scholarly journals The Composition and Antimicrobial Activities of Cyperus conglomeratus, Desmos chinensis var. lawii and Cyathocalyx zeylanicus Essential Oils

2012 ◽  
Vol 7 (5) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Abdulkhader Hisham ◽  
Koranappallil B. Rameshkumar ◽  
Neelam Sherwani ◽  
Salim Al-Saidi ◽  
Salma Al-Kindy
Keyword(s):  
Nmr Spectroscopy ◽  
Essential Oil ◽  
Essential Oils ◽  
Antimicrobial Activities ◽  
Moderate Activity ◽  
Benzyl Benzoate ◽  
Antibacterial And Antifungal Activities ◽  
Microbial Strains ◽  
Antibacterial And Antifungal ◽  
C Nmr

The essential oil compositions of the rhizomes of Cyperus conglomeratus (Cyperaceae) collected from Oman and the leaves of two Annonaceae plants, Desmos chinensis var. lawii and Cyathocalyx zeylanicus collected from India were studied by GC, GC-MS and 13C NMR spectroscopy. Twenty-six compounds, representing 84.4% of the oil were identified in C. conglomeratus, where eugenol (31.3%), α-cyperone (10.5%) and cyperotundone (8.4%) were the major compounds. Twelve compounds, constituting 100%, were identified in D. lawii oil, of which benzyl benzoate (58.7%), β-caryophyllene (23.2%), limonene (4.9%) and α-humulene (4.0%) were the major constituents. Thirty-two compounds, comprising 98.0%, were identified in C. zeylanicus oil, of which β-caryophyllene (21.6%), α-pinene (20.4%) and E-β-ocimene (11.8%) were the major components. The antibacterial and antifungal activities of the oils were tested against a panel of five bacterial and two fungal strains. The oils showed moderate activity against all the tested microbial strains. The minimum inhibitory concentrations of the oils were also determined.

scholarly journals Chemical Composition of the Essential Oils from Two Vietnamese Asarum Species: A. glabrum and A. cordifolium

2013 ◽  
Vol 8 (2) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Tran Huy Thai ◽  
Ophélie Bazzali ◽  
Tran Minh Hoi ◽  
Nguyen Anh Tuan ◽  
Félix Tomi ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Nmr Spectroscopy ◽  
Endangered Species ◽  
Essential Oil ◽  
Essential Oils ◽  
Spectroscopic Techniques ◽  
Red Data Book ◽  
Data Book ◽  
First Time ◽  
C Nmr

The essential oil isolated from Asarum cordifolium C. E. C. Fischer recently discovered in Vietnam, and A. glabrum Merr., an endangered species listed as vulnerable in the Red Data Book of Vietnam, have been analyzed by a combination of chromatographic and spectroscopic techniques including 13C NMR spectroscopy. The composition of A. cordifolium essential oil, investigated for the first time, was dominated by elemicin (82.5%). The essential oil isolated from A. glabrum contained safrole (41.9%) as its major component and was characterized by the diversity of phenylpropanoids contained in this oil (10 compounds).

scholarly journals Composition of Seed Essential Oils of Rhododendron tomentosum

2012 ◽  
Vol 7 (2) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Asta Judzentiene ◽  
Rita Butkiene ◽  
Jurga Budiene ◽  
Félix Tomi ◽  
Joseph Casanova
Keyword(s):  
Quantitative Analysis ◽  
Chemical Composition ◽  
Nmr Spectroscopy ◽  
Essential Oil ◽  
Essential Oils ◽  
Thermal Isomerization ◽  
Total Oil ◽  
First Time ◽  
Rhododendron Tomentosum ◽  
C Nmr

For the first time, the chemical composition of the seed essential oil of Rhododendron tomentosum was determined. Forty-seven compounds were identified, comprising 91.7% of the total oil. Palustrol (38.3%) and ledol (27.0%) were the predominant constituents. Some constituents, such as β-pinene oxide, iso-menthyl acetate, nerolidyl acetate, cadalene and guaiazulene were characteristic only for the seeds and were identified for the first time in Rh. tomentosum oils. For comparison purposes, the essential oil isolated from the shoots of the same plant were analyzed [GC(FID) in combination with RIs, GC-MS and 13C NMR]. More than a half of the oil was comprised of ledol (36.5%) and palustrol (21.0%). Quantitative analysis of ascaridol, a heat-sensitive compound, was carried out by 13C NMR spectroscopy. Indeed, ascaridol undergoes partial thermal isomerization to iso-ascaridol during GC analyses.

