scholarly journals Sulfur and Sulfur Compounds in Plant Defence

2012 ◽  
Vol 7 (3) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Ifeanyi D. Nwachukwu ◽  
Alan J. Slusarenko ◽  
Martin C. H. Gruhlke
Keyword(s):  
Natural Products ◽  
New Technologies ◽  
Plant Defence ◽  
Sulfur Compounds ◽  
Oxidation States ◽  
Chemical Structures ◽  
Wide Range ◽  
Sulfur Containing ◽  
Sulfur Containing Compounds

The multiplicity of chemical structures of sulfur containing compounds, influenced in part by the element's several oxidation states, directly results in diverse modes of action for sulfur-containing natural products synthesized as secondary metabolites in plants. Sulfur-containing natural products constitute a formidable wall of defence against a wide range of pathogens and pests. Steady progress in the development of new technologies have advanced research in this area, helping to uncover the role of such important plant defence molecules like endogenously-released elemental sulphur, but also deepening current understanding of other better-studied compounds like the glucosinolates. As studies continue in this area, it is becoming increasingly evident that sulfur and sulfur compounds play far more important roles in plant defence than perhaps previously suspected.

Review of the Syntheses and Activities of Some Sulfur-Containing Drugs

2020 ◽  
Vol 17 (3) ◽  
pp. 192-210 ◽  
Author(s):  
Criscieli Taynara Barce Ferro ◽  
Beatriz Fuzinato dos Santos ◽  
Caren Daniele Galeano da Silva ◽  
George Brand ◽  
Beatriz Amaral Lopes da Silva ◽  
...  
Keyword(s):  
Chemical Compounds ◽  
Sulfur Compounds ◽  
Important Class ◽  
Materials Chemistry ◽  
Drug Candidates ◽  
Wide Range ◽  
Synthetic Routes ◽  
Pharmaceutical Properties ◽  
Sulfur Containing ◽  
Sulfur Containing Compounds

Background: Sulfur-containing compounds represent an important class of chemical compounds due to their wide range of biological and pharmaceutical properties. Moreover, sulfur-containing compounds may be applied in other fields, such as biological, organic, and materials chemistry. Several studies on the activities of sulfur compounds have already proven their anti-inflammatory properties and use to treat diseases, such as Alzheimer’s, Parkinson’s, and HIV. Moreover, examples of sulfur-containing compounds include dapsone, quetiapine, penicillin, probucol, and nelfinavir, which are important drugs with known activities. Objective: This review will focus on the synthesis and application of some sulfur-containing compounds used to treat several diseases, as well as promising new drug candidates. Results: Due to the variety of compounds containing C-S bonds, we have reviewed the different synthetic routes used toward the synthesis of sulfur-containing drugs and other compounds.

Figures of Authority in Nineteenth-Century Ireland

2020 ◽  
Keyword(s):  
Nineteenth Century ◽  
New Technologies ◽  
First Century ◽  
Western World ◽  
Catholic Priests ◽  
Modern Age ◽  
Wide Range ◽  
Emotional Politics ◽  
Print Cultures

This interdisciplinary collection investigates the forms that authority assumed in nineteenth-century Ireland, the relations they bore to international redefinitions of authority, and Irish contributions to the reshaping of authority in the modern age. At a time when age-old sources of social, political, spiritual and cultural authority were eroded in the Western world, Ireland witnessed both the restoration of older forms of authority and the rise of figures who defined new models of authority in a democratic age. Using new comparative perspectives as well as archival resources in a wide range of fields, eleven chapters show how new authorities were embodied in emerging types of politicians, clerics and professionals, and in material extensions of their power in visual, oral and print cultures. Their analyses often eerily echo twenty-first-century debates about populism, the suspicion towards scholarly and intellectual expertise, and the role of new technologies and forms of association in contesting and recreating authority. Several contributions highlight the role of emotion in the way authority was deployed by figures ranging from O’Connell to Catholic priests and W.B. Yeats, foreshadowing the perceived rise of emotional politics in our own age. This volume stresses that many contested forms of authority that now look ‘traditional’ emerged from 19th-century crises and developments, as did the challenges that undermine authority.

