scholarly journals Proposal for a standardized discharge letter after hospital stay for acute myocardial infarction

2019 ◽  
Vol 9 (7) ◽  
pp. 788-801
Author(s):  
Francois Schiele ◽  
Gilles Lemesle ◽  
Denis Angoulvant ◽  
Michel Krempf ◽  
Serge Kownator ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Primary Care Physicians ◽  
Healthcare Providers ◽  
Therapeutic Targets ◽  
Lipid Lowering ◽  
Routine Practice ◽  
Discharge Letter ◽  
Acute Mi

In patients admitted for acute myocardial infarction, the communication and transition from specialists to primary care physicians is often delayed, and the information imparted to subsequent healthcare providers (HCPs) may be sub-optimal. A French group of cardiologists, lipidologists and diabetologists decided to establish a consensus to optimize the discharge letter after hospitalization for acute myocardial infarction. The aim is to improve both the timeframe and the quality of the content transmitted to subsequent HCPs, including information regarding baseline assessment, procedures during hospitalization, residual risk, discharge treatments, therapeutic targets and follow-up recommendations in compliance with European Society of Cardiology guidelines. A consensus was obtained regarding a template discharge letter, to be released within two days after patient’s discharge, and containing the description of the patient’s history, risk factors, acute management, risk assessment, discharge treatments and follow-up pathway. Specifically for post acute MI patients, tailored details are necessary regarding the antithrombotic regimen, lipid-lowering and anti-diabetic treatments, including therapeutic targets. Lastly, the follow-up pathway needs to be precisely mentioned in the discharge letter. Additional information such as technical descriptions, imaging, and quality indicators may be provided separately. A template for a standardized discharge letter based on 8 major headings could be useful for implementation in routine practice and help to improve the quality and timing of information transmission between HCPs after acute MI.

scholarly journals Routine Oxygen Therapy Does Not Improve Health-Related Quality of Life in Patients With Acute Myocardial Infarction—Insights From the Randomized DETO2X-AMI Trial

2021 ◽  
Vol 8 ◽  
Author(s):  
Robin Hofmann ◽  
Tamrat Befekadu Abebe ◽  
Johan Herlitz ◽  
Stefan K. James ◽  
David Erlinge ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Oxygen Therapy ◽  
Ambient Air ◽  
Related Quality ◽  
Health Related ◽  
Acute Mi

Background: After decades of ubiquitous oxygen therapy in all patients with acute myocardial infarction (MI), recent guidelines are more restrictive based on lack of efficacy in contemporary trials evaluating hard clinical outcomes in patients without hypoxemia at baseline. However, no evidence regarding treatment effects on health-related quality of life (HRQoL) exists. In this study, we investigated the impact of routine oxygen supplementation on HRQoL 6–8 weeks after hospitalization with acute MI. Secondary objectives included analyses of MI subtypes, further adjustment for infarct size, and oxygen saturation at baseline and 1-year follow-up.Methods: In the DETermination of the role of Oxygen in suspected Acute Myocardial Infarction (DETO2X-AMI) trial, 6,629 normoxemic patients with suspected MI were randomized to oxygen at 6 L/min for 6–12 h or ambient air. In this prespecified analysis, patients younger than 75 years of age with confirmed MI who had available HRQoL data by European Quality of Life Five Dimensions questionnaire (EQ-5D) in the national registry were included. Primary endpoint was the EQ-5D index assessed by multivariate linear regression at 6–10 weeks after MI occurrence.Results: A total of 3,086 patients (median age 64, 22% female) were eligible, 1,518 allocated to oxygen and 1,568 to ambient air. We found no statistically significant effect of oxygen therapy on EQ-5D index (−0.01; 95% CI: −0.03–0.01; p = 0.23) or EQ-VAS score (−0.57; 95% CI: −1.88–0.75; p = 0.40) compared to ambient air after 6–10 weeks. Furthermore, no significant difference was observed between the treatment groups in EQ-5D dimensions. Results remained consistent across MI subtypes and at 1-year follow-up, including further adjustment for infarct size or oxygen saturation at baseline.Conclusions: Routine oxygen therapy provided to normoxemic patients with acute MI did not improve HRQoL up to 1 year after MI occurrence.Clinical Trial Registration:ClinicalTrials.gov number, NCT01787110.

