scholarly journals Role of Herbal Medicines on Male Infertility - A Review

2021 ◽  
pp. 289-293
Author(s):  
B. Ashwinidevi ◽  
S. Kavitha ◽  
R. Yasodai
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
Histological Study ◽  
Sperm Concentration ◽  
Herbal Medicines ◽  
Testicular Tissue ◽  
Protective Mechanisms ◽  
Tissue Samples ◽  
Holistic Approaches ◽  
Male Reproductive Health

Infertility is one of the most serious social problems are caused by many Factors such as genetic, environmental factors about 70% of cases remain unknown, Protective Mechanisms of the Sperm is called Spermatogenesis. The formation of the sperm from a germ cell precursor, its maturation, transport, viability, and the final steps, any changes happens in this series which causes infertility condition. The clinical detection of infertility is identified by analysis of semen. The main parameters are sperm concentration, morphology and viability of sperm .the origin of infertility in men happened by a lot of factors are hormonal disorders, mental stress, physical abnormalities, lifestyle problems, obesity , sexual issues, genetic abnormalities and deficiency of single-genes. This article aimed on the histological study testicular tissue samples, the structure of male reproductive, causes for male infertility, procedures available to find the genes engaged in infertility, the current remedial measures for male infertility. Whereas, the herbal therapies, are better positioned to offer more holistic approaches to improve male reproductive health. In traditional medicine which helps to nourishes and stimulates the sexual tissues and ameliorate male reproductive health issues.

scholarly journals Fighting Bisphenol A-Induced Male Infertility: The Power of Antioxidants

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 289
Author(s):  
Joana Santiago ◽  
Joana V. Silva ◽  
Manuel A. S. Santos ◽  
Margarida Fardilha
Keyword(s):  
Male Infertility ◽  
Bisphenol A ◽  
Sperm Concentration ◽  
In Vivo Studies ◽  
Sperm Dna Damage ◽  
Testicular Cells ◽  
Low Concentrations ◽  
Sperm Dna ◽  
Male Reproductive Health

Bisphenol A (BPA), a well-known endocrine disruptor present in epoxy resins and polycarbonate plastics, negatively disturbs the male reproductive system affecting male fertility. In vivo studies showed that BPA exposure has deleterious effects on spermatogenesis by disturbing the hypothalamic–pituitary–gonadal axis and inducing oxidative stress in testis. This compound seems to disrupt hormone signalling even at low concentrations, modifying the levels of inhibin B, oestradiol, and testosterone. The adverse effects on seminal parameters are mainly supported by studies based on urinary BPA concentration, showing a negative association between BPA levels and sperm concentration, motility, and sperm DNA damage. Recent studies explored potential approaches to treat or prevent BPA-induced testicular toxicity and male infertility. Since the effect of BPA on testicular cells and spermatozoa is associated with an increased production of reactive oxygen species, most of the pharmacological approaches are based on the use of natural or synthetic antioxidants. In this review, we briefly describe the effects of BPA on male reproductive health and discuss the use of antioxidants to prevent or revert the BPA-induced toxicity and infertility in men.

Semen quality and male reproductive health: the controversy about human sperm concentration decline

Apmis ◽  
2001 ◽  
Vol 109 (S103) ◽  
pp. S48-S61 ◽  
Author(s):  
PIERRE JOUANNET ◽  
CHRISTINA WANG ◽  
FLORENCE EUSTACHE ◽  
TINA KOLD-JENSEN ◽  
JACQUES AUGER
Keyword(s):  
Reproductive Health ◽  
Semen Quality ◽  
Sperm Concentration ◽  
Human Sperm ◽  
Male Reproductive Health

scholarly journals Kisspeptin Protein in Seminal Plasma Is Positively Associated with Semen Quality: Results from the MARHCS Study in Chongqing, China

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Peng Zou ◽  
Xiaogang Wang ◽  
Qing Chen ◽  
Huan Yang ◽  
Niya Zhou ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Blood Plasma ◽  
Seminal Plasma ◽  
Semen Quality ◽  
Sperm Concentration ◽  
World Health ◽  
Reference Level ◽  
Sperm Number ◽  
Potential Marker ◽  
Male Reproductive Health

