incurred the analysis of 289 cases of the new coronavirus infection in the specialized hospital of the City Clinical Hospital No. 15 named after O.M. Filatov (Moscow) for the period March-June 2020. All patients underwent the analysis of clinical, laboratory, and instrumental data. The features of the course of stroke against the background of COVID-19 and changes in indicators of clinical, laboratory and instrumental research methods are considered. The most common forms of extracerebral pathology in stroke in patients with COVID-19 are shown. English version of the article on pp. 569-576 is available at URL: https://panor.ru/articles/features-of-the-acute-stroke-run-associated-with-the-new-coronavirus-infection-covid-19/70262.html

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