scholarly journals Chemical Composition and Antimicrobial Activities of the Essential Oil From Salvia mirzayanii Leaves

2017 ◽  
Vol 22 (4) ◽  
pp. 770-776 ◽  
Author(s):  
Kamiar Zomorodian ◽  
Mahmoodreza Moein ◽  
Keyvan Pakshir ◽  
Forough Karami ◽  
Zahra Sabahi
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Chemical Constituents ◽  
Antimicrobial Activities ◽  
Gas Chromatography Mass Spectrometry ◽  
Antifungal Activities ◽  
Global Challenge ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Resistance of many pathogens to available drugs is a global challenge and is leading to growing interest in natural alternative products. In this study, chemical composition and in vitro antibacterial and antifungal activities of the essential oil from Salvia mirzayanii were investigated. The chemical constituents of essential oil from S mirzayanii were analyzed by gas chromatography–mass spectrometry. The antimicrobial activity was determined by broth microdilution. The main identified compounds were 1,8-cineole (41.2 ± 1.3%), linalool acetate (11.0 ± 0.5%), and α-terpinyl acetate (6.0 ± 0.4%) (mL of essential oil/g of plant material). The MIC95 were 0.03 to 0.5 µL/mL and 16 to 128 µL/mL for gram-positive and gram-negative bacteria, respectively. These results indicated that Salvia mirzayanii essential oil significantly inhibited the growth of standard and clinically isolated tested yeasts by MIC50 0.03 to 1 µL/mL. Potent antibacterial and antifungal activities of Salvia mirzayanii essential oil may be considered in future study, particularly against antibiotic-resistant cases.

scholarly journals Photoinduced Synthesis of New Diisochromenochromen-4-ones and Their Antimicrobial Activities

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Mohamad Yusuf ◽  
Indu Solanki ◽  
Payal Jain
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activities ◽  
Significant Activity ◽  
Rigorous Analysis ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
C Nmr

The diisochromenochromen-4-one3a-3b,4a-4c,5a-6a  & 7have been prepared from the photocyclization reaction of bischromen-4-one2a-2e. The later compounds are obtained from the O-alkylation of the suitable 3-hydroxy-2-aryl-4H-chromen-4-one1a-1ewith 4,4′-bischloromethyl-diphenyl in dry acetone, anhydrous K2CO3, and PTC (Bu4N+I−) under refluxing conditions. The structures of compounds2a-2e,3a-3b,4a-4c,5a-6a  & 7have been characterized from the rigorous analysis of their IR,1H-NMR,13C-NMR, ESI-Mass, and elemental analysis. The antibacterial and antifungal activities of the synthesized products were also evaluated against theKlebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, andAspergillus janusandPenicillium glabrum, respectively. Some of the tested compounds showed significant activity against the above-said microorganisms.

scholarly journals Combined Analysis by GC (RI), GC/MS and 13C NMR Spectroscopy of Elsholtzia blanda, E. penduliflora and E. winitiana Essential Oils

2007 ◽  
Vol 2 (8) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Dominique Lesueur ◽  
Ange Bighelli ◽  
Nguyen Thi Tam ◽  
Nguyen Viet Than ◽  
Pham thi Kim Dung ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Nmr Spectroscopy ◽  
Essential Oil ◽  
Essential Oils ◽  
13C Nmr ◽  
13C Nmr Spectroscopy ◽  
Retention Indices ◽  
Aerial Parts ◽  
Two Samples ◽  
C Nmr

The chemical composition of six oil samples, isolated from aerial parts of Elsholtzia blanda, E. penduliflora and E. winitiana, harvested in two provinces of Vietnam, was investigated by GC, in combination with retention indices (RI), GC/MS and 13C NMR spectroscopy. Linalool was the major component (75.2 and 56.8%) of the two samples of E. blanda essential oil, whereas the two oil samples from E. penduliflora were dominated by 1,8-cineole (62.7 and 65.5%). Conversely, the two oil samples of E. winitiana exhibited different compositions, rosefuran (56.0%) and dehydroelsholtzia ketone (22.8%) being the major components of one sample, whilst the second sample was dominated by elsholtzia ketone (87.5%).

scholarly journals Essential Oil Compositions, Antibacterial and Antifungal Activities of Nigerian Members of the Burseraceae: Boswellia dalzielii and Canarium schweinfurthii

