Bioactive Secondary Metabolites Produced by the Fungal Endophytes of Conifers

This is a review of bioactive secondary metabolites isolated from conifer-associated endophytic fungi from 1990-2014. This includes compounds with antimicrobial, anti-inflammatory, anti-proliferative and cytotoxic activity towards human cancer cell lines, and activity against either plant pathogens or plant insect pests. Compounds that were originally reported without associated activity were included if other studies ascribed activity to these compounds. Compounds were not included if they were exclusively phytotoxic or if they were isolated from active extracts but were not determined to be the active component of that extract.

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A New Cycloartane Glucoside from Rhizophora stylosa

Natural Product Communications ◽

10.1177/1934578x1400900909 ◽

2014 ◽

Vol 9 (9) ◽

pp. 1934578X1400900 ◽

Cited By ~ 5

Author(s):

Phan Thi Thanh Huong ◽

Chau Ngoc Diep ◽

Nguyen Van Thanh ◽

Vu Anh Tu ◽

Tran Hong Hanh ◽

...

Keyword(s):

Secondary Metabolites ◽

Lung Adenocarcinoma ◽

Cell Lines ◽

Caspase 3 ◽

Methanol Extract ◽

Human Cancer ◽

Human Cancer Cell ◽

Rhizophora Stylosa ◽

Human Cancer Cell Lines ◽

C Nmr

Nine secondary metabolites, including a new cycloartane glucoside, rhizostyloside (1), were isolated from a methanol extract of Rhizophora stylosa leaves through several chromatographic experiments. The structures of the compounds were determined on the basis of NMR spectroscopic (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY) and HR-ESI-MS data and by comparison with literature values. Compound 1 exhibited significant cytotoxicity against three human cancer cell lines: KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), and SK-Mel-2 (melanoma). In addition, 1 strongly activated caspase-3/7 in LU-1 cells.

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Cytotoxic Compounds Derived from Marine Algicolous and Spongicolous Endophytic Fungi: A Review

Dhaka University Journal of Pharmaceutical Sciences ◽

10.3329/dujps.v20i2.57175 ◽

2021 ◽

Vol 20 (2) ◽

pp. 247-265

Author(s):

Nadia Tasnim Ahmed ◽

Sadia Noor ◽

Md Mustafizur Rahman ◽

Md Abdul Mazid

Keyword(s):

Secondary Metabolites ◽

Endophytic Fungi ◽

Fungal Endophytes ◽

Bioactive Secondary Metabolites ◽

Cytotoxic Compounds ◽

Cell Components ◽

Long Time ◽

Number Of Publications ◽

Functionally Diverse ◽

Antimicrobial Metabolites

Endophytes have gained particular interest in the search of potential pharmaceutical candidates for a long time due to their diversity, species richness and bioprospecting nature. They generally produce the essential metabolites for their expansion inside the plant which is involved in various biotransformation processes of utilizing host nutrients and cell components to continue microbial growth, sustenance, and reproduction. In above processes, they produce a huge amount of both structurally and functionally diverse secondary metabolites for maintaining an effective symbiosis with hosts. These compounds are proven to have significant bioactive properties like antibacterial, antifungal, antiviral, anti-inflammatory, antioxidants, antitumor activities. Despite the proven significance, a little is exploited so far about endophytes. Particularly marine fungal endophytes which are the centre of attention in this review have gained much less importance. Due to unique environmental feature, fungal endophytes derived from marine environment offer vast diversity in different bioactive secondary metabolites. This review has focused on algicolous endophytes and bioactive secondary metabolites discovered during the last two decades. Particular importance has been given to cytotoxic and antimicrobial metabolites. Due to intensive studies during last several years, an extensive number of publications are now available on cytotoxic compounds derived from endophytic fungi of marine algicolous and spongicolous origin that have been summarized in this review. Dhaka Univ. J. Pharm. Sci. 20(2): 247-265, 2021 (December)

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Two New Triterpenes from Basidiomata of the Medicinal and Edible Mushroom, Laetiporus sulphureus

Molecules ◽

10.3390/molecules26237090 ◽

2021 ◽

Vol 26 (23) ◽

pp. 7090

Author(s):

Khadija Hassan ◽

Blondelle Matio Kemkuignou ◽

Marc Stadler

Keyword(s):

Secondary Metabolites ◽

Spectroscopic Data ◽

Human Cancer ◽

Edible Mushroom ◽

Mouse Fibroblast ◽

Human Cancer Cell ◽

Mucor Hiemalis ◽

Natural Sources ◽

Human Cancer Cell Lines ◽

Mcf 7

In the search for novel anti-infectives from natural sources, fungi, in particular basidiomycetes, have proven to still harbor so much potential in terms of secondary metabolites diversity. There have been numerous reports on isolating numerous secondary metabolites from genus Laetiporus. This study reports on two new triterpenoids, laetiporins C and D, and four known triterpenes from the fruiting body of L. sulphureus. The structures of the isolated compounds were elucidated based on their 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. Laetiporin C exhibited weak antifungal activity against Mucor hiemalis. Furthermore, the compounds showed weak antiproliferative activity against the mouse fibroblast L929 and human cancer cell lines, including KB-3-1, A431, MCF-7, PC-3 and A549.

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