Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis

Liverworts are rich sources of terpenoids and aromatic compounds among which bis-bibenzyls are well known for their wide spectrum of biological activities. This is the first report of chemical analysis of the African liverwort Marchantia debilis Goebel. From the methanol extract marchantinquinone-1′-methyl ether was newly isolated together with three known bis-bibenzyls, marchantin C, marchantinquinone and perrottetin E. The presence of bis-bibenzyls with a quinone moiety is noted for the first time in the Marchantia genus.

Download Full-text

Seasonal Changes in Essential Oil Constituents of Cystoseira compressa: First Report

Molecules ◽

10.3390/molecules26216649 ◽

2021 ◽

Vol 26 (21) ◽

pp. 6649

Author(s):

Ivana Generalić Mekinić ◽

Martina Čagalj ◽

Giulia Tabanelli ◽

Chiara Montanari ◽

Federica Barbieri ◽

...

Keyword(s):

Essential Oil ◽

Biological Activities ◽

Wide Spectrum ◽

Marine Macroalgae ◽

Volatile Fraction ◽

First Report ◽

Cystoseira Compressa ◽

Volatile Organic ◽

Total Oil ◽

High Share

Marine macroalgae are well known to release a wide spectrum of volatile organic components, the release of which is affected by environmental factors. This paper aimed to identify the essential oil (EO) compounds of the brown algae Cystoseira compressa collected in the Adriatic Sea monthly, from May until August. EOs were isolated by hydrodistillation using a Clavenger-type apparatus and analyzed by gas chromatography coupled with mass spectrometry (GC–MS). One hundred four compounds were identified in the volatile fraction of C. compressa, accounting for 84.37–89.43% of the total oil. Samples from May, June, and July were characterized by a high share of fatty acids (56, 69, and 34% respectively) with palmitic acid being the dominant one, while in the August sample, a high content of alcohols (mainly phytol and oleyl alcohol) was found. Changes in the other minor components, which could be important for the overall aroma and biological activities of the algal samples, have also been noted during the vegetation periods. The results of this paper contribute to studies of algal EOs and present the first report on C. compressa EOs.

Download Full-text

Fucoidan Sulfatases from Marine Bacterium Wenyingzhuangia fucanilytica CZ1127T

Biomolecules ◽

10.3390/biom8040098 ◽

2018 ◽

Vol 8 (4) ◽

pp. 98 ◽

Cited By ~ 6

Author(s):

Artem S. Silchenko ◽

Anton B. Rasin ◽

Anastasiya O. Zueva ◽

Mikhail I. Kusaykin ◽

Tatiana N. Zvyagintseva ◽

...

Keyword(s):

Marine Bacterium ◽

Biological Activities ◽

Wide Spectrum ◽

Degradation Pathway ◽

Sulfated Polysaccharides ◽

Complex Structures ◽

Escherichia Coli Cells ◽

First Time ◽

Heterogeneous Class

Fucoidans belong to a structurally heterogeneous class of sulfated polysaccharides isolated from brown algae. They have a wide spectrum of biological activities. The complex structures of these polysaccharides hinder structure-activity relationships determination. Fucoidan sulfatases can make useful tools for the determination of the fine chemical structure of fucoidans. In this study, identification and preparation of two recombinant sulfatases able to catalyze the cleavage of sulfate groups from fragments of fucoidan molecules is described for the first time. Two genes of sulfatases swf1 and swf4 of the marine bacterium Wenyingzhuangia fucanilytica CZ1127T were cloned and the proteins were produced in Escherichia coli cells. Sulfatases SWF1 and SWF4 are assigned to S1_17 and S1_25 subfamilies of formylglycine-dependent enzymes of S1 family (SulfAtlas). Some molecular and biochemical characteristics of recombinant fucoidan sulfatases have been studied. Detailed specificity and catalytic features of sulfatases were determined using various sulfated fucooligosaccharides. Structures of products produced by SWF1 and SWF4 were established by nuclear magnetic resonance (NMR) spectroscopy. Based on the obtained data, the enzymes are classified as fucoidan exo-2O-sulfatase (SWF1) and fucoidan exo-3O-sulfatase (SWF4). In addition, we demonstrated the sequential action of sulfatases on 2,3-di-O-sulfated fucooligosacchrides, which indicates an exolitic degradation pathway of fucoidan by a marine bacterium W. fucanilytica CZ1127T.