2020 ◽  
Vol 15 (8) ◽  
pp. 1934578X2094694
Author(s):  
Moses S. Owolabi ◽  
Akintayo Ogundajo ◽  
Balogun Olaoye Solomon ◽  
Logunleko Olatunde ◽  
Noura S. Dosoky ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Stem Bark ◽  
Biologically Active ◽  
Gas Chromatography Mass Spectrometry ◽  
Chemical Compositions ◽  
Antibacterial And Antifungal Activities ◽  
The Family ◽  
Leaf Essential Oil ◽  
Antibacterial And Antifungal

The Burseraceae is an important family of resin-producing trees and shrubs, which have yielded biologically active essential oils. Boswellia dalzielii and Canarium schweinfurthii are members of the family that are used in West African traditional medicine for a variety of ailments. The leaf essential oils of B. dalzielii have been obtained from 2 different locations in north-central Nigeria, while the leaf and stem bark essential oils of C. schweinfurthii have been obtained from 3 locations. The chemical compositions of the essential oils have been determined by gas chromatography-mass spectrometry and show wide variation, especially for the leaf essential oils. The leaf essential oils of B. dalzielii and C. schweinfurthii have been screened for antibacterial and antifungal activity; C. schweinfurthii leaf essential oil showed remarkable activity against Aspergillus niger with a minimum inhibitory concentration of 78.1 μg/mL.

scholarly journals Deodarone Isomers in Cedrus atlantica Essential Oils and Tar Oils

2015 ◽  
Vol 10 (11) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Anne Marie Nam ◽  
Ange Bighelli ◽  
Mohamed Ghanmi ◽  
Badr Satrani ◽  
Joseph Casanova ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Essential Oil ◽  
Essential Oils ◽  
Cedrus Atlantica ◽  
Polar Column ◽  
C Nmr ◽  
Identification And Quantification

Deodarone [2,2,6-trimethyl-6-(4-methylcyclohex-3-enyl)-tetrahydro-4-pyrone] is a sesquiterpene tetrahydro-γ-pyrone related to bisabolene and atlantone, first isolated from Cedrus deodora essential oil. With respect to the stereochemistry of the asymmetric carbons C4 and C8, two diastereoisomers may be distinguished. Identification and quantification of both diastereoisomers in wood and tar oils from C. atlantica has been achieved using 13C NMR spectroscopy, in combination with GC (polar column). The contents of (4 R.8 R)- and (4 R.8 S)-deodarone varied between 1.1–2.8% and 1.0–3.0%, respectively.

scholarly journals Diversity of antibacterial and antifungal activities of Thymus kotschyanus essential oil collected from fourteen regions of Iran

2020 ◽  
pp. 60-75
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Biological Effects ◽  
Gastrointestinal Diseases ◽  
Plant Materials ◽  
Antibacterial And Antifungal Activities ◽  
Microdilution Method ◽  
Thymus Kotschyanus ◽  
Antifungal Effects ◽  
Antibacterial And Antifungal

Background and Aim: Thymus kotschyanus is one of the most famous medicinal plants in Iran from the mint family and it has many applications in traditional medicine, such as relieving the symptoms of colds and coughs and relieving some gastrointestinal diseases. It also has antibacterial and antifungal effects. This study was performed to investigate the diversity of antibiotic effects of this plant. Materials and Methods: Essential oils of fourteen different ecotypes of Thymus kotschyanus were extracted by using the Clevenger apparatus. After oil analyses with GC-MS device, the minimum inhibitory concentration of growth and also the minimum lethal concentration of 7 types of bacteria and 2 types of fungi were measured by microdilution method in the range of 0.01 to 5.12 mg/ml. Results: Oxygenated monoterpenes were the major fraction (64.60–90.60%) of the oils, and thymol and carvacrol were considered as the most abundant constituents (27.23–75.55%). The amount and concentration of these two phenolic substances in thyme essential oil were directly related to antibacterial and antifungal effects. The antibacterial and antifungal activity of the essential oils ranged from 0.24 to 5.12 and 0.08 to 0.96 mg/ml, respectively. The most active antimicrobial activity is related to the essential oil of Salmas and Nodoshan ecotypes and the least activity was seen in Rudbar ecotype. Conclusion: Geographical characteristics of the place where plants grow had a significant role in the type and amount of compounds in the essential oil of the plant. In this regard, different biological effects and antibacterial and antifungal properties can occur from each ecotype.