Objectives. To study the associations between kisspeptin levels in seminal plasma and blood plasma and semen quality. Materials and Methods. We conducted a male reproductive health survey in June 2014. A total of 666 volunteers were recruited from colleges in Chongqing, China. All volunteers completed a questionnaire including information on domestic characteristics and some potential confounders. We tested the kisspeptin levels in both blood and seminal plasma. Total seminal kisspeptin was calculated as the concentration of kisspeptin in seminal plasma multiplied by semen volume. Semen samples were tested according to the 2010 World Health Organization’s (WHO) guidelines. Spearman correlation and multivariate linear regression were used to explore the association between kisspeptin concentrations in seminal plasma and blood plasma and semen quality. Potential confounders that were adjusted for included age, abstinence time, body mass index (BMI), grade, and smoking. Results. The median of kisspeptin levels in seminal plasma was 60,000 times higher than kisspeptin in blood plasma (28.0 × 106 pg/ml versus 448.9 pg/ml). Each interquartile range (IQR) of kisspeptin in seminal plasma was associated with a 4.6% (95% confidence interval [CI]: 1.6%–7.6%) increase in sperm concentration. Each IQR of total kisspeptin was associated with a 7.7% (95% CI: 4.4%–11.0%) increase in total sperm number and a 7.8% (95% CI: 4.0%–11.7%) increase in total motile sperm count. Kisspeptin levels were further classified into quartiles and Q1 was set as the reference level. Subjects in the high total kisspeptin group had 57.5% (95% CI: 33.2%–86.2%) higher total sperm number than the reference group. Conclusion. The positive association between kisspeptin levels in seminal plasma and semen quality supported an important role for the KISS1/GPR54 system in male reproductive health. Kisspeptin may be a potential marker of male reproductive health and an alternative strategy for treating infertility.

scholarly journals Varicocele as one of the causes of the decreased male infertility

2019 ◽  
Vol 20 (3) ◽  
pp. 27-35
Author(s):  
T. M. Sorokina ◽  
M. V. Andreeva ◽  
V. B. Chernykh ◽  
L. F. Kurilo
Keyword(s):  
Experimental Data ◽  
Reproductive Health ◽  
Male Infertility ◽  
Reproductive System ◽  
Male Fertility ◽  
Male Reproductive System ◽  
Review Of The Literature ◽  
High Prevalence ◽  
Male Reproductive Health ◽  
Methods Of Treatment

Varicocele is one of the most common diseases of the male reproductive system. Despite the high prevalence of this pathology, the effect of varicocele on male fertility is still a controversial issue. Opinions of experts about the possible effects of varicocele on the male reproductive health, the causes and methods of treatment are contradictory, and the experimental data obtained often show directly opposed results. This article presents a review of the literature on the effects of varicocele on the male reproductive system and fertility.

Semen quality and male reproductive health: the controversy about human sperm concentration declineNote

Apmis ◽  
2001 ◽  
Vol 109 (5) ◽  
pp. 333-344 ◽  
Author(s):  
Pierre Jouannet ◽  
Christina Wang ◽  
Florence Eustache ◽  
Tina Kold-Jensen ◽  
Jacques Auger
Keyword(s):  
Reproductive Health ◽  
Semen Quality ◽  
Sperm Concentration ◽  
Human Sperm ◽  
Male Reproductive Health

Regulatory Functions of MicroRNAs in Male Reproductive Health: A New Approach to Understanding Male Infertility

2018 ◽  
pp. 193371911876597 ◽  
Author(s):  
Asghar Beigi Harchegani ◽  
Hossein Shafaghatian ◽  
Eisa Tahmasbpour ◽  
Alireza Shahriary
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
New Approach ◽  
Regulatory Functions ◽  
Male Reproductive Health

Decline in sperm count in European men during the past 50 years

2017 ◽  
Vol 37 (3) ◽  
pp. 247-255 ◽  
Author(s):  
P Sengupta ◽  
E Borges ◽  
S Dutta ◽  
E Krajewska-Kulak
Keyword(s):  
Reproductive Health ◽  
English Language ◽  
Sperm Count ◽  
Meta Analysis ◽  
Sperm Concentration ◽  
Scientific Research ◽  
Time Dependent ◽  
Evidence Based ◽  
The Past ◽  
Male Reproductive Health

Purpose: To investigate whether the sperm concentration of European men is deteriorating over the past 50 years of time. Materials and Methods: We analysed the data published in English language articles in the past 50 years in altering sperm concentration in European men. Results: A time-dependent decline of sperm concentration ( r = −0.307, p = 0.02) in the last 50 years and an overall 32.5% decrease in mean sperm concentration was noted. Conclusion: This comprehensive, evidence-based meta-analysis concisely presents the evidence of decreased sperm concentration in European male over the past 50 years to serve the scientific research zone related to male reproductive health.

scholarly journals Endocrine Disruption of Androgenic Activity by Perfluoroalkyl Substances: Clinical and Experimental Evidence

