Proton Spectroscopy of the Pediatric Brain

1992 ◽  
Vol 5 (1_suppl) ◽  
pp. 5-8 ◽  
Author(s):  
R.A. Zimmerman ◽  
Z. Wang
Keyword(s):  
Biochemical Markers ◽  
Pediatric Patients ◽  
Imaging Findings ◽  
Proton Spectroscopy ◽  
New Era ◽  
Tissue Abnormalities ◽  
Future Evaluation ◽  
Pediatric Brain ◽  
Initial Results

Initial results from proton spectroscopy performed on the brains of 80 pediatric patients indicate both a research and clinical investigative role for MRS in the future evaluation of pediatric patients. Proton spectroscopy in the evaluation of pediatric brain disease is only in its infancy. However, even though the number of cases that have been studied is not great, its value as a window into in vivo biochemistry is already obvious. The ability to correlate biochemical markers to imaging findings opens up a new era in magnetic resonance research. Proton spectroscopy remains a research tool, but one that has proven to be of value by adding in vivo biochemical information regarding tissue abnormalities seen and not seen on MRI.

In Vivo and In Vitro Taste Assessment of Artesunate-Mefloquine, Praziquantel, and Benznidazole Drugs for Neglected Tropical Diseases and Pediatric Patients

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Janine Boniatti ◽  
Marcelo R. R. Tappin ◽  
Rafaela G. da S Teixeira ◽  
Tamires de A V Gandos ◽  
Luis P. S. Rios ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Neglected Tropical Diseases ◽  
Tropical Diseases ◽  
Taste Assessment

In Vivo Evaluation of Bioprinted Cardiac Patches Composed of Cardiac-Specific Extracellular Matrix and Progenitor Cells in a Model of Pediatric Heart Failure

2021 ◽  
Author(s):  
Donald Bejleri ◽  
Matthew Robeson ◽  
Milton Brown ◽  
Jervaughn Hunter ◽  
Joshua Maxwell ◽  
...  
Keyword(s):  
Heart Failure ◽  
Extracellular Matrix ◽  
Congenital Heart ◽  
Pediatric Patients ◽  
Heart Defects ◽  
In Vivo Evaluation ◽  
Surgical Methods ◽  
Pediatric Heart Failure ◽  
The Right

Pediatric patients with congenital heart defects (CHD) often present with heart failure from increased load on the right ventricle (RV) due to both surgical methods to treat CHD and the...

Atlas of 99mTc-HMPAO SPECT brain perfusion in pediatric brain disorders

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Saleh A Othman ◽  
Keyword(s):  
Blood Flow ◽  
Neuronal Activity ◽  
Pediatric Patients ◽  
Brain Perfusion ◽  
Brain Disorders ◽  
Hmpao Spect ◽  
Perfusion Scan ◽  
Pediatric Brain ◽  
The Brain ◽  
99Mtc Hmpao

Background: Blood flow to the brain is in parallel with brain metabolism in almost all brain disorders except in brain tumors and therefore regional cerebral blood flow can be used as a marker of metabolic brain activity and hence it is closely linked to neuronal activity, the activity distribution is presumed to reflect neuronal activity levels in different areas of the brain. Purpose: The aim of this work is to demonstrate to pediatrician in general and pediatric neurologist in particular the variations in cerebral perfusion during normal development which should be taken into consideration at the time of interpreting SPECT brain perfusion scan in different pediatric brain disorders. Method: Brain SPECT was performed 10 minutes after an intravenous injection of 11.1 MBq/kg (0.3 mCi/kg), and the minimum dose is 185 MBq (5 mCi) of 99mTc-HMPAO (4). Results: This was a retrospective analysis of SPECT brain perfusion scan of pediatric patients performed between October 2015 and December 2019 at our institution. We selected normal and abnormal studies in pediatric population with age range (5 months - 14 years). Conclusion: Although anatomic cross sectional imaging give details of neurological structural changes, SPECT perfusion mirrors indirectly both metabolic and neuronal activity changes. Therefore, accurate interpretation of SPECT perfusion will consolidate its role as part of the diagnostic protocol and used when the findings of other imaging modalities do not explain the symptoms or fail partially or completely in determining the etiology of brain disorders in pediatric patients.

scholarly journals SALMONELLA TYPHIMURIUM INFECTION: ANTIOXIDANT STATUS OF INFECTED POULTRY AND EFFICACY OF TREATMENT WITH KHAYA GRANDIFOLIOLA EXTRACT

2021 ◽  
Vol 10 (3) ◽  
pp. 72-79
Author(s):  
Elodie Yamako Konack ◽  
Jean Baptiste Sokoudjou ◽  
Norbert Kodjio ◽  
Gabriel Tchuente Kamsu ◽  
Huguette Bocanestine Laure Feudjio ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Biochemical Markers ◽  
Broiler Chickens ◽  
Antioxidant Status ◽  
Antioxidant Activities ◽  
The Body ◽  
Control Group ◽  
Enzymatic Antioxidants ◽  
Salmonella Infections

Salmonella infections remain one of the major health problems in both poultry farming and human medicine. In addition, resistance to Salmonella has emerged as a global health problem in both sectors. The present study aimed at evaluating the in vivo antisalmonellal and antioxidant activities of 95° ethanol extract of Khaya grandifoliola using broiler chickens as animal model. Animals were divided into the normal control group, negative control group, positive control group and three test groups treated with the extract at 10, 20 and 40 mg/kg respectively. The antioxidant status of broiler chickens was also evaluated by measuring the concentration of enzymatic antioxidants (catalase, glutathione peroxidase) and biochemical markers (malondialdehyde and nitric oxide). The results showed that infected animals treated with the Khaya grandifoliola extract at 40 mg/kg recovered on day 11 after the beginning of the treatment and on day 13 for those treated at the 10 and 20 mg/kg. The antioxidant assay showed that the infection led to the reduction of enzymatic markers in the body of infected animals, while the treatment increases such makers. The infection resulted in a significant increase in serum and pulmonary malondialdehyde. It also caused a significant decrease in cardiac and pulmonary nitric oxide whereas the treatment depending on the doses of the extract tends to normalize these biochemical markers. The overall results showed that Khaya grandifoliola extract can be successfully used in the treatment of avian salmonellosis as well as the management of the oxidative stress caused by the infection.

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