Download Full-text

Phytochemical Isolation and Biological Activities of Corydalis adiantifolia from Baltistan

Journal of the chemical society of pakistan ◽

10.52568/000758/jcsp/41.03.2019 ◽

2019 ◽

Vol 41 (3) ◽

pp. 535-535

Author(s):

Iftikhar Ali Iftikhar Ali ◽

Zulfiqar Ali Zulfiqar Ali ◽

Alishba Alishba ◽

Zamarrud Zamarrud ◽

Hidayat Hussain and Viqar Uddin Ahmad Hidayat Hussain and Viqar Uddin Ahmad

Keyword(s):

Plant Material ◽

Reducing Sugars ◽

Methanol Extract ◽

Biological Activities ◽

Spectroscopic Methods ◽

Phytochemical Screening ◽

Whole Plant ◽

Hela Cell Lines ◽

Water Fractions ◽

First Time

The whole plant material of Corydalis adiantifolia Hook.f. andamp; Thomson was investigated for biological activities e.g. antifungal, antibacterial, insecticidal, cytotoxic, anticancer and phytotoxic activities and preliminary phytochemical screening. The methanol extract and dichloromethane fraction of the plant species exhibited 5% inhibition each against the fungus Aspergillus flavus. The methanol extract and water and dichloromethane fractions exhibited non-significant antibacterial activity and they showed inhibition against Hela cell lines and insignificant insecticidal activity. To understand the bioactive profile of C. adiantifolia, phytochemical screening approach is considered effective. The samples including methanol extract and n-hexane, dichloromethane, ethyl acetate and water fractions were subjected to qualitative phytochemical screening for the presence of various phytochemicals i.e. alkaloids, flavonoids, saponins, diterprenes, triterpenoids, anthraquinones, anthranol glycosides, reducing sugars and phenols. The results exhibited the efficacy of methanol extract showing the presence of more phytochemicals in comparison to the fractions of C. adiantifolia. Moreover, as a result of phytochemical isolation, 8-acetonyldihydrosanguinarine (1), β-sitosterol (2) and β-sitosterol-β-D-glucoside (3) were isolated, purified, and characterized by spectroscopic methods. To the best of our knowledge, all this study was carried out for the first time on C. adiantifolia.

Download Full-text

Biography of biophenols: past, present and future

Functional Foods in Health and Disease ◽

10.31989/ffhd.v3i6.51 ◽

2013 ◽

Vol 3 (6) ◽

pp. 230 ◽

Cited By ~ 13

Author(s):

Hassan K. Obied

Keyword(s):

Biological Activities ◽

Wide Spectrum ◽

Future Research ◽

Plant Metabolites ◽

Research Directions ◽

Secondary Plant Metabolites ◽

History Of ◽

Scientific Attention ◽

First Time ◽

Ubiquitous Presence

Background: The term “biophenols” was first coined by Romeo and Uccella in 1996 to denote bioactive phenols in olives replacing the more common and less chemically accurate term “polyphenols”. “Biophenols” has started gaining popularity beyond olive chemistry and currently used by researchers to refer to plant phenols in general. Biophenols constitute the largest group of secondary plant metabolites with ubiquitous presence in plants and wide spectrum of biological activities. During the last three decades, biophenols have seized scientific attention, lured industry and attracted consumers’ interest due to their antioxidative potential in preservation of food and maintaining human health. For the first time, a definition for “biophenols” has been proposed to present a more precise and comprehensive umbrella term to encompass all phenolic compounds of botanical origin. In this article, the author is tracing the landmarks of the history of biophenol research; profiling contemporary research directions; highlighting research controversies and uncertainties; and presenting an outlook of the biophenols future research. Keywords: polyphenols, chemistry, pharmacology, biological activities, antioxidant

Download Full-text

Primary investigating chemical constituents of bioactive extract from Centrostachys aquatica (R.Br.) Wall. ex Moq.-Tand.

Can Tho University Journal of Science ◽

10.22144/ctu.jen.2021.043 ◽

2021 ◽

Vol 13 (3) ◽

pp. 71-78

Author(s):

Quoc Luan Ngo ◽

Thao Cuong Ta ◽

Thi Manh Huynh Tran ◽

Minh Dan Le ◽

Khac Khong Minh Ngo ◽

...

Keyword(s):

Ethyl Acetate ◽

Methanol Extract ◽

Biological Activities ◽

Chemical Constituents ◽

Mekong Delta ◽

Cancer Cell Line ◽

Published Data ◽

Antioxidant Ability ◽

First Time ◽

Crude Methanol Extract

This study is aimed to screen the biological activities and chemical composition to find evidences for potential medicinal applications of Centrostachys aquatica in the Mekong Delta. Crude methanol extract and subextracts in n-hexane, ethyl acetate, and acetone from Centrostachys aquatica were tested bioactivities. The methanol extract, n-hexane and ethyl acetate subextracts exhibited antimicrobial activity with corresponding MIC values of 200, 100 and 200 µg/mL, respectively. The ethyl acetate subextract was inhibited cytotoxicity against cancer cell line LU-1 with IC50 of 27.66 µg/mL. None of the extracts showed antioxidant ability. Three known secondary metabolites including oleanolic acid (1), 20(E)-hydroxy-b-ecdysone (2), and b-spinasterol (3) were isolated for the first time from the bioactive (ethyl acetate) subextract of Centrostachys aquatica. Their structures were elucidated by modern spectra as MS, NMR and comparison with published data.