Short and Midterm Outcomes in Patients With Acute Myocardial Infarction: Results of the Nationwide TURKMI Registry

Angiology ◽  
2020 ◽  
pp. 000331972097530
Author(s):  
Mustafa Kilickap ◽  
Mustafa Kemal Erol ◽  
Meral Kayikcioglu ◽  
Ibrahim Kocayigit ◽  
Mesut Gitmez ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Hospital Mortality ◽  
Coronary Intervention ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Percutaneous Coronary ◽  
Acute Mi

This recent Turkish Myocardial Infarction registry reported that guidelines are largely implemented in patients with acute myocardial infarction (MI) in Turkey. We aimed to obtain up-to-date information for short- and midterm outcomes of acute MI. Fifty centers were selected using probability sampling, and all consecutive patients with acute MI admitted to these centers (between November 1 and 16, 2018) were enrolled. Among 1930 (mean age 62 ± 13 years, 26% female) patients, 1195 (62%) had non-ST segment elevation myocardial infarction (NSTEMI) and 735 (38%) had ST segment elevation myocardial infarction (STEMI). Percutaneous coronary intervention (PCI) was performed in 94.4% of patients with STEMI and 60.2% of those with NSTEMI. Periprocedural mortality occurred in 4 (0.3%) patients. In-hospital mortality was significantly higher in STEMI than in patients with NSTEMI (5.4% vs 2.9%, respectively; P = .006). However, the risk became slightly higher in the NSTEMI group at 1 year. Women with STEMI had a significantly higher in-hospital mortality compared with men (11.2% vs 3.8%; P < .001); this persisted at follow-up. In conclusion, PCI is performed in Turkey with a low risk of complications in patients with acute MI. Compared with a previous registry, in-hospital mortality decreased by 50% within 20 years; however, the risk remains too high for women with STEMI.

scholarly journals Quality of Life after Coronary Revascularization in Patients with Acute Myocardial Infarction

2016 ◽  
Vol 1 (1) ◽  
pp. 51-54
Author(s):  
Mihaela Susca ◽  
Monica Copotoiu ◽  
Horaţiu Popoviciu ◽  
Zsuzsanna Szőke ◽  
Balázs Bajka ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Revascularization ◽  
Self Care ◽  
Female Group ◽  
Limited Mobility ◽  
Acute Mi

Abstract Background: The quality of life (QoL) in acute myocardial infarction (MI) patients can be improved using 3 therapeutic methods — surgical, pharmaceutical and physical. Study aim: We sought to assess the QoL in patients following an acute MI, with or without percutanous coronary intervention (PCI). Material and methods: A number of 54 patients with acute MI were included in the study. All subjects were asked to complete the EQ-SD questionnaire at baseline, and during the 12-month follow-up. The questionnaire consists of 2 parts: 1st part – assesses the mobility, self care, activities of daily life (ADL), pain, depression and anxiety; 2nd part – visual analogue scale (VAS) for the overall state. Patients were divided into 4 groups: Group 1 – all patients (n = 54); Group 2 – males (n = 40), Group 3 – female patients (n = 14), and Group 4 – patients who underwent a PCI procedure (n = 48). Blood pressure (BP) was also monitored. Results: The mean age was 66.54 years. There were no differences between the groups at baseline, and after 1 year regarding the BP. No differences were observed regarding the VAS (baseline p = 0.990; 12-month p = 0.991). Concerning the PCI vs. non-PCI groups, no differences were found in relation to mobility, self-care, ADL, pain and depression at baseline or after 12 months. For all groups at baseline, the limited mobility was positively correlated with impaired self-care (p = 0.041) and lower ADLs (p = 0.003). After 1 year, a limited mobility was associated with defective self-care (p <0.001) and decreased ADLs (p = 0.004) and there was an improvement in mobility (p = 0.0002) and self-care (p <0.0001), compared to baseline. The PCI group associated pain with depression at baseline (p <0.001) and limited mobility with lack of ADLs (p = 0.005). At 12 months, we observed an improvement in mobility, self-care (p <0.001), and the ADLs (p <0.001). The males showed a positive association between depression and pain (p <0.001) at baseline, but not after 1 year. Mobility was the only parameter that had improved during follow-up (p = 0.043). In the female group, pain (p = 0.015) and mobility (p = 0.033) had improved after 12 months. Conclusions: The QoL had improved in terms of mobility, self-care and new skills acquired after PCI. Both depression and pain were ameliorated in the male group, despite the lack of improvement on VAS for the overall state.