scholarly journals Essential Oil and Its Antimicrobial Activity from Ethiopian Acokanthera schimperia

2019 ◽  
pp. 1-3
Author(s):  
Wondwosen Matebie ◽  
Wanchang Zhang ◽  
Shuo Zhang ◽  
Guangbo Xie
Keyword(s):  
Essential Oil ◽  
Steam Distillation ◽  
Chemical Constituents ◽  
Antimicrobial Activities ◽  
Traditional Healers ◽  
Gas Chromatography Mass Spectrometry ◽  
Dilution Method ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Background: Acokanthera schimperia is a medicinal plant, which has been used by traditional healers as a curing agent in Ethiopia. Objective: The constituents of the essential oil, which was extracted from the leaves of A. schimperia, were investigated, and its antibacterial and antifungal activities were studied. Materials and Methods: The essential oil was extracted by an ordinary steam distillation process, and its chemical constituents were analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). Antibacterial and antifungal activities of the oil were studied by micro-dilution method against Escherichia coli, Bacillus subtilis (for bacteria), and Candida albicans (for fungus) respectively. Result: From the essential oil, 21 compounds were recognized, and making up 56.06 %. However, the essential oil doesn’t show any antimicrobial activities. Conclusion: This is the first research on A. schimperia concerning its essential oil and antimicrobial activities.

Synthesis & Anticancer Evaluation of New Substituted 2-(3,4- Dimethoxyphenyl)benzazoles

2019 ◽  
Vol 15 (3) ◽  
pp. 287-297 ◽  
Author(s):  
Cigdem Karaaslan ◽  
Yalcin Duydu ◽  
Aylin Ustundag ◽  
Can O. Yalcin ◽  
Banu Kaskatepe ◽  
...  
Keyword(s):  
Hela Cells ◽  
Parp Inhibitor ◽  
A549 Cells ◽  
Human Tumor ◽  
Antimicrobial Activities ◽  
Sodium Metabisulfite ◽  
Human Tumor Cell Lines ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Mitotic Inhibitor

Background: The benzazole nucleus is found in many promising small molecules such as anticancer and antibacterial agents. Bendamustine (Alkylating agent), Nocodazole (Mitotic inhibitor), Veliparib (PARP inhibitor), and Glasdegib (SMO inhibitor) are being clinically used as anticancer therapeutic which bear benzimidazole moiety. Based on the principle of bioisosterism, in the present work, 23 compounds belonging to 2-(3,4-dimethoxyphenyl)benzazoles and imidazopyridine series were synthesized and evaluated for their anticancer and antimicrobial activities. Objective: A series of new 2-(3,4-dimethoxyphenyl)-1H-benz(or pyrido)azoles were synthesized and evaluated for their anticancer and antimicrobial activities. Method: N-(5-chloro-2-hdroxyphenyl)-3,4-dimethoxybenzamide 1, was obtained by the amidation of 2-hydroxy-5-chloroaniline with 3,4-dimethoxybenzoic acid by using 1,1&'-carbonyldiimidazole. Cyclization of 1 to benzoxazole derivative 2, was achieved by p-toluenesulfonic acid. Other 1H-benz(or pyrido)azoles were prepared by the reaction between 2-aminothiophenol, ophenylenediamine, o-pyridinediamine with sodium metabisulfite adduct of 3,4-dimethoxybenzaldehyde. The NMR assignments of the dimethoxy groups were established by the NOESY spectra. Results: Compound 12, bearing two chlorine atoms at the 5(4) and 7(6) positions of the benzene moiety of benzimidazole was found the most potent analogue against A549 cells with the GI50 value of 1.5 μg/mL. Moreover, 24 showed remarkable cell growth inhibition against MCF-7 and HeLa cells with the GI50 values of 7 and 5.5 μg/mL, respectively. The synthesized compounds have no important antibacterial and antifungal activities. Conclusion: It could be concluded that the introduction of di-chloro atoms at the phenyl ring of 2-(3,4-dimethoxyphenyl)-1H-benzimidazoles increases significant cytotoxicity to selected human tumor cell lines in comparison to other all benzazoles synthesized. Unsubstituted 2-(3,4- dimethoxyphenyl)-imidazopyridines also gave good inhibitory profile against A549 and HeLa cells.

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