2018 ◽  
Vol 104 (4) ◽  
pp. 1259-1271 ◽  
Author(s):  
Andrea Di Nisio ◽  
Iva Sabovic ◽  
Umberto Valente ◽  
Simone Tescari ◽  
Maria Santa Rocca ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
Experimental Evidence ◽  
Molecular Mechanisms ◽  
Nuclear Translocation ◽  
Seminal Fluid ◽  
Semen Quality ◽  
Substantial Impact ◽  
Gene Reporter Assay ◽  
Male Reproductive Health

Abstract Background Considerable attention has been paid to perfluoroalkyl compounds (PFCs) because of their worldwide presence in humans, wildlife, and environment. A wide variety of toxicological effects is well supported in animals, including testicular toxicity and male infertility. For these reasons, the understanding of epidemiological associations and of the molecular mechanisms involved in the endocrine-disrupting properties of PFCs on human reproductive health is a major concern. Objective To investigate the relationship between PFC exposure and male reproductive health. Design This study was performed within a screening protocol to evaluate male reproductive health in high schools. Patients This is a cross-sectional study on 212 exposed males from the Veneto region, one of the four areas worldwide heavily polluted with PFCs, and 171 nonexposed controls. Main Outcome Measures Anthropometrics, seminal parameters, and sex hormones were measured in young males from exposed areas compared with age-matched controls. We also performed biochemical studies in established experimental models. Results We found that increased levels of PFCs in plasma and seminal fluid positively correlate with circulating testosterone (T) and with a reduction of semen quality, testicular volume, penile length, and anogenital distance. Experimental evidence points toward an antagonistic action of perfluorooctanoic acid on the binding of T to androgen receptor (AR) in a gene reporter assay, a competition assay on an AR-coated surface plasmon resonance chip, and an AR nuclear translocation assay. Discussion This study documents that PFCs have a substantial impact on human health as they interfere with hormonal pathways, potentially leading to male infertility.

scholarly journals VIRAL EFFECT OF SARS-COV-2 ON MALE INFERTILITY

2021 ◽  
pp. 8-13
Author(s):  
Zh. Yu. Sapozhkova
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
Reproductive Medicine ◽  
Clinical Laboratory ◽  
Diagnostic Process ◽  
Laboratory Diagnostics ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Male Reproductive Health

Clinical laboratory diagnostics of male infertility is an integral part of the diagnostic process in the field of reproductive medicine. Studies conducted during the pandemia of novel coronavirus infection (COVID-19) indicate that RNA of SARS-CoV-2 can be detected in the testes, and that the possibility of disrupting spermatogenesis and the viral impact on male reproductive health has been predicted.

scholarly journals Research Funding for Male Reproductive Health and Infertility in the UK and USA [2016 to 2019]

2021 ◽  
Author(s):  
Eva Gumerova ◽  
Christopher J. De Jonge ◽  
Christopher LR Barratt
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
Research Funding ◽  
Open Data ◽  
Research Groups ◽  
Research Activity ◽  
Significant Difference ◽  
The Us ◽  
The Uk ◽  
Male Reproductive Health

There is a paucity of data on research funding for male reproductive health. We investigated the research funding for male reproductive health and infertility by examining publicly accessible databases from the UK and US government funding agencies. Information on the funding provided to male–based and 40 female–based research was collected using public accessed web databases from the UKRI–GTR, the NIHR's Open Data Summary, and the US' NIH RePORT. Funded projects that began research activity between January 2016 to December 2019 were recorded, along with their grant and project details. Strict inclusion–exclusion criteria were followed for both UK and US data with a primary research focus on male infertility, reproductive health and disorders, and contraception development. Funding support was divided into three research groups: male–based, female–based, and not–specified research. Between the 4–year period, the UK is divided into 5 funding periods, starting from 2015/16 to 2019/20, and the US is divided into 5 fiscal years, from 2016 to 2020. Between January 2016 to December 2019, UK agencies awarded a total of 11,767,190 GBP to 18 projects for male–based research and 29,850,945 GBP to 40 projects for female–based research. There was no statistically significant difference in funding average between the two research groups. The US NIH funded 76 projects totaling 59,257,746 US dollars for male–based research and 99 projects totaling 83,272,898 US dollars for female–based research. There was no statistically significant difference in funding average between the two groups. The findings of this study cannot be used to generalize and reflect global funding trends towards infertility and reproductive health as the data collected followed a narrow funding timeframe from government agencies and only two countries. Other funding sources such as charities, industry and major philanthropic organizations were not evaluated. This is the first study examining funding granted by main government research agencies from the UK and US for male reproductive health. This study should stimulate further discussion of the challenges of tackling male infertility and reproductive health disorders and formulate appropriate investment strategies.

Sign in / Sign up

Export Citation Format

Share Document