scholarly journals Biological Activity of Bicyclic and Tricyclic Diterpenoids from Salvia Species of Immediate Pharmacological and Pharmaceutical Interest

2011 ◽  
Vol 6 (8) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Maria Carmela Bonito ◽  
Carla Cicala ◽  
Maria Carla Marcotullio ◽  
Francesco Maione ◽  
Nicola Mascolo
Keyword(s):  
Biological Activities ◽  
Folk Medicine ◽  
Plant Defence ◽  
Experimental Studies ◽  
Scientific Basis ◽  
Chemical Structures ◽  
Wide Range ◽  
Real Value ◽  
Antimicrobic Activity ◽  
Cyclic Compounds

Diterpenoids are a class of compounds that derive from the condensation of four isoprene units that leads to a wide variety of complex chemical structures, including acyclic bi-, tri-and tetra-cyclic compounds; in Salvia species, only bi-, tri-and tetra-cyclic compounds have been found. This review covers a wide range of biological activities and mode of action of diterpenoids isolated from Salvia species that might raise some pharmacological and pharmaceutical interest. We have produced a synoptic table where the biological activities of the main active principles are summarized. Our analysis emphasizes that diterpenoids from Salvia species continue to be a plant defence system since their antimicrobic activity. Experimental studies show that most of diterpenoids considered have cytotoxic and / or antiproliferative activity. Some of them have also cardiovascular and central effects. In a less extended manner, diterpenoids from Salvia species show gastrointestinal, urinary, antinflammatory, antidiabetic, ipolipidemic and antiaggregating effects. In the last decade, several clinical trials have been developed in order to investigate the real value of Salvia extracts treatment; results obtained are promising and confer scientific basis in the use of medicinal plants from folk medicine.

scholarly journals Substrate recognition and ATPase activity of the E. coli cysteine/cystine ABC transporter YecSC-FliY

2020 ◽  
Vol 295 (16) ◽  
pp. 5245-5256 ◽  
Author(s):  
Siwar Sabrialabed ◽  
Janet G. Yang ◽  
Elon Yariv ◽  
Nir Ben-Tal ◽  
Oded Lewinson
Keyword(s):  
Atpase Activity ◽  
Abc Transporter ◽  
Conformational Changes ◽  
Binding Protein ◽  
Substrate Binding ◽  
Transporter Family ◽  
Wide Range ◽  
Substrate Binding Protein ◽  
Sulfur Containing ◽  
Sulfur Containing Compounds

Sulfur is essential for biological processes such as amino acid biogenesis, iron–sulfur cluster formation, and redox homeostasis. To acquire sulfur-containing compounds from the environment, bacteria have evolved high-affinity uptake systems, predominant among which is the ABC transporter family. Theses membrane-embedded enzymes use the energy of ATP hydrolysis for transmembrane transport of a wide range of biomolecules against concentration gradients. Three distinct bacterial ABC import systems of sulfur-containing compounds have been identified, but the molecular details of their transport mechanism remain poorly characterized. Here we provide results from a biochemical analysis of the purified Escherichia coli YecSC-FliY cysteine/cystine import system. We found that the substrate-binding protein FliY binds l-cystine, l-cysteine, and d-cysteine with micromolar affinities. However, binding of the l- and d-enantiomers induced different conformational changes of FliY, where the l- enantiomer–substrate-binding protein complex interacted more efficiently with the YecSC transporter. YecSC had low basal ATPase activity that was moderately stimulated by apo FliY, more strongly by d-cysteine–bound FliY, and maximally by l-cysteine– or l-cystine–bound FliY. However, at high FliY concentrations, YecSC reached maximal ATPase rates independent of the presence or nature of the substrate. These results suggest that FliY exists in a conformational equilibrium between an open, unliganded form that does not bind to the YecSC transporter and closed, unliganded and closed, liganded forms that bind this transporter with variable affinities but equally stimulate its ATPase activity. These findings differ from previous observations for similar ABC transporters, highlighting the extent of mechanistic diversity in this large protein family.