Abstract 3745: Asymmetric Dimethylarginine and Mortality after Acute Myocardial Infarction

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Marianne Zeller ◽  
Claudia Korandji ◽  
Jean-Claude Guilland ◽  
Pierre Sicard ◽  
Catherine Vergely ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
High Performance ◽  
Serum Levels ◽  
Competitive Inhibitor ◽  
Cardiovascular Risk Prediction ◽  
Acute Mi ◽  
The Mean ◽  
Traditional Risk Factors

Background . From a prospective cohort of patients with acute myocardial infarction (MI), we aimed to analyse the predictive value of ADMA concentrations on mortality at 1 year follow-up. ADMA is an endogenous competitive inhibitor of NO synthases. Patients . Blood samples from 204 consecutive patients hospitalised for acute MI < 24 hr were taken on admission. Serum levels of ADMA, its stereoisomer, symmetric dimethylarginine (SDMA), were determined using high-performance liquid chromatography and fluorescence. Results . The mean (SD) ADMA level was 1.07(0.37) μmol/L. ADMA was positively related to age, homocysteine, SDMA and L-arginine. The glomerular filtration rate (GFR) showed a trend toward an inverse relation with ADMA. ADMA concentrations showed a trend towards a higher level in women than in men (p=.101) and were lower in current smokers vs past or non smokers (p=0.022). Baseline ADMA and SDMA levels were higher in patients who had died than in patients who were alive at 1 year follow-up (respectively 1.22(1.06–1.54) vs 0.98(0.78–1.24), p=0.012 and 0.77(0.54–1.03) vs 0.47(0.35–0.64), p<0.001). By Cox stepwise multivariate analysis, high levels of ADMA were one of the strongest predictors for mortality (HR(95%CI), 6.63(2.55–17.21)), even when adjusted for potential confounders, such as biological and clinical factors, and reperfusion. In contrast, SDMA failed to independently predict the outcome (HR(95%CI): 1.88(0.33–10.70). Conclusion . Our study suggests that measurement of ADMA levels at baseline improves cardiovascular risk prediction after acute MI, beyond traditional risk factors and biomarkers. ADMA may thus constitute a novel and useful marker for risk stratification in acute MI.

Rates Of Fibrin Growth As A Predictor Of Acute Myocardial Infarction. A Prospective Blind Study

1981 ◽  
Author(s):  
D Joe Baughman ◽  
J B Kostis
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Risk Ratio ◽  
Thrombin Time ◽  
Lysis Time ◽  
Coagulation Tests ◽  
At Iii ◽  
Acute Mi ◽  
Artery Disease

A blind prospective coagulation profile was performed on 147 patients with coronary artery disease (CAD). Theprofile consisted of Prothrombin time (PT), the maximum rate of fibrin production (turbidity) when measuring the PT (PT Vmax), Activated Partial Thromboplastin time (APTT), APTT Vmax, Thrombin time (TT), TT Vmax, Fibrinogen (F), plasma and serum Antithrombin III (At-III), Lysis Time (LT) and Lipoproteins (LP). All clotting times and turbidities were measured using a BioData CP-7; At-III was measured as the loss of thrombin clotting activity; F was measured as the total thrombin clottable protein; LT was measured by a modified CLUE test; LP was measured as a heparin-Mg produced turbidity.During 41 months of follow-up, 12 patients developed a new myocardial infarction (MI), and had significantly higher APTT Vmax (7.46 ± .30U vs. 6.21 ± .09U, p=.0001); PT Vmax (7.83 ± .27U vs. 6.46 ± .10U, p=.0002); TT Vmax (5.33 ± .32U vs. 4.20 ± LOU, p=.0014); and F (339.6 ± 12.2 mg/dl vs. 292.76 ± 4.6 mg/dl, p=.003) than patients who did not. Out of 37 patients with the highest PT Vmax (upper 25%), 27% developed acute MI, while only 2 (1.8%) of the remaining 110 developed MI, giving a risk ratio of 15.4, p=.0001. Similarly, 9 out of 12 infarctions occurred in the upper 25% of APTT Vmax, giving a risk ratio of 8.9, p=0.0004. MI was also predicted by TT Vmax with a risk ratio of 5.9 (p=0.0004) and by fibrinogen with a risk ratio of 4.8 (p=0.0018). No relationship between MI and the other coagulation tests was noted. Thus, 1. rates of fibrin growth may predict the occurrence of MI in CAD, and 2. soluble coagulation parameters are important in the pathogenesis of acute myocardial infarction.