Download Full-text

Chemical analysis and biological activities of methanol extracts from Astragalus gombiformis Pomel (Fabaceae)

Planta Medica ◽

10.1055/s-0031-1282825 ◽

2011 ◽

Vol 77 (12) ◽

Author(s):

H Teyeb ◽

O Houta ◽

A Lamari ◽

M Neffati ◽

W Douki ◽

...

Keyword(s):

Chemical Analysis ◽

Biological Activities ◽

Methanol Extracts

Download Full-text

First report of Rinamba opacicollis Cameron (Hymenoptera: Braconidae, Doryctinae) in India as parasitoid of coffee stem borer, Xylotrechus quadripes (Chevrolat) (Coleoptera: Cerambycidae)

ENTOMON ◽

10.33307/entomon.v44i4.486 ◽

2020 ◽

Vol 44 (4) ◽

pp. 311-314

Author(s):

A. Roobakkumar ◽

H.G. Seetharama ◽

P. Krishna Reddy ◽

M.S. Uma ◽

A. P. Ranjith

Keyword(s):

Integrated Control ◽

Host Record ◽

Stem Borer ◽

Arabica Coffee ◽

First Report ◽

The World ◽

First Time

Rinamba opacicollis Cameron (Hymenoptera: Braconidae) was collected from Chikkamagaluru, Karnataka, India for the first time from the larvae of white stem borer, Xylotrechus quadripes Chevrolat infesting arabica coffee. Its role in the biological or integrated control of X. quadripes remains to be evaluated. White stem borer could be the first host record of this parasitoid all over the world.

Download Full-text

Dwindling status of Epimedium Elatum (Morren & Decne) and its geographical distribution in Kashmir Himalaya, India

Current Botany ◽

10.25081/cb.2018.v9.20180106 ◽

2018 ◽

pp. 47-52

Keyword(s):

Medicinal Plant ◽

Biological Activities ◽

Conservation Status ◽

Natural Populations ◽

Culture Techniques ◽

Kashmir Himalayas ◽

Near Future ◽

First Time ◽

Tissue Culture Techniques

Epimedium elatum (Morren & Decne) of family Berberidaceace is a rare perennial medicinal plant, endemic to high altitude forests of Northwestern Himalayas in India. Ethnobotanically, it has been used as an ingredient for treatment of bone-joint disorders, impotence and kidney disorders in Kashmir Himalayas. Phytochemically, it is rich in Epimedin ABC and Icariin; all of these have been demonstrated to possess remarkable biological activities like PDE-5 inhibition (treatment of erectile dysfunction), anticancer, antiosteoporosis antioxidant and antiviral properties. The present investigation reports its traditional usage, comprehensive distribution and conservation status from twenty ecogeographical regions in Kashmir Himalayas, India. The species was reported from Gurez valley for the first time. Numerous threats like excessive grazing, deforestration, habitat fragmentation, tourism encroachment, landslides and excessive exploitation have decreased its natural populations in most of the surveyed habitats. Consequently, its existence may become threatened in near future if timely conservation steps are not taken immediately by concerned stakeholders involved in medicinal plant research. Moreover, use of plant tissue culture techniques is recommended for development of its in vitro propagation protocols. Therefore, introduction of this medicinal plant in botanical gardens, protected sites and development of monitoring programmes are needed for its immediate conservation in Northwestern Himalayas, India.

Download Full-text

Diverse chemical and biological potentials of various pyridazine and pyridazinone derivatives

10.31221/osf.io/n5xvt ◽

2019 ◽

Author(s):

Chem Int

Keyword(s):

Heterocyclic Compounds ◽

Biological Activities ◽

Wide Spectrum ◽

Biological Properties ◽

Industrial Chemical ◽

Anti Inflammatory ◽

Pyridazinone Derivatives

A series of heterocyclic compounds incorporating pyridazine moiety were for diverse biological activities. Pyridazines and pyridazinones derivatives showed wide spectrum of biological activities such as vasodialator, cardiotonic, anticonvulsant, antihypertensive, antimicrobial, anti-inflammatory, analgesic, anti-feedant, herbicidal, and various other biological, agrochemical and industrial chemical activities. The results illustrated that the synthesized pyridazine/pyridazine compounds have diverse and significant biological activities. Mechanistic insights into the biological properties of pyridazinone derivatives and various synthetic techniques used for their synthesis are also described.

Download Full-text