scholarly journals Adopting Computer Technology to empower Rural School Learners: The Case for Katsande Rural School Library, Zimbabwe

2019 ◽  
Author(s):  
Hosea Tokwe
Keyword(s):  
Computer Technology ◽  
New Technologies ◽  
School Library ◽  
School Libraries ◽  
Rural School ◽  
Reading Material ◽  
Wide Range ◽  
The Impact ◽  
Technology In Schools

In most countries, the introduction of computer technology in schools has seen the role of school libraries transformed. Adoption of new technologies are now seen to be enhancing school libraries’ ability to perform their mission, vision and role, that is, providing learners access to a wide range of reading material to enable them to acquire knowledge as well as ability to read books online. This paper will address the impact computer technology is having on rural school learners at Katsande Primary School. It will explain how embracing of computer technology has influenced learners concerning achieving quality education. 

Envisioning the future role of librarians: skills, services and information resources

2018 ◽  
Vol 39 (1/2) ◽  
pp. 2-11 ◽  
Author(s):  
Philomena W. Mwaniki
Keyword(s):  
Academic Libraries ◽  
New Technologies ◽  
User Needs ◽  
Library Services ◽  
Content Type ◽  
Technological Advances ◽  
Wide Range ◽  
The Future ◽  
Evolution Of Technology

Purpose The purpose of this paper is to conceptualize the future of academic libraries in the era of new user needs, new skills for staff and services offered. The literature shows the evolution of new technologies and the implications they have on the staff, library services and new user needs. The discussions in this paper are surrounded by conceptualization of what the library products and services will be in future academic libraries. It also looks at future studies that explore opportunities for librarians to advance their professional role. Design/methodology/approach This is a literature-based conceptual paper that draws on a wide range of literature that hypothetically looks at the future roles of professional librarians, the collection, services and the evolution of technology on the new user needs. Findings The library today will give the basis for the future librarian’s role, the emerging user needs and impact of service delivery. Technological advances have also affected the establishment of library systems and services offered. The emerging future roles will generally depend on how advanced the libraries are in the region or country including Kenya. Originality/value This paper adds a flexible approach to the skills, services as a role of future librarians.

scholarly journals Introduction to the Special Issue on Role of Scalable Computing and Data Analytics in Evolution of Internet of Things

2020 ◽  
Vol 21 (1) ◽  
pp. 1-2
Author(s):  
Swaminathan JN ◽  
Gopi Ram ◽  
Sureka Lanka
Keyword(s):  
Internet Of Things ◽  
Data Analytics ◽  
New Technologies ◽  
The Internet ◽  
Real World Data ◽  
Scalable Computing ◽  
Private Data ◽  
Wide Range ◽  
The Individual

The evolution of Internet of Things has given way to a Smart World where there is an improved integration of devices, systems and processes in humans through all pervasive connectivity. Anytime, anywhere connection and transaction is the motto of the Internet of things which brings comfort to the users and sweeps the problem of physical boundary out of the way. Once it has come into the purview of developers, new areas have been identified and new applications have been introduced. Small wearables which can track your health to big automated vehicles which can move from one place to another self navigating without human intervention are the order of the day. This has also brought into existence a new technology called cloud, since with IoT comes a large number of devices connected to the internet continuously pumping data into the cloud for storage and processing. Another area benefited from the evolution of IoT is the wireless and wired connectivity through a wide range of connectivity standards. As with any technology, it has also created a lot of concerns regarding the security, privacy and ethics.   Data protection issues created by new technologies are a threat which has been recognized by developers, public and also the governing body long back. The complexity of the system arises because of the various sensors and technologies which clearly tell the pattern of the activities of the individual as well an organization making us threat prone. Moreover, the volume of the data in the cloud makes it too difficult to recognize the privacy requirement of the data or to segregate open data from private data. Data analytics is another technology which supposedly increases the opportunity of increasing business by studying this private data collected from IoT and exploring ways to monetize them. It also helps the individual by recognizing their priorities and narrowing their search. But the data collected are real world data and aggregation of this data in the cloud is an open invitation to the hackers to study about the behaviors of the individuals.   The special issues of Scalable Computing has attract related to the Role of Scalable Computing and Data Analytics in Evolution of Internet of Things has attracted 28 submissions from which were selected 12.    