scholarly journals Left Ventricular Ejection Fraction 1 Year After Acute Myocardial Infarction Identifies the Benefits of the Long-Term Use of β-Blockers

2021 ◽  
Vol 14 (4) ◽  
Author(s):  
Chan Soon Park ◽  
Han-Mo Yang ◽  
You-Jeong Ki ◽  
Jeehoon Kang ◽  
Jung-Kyu Han ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Acute Mi ◽  
Β Blockers

Background: β-Blockers can improve prognosis after acute myocardial infarction. However, it remains unclear how long β-blockers should be prescribed. Methods: We included patients from the prospective, nationwide Korea Acute Myocardial Infarction Registry-National Institutes of Health registry and collected data on β-blockers and left ventricular ejection fraction (LVEF) at 1-year follow-up. Patients were stratified into 2 groups: 1001 patients with a 1-year LVEF<50% and 3007 patients with a 1-year LVEF≥50%. The primary outcome was 2-year all-cause mortality from the 1-year follow-up. Results: A total of 3177 patients received β-blockers at 1 year, and 151 patients died during the 2-year follow-up from 1 year after index hospitalization. β-Blockers showed survival benefits in patients with a 1-year LVEF<50% (log-rank P =0.001) but not in those with a 1-year LVEF≥50% (log-rank P =0.311). After adjusting covariates, β-blockers were associated with a 51% reduction in mortality in patients with a 1-year LVEF<50% ( P =0.020) but not in their counterparts ( P =0.322). Indeed, there was a prognostic interaction between the use of β-blockers at 1 year and 1-year LVEF ( P for interaction=0.004). Conclusions: Use of β-blockers at 1-year follow-up after acute MI was associated with improved outcomes in patients with an LVEF<50% at 1 year but not in those with an LVEF>50% at 1 year. This study provides valuable information about differential responsiveness to β-blockers according to 1-year LVEF and might suggest the proper duration of β-blockers after acute MI. Registration: URL: http://cris.nih.go.kr/cris/en/ ; Unique identifier: KCT0000863.

EFFICACY OF INTRAVENOUS STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION: ACUTE AND FOLLOW UP STUDY

1987 ◽  
Author(s):  
R Lochan ◽  
S Tyagi ◽  
B S Yadav ◽  
D K M Rao ◽  
A Bhat ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Left Ventricular ◽  
Control Group ◽  
Coronary Angiogram ◽  
Intravenous Streptokinase ◽  
Follow Up Study ◽  
Group I ◽  
Acute Mi