scholarly journals Foresight as a tool of public administration in the field of science, technology and innovation

2021 ◽  
Vol 8 (1) ◽  
pp. 90-97
Author(s):  
T. Kvasha ◽  
◽  
L. Musina ◽  
Keyword(s):  
New Technologies ◽  
National Level ◽  
Research And Innovation ◽  
Science Technology ◽  
Wide Range ◽  
Smart Specialization ◽  
High Level ◽  
First Time ◽  
Science Technology And Innovation

Given the growing role of technological foresight as a tool for reconciling visions, goals and ways of STI development in an era of rapid technological change and global challenges, the approach to foresight research to select priorities for science and innovation in Ukraine for 2022–2026 has been improved. It takes into account a wide range of national targets for achieving SDGs by 2030. The developed Methodological recommendations provided a thorough analysis of more than 3,000 potentially acceptable technological and innovative proposals. The approach to setting STI priorities is new for Ukraine and involves a consistent process of selecting the top 30 most acceptable proposals in each of the seven thematic areas through five stages of discussions and evaluations. The result was the formation of a database of technology passports and developments on the experts’ proposals, their selection by practitioners, ranking, evaluation in terms of the potential of Ukrainian science and relevance in terms of world science and new technologies using international databases. They are the basis for decisions by the Expert Councils and the High-Level Working Group on key thematic areas and the preparation of a relevant draft government decision. Despite the conditions of quarantine, for the first time more than 2,500 experts from science, business, state and public organizations took part in the discussions, which is the basis for impartial and public decision-making. To strengthen the role of foresight as a tool for public planning and management in the field of STI, it is proposed to develop a STI roadmap as part of a research and innovation strategy for smart specialization (RIS 3) at the national level.

Sulfatase regulation and antibiotic synthesis in Cephalosporium acremonium

1969 ◽  
Vol 15 (2) ◽  
pp. 175-181 ◽  
Author(s):  
David W. Dennen ◽  
Diane D. Carver
Keyword(s):  
Amino Acid ◽  
Culture Medium ◽  
Sulfur Compounds ◽  
Cephalosporin C ◽  
Cephalosporium Acremonium ◽  
Antibiotic Synthesis ◽  
Cellular Processes ◽  
High Level ◽  
Sulfur Containing ◽  
Sulfur Containing Compounds

The sulfatase of Cephalosporium acremonium is regulated by exogenous sulfur compounds, repressed in cells in 0.02 M sulfate, and derepressed in 5 × 10−4 M sulfate. Organic sulfur sources, such as cysteine, homocysteine, and methionine, derepress the enzyme in varying degrees while the latter amino acid is also required for maximum synthesis of the antibiotics cephalosporin C and penicillin N. Sulfatase-repressed cells transferred from sulfate to methionine-containing medium produce a high level of these antibiotics in the culture medium and a proportionate derepression of the sulfatase. Cycloheximide inhibits sulfatase derepression in cultures transferred from sulfate to methionine medium while having negligible effect on antibiotic synthesis. Mutant cultures of C. acremonium, with an increased potential to synthesize sulfur-containing antibiotics, have decreased ability to degrade methionine for other cellular requirements and sulfatase derepression is proportionately increased. The sulfatase is thus regulated by the biosynthesis of cephalosporin C and penicillin N at the expense of sulfur-containing compounds required for other cellular processes.

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