The efficacy of intravenous streptokinase on recanalization of the 'infarct vessel' and its effect on left ventricular function was assessed in two groups of patients. Group I consisted of 90 consecutive patients (age 32-75 years, mean 56 years) received 500,000 units of intravenous streptokinase (STK) over 30 minutes within 6 hours of onset of acute myocardial infarction (MI). Forty-eight patients had anterior MI and forty-two had inferior MI. The control group consisted of forty survivors of acute MI comparable in age and site of infarction. In Group I, ten patients were administered STK after baseline coronary angiogram demonstrated total occlusion of infarct related coronary artery. In these patients, serial coronary angiogram were done at intervals of 30 minutes after STK infusion upto a period of 3 hours. Recanalization was seen in all cases within 75-135 minutes (average 120 minutes). Seventy-nine of STK group and all of the control group underwent selective coronary arteriography and contrast left ventriculography within 48 to 72 hours of acute MI. Recanalization of infarct related artery was demonstrated in 72 out of 79 patients (91%) in STK group while 8 (20%) in control group had spontaneous recanalization. Left ventricular ejection fraction (LVEF) was higher in STK group (58%) as compared to control group (49%). Among patients with anterior MI, LVEF was significantly better in STK compared to control group (59% Vs. 44%, p > 0.01)while in inferior MI the difference was not significant (63% Vs. 59.4%, p > 0.05) in the two groups. Follow up study in 20 STK patients at 6 months revealed a decrease in residual stenosis from 75 ± 8% to 60 ± 6% and improvement in LVEF from 59 ± 8% to 68 ± 12% (p > 0.01). In conclusion, intravenous STK in acute MI results in high rate of infarct vessel patency and improved global left ventricular function during both early and late follow up period.

scholarly journals Outpatient Register of Patients with Acute Myocardial Infarction: Assessment of the Hypertension Impact on Long-term Prognosis

2019 ◽  
Vol 15 (5) ◽  
pp. 706-712
Author(s):  
D. P. Sichinava ◽  
E. P. Kalaydzhyan ◽  
N. P. Kutishenko ◽  
S. Yu. Martsevich
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Unstable Angina ◽  
Hypertensive Crisis ◽  
Lipid Lowering ◽  
Cerebral Stroke ◽  
Long Term Outcomes

Aim. To assess the impact of arterial hypertension (AH) on the long-term outcomes in patients after acute myocardial infarction (AMI).Material and methods. 160 patients were included: 106 (66.2%) men and 54 (33.8%) women, average age 74.2±11.2 years, discharged from Moscow hospitals with a diagnosis of AMI (from March 01, 2014 till June 30, 2015) and applied to the city polyclinic №9 in Moscow or its branches for outpatient observation. The information was obtained on the basis of medical documentation of the polyclinic and data of patients’ examination/questioning by phone, conducted every 2 months. The follow-up duration was 1 year, the incidence of cardiovascular complications (CVC) was estimated: death, nonfatal AMI, nonfatal cerebral stroke, new cases of atrial fibrillation (AF), hospitalization for unstable angina, hypertensive crisis, heart failure, unplanned surgical interventions on the heart and blood vessels.Results. AH before the development of reference AMI was observed in 118 (73.4%) patients: 48 women and 70 men; in women, AH was recorded more often than in men: 88.9% and 66.0%, respectively, p<0.05. Patients with AH were older than patients without AH: 63.0 (54.0; 74.0) and 55.5 (49.0; 61.0) years, respectively, p<0.001, among them there were more retirees 76 (64.4%) and patients with disabilities 45 (38.1%), p<0.05. Patients with AH compared with patients without AH were less likely to smoke (18.6% and 38.1%, respectively) and drank alcohol (30.5% and 52.4%, respectively), p<0.05 for both; more likely to visit the outpatient clinic (89.0% and 66.7%, respectively), p<0.05. There were no significant differences between the groups of patients with and without AH in the history of cerebral stroke, AMI, arrhythmia by AF type, diabetes mellitus and obesity, except for angina of tension (18.6% and 2.4%, respectively) and hypercholesterolemia (37.3% and 11.9%, respectively), p<0.05 for both. Despite the fact that patients with AH were significantly more often prescribed antihypertensive, lipid-lowering and antithrombotic drugs before reference AMI, the frequency of their use was low: renin-angiotensin-aldosterone system blockers were prescribed in 70 (59.3%) patients, beta-blockers – in 35 (29.7%), calcium antagonists – in 20 (16.9%), diuretics – in 13(11.0%), antiplatelet agents – in 39 (33.1%), statins – in 9 (7.6%) patients. After one year of follow-up, CVC was registered in 33 (28.0%) patients with AH and 9 (21.4%) patients without AH (p=0.41). There was no statistically significant effect of AH on long-term outcomes of AMI, adjusted risk ratio =1.30 [95% confidence interval 0.68- 2.49], p>0.05. The effect of AH on the development of CVC, estimated using the Kaplan-Mayer curve, was not statistically significant (p=0.120).Conclusion. During 1 year of follow-up after AMI in patients with AH the frequency of CVC – death, nonfatal AMI, nonfatal cerebral stroke, new cases of AF, hospitalization for unstable angina, hypertensive crisis, heart failure – did not exceed the overall frequency of CVC in patients without AH.

scholarly journals Changes in pattern of complications in acute myocardial infarction over a ten-year follow-up: gender specificities

2020 ◽  
Vol 19 (3) ◽  
pp. 2325
Author(s):  
S. A. Okrugin ◽  
A. N. Repin
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
World Health ◽  
Men And Women ◽  
Conduction Disorders ◽  
Number Of Patients ◽  
Acute Mi ◽  
Complicated Course ◽  
Health Organization

Aim. To compare changes in pattern of complications in acute myocardial infarction (MI) among Tomsk population at the age of >20 years over a ten-year follow-up period (2008-2017).Material and methods. The study was carried out on the basis of the World Health Organization Acute Myocardial Infarction Registry. In 2008, 800 MI cases were recorded (62,4% — men; 37,6% — women (p<0,001)). In 2017, acute MI was restarted in 906 patients (58,1% — men; 41,9% — women (p<0,05)). According to age pattern in 2008, there were 62,1% of patients >60 years of age (among men — 49,1%; among women — 83,7% (p<0,0001)), which after 10 years were 74,5 % (p<0,001).Results. In 2008, a complicated course of MI was observed in 49,9% of patients, in 2017, much more often — in 80,4% of patients (p<0,001). Over the analyzed period, incidence of acute aneurysm, myocardial rupture, and recurrent MI decreased. At the same time, the number of patients with post-MI heart failure (HF) significantly increased. In 2008, there were no significant differences in the incidence of MI complications in men and women. The most common complication in both men and women was arrhythmias and conduction disorders. After 10 years, the statistics remained virtually unchanged, with the exception of pulmonary embolism, which was significantly more common in women. Noteworthy is a significant increase in the number of HF patients (among men and women).Conclusion. Over a ten-year follow-up period, significant changes in patterns of MI complications in Tomsk were not revealed. It should be noted that MI became more severe and was more often accompanied by complications, the most common of which was HF. This is due to an increase in the age pattern of elderly and senile patients.

scholarly journals Mobilization of CD34+CXCR4+ Stem/Progenitor Cells and the Parameters of Left Ventricular Function and Remodeling in 1-Year Follow-up of Patients with Acute Myocardial Infarction

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Rafał Wyderka ◽  
Wojciech Wojakowski ◽  
Tomasz Jadczyk ◽  
Katarzyna Maślankiewicz ◽  
Zofia Parma ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Significant Positive Correlation ◽  
Troponin I ◽  
Left Ventricular ◽  
Prospective Evaluation ◽  
Acute Mi ◽  
Cell Mobilization ◽  
Number Of Cells

Mobilization of stem cells in acute MI might signify the reparatory response.Aim of the Study. Prospective evaluation of correlation between CD34+CXCR4+ cell mobilization and improvement of LVEF and remodeling in patients with acute MI in 1-year followup.Methods. 50 patients with MI, 28 with stable angina (SAP), and 20 individuals with no CAD (CTRL). CD34+CXCR4+ cells, SDF-1, G-CSF, troponin I (TnI) and NT-proBNP were measured on admission and 1 year after MI. Echocardiography and ergospirometry were carried out after 1 year.Results. Number of CD34+CXCR4+ cells in acute MI was significantly higher in comparison with SAP and CTRL, but lower in patients with decreased LVEF ≤40%. In patients who had significant LVEF increase ≥5% in 1 year FU the number of cells in acute MI was significantly higher versus patients with no LVEF improvement. Number of cells was positively correlated () with absolute LVEF change and inversely with absolute change of ESD and EDD in 1-year FU. Mobilization of CD34+CXCR4+ cells in acute MI was negatively correlated with maximum TnI and NT-proBNP levels.Conclusion. Mobilization of CD34+CXCR4+ cells in acute MI shows significant positive correlation with improvement of LVEF after 1 year.

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